LRRKb

Species: Sea Urchin
Alias: SPU_022680, Spk308, LRRKb
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
LRRKb.AA Protein None 3060 None Fasta, JSON
LRRKb.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of LRRKb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 LRRKb.AA LRR_1 1504-1524 22 14.379053 2.64 Pfam 1-26 (26) Show / Hide
Range on Protein: 1504-1524
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

CIKFVDLSA-N--NVS-DLTP--LSRA
 ..  |||  |  |.. .. |  .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP LRRKb.AA LRR_TYP 1651-1674 54 0.00036 21.1 SMART 1-24 (24) Show / Hide
Range on Protein: 1651-1674
Range on HMM: 1-24/24
Sequence Identity: 54% (13 aa)

LQLLKILDLSNNKLTTLTPVFLHG
|  |. ||||||.||.| |  ..|
LPNLRELDLSNNQLTHLPPGAFQG

LRR_1 LRRKb.AA LRR_1 1558-1579 29 0.003819 15.32 Pfam 1-26 (26) Show / Hide
Range on Protein: 1558-1579
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

ELQELNLRS-N--GIT-ELPTH-LLSL
 ||.|.|.. |   .| ..|   . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRRKb.AA LRR_1 1653-1675 33 0.009235 13.96 Pfam 1-26 (26) Show / Hide
Range on Protein: 1653-1675
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

LLKILDLSN-N--KLT-TLTPVFLHGC
 |..||||. |  .|| .. |  . ..
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP LRRKb.AA LRR_TYP 1579-1607 37 0.017449 14.26 SMART 1-24 (24) Show / Hide
Range on Protein: 1579-1607
Range on HMM: 1-24/24
Sequence Identity: 37% (11 aa)

LSKLTLLDLSHNQIKDLNKTRPGDTAFKL
|..|. ||||.||.. |      . ||  
LPNLRELDLSNNQLTHLP-----PGAFQG

LRR_1 LRRKb.AA LRR_1 1534-1555 33 0.019237 12.83 Pfam 1-26 (26) Show / Hide
Range on Protein: 1534-1555
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

FLEKLDLSD-N--GLT-EFPKE-LTDY
 |..||||. |   || ..|.. .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP LRRKb.AA LRR_TYP 1556-1578 37 0.020481 13.69 SMART 1-24 (24) Show / Hide
Range on Protein: 1556-1578
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

MPELQELNLRSNGITELPTHL-LS
.|.|.||.| .| .|.||  .  .
LPNLRELDLSNNQLTHLPPGAFQG

LRR_TYP LRRKb.AA LRR_TYP 1532-1555 37 0.04411 10.96 SMART 1-24 (24) Show / Hide
Range on Protein: 1532-1555
Range on HMM: 1-24/24
Sequence Identity: 37% (9 aa)

FRFLEKLDLSDNGLTEFPKELTDY
 . |..||||.| ||. | .. . 
LPNLRELDLSNNQLTHLPPGAFQG

LRR_TYP LRRKb.AA LRR_TYP 1628-1650 25 0.050339 10.49 SMART 1-24 (24) Show / Hide
Range on Protein: 1628-1650
Range on HMM: 1-24/24
Sequence Identity: 25% (6 aa)

VPSLQRLSLASNKIETIPDK-PLA
 |.|..|.| .|.....|.     
LPNLRELDLSNNQLTHLPPGAFQG

LRR_1 LRRKb.AA LRR_1 1630-1651 29 0.109641 10.15 Pfam 1-26 (26) Show / Hide
Range on Protein: 1630-1651
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

SLQRLSLAS-N--KIE-TIPDK-PLAL
.||.|.| . |  ... .||.    .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRRKb.AA LRR_1 1581-1595 31 0.870206 6.96 Pfam 1-19 (26) Show / Hide
Range on Protein: 1581-1595
Range on HMM: 1-19/26
Sequence Identity: 31% (6 aa)

KLTLLDLSH-N--QI-KDL
.|. ||||. |  .. ...
NLQHLDLSGCNCCNLTGHI

LRR_1 LRRKb.AA LRR_1 1606-1627 25 6.264471 3.92 Pfam 1-26 (26) Show / Hide
Range on Protein: 1606-1627
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

KLVELDLSY-N--ATV-RFPSW-LSMF
.| .||||. |    .  .|.. .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRRKb.AA LRR_1 1677-1698 22 0.322205 8.49 Pfam 1-26 (26) Show / Hide
Range on Protein: 1677-1698
Range on HMM: 1-26/26
Sequence Identity: 22% (6 aa)

ALEQLCASN-N--QI-DSLPGD-LDNI
 |. |  |. |  .. ...| . . | 
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP LRRKb.AA LRR_TYP 1727-1750 41 0.220104 5.24 SMART 1-24 (24) Show / Hide
Range on Protein: 1727-1750
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

LPLLRDIDLSDNGIIDIPPPSEWK
|| ||  |||.| .  .||   . 
LPNLRELDLSNNQLTHLPPGAFQG

LRR_1 LRRKb.AA LRR_1 1729-1749 29 3.251566 4.93 Pfam 1-26 (26) Show / Hide
Range on Protein: 1729-1749
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

LLRDIDLSD-N--GII-DIPP--PSEW
 |. .|||. |   .  .|||      
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRRKb.AA LRR_1 1701-1727 28 3.35886 4.88 Pfam 1-26 (26) Show / Hide
Range on Protein: 1701-1727
Range on HMM: 1-26/26
Sequence Identity: 28% (9 aa)

KLKILKLAK-N--QL-GLPEHPFIPKF-VLHL
.|..| |   |  .| |      ||.    .|
NLQHLDLSGCNCCNLTGH-----IPPSCF-NL

LRR_1 LRRKb.AA LRR_1 1778-1799 33 0.000674 17.99 Pfam 1-26 (26) Show / Hide
Range on Protein: 1778-1799
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

KLERLILSH-N--KLT-KVPKE-LGQL
.|..| ||. |  .|| ..|.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 LRRKb.AA LRR_1 1801-1823 37 0.00461 15.03 Pfam 1-26 (26) Show / Hide
Range on Protein: 1801-1823
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

LLASLDLSH-N-RSIT-TIPDE-LGQL
 | .||||. |  ..| .||.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_TYP LRRKb.AA LRR_TYP 1799-1823 40 0.016542 14.45 SMART 1-24 (24) Show / Hide
Range on Protein: 1799-1823
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

LTLLASLDLSHNRSITTIPDELGQL
|. | .||||.|. .|..|... | 
LPNLRELDLSNNQ-LTHLPPGAFQG

LRR_TYP LRRKb.AA LRR_TYP 1776-1798 33 0.130141 7.11 SMART 1-24 (24) Show / Hide
Range on Protein: 1776-1798
Range on HMM: 1-24/24
Sequence Identity: 33% (8 aa)

WSKLERLILSHNKLTKVPKEL-GQ
 ..|..| ||.|.|| .| .. . 
LPNLRELDLSNNQLTHLPPGAFQG

LRR_1 LRRKb.AA LRR_1 1753-1776 13 5.325923 4.17 Pfam 1-26 (26) Show / Hide
Range on Protein: 1753-1776
Range on HMM: 1-26/26
Sequence Identity: 13% (4 aa)

TLREVILSR-N--KI-KKLTLGDN-LKSW
.|..  ||. |  .. ..  . .. . . 
NLQHLDLSGCNCCNLTGH--IPPSCF-NL

COR LRRKb.AA COR 1992-2362 16 2.3e-62 200.95 In-house 1-434 (434) Show / Hide
Range on Protein: 1992-2362
Range on HMM: 1-434/434
Sequence Identity: 16% (77 aa)

LNEKIKGQPI-------FGQMIPYSYLRLEQLLQEQ--VRRLKSEGQPPVMLHKQVIKMIREND---------LQLDDNELSQAVRFLHETGVLLHYD--
. . .| ...        .|..| |.....| |.|    .....|   |.|  |..... .|.          ...|..|| .....||..|...|..  
IRKTAKKIKHKQMFEDYMCQPVPQSWWKCKQKLEEMRKWMNRHNEK--PWMSWKEFCQICQEHGPPKRLRHQNIIIDEDELHTVAMYLHDLGHIIHFKIW

DPSQQLRNVYFIEPQWLCKVMARVITVREINPLV--SKEGI-MKVKDISLLFND---GD-------VPKQLIPQYLKLLERFEVSLPVSD----------
|.  .|.......|||.|..|.......|....    . || ....|.. ..|.   ..       .|. . .....|.|.||...|...          
DHDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFWHQET

DKILLPCKVPIQKPNIT-LPIS------DATQDLLLRYYDM------PYIPLGLWSRMILRLLLFSKHMMNGEEDHAETIPIWHMPVLNTQGSAVSTHRQ
.  | |. .| ..|..  ..        .. .  | | |..      ...| |.|.| . ||. |...|..                             
TTYLIPQLLPDDRPQHWEWWQWPQWETNEHDCRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKC----------------------------

FRMRSHEEPETVFWREGIYVCWSEE--AFFLIEPLKKGADTLKITVPKTKQ-----GYRLLGLVSDHLDDLIEEWF--PGLC----ELDPRLGRPLVQRL
|. ||   .|...|| |..  |...  ...|..  .  .  ..|||   .      ...|.... .|.... ..|.  |||     ..       ..  .
FYERSC--CEWMYWRNGMVLKWEGHNKNEALVKCDN-HDNKIYITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHW-------VCREW

VPCVMC-------EGRPHLHDLSELLEQSETS-DTITCPNHP-------------------------TR-KVPL
.|| .|         ..  . . ..... | . |...||.                           .  ..  
IPCPHCIQDHWDTCCDICYYQYDWCIRAEEMGMDSYPCPKCDQYCDAFEMMCCYQHHWHYSHDQNGQWIQRISD

ROC LRRKb.AA ROC 1864-1941 32 2.3e-30 99.13 In-house 1-93 (215) Show / Hide
Range on Protein: 1864-1941
Range on HMM: 1-93/215
Sequence Identity: 32% (30 aa)

YNRMKLMVVGYGGRGKSTLLSRMQGQKFDKK-------GDNIATVGVV-VKEWVIQIR-------KKDFCLSTWDFAGQEDFYSTHPCFLTDH
.|.|||| .|.|| ||..|.... ..||. .       |.. .|.|.  ...||....       .... .. |||.||| ...||  ||| |
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSCDKGNHPTTHGIEPIQQWVLDCKDMMFRKKEDEIKFNVWDFGGQEIYHATHQFFLTNH

Miro LRRKb.AA Miro 1868-1943 17 2e-08 32.29 Pfam 1-96 (140) Show / Hide
Range on Protein: 1868-1943
Range on HMM: 1-96/140
Sequence Identity: 17% (17 aa)

KLMVVGYGGRGKSTLLSRMQGQKFD----------KKGDNIATVGVVVKEWVIQIRKKD--------FCLSTWDFAGQEDFYSTHPCF--LTDHAA
|..|.|  | |||...... | .|.          .   .. . ...|.. .... ..         . .. ||..|.|.....|. |  ...  |
KVVVCGDKGCGKSSFIHQYCGEEFPPNIPRVLPDKTMPREMHGHTYYVDTMQVDWDTQSENVDRVKMCYFHIWDCGGREYWKFEHMHFACMKWADA

RAB LRRKb.AA RAB 1867-1993 20 0.000218 -87.88 SMART 1-172 (172) Show / Hide
Range on Protein: 1867-1993
Range on HMM: 1-172/172
Sequence Identity: 20% (36 aa)

MKLMVVGYGGRGKSTLLSRMQGQKFDKKGDNIATVGVVVKEWVIQIRKKDFCLSTWDFAGQEDFYSTHPCF----------------------------L
.|....|  | ||| ||.|    ||.   . ..|.||  |  .|... |   |  || |||| | |  . .                            .
FKIILIGDSGVGKSCLLHRFTDDKFSE--QYKHTIGVDFKTKTIEVDGKRVKLQIWDTAGQERFRSITSSYYRGAHGCILVYDITNRESFENVKNWLKEI

TDHAAD------FI-----SDMEM-RVLEVCRSPGF----PTIKGYINL---SAVTDSGGINELRGMIENVILN
 .|| .      ..     .|.|  |.    .   |        |   .   || | .   .  . ... .. .
RMHANPPPENVVIMLVGNKCDLEHQRQVSTEEAQKFCCDCAEKHGMPFMFETSAKTNTNVEEAFQCLARKIYQR

ROC LRRKb.AA ROC 1962-1986 25 0.173171 1.5 In-house 181-215 (215) Show / Hide
Range on Protein: 1962-1986
Range on HMM: 181-215/215
Sequence Identity: 25% (9 aa)

FPTI----------KGYINLSAVTDSGGINELRGM
|| |          .| .. .. |.. ||..||..
FPNICHSWMQIEHYQGFFHVDCETGCKGIDKLRHH

Kinase LRRKb.AA LRRK 2389-2646 27 9.80000000001e-132 443.94 In-house 1-351 (351) Show / Hide
Range on Protein: 2389-2646
Range on HMM: 1-351/351
Sequence Identity: 27% (98 aa)

QRAENLLGDGSFG-SVYKGTYRD----------------------------KPVAVKVFSKG---------------------------------GESHP
.. |...|.|.|| .||....|.                            ..||.|.. ..                                 . .. 
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

HRLLRQEVTVLRHLQHPSLVSMEGVGLNPRILVMELAPLGSLNTLLA---SGR-----IK-NRNLQHRIAMQVAEGLAFLHKNR--IVYRDLKPDNVLIF
.|..|.||....||.||..||. |....|...|||.||.|.|...|    . .     .. ...|...||.|.|.|...||...  |..||||..|.|..
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILLW

SL-------ALGTLQNAKISDYGISR--FATPYG-LKSSEGTPGYRAPEVIR--GTSNYNTEVDIYSFGILLYELVSEGHRPFEEMEFR-----TEIDEA
|.       .... ..|||.|.||||  .....| .| ..|.||..|||..|  |...|...||.||||..|.||.. .|.||.|..|.     .|..| 
SSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIED

VIKGQHLPPIS---QGGVAPWPDLQELIDHCTEHVPESRPTAQEAFEKLSS
 |.... |.|.   .....||...|.||.|| .| |..||.... ...||.
KIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ

Kinase LRRKb.AA TKL 2395-2644 23 2.2e-78 266.74 In-house 1-364 (364) Show / Hide
Range on Protein: 2395-2644
Range on HMM: 1-364/364
Sequence Identity: 23% (87 aa)

LGDGSFGSVYKGTYRD----------KPVAVKVFSKGG--------------------------ESHPHRLLRQEVTVLRHLQHPSLVSMEG--------
.| |.|| ||||..|           |.||||.|..                             |.    ...|. ... |.|| .|.. |        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-VGLNP------RILVMELAPLGS-LNTLLASGRIKNRNLQHRIAMQVAEGLAFLHKNR--------IVYRDLKPDNVLIFSL---------ALGTLQNA
 | ..|        .|||..| || |..|.        .. .|.|...| |...|| ..        |..||||..|.|...          .     ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KISDYGISRFATPYG--------------------LKSSEG-TPGYRAPEVIRGT---------------SNYNTEVDIYSFGILLYELVSEGHRPFEEM
||.|.|.||| .. |                     ..... ||.. ||||.||.               . |.. .|.|||||.|.|...  . |....
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYDY

EFRT--------EIDEAVIKGQHLPPIS---------QGGVAPWPDLQELIDHCTEHVPESRPTAQEAFEKL
 ...        |. . |.. .. |||          .     .|.. .|. .| .| ||.||..||  ..|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase LRRKb.AA S_TKc 2389-2650 24 5.7e-57 196.49 SMART 1-231 (231) Show / Hide
Range on Protein: 2389-2650
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

QRAENLLGDGSFGSVYKGTYRD--KPVAVKVFSKGGESHPHRLLRQEVTVLRHLQHPSLVSMEGVGL-NPRILVMELAPL--GSLNTLLASGRI------
 .  ...| |.||.|||.. ..  . ||.|. .        . .|.|. .|.. .|| .| . .|   .   .|||...   |.| ... . .       
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

KNRNLQHRIAMQVAEGLAFLHKNRIVYRDLKPDNVLIFSLALGTLQNAKISDYGISRFATPYGLKSSEGTPGYRAPEVIRGTSNYNT-EVDIYSFGILLY
 .     ... |....|...|...|..|||||.|.|. .       . ||.| |..|.      ..  ||| |.||||.     |.. ..|..|.|..||
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------HIKICDFGLARQL-----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILY

ELVSEGHRPFEEMEFRTEIDEAVIKGQHLPPISQGGVAPWPDLQELIDHCTEHVPESRPTAQEAFE---KLSSAEML
|... |  ||.  .  . ..  .                 |.. ..|..| .  || |||| ||..   .  . . .
EMLC-GYPPFP--QMQMMFKKIG----------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase LRRKb.AA Pkinase 2395-2644 25 5.3e-46 163.74 Pfam 7-293 (293) Show / Hide
Range on Protein: 2395-2644
Range on HMM: 7-293/293
Sequence Identity: 25% (76 aa)

LGDGSFGSVYKGTYRDKP--VAVKVFSKGGESH--PHRLLR-QEVTVLRHLQHPSLVSMEGVGL-NPRIL-VMELAPLG----SLNTLLA---SGRI--K
.| ||||.|||.. .. .  ||||...| .|..  . ...| .|. ....|.||  | . ..   ...|  |||... |    .| ...    .|..   
IGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFS

NRNLQHRIAMQVAEGLAFLHKNRIVYRDLKPDNVLIF-SLALGTLQNAKISDYGISRF--ATPYGLKSSEGTPGYRAPEVIRGTSNYNTEVDIYSFGILL
 . ... .. |...||...|...|..|||||.|.||     ...    ||.| |....    ......  |||.|.||||||| . | ..||..|.|..|
EWECKF-YMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA--CVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCIL

YELVSEGHRPFEEM-EFRTEIDEAVIKGQHLPPISQGGVAPW---------------------PDLQELIDHCTEHVPESRPTAQEAFEK--L
||... |. || .     . .|. ..  . ..|.       |                     ......|. | .  |..||||.....   .
YEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase LRRKb.AA TK 2389-2644 16 2.7e-45 149.36 In-house 1-486 (486) Show / Hide
Range on Protein: 2389-2644
Range on HMM: 1-486/486
Sequence Identity: 16% (82 aa)

QRAENLLGDGSFG---SVYKGTYRDK---------------------------PVAVKVFSKG-GESHPHRLL---------------RQEVTVLRH--L
 . .. || | ||    ||||..|..                           |||||.  .| ..|   ...                .|  ...|  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHPSLVSMEG----VGL----------NPRILVMELAPLGS----LNTLLASGRIKNRN-----------------------------------------
.|| .|.. |    ..            | ..|||..|.|.    | . | . | | ..                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------------------------------LQHRIAMQVAEGLAFLHKN------RIVYRDLKPDNVLIFSLALGTLQN------AKISDYGISR
                                    .. ...|.|.|...||..      ..| |||   |.|...    .  .      .||.|.| ||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

FAT-----------PYGLKSSEGTPG-------------------------YRAPEVIRG--------TSNYNTEVDIYSFGILLYELVSEG-HRPFEEM
  .            |  |||.||..                         . |||....        .  . |. |..|||.|..|... |   . ..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

EF--------RTEIDEAVIKG--------------QHLPPISQGG----------VAPWPDLQELIDHCTEHVPESRPTAQEAFEKL
           .|. | . .|                .|.  .             .| .....|.  | .. || ||| ..  |.|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase LRRKb.AA TKL-Unique 2393-2644 28 6.8e-45 155.47 In-house 3-290 (290) Show / Hide
Range on Protein: 2393-2644
Range on HMM: 3-290/290
Sequence Identity: 28% (83 aa)

NLLGDGSFGSVYKGTYRDKPVAVKVFSKGGESHPHRLLRQ----EVTVLRHLQ-HPSLVSMEGVGL----NPR--ILVMELAPLGSLNTLLAS-------
|..| |..|.||||..| .|||.|.|..  .. ..  ..|    ||...  |. || .|   |.       |   ..|||  |.|||. .|.        
NKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

-GRIKNRNLQHRIAM--QVAEGLAFLHKNR--IVYRDLKPDNVLIFSLALGTLQNAKISDYGISRFAT-----PYGLK------SSEGTPGYRAPEVIRG
  . .. |.| |. |  ..| |. .|| .   |  ||||. |.|. .       |.||.| |.|.|..     ... .      . .|.. ..||||.|.
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM

T-SNYNTEVDIYSFGILLYELVSEGHR------PFEEMEFR--TEIDEAVIKGQHLPPISQGGVAPWPDLQELIDHCTEHVPESRPTAQEAFEKL
  . |.. .|.||||| |.|... ...      |...|..    |.   . .... |||..      .....||. |  | |. ||. .|  ..|
NFCQYSEKSDVYSFGIVLWEIAT-RKITKTYKKPYQGMDQEQWCEMVHYMEENYR-PPIPNHCP---KEYRDLIQQCWHHDPSQRPSFDEIIHRL

Kinase LRRKb.AA MLK 2389-2644 27 2.6e-43 148.14 In-house 1-291 (291) Show / Hide
Range on Protein: 2389-2644
Range on HMM: 1-291/291
Sequence Identity: 27% (84 aa)

QRAENLLGDGSFGSVYKGTYRDKP-----VAVKVFS-----KGGESHPHRLLRQEVTVLRHLQHPS----LVSMEGVGLNP---RILVMELAPLGSLNTL
 . .  .| ||||.|.||..| |      |||| .      |. ..   . ...|.  ||.|.||      .   || |.|     .||| .. |||...
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LASGRIKNR---NLQH-----------RIAMQVAEGLAFLHKNR---IVYRDLKPDNVLIFS----LALGTLQNAKISDYGISRFATPYGLK---SSEGT
|...|.|     . |            ..|.|.|.|...||..    |. ||||. |.||      .. |||   ||.| |.||. .  . .   |  ||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTL---KICDFGTSRDWHQMC-TNMMSNAGT

PGYRAPEVI---RGTSNYNTEVDIYSFGILLYELVSEGHRPFE-EMEFRTEIDEAVIKGQHLPPISQGGVAPWPDLQELIDHCTEHVPESRPTAQEAFEK
. ..|||||   |. . |.  .|..|.|..|.|... .  |.. ...  . . ... .|...| .|.   .| . . .|.  | .  |..||. ..  ..
YAWMAPEVIQQFRC-EKYSEKCDVWSWGVVLWEMLT-REVPYKQHYDPMAIAWWVAYNGLRPPIPST---CP-EHWKKLMKQCWNQDPHKRPSFRQIVQH

L
|
L

Kinase LRRKb.AA STE 2389-2639 18 1.3e-38 133.93 In-house 1-350 (359) Show / Hide
Range on Protein: 2389-2639
Range on HMM: 1-350/359
Sequence Identity: 18% (66 aa)

QRAENLLGDGSFGSVYKGTYRDKP-----------------VAVKVFSKGGES----------------HPHRLLRQEVTVLRHLQ--HPSLVSMEGVGL
..    .| |.||.|||. .....                 .|.|. ..  ..                  .  . .|. ......  ||  |   |  .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

---------NPRILVMELAPLGSLNTLLASGRIKNR-------------NLQH-RIAMQVAEG-LAFLHKNRIVYRDLKPDNVLIFSLALGTLQNAKISD
         .   ..||. . |||  .. .  ....               |  .|. |. .| |..||...|. ||.||.|.|.          .|..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------VKLCD

YGISRFATP------------------YGLKSSEGTPGYRAPEVIRG-----TSNYNTEVDIYSFGILLYELVSEGHRPFEEMEFRTEIDEAVIKG----
 |..   |.                     ..  ||| . |||||..      . |.| .||.|.|... |.. .|. |. .|     . .. ...    
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA-TGKPPWHDMHPMRAMFMIPFNYHMQQ

---------QHLPPISQ----------GGVAPW---------PDLQELIDHCTEHVPESRPTAQE
         .. ||. .          | .            |.... |..| .  |. ||||..
QFEQLCIVNGPPPPLPDHLSQNEMISYG-G--SGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ

Kinase LRRKb.AA CAMK 2394-2640 18 3e-37 117.07 In-house 1-419 (425) Show / Hide
Range on Protein: 2394-2640
Range on HMM: 1-419/425
Sequence Identity: 18% (76 aa)

LLGDGSFGSVYKGTYRDKP--------------VAVKVFSKGG---------------------------ESHPHRLLRQEVTVLRHLQ-------HPSL
 || |||| |.... .  .              ||.|. .|                             . .  . .|.|. ....||       || .
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VSMEGVGLNPR---------------------ILVM---ELAPLG----S-LNTLLASGR---------IKNRN------LQHRIAMQVAEGLAFLHKNR
...  |  .|.                     ..||   |... |      .. . . |.         |  ..        .|.  |........|.. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSHN

IVYRDLKPDNVLIFSLALGTL------------QNAKISDYGISRFATPYG-------------------------LKSSEGTPGYRA-PEVIRG-----
|| |||||.|.|. .   ..              | ||.| | ... .|                           .| . |||.| | |||..|     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------TSNYNTEVDIYSFGILLYELVSEGHRPFEEM---EFR---------TEIDEAVIKGQHL-PPISQGGVAP------WP------------DL
           |. ..|. | |..|| ... |. ||..    | .          |. | ..||.   ||    .. .      |             . 
MQNATDEEKPYYGPKCDMWSCGVILYIMLC-GYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

QELIDHCTEHVPESRPTAQEA
. || .. .  || |.|....
KDLIRKMLQVDPEKRMTIEQC

Kinase LRRKb.AA TyrKc 2389-2644 25 2.7e-36 127.79 SMART 1-280 (280) Show / Hide
Range on Protein: 2389-2644
Range on HMM: 1-280/280
Sequence Identity: 25% (76 aa)

QRAENLLGDGSFGSVYKGTYRDKPVAVKVFSKGGESHPHRLLRQEVTVLRHL--QHPSLVSMEGVGL---------NPRILVMELAPLGSLNTLLASGR-
 . .  || | || |||||..  .||||.  ..     .. ...|  ....|  .|| .| . || .          |  .|||..|.|.|.  | . | 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-IKNRNLQHRIAMQVAEGLAFLHKNRIVYRDLKPDNVLIFSLALGTLQNAKISDYGISRFATPY-------GLKSSEGTPGYR--------APEVIRGTS
 .... | . .. |.|.| ..||..... |||   |.|. .        .|||| | ||. . .         ... .. | .        |||.|    
KLCMKDL-LSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NY

N-YNTEVDIYSFGILLYELVSEGHRPFEE-----MEFRTEIDEAVIKGQHLPPISQ-----GGVAPWPDLQELIDHCTEHVPESRPTAQEAFEKL
. ..|. |..|||....|. . |  | ..     |. . |. | | .|  .|.          |   ... ...  | .. ||.||| .|  |..
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ-EVIEYVKQGYRMPQPPNDYPMSF-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase LRRKb.AA Dicty4 2390-2579 31 3e-36 118.51 In-house 2-211 (277) Show / Hide
Range on Protein: 2390-2579
Range on HMM: 2-211/277
Sequence Identity: 31% (69 aa)

RAENLLGDGSFGSVYKGTYRDKPVAVKVF--SKGG-ESHPHRLLRQEVTVLRHLQHPSLVSMEGVGL----NP--RILVMELAPLGSLNTLLAS------
  |...|.||||.||||| | | ||||..   . . ..     .|.||. .  ..|| ..   |  .    .|     |.|. | |.| .|| .      
NIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQ

GRIKNR-NLQHR---IAMQVAEGLAFLHK-N-RIVYRDLKPDNVLIFSLALGTLQNAKISDYGISR----FATPYG-LKSSEGTPGYRAPEVIRGTSNYN
 .||    |  |   .|  .| |.. ||  | .|. ||||..| |.         ..|..| |.|.      .    ...  |||.. |||| .. . ||
QSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLV-----DKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQP-YN

TEVDIYSFGILLYELV
  .| |||||.|.|..
EKADVYSFGIVLWEIL

Pkinase_Tyr LRRKb.AA Pkinase_Tyr 2385-2589 27 2e-35 120.57 Pfam 1-219 (270) Show / Hide
Range on Protein: 2385-2589
Range on HMM: 1-219/270
Sequence Identity: 27% (64 aa)

LNFTQRAENLLGDGSFGSVYKGTYR------DKPVAVKVFSKGGESHP---HRLLRQEVTVLRHL-QHPSLVSMEGVGL---NP--RILVMELAPLGSLN
. | .     || |.||.|||||..      . |||||.  | | .|.   .. . .|. ....| .|| .|.. || .    |   ..|||..|.|.| 
ITFGKK----LGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

TLLAS----GRIKNRNLQHRIAMQVAEGLAFLHKNRIVYRDLKPDNVLIFSLALGTLQNAKISDYGISRFATP---YGLKSSEGTPG---YRAPEVIRGT
. | .    ..  .      ...|.|.|...|. .... |||   |.|. .    ..  .||.| | .|  ..   | .....|..      |||.|.  
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NN-VVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYG

SNYNTEVDIYSFGILLYELVSEGHRP-FEEM
  ..|. |..|||.|..|... |  | ...|
K-FTTKSDVWSFGVLMWEIFTYGEQPTYPGM

Kinase LRRKb.AA Dicty4-Unclassified 2390-2644 28 3.3e-35 117.99 In-house 2-263 (263) Show / Hide
Range on Protein: 2390-2644
Range on HMM: 2-263/263
Sequence Identity: 28% (77 aa)

RAENLLGDGSFGSVYKGTYRDKPVAVKVFSKGGESHP---HRLLRQEVTVLRHLQHPSLVSMEGVGLNP------RILVMELAPLGSLNTLLA---SGRI
.    .| | |  |.||  . | |||| |  .  .         . || .|  .||| || . |  .||       . |||. . | |  .     | . 
QIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQ

KNRNLQH----RIAMQVAEGLAFLHKNRIVYRDLKPDNVLIFSLALGTLQNAKISDYGISR-FATPYGLKSSEGTPGYRAPEVIRGTSNYNTEVDIYSFG
.   |      ..|. .| |...||   .. ||.|  |.|.         |.|| | ||||     . .    |||   .||. .. | ||   |.||..
QPIKLDDTLIIKYAFDIAQGMQHLHTRNFIHRDIKSSNILM-----DKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHES-YNQKSDVYSYA

ILLYELVSEGHRPFEEMEFRTEIDEAVIKGQHLPPISQGGVAPWPDLQELIDHCTEHVPESRPTAQEAFEKL
..||||.  |  |. |     ..   |      | |.   . .   .. ||  |    |  |||  .  ..|
MMLYELAT-GDEPYQEIQSIMNAARSVCDKKLRPKIPD-NCDNF--WKKLIKWCWHNDPNKRPTMNQIIQYL

Kinase LRRKb.AA TK-Unique 2389-2644 23 1.5e-33 113.1 In-house 1-294 (294) Show / Hide
Range on Protein: 2389-2644
Range on HMM: 1-294/294
Sequence Identity: 23% (72 aa)

QRAENLLGDGSFGSVYKGTYR--------DKPVAVKVFSKGGESHPHRLLRQEVTVLRHLQ-HPSLVSMEGVGL---NPRILVMELAPLGSLNTLLASGR
 . ....|.|.|| |..|...        .| ||||   ..   . .. . .|  ....|  || .|...|.     .|  ..|| .| |.| ..| . |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

---------------------IKNRN-LQ----HRIAMQVAEGLAFLHK--NRIVYRDLKPDNVLIFSLALGTLQNAKISDYGISR---FATPYGLKSSE
                     ..... ..     ..| |.| |...|..   .||.|||   |||. .       ..||.|.|..|     ..|  . |.
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-----DKVCKICDFGMARDVYTNGVYSMMCSQ

GTPGYR--APEVIR--GTSNYNTEVDIYSFGILLYELVSEGHRPFEEMEFRTEIDEAVIKGQHLPPISQGGVAPWPDLQELIDHCTEHVPESRPTAQEAF
|.  .|  |||...  .   ..|. |..|||.|..|... | .|. .|  .  | |.. .|  .|   |    . ... .|.  |. ..||.||.  .  
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKD-IMECIRDGYRMP---QPEHCCSHEMYNLMKSCWQWEPEERPSFRQIK

EKL
 .|
HRL

Kinase LRRKb.AA Dicty4 2617-2646 31 0.024669 3.79 In-house 246-277 (277) Show / Hide
Range on Protein: 2617-2646
Range on HMM: 246-277/277
Sequence Identity: 31% (10 aa)

PDLQELIDHCTEHVPESRPTAQEAFEK--LSS
| . .||  | .| |..||. .|  ..  | .
PSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH