Gene VEGFR1 (Sea Urchin)

VEGFR1

Species: Sea Urchin
Alias: VEGFR1, SPU_000310, Spk280
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TK
Family: VEGFR

Sequence

Name Sequence Type Origin Length Description Download
VEGFR1.AA Protein None 1839 None Fasta, JSON
VEGFR1.kin_dom Protein Kinase Domain None 242 None Fasta, JSON

Protein domain

Protein domains of VEGFR1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG VEGFR1.AA IG 111-199 12 9e-07 29.74 SMART 1-58 (58) Show / Hide 
Range on Protein: 111-199
Range on HMM: 1-58/58
Sequence Identity: 12% (12 aa)

SSTLLISQNNTLQLSCHGGFRLDWIYPYEIERTRISIEQEHCSACSPKRHRSVLTIASADVGDT---GKYQCLYKKYDTKINNET--SAKVYVY
.. .. .   |..|.|    .. |                             ||| .. . |.   | |.|  .    . . .   .....|.
PP-VTVKEGETVTLTC-VS-QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQAT----HGQYWSIQGTTLTVQ
IGc2 VEGFR1.AA IGc2 117-186 13 0.000764 11.74 SMART 1-56 (56) Show / Hide 
Range on Protein: 117-186
Range on HMM: 1-56/56
Sequence Identity: 13% (10 aa)

SQNNTLQLSCH----GGFRLDWIYPYEIERTRISIEQEHCSACSPKRHRSVLTIASADVGDTGKYQCLYKKYDT
 . ....| |.     .    |..      ....             ... ||| .. ..| |.|.|.      
HEGQSVTLTCPATGNPDPNIHWYK-----GQPLP-------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set VEGFR1.AA I-set 161-179 42 0.370617 6.44 Pfam 57-75 (92) Show / Hide 
Range on Protein: 161-179
Range on HMM: 57-75/92
Sequence Identity: 42% (8 aa)

RSVLTIASADVGDTGKYQC
.. |||  .. .|.||| |
TYTLTISNVQPDDEGKYTC
V-set VEGFR1.AA V-set 156-198 20 2.046469 3.26 Pfam 87-128 (128) Show / Hide 
Range on Protein: 156-198
Range on HMM: 87-128/128
Sequence Identity: 20% (9 aa)

SPKRHRSVLTIASADVGDTGKYQCLYKKYDTKINNETSAKVYV
.| ...  ||| .. . |.| | |  . .  ... ... .. |
NPSKNDFSLTISNLQPSDSGTYYCAVWNC-NEDYFGHGTRLTV
IG VEGFR1.AA IG 212-294 12 0.266745 2.25 SMART 1-58 (58) Show / Hide 
Range on Protein: 212-294
Range on HMM: 1-58/58
Sequence Identity: 12% (11 aa)

WTQNNIYRGQPFVLPCRTTSPNLNVTLVQRGTGRDITDHRYHRYDPKKGFHISANHHELD---GHVCCKAQNGEHIDRS--CFNLNFQ
       .|.. .|.|  .    ....                      ..|     |     |   | |.   . . |   ..|  |
PP-VTVKEGETVTLTC-VS----QIWWY---------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IG VEGFR1.AA IG 309-410 15 6e-05 23.69 SMART 1-58 (58) Show / Hide 
Range on Protein: 309-410
Range on HMM: 1-58/58
Sequence Identity: 15% (17 aa)

TEVLEGWEGFSV--SCEVSAPADSLLDDLSWDYPAEMIAERQDSNYKIVTDGSTESVRGSSLAMQKYVSTLNVVRAHSYDN---GTYVCIATNFWDSYFA
 . ... || .|  .| ||         ..|                                       |.. ..   |    |||.| ||  . .|..
PP-VTVKEGETVTLTC-VS--------QIWWY--------------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWS

--EASINVI
  .. . | 
IQGTTLTVQ
I-set VEGFR1.AA I-set 386-409 37 1.604811 4.28 Pfam 69-92 (92) Show / Hide 
Range on Protein: 386-409
Range on HMM: 69-92/92
Sequence Identity: 37% (9 aa)

DNGTYVCIATNFWDSYFAEASINV
| |.| |.|||   .  ..|. .|
DEGKYTCVATNSFGEAECTAELTV
IGc2 VEGFR1.AA IGc2 433-502 14 0.000603 12.72 SMART 1-56 (56) Show / Hide 
Range on Protein: 433-502
Range on HMM: 1-56/56
Sequence Identity: 14% (11 aa)

RENSTLEIRCT----GGVALEWIYPEAVRSRVSLGSQACPTCDSNAHFTSTLTVRSARPQDSGQFQCIYSRYVD
.|  .....|      .    |..    .                    .|||.....| |||  .|. .  . 
HEGQSVTLTCPATGNPDPNIHWYK--GQPLP----------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG VEGFR1.AA IG 427-517 12 0.004852 17.34 SMART 1-58 (58) Show / Hide 
Range on Protein: 427-517
Range on HMM: 1-58/58
Sequence Identity: 12% (12 aa)

TTERFLRENSTLEIRCTGGVALEWIYPEAVRSRVSLGSQACPTCDSNAHFTSTLTVRSARPQDS---GQFQCIYSRYVDHINNATA-AEINIFVA
      .| .|....|     . |                             ||. ...|.||   | ..|  .       ....  .... | 
PP-VTVKEGETVTLTC-VS-QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQAT-----HGQYWSIQGTTLTVQ
I-set VEGFR1.AA I-set 477-496 40 7.042709 2.1 Pfam 57-76 (92) Show / Hide 
Range on Protein: 477-496
Range on HMM: 57-76/92
Sequence Identity: 40% (8 aa)

TSTLTVRSARPQDSGQFQCI
|.|||.. . | |.|.  |.
TYTLTISNVQPDDEGKYTCV
IG VEGFR1.AA IG 535-621 15 6.9e-05 23.48 SMART 1-58 (58) Show / Hide 
Range on Protein: 535-621
Range on HMM: 1-58/58
Sequence Identity: 15% (14 aa)

NSHIIQNEYQNLELRCTGSSTIDWSWPQDATERVEQRSIECPTCPVALQSTSTLKVSNASYKDT---GFYRCFYSRFSDRLT-PETSAEVY
 . .  .| ....|.|  | .| |.                            | . |... |.   | |.|  .   .    ..|  .|.
PP-VTVKEGETVTLTC-VS-QIWWY----------------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
V-set VEGFR1.AA V-set 583-603 33 2.032852 3.27 Pfam 90-110 (128) Show / Hide 
Range on Protein: 583-603
Range on HMM: 90-110/128
Sequence Identity: 33% (7 aa)

QSTSTLKVSNASYKDTGFYRC
... .|. ||..  |.| | |
KNDFSLTISNLQPSDSGTYYC
IG VEGFR1.AA IG 734-838 15 1.6e-09 38.84 SMART 1-58 (58) Show / Hide 
Range on Protein: 734-838
Range on HMM: 1-58/58
Sequence Identity: 15% (17 aa)

QGPIEQVKGYTFNVTCNVESPLGIQIRWKWDYPGLHNPNANPNNYRTEKSSRELQAEVGDSTRAFRRFKGTLTVFQASPIDN---GTYTCTVINNNGNGS
.. .. . | | . || |.     ||.|.                                          ||. ...| |    |||.|..   .|...
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYW

T--THAVSIL
   .  ....
SIQGTTLTVQ
IGc2 VEGFR1.AA IGc2 740-827 20 0.000152 18.45 SMART 1-56 (56) Show / Hide 
Range on Protein: 740-827
Range on HMM: 1-56/56
Sequence Identity: 20% (18 aa)

VKGYTFNVTCNVESPLGIQIRWKWDYPGLHNPNANPNNYRTEKSSRELQAEVGDSTRAFRRFKGTLTVFQASPIDNGTYTCTVINNNG
  | ..  || ..   . .|.|.    | . |                              ..|||.  ..| | |.|||.. |..|
HEGQSVTLTCPATGNPDPNIHWYK---GQPLP-----------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
V-set VEGFR1.AA V-set 765-838 18 0.001872 13.74 Pfam 62-128 (128) Show / Hide 
Range on Protein: 765-838
Range on HMM: 62-128/128
Sequence Identity: 18% (14 aa)

YPGLHNPNANPNNYRTEKSSRELQAEVGDSTRAFRRFKGTLTVFQASPIDNGTYTCTVINNNGNGSTTHAVSIL
| .. ... ... |   | ......  .       . . .||  ...| |.|||.| |.| |  .  .    . 
YTHYYYNFGHGYYYPRFKGRVTFSGNPS-------KNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set VEGFR1.AA I-set 800-822 37 1.190611 4.72 Pfam 51-77 (92) Show / Hide 
Range on Protein: 800-822
Range on HMM: 51-77/92
Sequence Identity: 37% (10 aa)

RFKG----TLTVFQASPIDNGTYTCTV
...|    |||. .. | | |.|||..
TYDGDGTYTLTISNVQPDDEGKYTCVA
IG VEGFR1.AA IG 857-941 7 0.032741 10.15 SMART 1-58 (58) Show / Hide 
Range on Protein: 857-941
Range on HMM: 1-58/58
Sequence Identity: 7% (7 aa)

SGEEHAKDRDRIMVHLKYFPNADFTWFKDGIEVDALDQYLFKSRIKQDVAQVKLLNINAQHA---GNYTLIGDNGDVQESV--TIRVVVH
..   .|  ...  .  .     ..|.                          . |. ....   |.|.        | .   .... |.
PP-VTVKEGETVTLTC-VS---QIWWY------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
IG VEGFR1.AA IG 953-1053 16 1.3e-10 42.53 SMART 1-58 (58) Show / Hide 
Range on Protein: 953-1053
Range on HMM: 1-58/58
Sequence Identity: 16% (17 aa)

EETTIVEEKGNLTLHCKSSSHIFDNIKWLVVRSHGSTNESRLLRPREERVTITSYSDGDFNVTQLHIQDMGRSDD---GIYICLAHSVLDSRDTKEV--E
 . . | | ...||.|  |     .|.|.                                   |.| .  ..|    |.| | |.       ...   .
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------------------LTI-NVQPEDSQQHGTYYCQAT-----HGQYWSIQG

AAVQVQ
. ..||
TTLTVQ
V-set VEGFR1.AA V-set 946-1032 17 4.1e-08 29.8 Pfam 1-110 (128) Show / Hide 
Range on Protein: 946-1032
Range on HMM: 1-110/128
Sequence Identity: 17% (19 aa)

GLTIEG-QEE----TTIVEEKGNLTLHCKSS-SH----IFDNIKWLV-VRS------------HGSTNESRLLRPREERVTITSYSDGDFNVTQLHIQDM
 ..... ...       |.| ...||.|. | ..        | |    ..            | ..|. .   . . . ..| ..... |  .|.|...
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

GRSDDGIYIC
 .|| |.| |
QPSDSGTYYC
IGc2 VEGFR1.AA IGc2 959-1039 18 7e-05 21.69 SMART 1-56 (56) Show / Hide 
Range on Protein: 959-1039
Range on HMM: 1-56/56
Sequence Identity: 18% (15 aa)

EEKGNLTLHCKSSSHIFDNIKWLVVRSHGSTNESRLLRPREERVTITSYSDGDFNVTQLHIQDMGRSDDGIYICLAHSVLD
.| ...|| |. .     ||.|.     |.  .                     .   |.|... ..|.|.| |.| .   
HEGQSVTLTCPATGNPDPNIHWYK----GQPLP---------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set VEGFR1.AA I-set 1013-1034 31 2.876276 3.42 Pfam 56-77 (92) Show / Hide 
Range on Protein: 1013-1034
Range on HMM: 56-77/92
Sequence Identity: 31% (7 aa)

NVTQLHIQDMGRSDDGIYICLA
. . | |..  ..| |.| | |
GTYTLTISNVQPDDEGKYTCVA
I-set VEGFR1.AA I-set 1077-1149 31 2.4e-16 57.96 Pfam 19-92 (92) Show / Hide 
Range on Protein: 1077-1149
Range on HMM: 19-92/92
Sequence Identity: 31% (23 aa)

TLECEASGFPTPKITWFKDGSKLEIKDSTVVLPNDH-AVSTLRRTRINMVDSGLYCCVASNAGGQVNSSAVIII
..||...| |.|...|||||..|   .. ..  .|.   .||. ....  |.| | |||.| .|.. ..|  ..
RFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IGc2 VEGFR1.AA IGc2 1071-1139 31 8.8e-13 49.7 SMART 1-56 (56) Show / Hide 
Range on Protein: 1071-1139
Range on HMM: 1-56/56
Sequence Identity: 31% (22 aa)

KSLKDFTLECEASGFPTPKITWFKDGSKLEIKDSTVVLPNDHAVSTLRRTRINMVDSGLYCCVASNAGG
..  ..||.|.|.|.|.| |.|.| |..|.              .||. ... . |||.| |.|.|. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG VEGFR1.AA IG 1064-1150 17 0.000573 20.43 SMART 1-58 (58) Show / Hide 
Range on Protein: 1064-1150
Range on HMM: 1-58/58
Sequence Identity: 17% (16 aa)

LETEEINKSLKDFTLECEASGFPTPKITWFKDGSKLEIKDSTVVLPNDHAVSTLRRTRINMVDS---GLYCCVASNAGGQVNS--SAVIIIL
 .  . .    . ||.| .|      |.|.                       |.  .. . ||   | | |.|.  .||. |  .. ....
PP-VTVKE-GETVTLTC-VS-----QIWWY-----------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set VEGFR1.AA V-set 1077-1150 14 2.277165 3.1 Pfam 25-128 (128) Show / Hide 
Range on Protein: 1077-1150
Range on HMM: 25-128/128
Sequence Identity: 14% (15 aa)

TLECEAS-GF----PTPKITWFK-DGS-----------------------KLEIKDSTVVLPNDH-AVSTLRRTRINMVDSGLYCCVASNAGGQVNSSAV
||.|  | .     ..  |.|..   .                       . . |... . .|      .|. . . . ||| | |...| . ..  . .
TLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNLQPSDSGTYYCAVWNCNEDYFGHGT

IIIL
  . 
RLTV
IGc2 VEGFR1.AA IGc2 1165-1234 27 2.5e-13 51.5 SMART 1-56 (56) Show / Hide 
Range on Protein: 1165-1234
Range on HMM: 1-56/56
Sequence Identity: 27% (19 aa)

AMGGTANITCHDGGNPKPTIVWYHQPKDQASEMRILPAQMYNSTEGVLVLHDVQKDQQGTYLCNATNRLG
 .|... .||.  ||| |.| ||.   .|  .           ... | . .|.... |.| | |.|. |
HEGQSVTLTCPATGNPDPNIHWYK---GQPLP-----------WNWTLTIKNVTPEDSGYYTCYARNPWG
I-set VEGFR1.AA I-set 1153-1244 24 9.6e-11 38.97 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1153-1244
Range on HMM: 1-92/92
Sequence Identity: 24% (23 aa)

PYMRVKEDVKLVAMGGTANITCHDGGNPKPTIVWYHQPKDQAS---EMRILPAQMYNSTEGVLVLHDVQKDQQGTYLCNATNRLGSSTRTVSIKL
|..  |     |  | ||. .|.  |.|.|...|..  .. ..    ...   .   . .  |   .||.|  |.| | |||..|... |.. . 
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDG---DGTYTLTISNVQPDDEGKYTCVATNSFGEAECTAELTV
IG VEGFR1.AA IG 1159-1245 19 6.1e-08 33.62 SMART 1-58 (58) Show / Hide 
Range on Protein: 1159-1245
Range on HMM: 1-58/58
Sequence Identity: 19% (18 aa)

EDVKLVAMGGTANITCHDGGNPKPTIVWYHQPKDQASEMRILPAQMYNSTEGVLVLHDVQKDQQ---GTYLCNATNRLGSSTR--TVSIKLD
    .|  |.|...||        .| ||                        |.. .||.. .   ||| | ||   |. .   .. ..  
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
Kinase VEGFR1.AA VEGFR 1366-1606 63 8.4e-188 630.19 In-house 80-332 (332) Show / Hide 
Range on Protein: 1366-1606
Range on HMM: 80-332/332
Sequence Identity: 63% (161 aa)

DLFVISEFCPFGNLSDYLKTKRKNYVAEPDL-----LAIACMGPVDRSSRGSSRGGGDGFMGARGGS--TLEVGD----DDVFEYMEKEQPLTLKDLICY
.|.||.|.|.|||||.||.|||...|..||.     ....||||.|.......|..|..|....|..  .....|    |.|||.|. ..|||..|||||
PLMVIVEYCCFGNLSNYLRTKRMYFVPYPDKSPHMRQRKECMGPQDHQDHKRRRDSGNSFQSSFGSFFRMKKSYDDVEPDEVFEDMW-KDPLTMEDLICY

SYQVARGMEFLTSKKCIHRDLAARNVLLAENNIVKICDFGLARD-IYSDPDYVTQTG-GRLPIKWMAPESIFDKVFTIYSDVWSFGVFMWECFALGGSPY
|.|||||||||.|.|||||||||||.||.|||.||||||||||. ||.|||||.... |||||||||||||||||.|.||||||.|||.||.|.||||||
SFQVARGMEFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEIFSLGGSPY

PGVVVDEEFYNRLKSGYRMYTPDYAPIEIYHVMLDCWHTEPKERPHFSELVHKL
|||..||||.||||.||||..|||...||||.||||||.||.|||||||||..|
PGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase VEGFR1.AA Pkinase_Tyr 1367-1606 44 1.6e-110 374.94 Pfam 82-270 (270) Show / Hide 
Range on Protein: 1367-1606
Range on HMM: 82-270/270
Sequence Identity: 44% (107 aa)

LFVISEFCPFGNLSDYLKTKRKNYVAEPDLLAIACMGPVDRSSRGSSRGGGDGFMGARGGSTLEVGDDDVFEYMEKEQPLTLKDLICYSYQVARGMEFLT
.... |..| |.| |||...|                                                     | .||||.|||.....|.|.|||.| 
IYIVMEYMPHGDLLDYLRKHR-----------------------------------------------------EDKQPLTMKDLLQMCWQIAKGMEYLE

SKKCIHRDLAARNVLLAENNIVKICDFGLARDIYSDPDY-VTQTGGRLPIKWMAPESIFDKVFTIYSDVWSFGVFMWECFALGGSP-YPGVVVDEEFYNR
||.||||||||||.|..|||.|||||||||||||.|  | ....||.|||||||||.|....||. |||||||| ||| | .|..| |||.  .||.|..
SKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEY

L-KSGYRMYTPDYAPIEIYHVMLDCWHTEPKERPHFSELVHKL
. ..||||  |...| |||..|..||| .|..|| |||....|
IYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase VEGFR1.AA PDGFR 1441-1606 59 2.6e-110 355.44 In-house 193-358 (358) Show / Hide 
Range on Protein: 1441-1606
Range on HMM: 193-358/358
Sequence Identity: 59% (99 aa)

EKEQPLTLKDLICYSYQVARGMEFLTSKKCIHRDLAARNVLLAENNIVKICDFGLARDIYSDPDYVTQTGGRLPIKWMAPESIFDKVFTIYSDVWSFGVF
. ...||..||.|.|||||.||||| || |.|||||||||||..  .|||||||||||| .|  ||     |||.|||||||||| |.|. |||||.|..
DDSNVLTYWDLLCFSYQVAKGMEFLASKNCVHRDLAARNVLLCHGKVVKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTTQSDVWSYGIL

MWECFALGGSPYPGVVVDEEFYNRLKSGYRMYTPDYAPIEIYHVMLDCWHTEPKERPHFSELVHKL
 || | |||.||||. ||..||.  |.||||  |..|| ||| .|  ||  .|. || |..|.  |
LWEIFSLGGNPYPGMPVDSKFYKMIKEGYRMAQPFHAPEEIYEIMQKCWDFDPEKRPTFQQLCQFL
TyrKc VEGFR1.AA TyrKc 1328-1606 32 9.1e-101 341.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 1328-1606
Range on HMM: 1-280/280
Sequence Identity: 32% (111 aa)

LKIGPVIGRGAFGRVMRSSAFGIDKVDTCTTVAVKMLK------------------------------------------DLFVISEFCPFGNLSDYLKT
.. | ..|.||||.|..  .         ..|||||||                                           |... |..| |.| |||. 
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

KRKNYVAEPDLLAIACMGPVDRSSRGSSRGGGDGFMGARGGSTLEVGDDDVFEYMEKEQPLTLKDLICYSYQVARGMEFLTSKKCIHRDLAARNVLLAEN
.|..                                                        |..|||. ...|.|.|||.| ||.||||||||||.|..||
HRPK--------------------------------------------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGEN

NIVKICDFGLARDIYSD-------PDYVTQT--GGR--LPIKWMAPESIFDKVFTIYSDVWSFGVFMWECFALGGSPYPGV----VVDEEFYNRLKSGYR
..|||.||||.||||.|         |....  ||.  |||.|||||.|....||. |||||||| ||| | .|..||||.    . ..| ....|.|||
HTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYR

MYTPDY--------APIEIYHVMLDCWHTEPKERPHFSELVHKL
|  |..        .| |.| .|..||| .|..|| |||.....
MPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase VEGFR1.AA TK 1367-1606 28 5e-96 322.42 In-house 130-486 (486) Show / Hide 
Range on Protein: 1367-1606
Range on HMM: 130-486/486
Sequence Identity: 28% (107 aa)

LFVISEFCPFGN----LSDYLKTKRKNYVAEPDLLAI-----------ACMGPVDRSSRGSSRGGGDGFMGARGG---STLEVGDDDVFEYMEKEQ----
. .. |..| |.    | |||...|..   |.|  .            .|                   |  .|.   |. ..... ..| . ...    
WMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHC-------------------M--KGDITYSHESNSPC-PEEQDYDDDLIKD

---PLTLKDLIC-------------------YSYQVARGMEFLTSKKC------IHRDLAARNVLLAENNI-----------VKICDFG--------LAR
   |||.|||..                   ...|.|.|||.| ||.|      .||||||||.|..|||.           .||.|||        |||
HPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLAR

DIYSDPDYVTQT------------------------GGRLPIKWMAPESIFDKV---------FTIYSDVWSFGVFMWECFALGGSPYPGVVVD------
||||| ||....                        ||.|||.|||||...|.|         ||. ||||||||.|||.| .|  ||.| . .      
DIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKD

---EEFYNRLKSG--------------YRMYTPDYAP--------------IEIYHVMLDCWHTEPKERPHFSELVHKL
   .|....|..|              .||  |...|               |.| .|..||| .|..|| ||.|...|
GDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase VEGFR1.AA FGFR 1443-1606 55 1.6e-94 320.37 In-house 122-293 (293) Show / Hide 
Range on Protein: 1443-1606
Range on HMM: 122-293/293
Sequence Identity: 55% (96 aa)

EQP--------LTLKDLICYSYQVARGMEFLTSKKCIHRDLAARNVLLAENNIVKICDFGLARDIYSDPDYVTQTGGRLPIKWMAPESIFDKVFTIYSDV
||.        || |||.   ||||||||.| |.|||||||||||||  .... ||||||||||| .   |   | |||||||||||. ||.|.|  |||
EQQDDIELIPNLTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDV

WSFGVFMWECFALGGSPYPGVVVDEEFYNRLKSGYRMYTPDYAPIEIYHVMLDCWHTEPKERPHFSELVHKL
||.|| .|| . .||.|||..   || |  ||.|.||  |   . ||||.| .|||..|..|| | .||  |
WSYGVLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase VEGFR1.AA TK-Unique 1368-1606 36 5.3e-83 282.05 In-house 81-294 (294) Show / Hide 
Range on Protein: 1368-1606
Range on HMM: 81-294/294
Sequence Identity: 36% (94 aa)

FVISEFCPFGNLSDYLKTKRKN--------YVAEPDLLAIACMGPVDRSSRGSSRGGGDGFMGARGGSTLEVGDDDVFEYMEKEQP---LTLKDLICYSY
. | |.|| ||| .||.|.|..         .                                             |..|.....   ...|||. . .
MIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLK------------------------------------------FDFHHMPDKPRTEPISPKDLYHFAW

QVARGMEFLTS--KKCIHRDLAARNVLLAENNIVKICDFGLARDIYSDPDYVTQTG-GRLPIKWMAPESIF--DKVF-TIYSDVWSFGVFMWECFALGGS
|.|.|||.| |  ||..||||.||||||.|....||||||.|||.| . .|..... ||.||.||||||.   .... |. ||||||||.|||.| ||. 
QIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGAC

PYPGVVVDEEFYNRLKSGYRMYTPDYA-PIEIYHVMLDCWHTEPKERPHFSELVHKL
||||.  .. . .... ||||  |..  . |.| .|  ||. ||.||| |....|.|
PYPGMPWKD-IMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase VEGFR1.AA Src 1368-1606 35 4.5e-71 240.7 In-house 70-255 (255) Show / Hide 
Range on Protein: 1368-1606
Range on HMM: 70-255/255
Sequence Identity: 35% (86 aa)

FVISEFCPFGNLSDYLKTKRKNYVAEPDLLAIACMGPVDRSSRGSSRGGGDGFMGARGGSTLEVGDDDVFEYMEKEQPLTLKDLICYSYQVARGMEFLTS
. . |.   |.| ||||                                                        .... | |..||  . |||.||..| |
YIVTEYMSHGSLLDYLKK------------------------------------------------------DGEGRHLHLPQLIDMAAQVAEGMAYLES

KKCIHRDLAARNVLLAENNIVKICDFGLARDIYS--DPDYVTQTGGRLPIKWMAPESIFDKVFTIYSDVWSFGVFMWECFALGGSPYPGVVVDEEFYNRL
.. |||||||||||  |||..|..|||||| .    |  |. ..| ..||||.||| |   .||| |||||||. ..| .  |  ||||    .|   ..
MNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPG-MTNHEVLQQV

KSGYRMYTPDYAPIEIYH-VMLDCWHTEPKERPHFSELVHKL
. ||||  |.  | |.|. .|| ||| .|..|| |  | ..|
ERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase VEGFR1.AA KIN6 1446-1606 47 4.4e-69 227.4 In-house 141-305 (305) Show / Hide 
Range on Protein: 1446-1606
Range on HMM: 141-305/305
Sequence Identity: 47% (79 aa)

LTLKDLICYSYQVARGMEFLTSKKCIHRDLAARNVLLAENN---IVKICDFGLARDIYSDPDYVTQTGGR-LPIKWMAPESIFDKVFTIYSDVWSFGVFM
...|||   ..|.. |||.| || ||||||||||||. | .     || ||||.| .| |    |  ||| |||||||||..    | . |||||||| |
IRHKDLYMFAWQICDGMEYLHSKNCIHRDLAARNVLVTEGCRMKTCKISDFGLCRYPYMDQFQYTSKGGRYLPIKWMAPECLKHYEFSYKSDVWSFGVLM

WECFALGGSPYPGVVVDEEFYNRLKSGYRMYTPDYAPIEIYHVMLDCWHTEPKERPHFSELVHKL
.| | ||..|||..   .|    ..|| |.  |...| ||| .|  ||   | .|| |.|.  ..
FEMFSLGDVPYPEMQRPTEMIEHHRSGRRPKHPKWCPEEIYDIMQSCWQEKPDDRPEFNEMRMQF
Kinase VEGFR1.AA Ret 1443-1608 44 5.5e-69 234.75 In-house 124-293 (293) Show / Hide 
Range on Protein: 1443-1608
Range on HMM: 124-293/293
Sequence Identity: 44% (76 aa)

EQPLT-----LKDLICYSYQVARGMEFLTSKKCIHRDLAARNVLLAENNIVKICDFGLARDIYSDPDYVTQTGGRLPIKWMAPESIFDKVFTIYSDVWSF
. ...     .|..| .  |. .|| .| . | .||||||||||.||  | || |||| ||.| |  || .  .|.|.||||.|| .| |.|  ||||||
KDVINRFDIGMKMIISFAWQICKGMHYLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDDSYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSF

GVFMWECFALGGSPYPGVVVDEEFYNRLKSGYRMYTPDYAPIEIYHVMLDCWHTEPKERPHFSELVHKLGD
|| .||   .|..||||.   |  .. || ||||  |.    |.| .|. ||  ||  || |  .   .  
GVLCWEIVTMGANPYPGIPP-ERLWQLLKTGYRMDRPENCSEEMYRIMRQCWKQEPDKRPVFKFISKDFEK
Kinase VEGFR1.AA UTK 1369-1606 29 3.8e-68 232.21 In-house 87-296 (296) Show / Hide 
Range on Protein: 1369-1606
Range on HMM: 87-296/296
Sequence Identity: 29% (76 aa)

VISEFCPFGNLSDYLKTKRKNYVAEPDLLAIACMGPVDRSSRGSSRGGGDGFMGARGGSTLEVGDDDVFEYMEKEQPLTLKDLICYSYQVARGMEFLTSK
...|... |.|..|| . |..                                                   . .  ||| ...|.....||||..| |.
IVTEYMENGDLRSYLRRHRPTPP-------------------------------------------------ACPHWLTLHQRLCMAWDIARGMQYLHSC

KCIHRDLAARNVLLAEN-------NIVKICDFG---LARDIY---------SDPDYVTQTGGRLPIKWMAPESIFDK-VFTIYSDVWSFGVFMWECFALG
...||||||||.|....       ...||.|||   ..|...         ... |  |  .|.||.|||||.. .   ||. ||||||||..||... |
GFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWG

GSPYPGVVVDEEFYNRLKSG-YRMYTPDYAPIEIYHVMLDCWHTEPKERPHFSELVHKL
  ||||   .. . . .. | |||  |.  | ..| .|..|||..| ||| | .|| ..
RLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase VEGFR1.AA RTKB 1441-1606 45 7e-65 217.66 In-house 101-264 (264) Show / Hide 
Range on Protein: 1441-1606
Range on HMM: 101-264/264
Sequence Identity: 45% (76 aa)

EKEQPLTLKDLICYSYQVARGMEFLTSKKCIHRDLAARNVLLAENNIVKICDFGLARDIYSDPDYVTQTGGRLPIKWMAPESIFDKVFTIYS-DVWSFGV
.. |.|  . |. .. |.|.|| || ... |||||.|||||.  .   ||||||.|| |  | . .. |  |||||||||||. .. .|. | |||||||
HNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREI--DHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGV

FMWECFALGGSPYPGVVVDEEFYNRLKSGYRMYTPDYAPIEIYHVMLDCWHTEPKERPHFSELVHKL
 ||| | ||| ||.   .  .  . | ||.|. .|  .| ...|.| .||  |. .|| |.|||  .
TMWEIFSLGGTPYQQYRN-GDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase VEGFR1.AA Pkinase 1366-1606 18 4.6e-26 93.24 Pfam 74-293 (293) Show / Hide 
Range on Protein: 1366-1606
Range on HMM: 74-293/293
Sequence Identity: 18% (53 aa)

DLFVISEFCPFG----NLSDYLKTKRKNYVAEPDLLAIACMGPVDRSSRGSSRGGGDGFMGARGGSTLEVGDDDVFEYMEKEQPL--TLKDLICYSYQVA
.. .. |.|. |     |.||..|                                                       ... ..  . .....| ||..
HIYMVMEYCEGGLYVMDLFDYIST-------------------------------------------------------WRHGCFYFSEWECKFYMYQIL

RGMEFLTSKKCIHRDLAARNVLLAENNIV----KICDFGLARD--IYSDPDYVTQTGGRLPIKWMAPESIF-DKVFTIYSDVWSFGVFMWECFALGGSPY
||.|.. |...|||||   |.|. .|. .    ||||||||.   . ... . | .| .    .|||| |  ..  .  .|.||.|. ..| .  |  |.
RGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPF

PGV------VVDEEFYNRLKSGYRMYTPDYAP-------------------IEIYHVMLDCWHTEPKERPHFSELVHK--L
||         .. ......  ..   |   .                    |  ... .|..  ||.|| . ....   .
PGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
S_TKc VEGFR1.AA S_TKc 1328-1610 21 1.8e-23 85.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 1328-1610
Range on HMM: 1-231/231
Sequence Identity: 21% (66 aa)

LKIGPVIGRGAFGRVMRSSAFGIDKVDTCTTVAVKMLKDLFVISEFCPFGNLSDYLKTKRKNYVAEPDLLA-----IACMGPVDRSSRGSSRGGGDGFMG
 .|. .||.||||.|..    .     |   ||.|..|                      ..   | ..|      |  .  | ..              
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK----------------------EHIRREIQILKKHHPNIVKLYDVFQD--------------

ARGGSTLEVGDD---DVFEYMEKEQP------LTLKDLICYSYQVARGMEFLTSKKCIHRDLAARNVLLAENNIVKICDFGLARDIYSDPDYVTQTGGRL
 .    .|  |    |.|.|..| ..      ..  .  .| ||.....|.. |.. |||||   |.|| |   .||||||||| .         |    
DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCG

PIKWMAPESIFDKVFTI-YSDVWSFGVFMWECFALGGSPYPGVVVDEEFYNRLKSGYRMYTPDYAPIEIYHVMLDCWHTEPKERPHFSELVH-----KLG
   .|||| .    ..   .|.||.|. ..|... |  |.|    ... .....           . |  . .  |.. .|..||   |. .     |. 
TPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

DQL
  .
PWF
Kinase VEGFR1.AA VEGFR 1328-1365 71 8.4e-19 67.67 In-house 1-38 (332) Show / Hide 
Range on Protein: 1328-1365
Range on HMM: 1-38/332
Sequence Identity: 71% (27 aa)

LKIGPVIGRGAFGRVMRSSAFGIDKVDTCTTVAVKMLK
||.| ..|||||| |.  |||||.|  |||||||||||
LKLGKMLGRGAFGQVHEASAFGIRKMETCTTVAVKMLK
Kinase VEGFR1.AA PDGFR 1328-1365 47 1.5e-14 42.76 In-house 1-38 (358) Show / Hide 
Range on Protein: 1328-1365
Range on HMM: 1-38/358
Sequence Identity: 47% (18 aa)

LKIGPVIGRGAFGRVMRSSAFGIDKVDTCTTVAVKMLK
|. | . | ||||.|.   |.|. | .   .|||||||
LQFGKTLGSGAFGKVVEATAYGLSKSQAVMKVAVKMLK
Kinase VEGFR1.AA FGFR 1328-1366 46 1.4e-12 39.17 In-house 1-41 (293) Show / Hide 
Range on Protein: 1328-1366
Range on HMM: 1-41/293
Sequence Identity: 46% (19 aa)

LKIGPVIGRGAFGRVMRSSAFGIDKV--DTCTTVAVKMLKD
| .| ..| |.||.| .  |.|||.   .  .||||||||.
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKM
Kinase VEGFR1.AA TK 1328-1365 26 8.6e-11 31.62 In-house 1-61 (486) Show / Hide 
Range on Protein: 1328-1365
Range on HMM: 1-61/486
Sequence Identity: 26% (16 aa)

LKIGPVIGRGAFG---RVMRSSAFGID--------------------KVDTCTTVAVKMLK
...| ..|.|.||   .|..  ..|..                    |....|.|||||||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLK
Kinase VEGFR1.AA Ret 1328-1365 47 1.7e-09 28.53 In-house 1-38 (293) Show / Hide 
Range on Protein: 1328-1365
Range on HMM: 1-38/293
Sequence Identity: 47% (18 aa)

LKIGPVIGRGAFGRVMRSSAFGIDKVDTCTTVAVKMLK
|  . . | | ||.|..  || |      |||||||||
LQLDDTLGEGHFGQVVKAQAFHIRGHPGYTTVAVKMLK
Kinase VEGFR1.AA Pkinase_Tyr 1328-1366 43 6.7e-09 30.76 Pfam 1-38 (270) Show / Hide 
Range on Protein: 1328-1366
Range on HMM: 1-38/270
Sequence Identity: 43% (17 aa)

LKIGPVIGRGAFGRVMRSSAFGIDKVDTCTTVAVKMLKD
...| ..|.||||.|..  ..| |. .|...|||||||.
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKE
Kinase VEGFR1.AA TK-Unique 1328-1366 55 2.5e-07 21.46 In-house 1-40 (294) Show / Hide 
Range on Protein: 1328-1366
Range on HMM: 1-40/294
Sequence Identity: 55% (22 aa)

LKIGPVIGRGAFGRVMRSSAFGID-KVDTCTTVAVKMLKD
|..| |||.|||| | |  ..||. . |  . ||||||||
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKD
Kinase VEGFR1.AA FGFR 1367-1387 52 0.000303 10.31 In-house 80-100 (293) Show / Hide 
Range on Protein: 1367-1387
Range on HMM: 80-100/293
Sequence Identity: 52% (11 aa)

LFVISEFCPFGNLSDYLKTKR
|.|| |.|. ||| |.|. .|
LYVIVEYCHHGNLRDFLRARR
Kinase VEGFR1.AA Pkinase 1328-1365 36 0.008564 10.96 Pfam 1-33 (293) Show / Hide 
Range on Protein: 1328-1365
Range on HMM: 1-33/293
Sequence Identity: 36% (14 aa)

LKIGPVIGRGAFGRVMRSSAFGIDKVDTCTTVAVKMLK
..|| .||.|.||.|     .   ...|. .|||| .|
YHIGRKIGSGSFGCV-----YKCHHKGTGKIVAVKIIK
Kinase VEGFR1.AA RTKB 1328-1342 46 0.042248 2.9 In-house 1-15 (264) Show / Hide 
Range on Protein: 1328-1342
Range on HMM: 1-15/264
Sequence Identity: 46% (7 aa)

LKIGPVIGRGAFGRV
...|.  | |||| |
VWLGEKLGNGAFGEV
Kinase VEGFR1.AA UTK 1328-1342 46 0.06234 2.4 In-house 1-15 (296) Show / Hide 
Range on Protein: 1328-1342
Range on HMM: 1-15/296
Sequence Identity: 46% (7 aa)

LKIGPVIGRGAFGRV
...|  .|.|||| |
VQLGRQLGQGAFGEV
Kinase VEGFR1.AA PDGFR 1368-1387 45 0.128595 0.54 In-house 79-98 (358) Show / Hide 
Range on Protein: 1368-1387
Range on HMM: 79-98/358
Sequence Identity: 45% (9 aa)

FVISEFCPFGNLSDYLKTKR
..| |.| .| | .||. ||
YIITEYCCYGDLLNYLHRKR