Gene VEGFR2 (Sea Urchin)

VEGFR2

Species: Sea Urchin
Alias: SPU_021021, VEGFR2, Spk282
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: VEGFR

Sequence

Name Sequence Type Origin Length Description Download
VEGFR2.AA Protein None 1582 None Fasta, JSON
VEGFR2.kin_dom Protein Kinase Domain None 316 None Fasta, JSON

Protein domain

Protein domains of VEGFR2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG VEGFR2.AA IG 116-228 18 7e-12 46.71 SMART 1-58 (58) Show / Hide 
Range on Protein: 116-228
Range on HMM: 1-58/58
Sequence Identity: 18% (22 aa)

PDTVQVTEGLSATLHCNYTVPIIDSSLDQLDQDLEPVQVSNQDPTITWLKDGAVLRTYSGVGRNTVTQSDRIAIVAPTSLMISRAVDEDA---GTYTCQI
|  | | || ..||.| ..                         .|.|.                              | | ..  ||.   |||.|| 
PP-VTVKEGETVTLTC-VS-------------------------QIWWY------------------------------LTI-NVQPEDSQQHGTYYCQA

EQGALIGSA--SATLNVV
.  .  ...  ..|| | 
T--HGQYWSIQGTTLTVQ
I-set VEGFR2.AA I-set 156-227 27 1.6e-09 34.84 Pfam 27-92 (92) Show / Hide 
Range on Protein: 156-227
Range on HMM: 27-92/92
Sequence Identity: 27% (21 aa)

NQDPTITWLKDGAVLRTYSGVGRNTVTQSDRIAIVAPT----SLMISRAVDEDAGTYTCQIEQGALIGSASATLNV
. .|...|.|||. ||.           |||. ...      .|.||..  .|.|.|||. .  .   ...|.|.|
DPPPQVSWFKDGQPLRP----------DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
V-set VEGFR2.AA V-set 109-227 19 8.5e-09 32.17 Pfam 1-128 (128) Show / Hide 
Range on Protein: 109-227
Range on HMM: 1-128/128
Sequence Identity: 19% (28 aa)

NILVTV-HPD----TVQVTEGLSATLHCNYTVPIIDSSLDQLDQDLEPVQVSNQDPTITWLK-DGA------------VLRTYSGVGRNTVTQSDRIAIV
 . ||. .|      | | || |.||.| |.               ..   .... .|.| .   .             . . .| |. .   ..|. . 
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYS---------------DDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFS

APTS-----LMISRAVDEDAGTYTCQIEQG-ALIGSASATLNV
. .|     | || .  .| |||.|..  .  ..  .. .| |
GNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
IGc2 VEGFR2.AA IGc2 147-217 22 0.000297 15.66 SMART 1-56 (56) Show / Hide 
Range on Protein: 147-217
Range on HMM: 1-56/56
Sequence Identity: 22% (17 aa)

QDLEPVQVS-----NQDPTITWLKDGAVLRTYSGVGRNTVTQSDRIAIVAPTSLMISRAVDEDAGTYTCQIEQGAL
.  ..|.       | ||.|.|.| |  |                       .| |...  ||.|.|||. .  . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set VEGFR2.AA I-set 112-132 38 15.259193 0.96 Pfam 3-23 (92) Show / Hide 
Range on Protein: 112-132
Range on HMM: 3-23/92
Sequence Identity: 38% (8 aa)

VTVHPDTVQVTEGLSATLHCN
.| .|  |.|.|| .|.. |.
FTQKPKDVEVQEGETARFECQ
IG VEGFR2.AA IG 240-328 17 6.4e-09 36.88 SMART 1-58 (58) Show / Hide 
Range on Protein: 240-328
Range on HMM: 1-58/58
Sequence Identity: 17% (16 aa)

SYETSILEGETLRLQCKGSYPLSWTYYQGIDHSKVFIRSTLTPILDSSSWNETSELLVVNATTTDT---GYFTCTHTHDSEDFS-RDIYVYVN
.  ..  ||||..|.|  |  ..|.                              | . |..  |.   | ..|. |   ...|   ....| 
PP-VTVKEGETVTLTC-VS-QIWWY------------------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
IGc2 VEGFR2.AA IGc2 246-317 18 0.00019 17.52 SMART 1-56 (56) Show / Hide 
Range on Protein: 246-317
Range on HMM: 1-56/56
Sequence Identity: 18% (14 aa)

LEGETLRLQCK----GSYPLSWTYYQGIDHSKVFIRSTLTPILDSSSWNETSELLVVNATTTDTGYFTCTHTHDSE
.||....|.|.      .  .|.. | ..                      ..| . |.|  | || ||. ..   
HEGQSVTLTCPATGNPDPNIHWYKGQPLP--------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG VEGFR2.AA IG 341-423 13 0.127168 5.04 SMART 1-58 (58) Show / Hide 
Range on Protein: 341-423
Range on HMM: 1-58/58
Sequence Identity: 13% (12 aa)

TTTISVYALDPFILPCRVTVPSTEVNLVLPNGGVVSRDELPSYDNKIGFSVSGVEADLYQ--GDVSCRATYEGSTVE-QTYFVQII
   ..| . ..  |.| |.    .. .                     . . .|...  |  |.  |.||  |..   |.  ... 
PP-VTVKEGETVTLTC-VS----QIWWY--------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
IG VEGFR2.AA IG 432-519 13 0.10616 5.72 SMART 1-58 (58) Show / Hide 
Range on Protein: 432-519
Range on HMM: 1-58/58
Sequence Identity: 13% (13 aa)

TADIKIKEFTKLTLVCEGAQPLIWVHELPDLEVNIIVSTLRRPNGDVYYRSILDIDPAQYSNT---GYFSCLFLRYIKSEDLSL--RTSVYVF
   .  ||   .|| |  .  . |                            | | ..|....   | . |       . . .    | ..|.
PP-VTVKEGETVTLTC-VS-QIWWY---------------------------LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ
I-set VEGFR2.AA I-set 719-752 26 0.000965 15.21 Pfam 59-92 (92) Show / Hide 
Range on Protein: 719-752
Range on HMM: 59-92/92
Sequence Identity: 26% (9 aa)

FMIVENATLEEDGTYTCYAENIGLALEEEITVQV
. ...|.. .  |.|||.|.| .   | .....|
TLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG VEGFR2.AA IG 649-753 12 0.002472 18.32 SMART 1-58 (58) Show / Hide 
Range on Protein: 649-753
Range on HMM: 1-58/58
Sequence Identity: 12% (14 aa)

DKQEVIAYKEGFQLNCIGTVAAYLLSLENSVEYQPSFAWVRPGGQRPTELERKYDEFGFDTTTYDAQFIKFMIVENATLEED---GTYTCYAENIGLALE
 .  .    |  .|.|  .                .. |                                ... |...|     |||.| |.  | .  
PP-VTVKEGETVTLTC-VS----------------QIWWY-------------------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWS

-EEITVQVH
 ...|..|.
IQGTTLTVQ
I-set VEGFR2.AA I-set 820-848 31 1.940572 4.0 Pfam 64-92 (92) Show / Hide 
Range on Protein: 820-848
Range on HMM: 64-92/92
Sequence Identity: 31% (9 aa)

NVSEAHEGDYTVYVWNEYENATISFFFSV
||  . || ||... |..  |. ...  |
NVQPDDEGKYTCVATNSFGEAECTAELTV
IG VEGFR2.AA IG 859-952 15 1.2e-08 35.97 SMART 1-58 (58) Show / Hide 
Range on Protein: 859-952
Range on HMM: 1-58/58
Sequence Identity: 15% (15 aa)

TGSDIAYISDDLTLECHATVFFFTEIKWVFISPNGTDVWLNSSAPKYSFPLYSLVSTLLVTNVSFSDA---GSYVCVATNGSNPNWEKNA--SQVISVR
 .   .   ...||.| ..     .|.|                             | . ||...|.   | |.|.||     . .. .  .  ..|.
PP-VTVKEGETVTLTC-VS-----QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQAT-----HGQYWSIQGTTLTVQ
IGc2 VEGFR2.AA IGc2 865-938 24 1.7e-07 32.13 SMART 1-56 (56) Show / Hide 
Range on Protein: 865-938
Range on HMM: 1-56/56
Sequence Identity: 24% (18 aa)

YISDDLTLECHATVFFFTEIKWVFISPNGTDVWLNSSAPKYSFPLYSLVSTLLVTNVSFSDAGSYVCVATNGSN
 . ...||.|.|| .   .|.|..      . .|.              .|| ..||...|.| |.|.|.|  .
HEGQSVTLTCPATGNPDPNIHWYK------GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set VEGFR2.AA I-set 914-935 54 0.000344 16.73 Pfam 58-79 (92) Show / Hide 
Range on Protein: 914-935
Range on HMM: 58-79/92
Sequence Identity: 54% (12 aa)

STLLVTNVSFSDAGSYVCVATN
.|| ..||  .|.|.| |||||
YTLTISNVQPDDEGKYTCVATN
V-set VEGFR2.AA V-set 915-951 24 0.048025 8.88 Pfam 94-128 (128) Show / Hide 
Range on Protein: 915-951
Range on HMM: 94-128/128
Sequence Identity: 24% (9 aa)

TLLVTNVSFSDAGSYVCVATNGSNPNWEKNASQVISV
.|  .|.. || | | |...|.  . .   ..    |
SLTISNLQPSDSGTYYCAVWNC--NEDYFGHGTRLTV
IGc2 VEGFR2.AA IGc2 967-1028 24 0.004506 4.36 SMART 1-56 (56) Show / Hide 
Range on Protein: 967-1028
Range on HMM: 1-56/56
Sequence Identity: 24% (15 aa)

KAGENVTIRCFLVRGHPIPKVQLKKENVQVYLWQGVGNISYTLTADINAGGNYYCEALDANS
. |..||..|. ..| | | .. .| . ..  | .  .|.    .|    |.| |.|  ...
HEGQSVTLTCP-ATGNPDPNIHWYK-GQPLP-WNWTLTIKNVTPEDS---GYYTCYARNPWG
IG VEGFR2.AA IG 961-1038 16 0.006412 16.29 SMART 1-58 (58) Show / Hide 
Range on Protein: 961-1038
Range on HMM: 1-58/58
Sequence Identity: 16% (14 aa)

IGDSEVKAGENVTIRCFLVRGHPIPKVQLKKENVQVYLWQGVGNISYTLTADINAG---GNYYCEALDANSTSE--YAELVIE
 .  .||.||.||..|          ....                 |. .  .     |.|||.|  . ...    ..| ..
PP-VTVKEGETVTLTC-VS------QIWWY----------------LTINVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
I-set VEGFR2.AA I-set 955-988 38 16.440894 0.85 Pfam 1-33 (92) Show / Hide 
Range on Protein: 955-988
Range on HMM: 1-33/92
Sequence Identity: 38% (13 aa)

PKLKIEIGDSEVKAGENVTIRCFLVRGHPIPKVQ
||  . . | ||. || ..  |  |.|.| |.|.
PKFTQKPKDVEVQEGETARFEC-QVTGDPPPQVS
Kinase VEGFR2.AA VEGFR 1122-1439 61 1.1e-250 839.12 In-house 1-332 (332) Show / Hide 
Range on Protein: 1122-1439
Range on HMM: 1-332/332
Sequence Identity: 61% (203 aa)

LKLGGVIGKGAFGMVIKAVAVGIDGTENNITVAVKKLKSGATSLEKKALWAELKMLGHIGKHLNVVNFLGACT---QNGPVLAIVEFCCHGNLLDFLRSK
||||...|.||||.|..|.|.||...|...|||||.||.|||..|..||..|||||.|||.|||||||||.||   |.||...|||.||.|||...||.|
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLKEGATASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYLRTK

RKYFSETP----------EGTGSQSHTGHSSSTGASNTFQTSSGSERRMKAVYDQIIPEEVFSPLQDDPINSQDLLCYSFQVARGMEFLASKNVIHRDLA
|.||...|          |..|.|.|..|.......|.||.|.||..|||..||...|.|||.....||....||.|||||||||||||||...||||||
RMYFVPYPDKSPHMRQRKECMGPQDHQDHKRRRDSGNSFQSSFGSFFRMKKSYDDVEPDEVFEDMWKDPLTMEDLICYSFQVARGMEFLASRKCIHRDLA

ARNVLVTENYTLKICDFGLAKH-LYDDPDYVASGKQGRLPIKWMAPESIFDKVFTTYSDVWAYAVFLWEVFSLGGSPYPGIQIDEKFYNKIKNGYRMNAP
|||.|..||...||||||||.| .|.|||||..|.||||||||||||||||||.|||||||.|.|||||.||||||||||.||||.|.|..|.||||.||
ARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAP

DYAPPGVYDTMLECWTPEPEARPSFSILAVRL
||..|..|..||.||..|||.||.||.|...|
DYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase VEGFR2.AA Pkinase_Tyr 1122-1439 38 1.2e-138 470.2 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1122-1439
Range on HMM: 1-270/270
Sequence Identity: 38% (125 aa)

LKLGGVIGKGAFGMVIKAVAVGIDGTENNITVAVKKLKSGATSLE--KKALWAELKMLGHIGKHLNVVNFLGACT-QNGP--VLAIVEFCCHGNLLDFLR
...| ..|.||||.| |... | |. ...|.||||.|| ||.. .  .... .|.|.. ..|.| |.|...|.|| | .|  .. ..|...||.|||.||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

SKRKYFSETPEGTGSQSHTGHSSSTGASNTFQTSSGSERRMKAVYDQIIPEEVFSPLQDDPINSQDLLCYSFQVARGMEFLASKNVIHRDLAARNVLVTE
..|                                                      ...|.. .|||....|.|.|||.|.||| |||||||||.||||
KHR-----------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE

NYTLKICDFGLAKHLYDDPDYVASGKQGRLPIKWMAPESIFDKVFTTYSDVWAYAVFLWEVFSLGGSP-YPGIQIDEKFYNKI-KNGYRMNAPDYAPPGV
| . ||||||||. .|.|  |. ... |.|||||||||.|....||| ||||.. | .||.|..|..| |||.  .| .|..| ..|||| .|...|. .
NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEI

YDTMLECWTPEPEARPSFSILAVRL
|| |..|| ..|| ||.|| .  .|
YDLMKQCWHYDPEDRPTFSEIHEQL
Kinase VEGFR2.AA TyrKc 1122-1439 33 4.4e-133 449.34 SMART 1-280 (280) Show / Hide 
Range on Protein: 1122-1439
Range on HMM: 1-280/280
Sequence Identity: 33% (115 aa)

LKLGGVIGKGAFGMVIKAVAVGIDGTENNITVAVKKLKSGATSLEKKALWAELKMLGHIG-KHLNVVNFLGACTQN-------GPVLAIVEFCCHGNLLD
..|| ..| |||| | |...         |.||||.||..|    ....  |.... ..| .| |.|...|.|||        .|.. ..|...||.|.|
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRSKRKYFSETPEGTGSQSHTGHSSSTGASNTFQTSSGSERRMKAVYDQIIPEEVFSPLQDDPINSQDLLCYSFQVARGMEFLASKNVIHRDLAARNVL
.||..|.                                                         .. .||| ...|.|.|||.|.|||.|||||||||.|
YLRKHRPK--------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL

VTENYTLKICDFGLAKHLYDD-------PDYVASG-KQGR--LPIKWMAPESIFDKVFTTYSDVWAYAVFLWEVFSLGGSPYPGI----QIDEKFYNKIK
|.||.| ||.||||.. .|||         |.... |.|.  |||.|||||.|....||| ||||.. | .||.|..|..||||.      ..  ....|
VGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK

NGYRMNAPDY--------APPGVYDTMLECWTPEPEARPSFSILAVRL
.||||  |..        .|. .|. |..||  .|| ||.|| .  ..
QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase VEGFR2.AA TK 1122-1439 24 9.1e-121 406.82 In-house 1-486 (486) Show / Hide 
Range on Protein: 1122-1439
Range on HMM: 1-486/486
Sequence Identity: 24% (124 aa)

LKLGGVIGKGAFG---MVIKAVAVGID--------------------GTENNITVAVKKLKSG-ATSLE-KKA--------------LWAELKMLGH-IG
..|| ..|.|.||   .| |. . |..                    .......|||| ||.| |.| | ...              ...|.||. | .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

KHLNVVNFLGACTQN------------GPVLAIVEFCCHGN----LLDFLRSKRKYFSETPEGTGSQSHTGHSSSTG-ASNTFQTSSGSERRMKA-----
.| |.|...|.|||.            .|.. ..|...||.    |.|.||..|..|.. ... . |......|. . ..            |       
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSK-LHHC------------M-KGDITY

VYDQIIPEEVFSPLQDD----------------------------PINSQDLLCYSFQVARGMEFLASK------NVIHRDLAARNVLVTENYT------
  ..  |. .. . .||                            ... ..|| ...|.|.|||.|.||      |..||||||||.||.||..      
SHESNSPC-PEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFD

-----LKICDFG--------LAKHLYDDPDYVASG-----------------------KQGRLPIKWMAPESIFDKV---------FTTYSDVWAYAVFL
      ||.|||        ||. .|.| ||....                       ..|.|||.|||||...|.|         ||| ||||.. |..
GCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLM

WEVFSLG-GSPYPGIQI--------DEKFYNKIKNG--------------YRMNAPDYAP--------------PGVYDTMLECWTPEPEARPSFSILAV
||.|..| . .|.|.          .. .......|              .|| .|...|              . .|| |..|| ..|| ||.|| |  
WEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHE

RL
.|
QL
Kinase VEGFR2.AA TK-Unique 1122-1439 35 4e-109 368.83 In-house 1-294 (294) Show / Hide 
Range on Protein: 1122-1439
Range on HMM: 1-294/294
Sequence Identity: 35% (121 aa)

LKLGGVIGKGAFGMVIKAVAVGID-GTENNITVAVKKLKSGATSLEKKALWAELKMLGHIGKHLNVVNFLGACTQNG-PVLAIVEFCCHGNLLDFLRSKR
|..| |||.|||| |... ..||. . .  . ||||.|| .|| ..|...  |..|. ..|.| |.|..||.|| .. |.. | |.|  |||...||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

------------KYFSETPEGTGSQSHTGHSSSTGASNTFQTSSGSERRMKAVYDQIIPEEVFSPLQDDPINSQDLLCYSFQVARGMEFLAS--KNVIHR
            |                                           .... . .  ...||...||. . .|.|.|||.|||  |...||
PAMRQHQTYGNLK-------------------------------------------FDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHR

DLAARNVLVTENYTLKICDFGLAKHLYDDPDYVASGKQGRLPIKWMAPESIF--DKVF-TTYSDVWAYAVFLWEVFSLGGSPYPGIQIDEKFYNKIKNGY
||.|||||.||....||||||.|...|.. .|. ...|||.||.||||||.   .... || ||||...|..||.|.||. ||||.  .. . ..|..||
DLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGY

RMNAPDYA-PPGVYDTMLECWTPEPEARPSFSILAVRL
||. |..  .. .|  | .||. ||| ||||. .. ||
RMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase VEGFR2.AA PDGFR 1281-1439 60 9e-98 314.49 In-house 201-358 (358) Show / Hide 
Range on Protein: 1281-1439
Range on HMM: 201-358/358
Sequence Identity: 60% (96 aa)

QDLLCYSFQVARGMEFLASKNVIHRDLAARNVLVTENYTLKICDFGLAKHLYDDPDYVASGKQGRLPIKWMAPESIFDKVFTTYSDVWAYAVFLWEVFSL
.||||.|.|||.||||||||| .||||||||||...    ||||||||     |  ||  |   |||.|||||||||| |.|| |||| | ..|||.|||
WDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKG-NARLPVKWMAPESIFDCVYTTQSDVWSYGILLWEIFSL

GGSPYPGIQIDEKFYNKIKNGYRMNAPDYAPPGVYDTMLECWTPEPEARPSFSILAVRL
||.||||. .|.|||..||.||||  |..|| ..|. | .||  .|| ||.|. |   |
GGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
Kinase VEGFR2.AA UTK 1122-1439 27 8.3e-86 291.38 In-house 1-296 (296) Show / Hide 
Range on Protein: 1122-1439
Range on HMM: 1-296/296
Sequence Identity: 27% (97 aa)

LKLGGVIGKGAFGMVIKAVAVGIDGTENNITVAVKKLKSGATSLEKKA---LWAELK----MLGHIGKHLNVVNFLGACTQNGPVLAIVEFCCHGNLLDF
..||  .|.||||.| || .. ... .    ||||.....|..  ...    . |.     |...   | ||....| ||| .| . ..|... |.|...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRSKRKYFSETPEGTGSQSHTGHSSSTGASNTFQTSSGSERRMKAVYDQIIPEEVFSPLQDDPINSQDLLCYSFQVARGMEFLASKNVIHRDLAARNVLV
||. |. .                                                   ...  .. ..||.. ..||||..|.|....||||||||.||
LRRHRPTPP-------------------------------------------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLV

TEN-------YTLKICDFG---LAKHLY---------DDPDYVASGKQGRLPIKWMAPESIFDK-VFTTYSDVWAYAVFLWEVFSLGGSPYPGIQIDEKF
...       .. ||.|||   ... ..         ... | |.. |.|.||.|||||.. .   ||| ||||.. |..||... |  ||||.  ... 
HMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQH-QDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMS-NMQV

YNKIKNG--YRMNAPDYAPPGVYDTMLECWTPEPEARPSFSILAVRL
   . ||  |||..|.  |  ||. |..||...|. ||.|  |  ..
WHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase VEGFR2.AA Src 1122-1439 31 7.7e-76 257.13 In-house 1-255 (255) Show / Hide 
Range on Protein: 1122-1439
Range on HMM: 1-255/255
Sequence Identity: 31% (102 aa)

LKLGGVIGKGAFGMVIKAVAVGIDGTENNITVAVKKLKSGATSLEKKALWAELKMLGHIGKHLNVVNFLGACTQNGPVLAIVEFCCHGNLLDFLRSKRKY
.||   .|.| || | ...        .|. |||| ||.|   .. .|. .| . .    .| ..|. .  |.|  |.. . |. .||.|||.|.     
IKLCRKLGQGQFGEVWMGYW------NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----

FSETPEGTGSQSHTGHSSSTGASNTFQTSSGSERRMKAVYDQIIPEEVFSPLQDDPINSQDLLCYSFQVARGMEFLASKNVIHRDLAARNVLVTENYTLK
                                                    .   .. ..|.  . |||.||..| |.|.|||||||||||| ||   |
--------------------------------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCK

ICDFGLAKHLY-DDPDYVASGKQGRLPIKWMAPESIFDKVFTTYSDVWAYAVFLWEVFSLGGSPYPGIQIDEKFYNKIKNGYRMNAPDYAPPGVYD-TML
..|||||. .  ||  |.|.    ..||||.||| |   .||. |||| . . |.|... |  |||| .  | .  ....||||  |.  |. .|.  ||
VADFGLARLIKEDDDEYCARH-GAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVL-QQVERGYRMPCPHNCPDELYEQIML

ECWTPEPEARPSFSILAVRL
.||  .|| || | .|   |
QCWHKDPEQRPTFEYLQWFL
Kinase VEGFR2.AA FGFR 1280-1439 51 1.2e-74 253.86 In-house 135-293 (293) Show / Hide 
Range on Protein: 1280-1439
Range on HMM: 135-293/293
Sequence Identity: 51% (83 aa)

SQDLLCYSFQVARGMEFLASKNVIHRDLAARNVLVTENYTLKICDFGLAKHLYDDPDYVASGKQGRLPIKWMAPESIFDKVFTTYSDVWAYAVFLWEVFS
. ||    .|||||||.|||. .|||||||||||||..| .||||||||     . ||      |||||||||||. ||.|.|. |||| | | |||.. 
QKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDI-HCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMT

LGGSPYPGIQIDEKFYNKIKNGYRMNAPDYAPPGVYDTMLECWTPEPEARPSFSILAVRL
.||.|||.|   |  |   | |.||  |   .  .|  | .||  .|..||.|  |   |
YGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase VEGFR2.AA Tie 1280-1439 51 5e-61 184.19 In-house 113-267 (267) Show / Hide 
Range on Protein: 1280-1439
Range on HMM: 113-267/267
Sequence Identity: 51% (82 aa)

SQDLLCYSFQVARGMEFLASKNVIHRDLAARNVLVTENYTLKICDFGLAKHLYDDPDYVASGKQGRLPIKWMAPESIFDKVFTTYSDVWAYAVFLWEVFS
|| .| .   |||||..|. |..|||||||||.|| |||  || ||||..    |  ||     ||||..||| ||.   |.|| ||||.| |.|||. |
SQQILHFAADVARGMQYLSQKQCIHRDLAARNILVCENYVCKIADFGLSR---GDEVYVKK-TMGRLPVRWMAIESLNYSVYTTKSDVWSYGVLLWEIVS

LGGSPYPGIQIDEKFYNKIKNGYRMNAPDYAPPGVYDTMLECWTPEPEARPSFSILAVRL
||| || |.   | .|.|.  ||||. |      ||| | .||   |  ||.|. .||.|
LGGTPYCGMTCAE-LYEKLPQGYRMEQPRNCDDEVYDLMRQCWRDRPYERPPFAQIAVQL
Kinase VEGFR2.AA Ret 1276-1441 41 3e-58 197.55 In-house 125-293 (293) Show / Hide 
Range on Protein: 1276-1441
Range on HMM: 125-293/293
Sequence Identity: 41% (71 aa)

DPIN-----SQDLLCYSFQVARGMEFLASKNVIHRDLAARNVLVTENYTLKICDFGLAKHLYDDPDYVASGKQGRLPIKWMAPESIFDKVFTTYSDVWAY
|.||       ... .  |. .|| .|..  ..||||||||||| |   .|| ||||    | |  ||   | .|.|.||||.|| .| |.|| |||| .
DVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSK-DRIPVKWMAIESLYDHVYTTKSDVWSF

AVFLWEVFSLGGSPYPGIQIDEKFYNKIKNGYRMNAPDYAPPGVYDTMLECWTPEPEARPSFSILAVRLGD
 | .||.  .|..|||||   |. ..  | ||||  |.     .|  |. ||  ||. ||.|  ..  .  
GVLCWEIVTMGANPYPGIPP-ERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase VEGFR2.AA RTKB 1277-1439 42 9.3e-57 189.86 In-house 105-264 (264) Show / Hide 
Range on Protein: 1277-1439
Range on HMM: 105-264/264
Sequence Identity: 42% (70 aa)

PINSQDLLCYSFQVARGMEFLASKNVIHRDLAARNVLVTENYTLKICDFGLAKHLYDDPDYVASGKQGRLPIKWMAPESIFDKVFTTYS-DVWAYAVFLW
.. .. |. .. |.|.|| || ..|||||||.||||||. . . ||||||.|  . |. .|       |||||||||||. .. .|| | |||.. |  |
SLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREI-DHECYETTCT--RLPIKWMAPESWAHRIYTTKSGDVWSFGVTMW

EVFSLGGSPYPGIQIDEKFYNKIKNGYRMNAPDYAPPGVYDTMLECWTPEPEARPSFSILAVRL
|.||||| ||.  .  . ||     |.|.  |  .|. ... |  ||  |...||.|. |.  .
EIFSLGGTPYQQYRNGDIFYW-LESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase VEGFR2.AA PDGFR 1122-1222 49 1.6e-46 147.18 In-house 1-101 (358) Show / Hide 
Range on Protein: 1122-1222
Range on HMM: 1-101/358
Sequence Identity: 49% (50 aa)

LKLGGVIGKGAFGMVIKAVAVGIDGTENNITVAVKKLKSGATSLEKKALWAELKMLGHIGKHLNVVNFLGACTQNGPVLAIVEFCCHGNLLDFLRSKRKY
|..| . | |||| |. | | |.  ..  ..|||| ||. | | || ||  |||.. | |.|.|.|| |||||  ||.. | |.|| | ||..|..||  
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLKPTAHSSEKEALMSELKIMSHLGQHMNIVNLLGACTHGGPIYIITEYCCYGDLLNYLHRKRHS

F
|
F
Kinase VEGFR2.AA FGFR 1122-1219 52 1.3e-37 125.76 In-house 1-100 (293) Show / Hide 
Range on Protein: 1122-1219
Range on HMM: 1-100/293
Sequence Identity: 52% (52 aa)

LKLGGVIGKGAFGMVIKAVAVGIDGT--ENNITVAVKKLKSGATSLEKKALWAELKMLGHIGKHLNVVNFLGACTQNGPVLAIVEFCCHGNLLDFLRSKR
| || ..| |.|| |..| |.|||    |..||||||.||...|  .   |  |. |.  |||| |..| ||.|||.||   |||.| |||| ||||..|
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRARR
Kinase VEGFR2.AA Pkinase 1122-1432 19 1.1e-33 120.19 Pfam 1-284 (293) Show / Hide 
Range on Protein: 1122-1432
Range on HMM: 1-284/293
Sequence Identity: 19% (67 aa)

LKLGGVIGKGAFGMVIKAVAVGIDGTENNITVAVKKL-KSGATSLEKKALWA--ELKMLGHIGKHLNVVNFLGACTQNGPVLAIVEFCCHG----NLLDF
...|..||.|.|| | |.. .|        .||||.. |... | ......   |.... .. .| |.| ...... .. .  . |.| .|     | |.
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDY

LRSKRKYFSETPEGTGSQSHTGHSSSTGASNTFQTSSGSERRMKAVYDQIIPEEVFSPLQDDPI--NSQDLLCYSFQVARGMEFLASKNVIHRDLAARNV
..                                                         .. ..    ... .|  |..||.|.. |...|||||   |.
IST-------------------------------------------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENI

LVTENYTL----KICDFGLAKHLYDDPDYVASGKQGRLP-IKWMAPESIF-DKVFTTYSDVWAYAVFLWEVFSLGGSPYPGI------QIDEKFYNKIKN
|. .|...    |||||||||...       |  ...   . .|||| |  ..  .. .|.|.. . |.|... |  |.||         ....... . 
LIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGP

GYRMNAPDYAP-------------------PGVYDTMLECWTPEPEARPSF
 .. . |   .                   .   | .  |... |. ||..
PLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTA
Kinase VEGFR2.AA S_TKc 1122-1443 20 5e-26 93.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 1122-1443
Range on HMM: 1-231/231
Sequence Identity: 20% (66 aa)

LKLGGVIGKGAFGMVIKAVAVGIDGTENNITVAVKKLKSGATSLEKKALWAELKMLGHIGKHLNVVNFLGACTQNGPVLAIVEFCCH--GNLLDFLRSKR
 ... .||||||| | |.. ..      .  ||.|..|        . .. |...| .  .| |.|......   . .  . |.| .  |.|.|......
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRG

KYFSETPEGTGSQSHTGHSSSTGASNTFQTSSGSERRMKAVYDQIIPEEVFSPLQDDPINSQDLLCYSFQVARGMEFLASKNVIHRDLAARNVLVTENYT
.                                                   .  . |..  .  .|  |.....|.. |...|||||   |.|..|  .
R---------------------------------------------------HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--H

LKICDFGLAKHLYDDPDYVASGKQGRLPIKWMAPESIFDKVFTT-YSDVWAYAVFLWEVFSLGGSPYPGIQIDEKFYNKIKNGYRMNAPDYAPPGVYDTM
.||||||||..|          .       .|||| .    ...  .|.|.  . |.| .. |  |.|    ... ..||.           .| . | .
IKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG-----------SPEAKDFI

LECWTPEPEARPSFSILA----VRLGDML
  |.. .|| ||.  .|.    ...   .
RKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase VEGFR2.AA Ret 1122-1220 42 1.4e-25 84.31 In-house 1-101 (293) Show / Hide 
Range on Protein: 1122-1220
Range on HMM: 1-101/293
Sequence Identity: 42% (43 aa)

LKLGGVIGKGAFGMVIKAVAVGIDGTENNITVAVKKLKSG-ATSLEKKALWAELKMLGHIGKHLNVVNFLGACTQNG--PVLAIVEFCCHGNLLDFLRSK
| |. . | | || |.|| |  | |     ||||| || . |.| | ..|  |. .|  .  | .|.  .|||.| .  | . |||.|  | |  |||  
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLKRNTANSSEYHDLLSEFQLLKQV-NHPHVIKLYGACIQDDPFPTCLIVEYCKYGCLREFLRLS

RK
||
RK
Kinase VEGFR2.AA Tie 1130-1219 36 7.7e-25 71.96 In-house 1-87 (267) Show / Hide 
Range on Protein: 1130-1219
Range on HMM: 1-87/267
Sequence Identity: 36% (33 aa)

KGAFGMVIKAVAVGIDGTENNITVAVKKLKSGATSLEKKALWAELKMLGHIGKHLNVVNFLGACTQNGPVLAIVEFCCHGNLLDFLRSKR
 | || |.||  .  || .  . ||.|..| .|   ...    || ..  .|.| |..| .||| . | .   .|.  .||||||||. |
EGNFGQVMKAM-IKKDGLK--MEVAIKMMKEYASEDDHRDFMGELEVMCKVGHHPNIINLVGACEHRGYLYVAIEYAPYGNLLDFLRKSR
Kinase VEGFR2.AA RTKB 1122-1219 36 2.1e-17 55.26 In-house 1-97 (264) Show / Hide 
Range on Protein: 1122-1219
Range on HMM: 1-97/264
Sequence Identity: 36% (36 aa)

LKLGGVIGKGAFGMVIKAVAVGIDGTENNITVAVKKLKSGATSLEKKALWAELKMLGHIGKHLNVVNFLGACTQNGPVLAIVEFCCHGNLLDFLRSKR
..||   | |||| | .|  |   ..     .|.| || || . |. .  .|. ..  .| | ||.  .| | |  | .  ||.| .||| |.||  |
VWLGEKLGNGAFGEVFQAW-VRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCR