Gene LRRKa (Sea Urchin)

LRRKa

Species: Sea Urchin
Alias: SPU_009036, Spk309, LRRKa
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: LRRK

Sequence

Name Sequence Type Origin Length Description Download
LRRKa.AA Protein None 2417 None Fasta, JSON
LRRKa.kin_dom Protein Kinase Domain None 303 None Fasta, JSON

Protein domain

Protein domains of LRRKa.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
ROC LRRKa.AA ROC 70-277 25 2.9e-73 244.16 In-house 1-215 (215) Show / Hide 
Range on Protein: 70-277
Range on HMM: 1-215/215
Sequence Identity: 25% (63 aa)

YTRMKLMFVGKAGIGKTTLLNELRRDGVGAYIAQSLGTFGERQGNSHISGKTLKGNHLSTVGVD-VCEWTYNKK----KAKHGKVTFSTWDFGGQQEFYA
...||||..|..|.|||.|.. |..|.  .....|.                .|||| .|.|.. ...|....|    ..|.....|. ||||||....|
CNEMKLMLCGQGGVGKTSLCKQLMHDKFSDCSCYSC----------------DKGNHPTTHGIEPIQQWVLDCKDMMFRKKEDEIKFNVWDFGGQEIYHA

THQYFLTK-RSLYLVVCKITD----GSKV----INE--LQQWLVNIQARAPN--------SPVIIVGTHYDVILRDK-----KYSKE--YW--PELKRTI
|||.|||. ||.||.|... .    |..     ...  |..|| .|..|.|.        |||||||||.|.. |..     .....  ..   .  . |
THQFFLTNHRSVYLLVWDCRTKCCDGQPEMIVRECNYELEYWLRFIKSRGPQSEHHCMQPSPVIIVGTHWDKVPRQDNKVYQHKQCCRMWQKLRNKFPNI

F---------DRFINIAHPQDAGLPHVIACVEVSCAASSKSYNVNMLRDL
.         . |..... ..                   ......||. 
CHSWMQIEHYQGFFHVDCETG-------------------CKGIDKLRHH
Miro LRRKa.AA Miro 151-216 25 2.1e-08 32.24 Pfam 70-140 (140) Show / Hide 
Range on Protein: 151-216
Range on HMM: 70-140/140
Sequence Identity: 25% (18 aa)

FSTWDFGGQQEFYATHQYF--LTKRSLYLVVCKITDGS--KVINELQQWLVNIQARAPN-SPVIIVGTHYD
|. ||.||. .....|. |  ..... ...|   ||..      ..  || ...... . .|||.||.. |
FHIWDCGGREYWKFEHMHFACMKWADAICFVYDCTDYESFNRVSNYMAWLPHFRKWGKKAIPVIVVGNKCD
Miro LRRKa.AA Miro 74-89 31 0.101598 8.35 Pfam 1-16 (140) Show / Hide 
Range on Protein: 74-89
Range on HMM: 1-16/140
Sequence Identity: 31% (5 aa)

KLMFVGKAGIGKTTLL
|.. .|. |.||....
KVVVCGDKGCGKSSFI
COR LRRKa.AA COR 286-375 24 1.9e-32 102.29 In-house 89-210 (434) Show / Hide 
Range on Protein: 286-375
Range on HMM: 89-210/434
Sequence Identity: 24% (30 aa)

TGILLHYE----DSMLNDYFFLDPQWLCDTLAKVVTIPEINPD---VKKGV-MLVRDLHRKFED--------------SSVKEFIVSLLNKFEVAVTYDP
.|...|..    |.||.|...|||||.|. ....... |....    .||. . ..||.. ...              ....|..|.|..|||... .||
LGHIIHFKIWDHDPMLKDFVVLDPQWFCQMMYHIFNHKESRCFHKLHNKGIFFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDP

----------KHLLIPSRLPQE
          ...|||..||..
DWTHFWHQETTTYLIPQLLPDD
COR LRRKa.AA COR 566-737 10 9.4e-28 86.82 In-house 230-434 (434) Show / Hide 
Range on Protein: 566-737
Range on HMM: 230-434/434
Sequence Identity: 10% (23 aa)

KTAIRRLYIL------QYIPSGFWSHLISRLLSDQMIPGLINSMYLLSDDVHRFFEGEPLSEFTNEFQWVCWQSGIELKFMSV--TVFHVKAVVREKLLS
....|| | .      ...|.|||.... ||..... .. .                  ..|... ..|..|..|. ||..    ....||.........
CRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKC------------------FYERSC-CEWMYWRNGMVLKWEGHNKNEALVKCDNHDNKIY

SVFERERRP----ESVHVLSLTDDPDHFPRNVSLSRSGQ-------LEILIPNQTL-----E-VTH--RIQQREANGKGMSD--SVKILTSL--------
 ........     . .. .... ..|. .. ..... |       .. .|| ..      .   .   .|...  .. ...  |..  ..         
ITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHWVCREWIPCPHCIQDHWDTCCDICYYQYDWCIRAEEMGMDSYPCPKCDQYCDAFEM

----------------ETVSRLLAT
                ... ... .
MCCYQHHWHYSHDQNGQWI-QRISD
COR LRRKa.AA COR 987-1033 21 1.7e-10 29.9 In-house 140-210 (434) Show / Hide 
Range on Protein: 987-1033
Range on HMM: 140-210/434
Sequence Identity: 21% (15 aa)

VMLVRDLHRKFED--------------SSVKEFIVSLLNKFEVAVTYDP----------KHLLIPSRLPQE
.. ..||.. ...              ....|..|.|..|||... .||          ...|||..||..
FFTHQDLEKIWNPPCRHNPHMNWRRYPDHDHEYLVELMEKFELCYPIDPDWTHFWHQETTTYLIPQLLPDD
COR LRRKa.AA COR 1224-1395 10 9.5e-28 86.81 In-house 230-434 (434) Show / Hide 
Range on Protein: 1224-1395
Range on HMM: 230-434/434
Sequence Identity: 10% (23 aa)

KTAIRRLYIL------QYIPSGFWSHLISRLLSDQMIPGLINSMYLLSDDVHRFFQGEPLSEFTNEFQWVCWQSGIELKFMSV--TVFHVKAVVREKLLS
....|| | .      ...|.|||.... ||..... .. .                  ..|... ..|..|..|. ||..    ....||.........
CRYLRRHYHYCMDHHHMFLPAGFWPRFQVRLHHFIHDMFKC------------------FYERSC-CEWMYWRNGMVLKWEGHNKNEALVKCDNHDNKIY

SVFERERRP----ESVHVLSLTDDPDHFPRNVSLSRSGQ-------LEILIPNQTL-----E-VTH--RIQQREANGKGMSD--SVKILTSL--------
 ........     . .. .... ..|. .. ..... |       .. .|| ..      .   .   .|...  .. ...  |..  ..         
ITVRGCQDCWIDMCCQLWQIIRQHIQHIHNSWWPWPGLQYQCQHWVCREWIPCPHCIQDHWDTCCDICYYQYDWCIRAEEMGMDSYPCPKCDQYCDAFEM

----------------ETVSRLLAT
                ... ... .
MCCYQHHWHYSHDQNGQWI-QRISD
Kinase LRRKa.AA LRRK 1658-1963 34 7.1e-162 544.07 In-house 1-351 (351) Show / Hide 
Range on Protein: 1658-1963
Range on HMM: 1-351/351
Sequence Identity: 34% (121 aa)

LEIQRLLGSGTFG-LVFQGVMARASEHRRPIAAKMLQPYPPGQGAGNTDRRRYDNDNTKWHRDP------------------------------LRFSCE
|.|....|.|.|| .|... . ....|......|||||| ..|||.|...........||.|||                              ....|.
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPY-MYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCR

AYRTARKELSIINNLDHPHIVPLLGFCRHPMCLILELAPQGALDTRMENFKRVG-----ARLTPHTLQELVVQVSSAVAYLHSKD--IIYRDLKAENVLV
|.|..|.|..|...|.||.||.|.||| ||.|...|.||.|.|.....|.|. |     |............|......||||..  ||.|||| .|.|.
AFREFRHEVWIMSHLNHPNIVSLKGFCIHPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNILL

WKFPQPYSPN-PADPIKVKLADYGISV--TALPSG-TKGYGGTPGYMAPEIVQYDGKETYNEKVDCFSFGMFMFELMSLQ-RPFECLVGKDVGRLSEVIK
|..||..||| |......|.||.|||   .....| .||..|.||.|||||..|.|.|.|.|||||.||||...||...| .||......|.... | |.
WSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIE

QLIKDGQRPVLS---RKEKSYPTYMLDLLSWCWAQDSRDRPSMEQIKDVSKT
..|..|.||...   ...........||. .||..| ..||...|| .. ..
DKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase LRRKa.AA TKL 1664-1961 19 6.6e-71 241.87 In-house 1-364 (364) Show / Hide 
Range on Protein: 1664-1961
Range on HMM: 1-364/364
Sequence Identity: 19% (79 aa)

LGSGTFGLVFQGVMARASEHRRPIAAKMLQPYPPGQGAGNTDRRRYDNDNTKWHRDP-----------------------LRFSCEAYRTARKELSIINN
.|||.|| |..|.    .. ..                 .. .. .|    |....                         .... .  . ..|. ....
IGSGGFGEVYKGKWRGWGG-KC-----------------PS-DTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSR

LDHPHIVPLLG---------FCRHP------MCLILELAPQGA-LDTRMENFKRVGARLTPHTLQELVVQVSSAVAYLHSKD--------IIYRDLKAEN
|.||.||...|         .| ||      .|.. |..| |  |..             .| .  .. .......||||..        ||.|||| .|
LRHPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKN

VLVWKFPQPYSPN----PADPIKVKLADYGISVTALPSGTKGY---------------------GGTPGYMAPEIVQYD-------------GKETYNEK
.||..  ...| |    |......|..|.|.| .  .|| .                       .|||..||||. . .             ....|.||
ILVDENWTNVS-NYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEK

VDCFSFGMFMFELMSLQRPFECL-----VGKDVGRLSEVIKQLIKDGQRPVLS---------RKEKSYPTYMLDLLSWCWAQDSRDRPSMEQIKDVS
.|..|||. ..|... .||....     .. |   . | ... ...|.|| .           .... |. | .|. .||..| ..|||...|..  
CDVYSFGIVLWEILTRCRPYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase LRRKa.AA S_TKc 1658-1967 20 2.4e-56 194.4 SMART 1-231 (231) Show / Hide 
Range on Protein: 1658-1967
Range on HMM: 1-231/231
Sequence Identity: 20% (65 aa)

LEIQRLLGSGTFGLVFQGVMARASEHRRPIAAKMLQPYPPGQGAGNTDRRRYDNDNTKWHRDPLRFSCEAYRTARKELSIINNLDHPHIVPLLGFCR-HP
 || |..|.|.|| |....  .     |  | |..                                    ...|.|..|  . .||.|| |..... . 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----------------------------------EHIRREIQILKK-HHPNIVKLYDVFQDDH

MCLILELAPQ--GALDTRMENFKRVGAR--LTPHTLQELVVQVSSAVAYLHSKDIIYRDLKAENVLVWKFPQPYSPNPADPIKVKLADYGISVTALPSGT
.....|....  | | ..... .| | |  ... . . .. |. .|..|.||. ||.|||| ||.|. .              .|..| |..        
LYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-------------HIKICDFGLARQL-----

KGYGGTPGYMAPEIVQYDGKETYNE-KVDCFSFGMFMFELMSLQRPFECLVGKDVGRLSEVIKQLIKDGQRPVLSRKEKSYPTYMLDLLSWCWAQDSRDR
. . ||| |||||..       |.  |.|  |.|  ..|... . ||.     .. .. ..|.                  .  ..|... |.  | ..|
TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKR

PSMEQIKD---VSKTAEFA
|.  ..     . |  .. 
PTA-EALQDEWDIKCHPWF
Kinase LRRKa.AA Pkinase 1658-1958 21 1.6e-41 147.85 Pfam 1-288 (293) Show / Hide 
Range on Protein: 1658-1958
Range on HMM: 1-288/293
Sequence Identity: 21% (73 aa)

LEIQRLLGSGTFGLVFQGVMARASEHRRPIAAKMLQPYPPGQGAGNTDRRRYDNDNTKWHRDPLRFSCEAYRTARKELSIINNLDHPHIVPLLGFCRHP-
..| | .|||.|| |....    ..     | | .       .   |.||.                         |..| ..|.||.|| |..... . 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRL------------------------SEIQIMKRLNHPNIVRLYDWFEDKD

-MCLILELAPQG----ALD----TRMENFKRVGARL--TPHTLQELVVQVSSAVAYLHSKDIIYRDLKAENVLVWKFPQPYSPNPADPIKVKLADYGISV
 .....|... |     |     |      . . ..  ......  . |. ....|.||. ||.|||| ||.|. . ... .       .||..| |.. 
HIYMVMEYCEGGLYVMDLFDYIST------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-------CVKICDFGLAK

---TALPSGTKGYGGTPGYMAPEIVQYDGKETYNEKVDCFSFGMFMFELMSLQRPFECL----VGKDVGRLSEVIKQLIKDGQRPVLSRKE---------
   .   | .... |||.|||||...  | . |  ||| .|.|  ..|... . ||          |   . . |.. . . ..| ....          
QFDY-NNS-MTTFCGTPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHF

----KSYPTYMLDLLSWCWAQDSRDRPSMEQIK
    .  .  ..|...||...|  .||. |||.
HWTFHNWSEECKDFIKWCLCKDPKKRPTAEQIL
Kinase LRRKa.AA TK 1658-1961 15 1.1e-37 123.4 In-house 1-486 (486) Show / Hide 
Range on Protein: 1658-1961
Range on HMM: 1-486/486
Sequence Identity: 15% (81 aa)

LEIQRLLGSGTFG---LVFQGVMAR----------------------ASEHRRPIAAKMLQPYPPGQGAGNTD----RRRYDNDNTKWHRDPLRFSCEAY
... . ||.| ||    |..| . .                       .. . | | ||| .  . . .   |    . | |               .  
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHD-R-D---------------G--

RT-----ARKELSIINN--LDHPHIVPLLGFC--------------RHPMCLILELAPQGA----LDTRMENFKRVGAR---------------------
 .        |... ..  ..||.|| |.| |              ..|.....|..| |     |..   . .. .                       
-GEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCM

---------------------------------------------------LTPHTLQELVVQVSSAVAYLHSKDI------IYRDLKAENVLVWKFPQP
                                                   ||.|.|    .|.... .||||| .      . ||| | |.||      
KGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLV------

YSPNPADPIK---------VKLADYGISV-------TALPSGTKGYGGTPGY-----------------------------MAPEIVQYDG------KET
   .  ...|         .|.||.| |         ...|..  |  ....                             |||| ...        . .
---GENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGK

YNEKVDCFSFGMFMFELMSLQ-RPFEC-LVGKDVGR---LSEVIKQLIKD-----------GQRPVLSRKEKSYP-------------TYMLDLLSWCWA
. .| | .||| .|.|....   |.   .   ||     . ||...| .            |.|  . . .   .             . . ||.  ||.
FTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWH

QDSRDRPSMEQIKDVS
 | .|||...|...  
YDPEDRPTFSQLHEQL
Kinase LRRKa.AA Ciliate-E2 1733-1921 20 3e-35 118.45 In-house 65-304 (365) Show / Hide 
Range on Protein: 1733-1921
Range on HMM: 65-304/365
Sequence Identity: 20% (56 aa)

KELSIIN----------------NLDHPHIVPLLGFC----RHPMCLILELAPQGALDTRMENF---------KRVGARLTPHTLQELVVQVSS------
.|..|..                .|.||.|. .  .     .. . |..|.. .| |  ...|.         |    ..|    ...  |. .      
QEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEK-D-KYFTEKEIKYIMKQILQGFKTKA

---------AVAYLHSKD-IIYRDLKAENVLVWKFPQPYSPNPADPIKVKLADYGISVTALPS--------------------GTKGYG-----------
         |. |||||  ||.||.| ||.|.                .|..| |.|  . ..                    .| ||            
EFYIACIILALEYLHSKNNIIHRDIKPENILF----------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNT

--GTPGYMAPEIVQYDG------KETYNEKVDCFSFGMFMFELMSLQRPFECLVGKDVGRLSEVIKQLIKDGQ
  ||||||||||... .      .. |..|.| .|.|. ..|... ..||                | ||...
ICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---------------QQQIKQCK
Kinase LRRKa.AA CAMK 1663-1885 19 6.9e-34 106.05 In-house 1-321 (425) Show / Hide 
Range on Protein: 1663-1885
Range on HMM: 1-321/425
Sequence Identity: 19% (66 aa)

LLGSGTFGLVFQGVMARAS-EHR--------RPIAAKM-----LQPYPPGQGAGNTDRRRYDNDNTKWHRDPLRFSC------EAYRT-ARKELSIINN-
 ||.|.|| |. ..  .   ..|        .  |.|.     |.   . |.  .       |  ..  .|  . ..      .  |   |.|..| .. 
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQN-QDY-S-------N--CY-KIDKSKCKHRYCWRRPKDRKNVRREIEIMKKL

------LDHPHIVPLLG---------------FCRHP-------MCLIL---ELAPQGAL----DTRMENFKRVG-----------ARLTPHTLQELVVQ
      ||||.|. |.                . ...       |....   |... | |      .    .. |            |.| .  . .. |
QGIGNKLDHPNIIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQ

VSSAVAYLHSKDIIYRDLKAENVLVWK-------------FPQPYSPNPADPIKVKLADYGISVTALPSG-------------------------TKGYG
. |||.|.||..|. |||| ||.|. .             |.        .  ..|..| | .    |.                           | . 
ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFD-------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFC

GTPGYMA-PEIVQYDG-----------KETYNEKVDCFSFG
|||.||| ||.... |           |. |..|.|. | |
GTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCG
Kinase LRRKa.AA TKL-Unique 1732-1957 22 1.8e-27 94.0 In-house 43-286 (290) Show / Hide 
Range on Protein: 1732-1957
Range on HMM: 43-286/290
Sequence Identity: 22% (59 aa)

RKELSIINNLD-HPHIVPLLGFCR----HPM--CLILELAPQGALDTRME------NFKRVGARLTPHTLQELVVQVSSAVAYLHSKD--IIYRDLKAEN
..|......|. || || . |.|     .|   |...|  | | |.          |  .    |..     .. .....  |||...  || ||||  |
ENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSN

VLVWKFPQPYSPNPADPIKVKLADYGISVTALPSGTKGYG-----------GTPGYMAPEIVQYDGKETYNEKVDCFSFGMFMFELMSLQR------PFE
.||  .      ..  ....|..| |.| ..  . .. ..           |.. .||||.      ..|.||.| .|||. . |. . ..      |..
FLVDNN------SNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF-CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQ

CLVGKDVGRLSEVIKQLIKDGQRPVLSRKEKSYPTYMLDLLSWCWAQDSRDRPSMEQI
 .  . .    |....  ....|| ..    . |    ||.  ||..|. .||| ..|
GMDQEQWC---EMVHYM-EENYRPPIP---NHCPKEYRDLIQQCWHHDPSQRPSFDEI
Kinase LRRKa.AA TK-Unique 1733-1961 26 7.6e-27 89.67 In-house 52-294 (294) Show / Hide 
Range on Protein: 1733-1961
Range on HMM: 52-294/294
Sequence Identity: 26% (69 aa)

KELSIINNLD-HPHIVPLLGFCR---HPMCLILELAPQGALDTRMENFKRV-------------------GAR---LTPHTLQELVVQVSSAVAYLHS--
||... ..|. ||.|| .|| |     |...|.| .|.| |..   .....                   . |   ..|..|    .|. .. .||.|  
KEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQR

KDIIYRDLKAENVLVWKFPQPYSPNPADPIKVKLADYGISV----TALPSGTKGYGGTPG-YMAPEIVQYDGKETY-NEKVDCFSFGMFMFELMSL-QRP
| |..||| | |||.               ..|..|.|..     .   | ....| .|  .||||. . . ...| ..| |  ||| .|.|...| ..|
KKIVHRDLCARNVLLTE-----------DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCY-HGMYHTTKSDVWSFGVLMWEIFTLGACP

FECLVGKDVGRLSEVIKQLIKDGQRPVLSRKEKS-YPTYMLDLLSWCWAQDSRDRPSMEQIKDVS
.  .  ||       | ..|.|| |. .   |.. ...   .. | ||  .  .||| .|||.. 
YPGMPWKD-------IMECIRDGYRMPQP--EHCCSHEMYNLMKS-CWQWEPEERPSFRQIKHRL
Kinase LRRKa.AA CAMK-Unique 1731-1900 21 1e-26 85.02 In-house 63-295 (363) Show / Hide 
Range on Protein: 1731-1900
Range on HMM: 63-295/363
Sequence Identity: 21% (50 aa)

ARKELSIINNLDHPHIVPLLGF------CRH---------------PMCLILELAPQG-ALDTRMENFK---------------RVGARLTP--HTLQEL
...|..|   .|||.|..|...       |                .| ...|... |  .|  .....               |.  ...      . .
LKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFI

VVQVSSAVAYLHSKDIIYRDLKAENVLVWKFPQ-----PYSPNPADPIKVKLADYGISVTALPSGTKG----YGGTPGYMAP--------------EIVQ
. .. |||||.||.||. ||||.||..| . ..       .|.     ..||.|.|...    .        . ||| ||||              |.. 
MQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVIN

YDGKETYNEKV----DCFSFGMFMFELMSLQRPFEC
 ..   | ...    |. | |  |... .   ||.|
MQC---YDQQCSPASDIWSLGVIMYYMLCGCPPFDC
Kinase LRRKa.AA TyrKc 1658-1966 21 1.6e-26 95.36 SMART 1-280 (280) Show / Hide 
Range on Protein: 1658-1966
Range on HMM: 1-280/280
Sequence Identity: 21% (73 aa)

LEIQRLLGSGTFGLVFQGVMARASEHRRPIAAKMLQPYPPGQGAGNTDRRRYDNDNTKWHRDPLRFSCEAYRTARKELSIINNL--DHPHIVPLLGFCR-
..  . ||.| || |..|..       .. | |||...                                 .  ..|..|  .|  .||.|| |.| |. 
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-------------------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQ

--------HPMCLILELAPQGALDTRMENFKRVGARLTPHTLQELVVQVSSAVAYLHSKDIIYRDLKAENVLVWKFPQPYSPNPADPIKVKLADYGISVT
        .|.....|..| |.|. .  . ..    |.. .| .  .|...  .||||| .| ||| | |.|| .              || .| | |  
QGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-----------TVKISDFGLSRD

ALPS-------GTKGYG---GTPG-----YMAPEIVQYDGKETYNEKVDCFSFGMFMFELMSLQRPFECLVGKDVGRLSEVIKQLIKDGQRPVLSRKEKS
            ..      |. .      ||||  .|    ....| | .|||  |.|....  .    . .      . . ...|.| |.   .. ..
IYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG---KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRM---PQPPN

--------YPTYMLDLLSWCWAQDSRDRPSMEQIKDVSKTAEF
         |. | .. ..||. |  |||....|       .|
DYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-----HECF
Kinase LRRKa.AA STE 1733-1898 22 3.8e-24 82.24 In-house 77-268 (359) Show / Hide 
Range on Protein: 1733-1898
Range on HMM: 77-268/359
Sequence Identity: 22% (48 aa)

KELSIINNLD--HPHIVPLLGFCRHP---------MCLILELAPQGALDTRMENFKRVGARLT----------PHTLQELVVQVSSA-VAYLHSKDIIYR
||..| ....  ||.||  .| . .           ....|. . | ||  ... . .| .|.           . .   ..|.  .  .||||. || |
KEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHR

DLKAENVLVWKFPQPYSPNPADPIKVKLADYGISVTALPS------------------GTKGYGGTPGYMAPEIVQYDG---KETYNEKVDCFSFGMFMF
|.|. |.|.                |||.| |..    .|                   ..   ||| .||||..| .|   .  |..|.|  |.|  . 
DIKPANILL----------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTII

ELMSLQRPF
|.   . |.
EMATGKPPW
Kinase LRRKa.AA MLK 1733-1819 24 8.1e-15 47.95 In-house 57-160 (291) Show / Hide 
Range on Protein: 1733-1819
Range on HMM: 57-160/291
Sequence Identity: 24% (25 aa)

KELSIINNLD-HPHIVPLLGFCRHP---MCLILELAPQGALDTRMENFKRVGA----------RLTPHTLQELVVQVSSAVAYLHSKD---IIYRDLKAE
..|.|.. .  || |....| |  |    |...| .. | | .   . .  ..          . ... .    .|......||||..   || ||||  
RHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSH

NVLV
|.|.
NILI
Kinase LRRKa.AA Pkinase_Tyr 1733-1844 29 1.9e-14 49.58 Pfam 52-158 (270) Show / Hide 
Range on Protein: 1733-1844
Range on HMM: 52-158/270
Sequence Identity: 29% (35 aa)

KELSIINNL-DHPHIVPLLGFCR---HP--MCLILELAPQGALDTRMENFKRVGARLTPHTLQELVVQVSSAVAYLHSKDIIYRDLKAENVLVWKFPQPY
.|..|  .| .||.|| |.| |     |  .....|..| | |..   . .  . .||...| .  .|.... .||.|| .| ||| | |.|| .     
REAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-----

SPNPADPIKVKLADYGIS
      . .|| .| | .
------NNVVKICDFGLA
Kinase LRRKa.AA MLK 1857-1957 29 9.8e-14 44.14 In-house 195-287 (291) Show / Hide 
Range on Protein: 1857-1957
Range on HMM: 195-287/291
Sequence Identity: 29% (30 aa)

GTPGYMAPEIVQYDGKETYNEKVDCFSFGMFMFELMSLQRPFECLVGKDVGRLS--EVIKQLIKDGQRPVLSRKEKSYPTYMLDLLSWCWAQDSRDRPSM
||. .||||. |    |.|.||.| .|.|. . |... . |..       . ..  ... . .  |.|| .   ... |  .  |.. || ||...|||.
GTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYK-------QHYDPMAIAWWVAYNGLRPPI---PSTCPEHWKKLMKQCWNQDPHKRPSF

EQI
 ||
RQI
Kinase LRRKa.AA TK-Unique 1658-1699 26 9e-06 16.06 In-house 1-45 (294) Show / Hide 
Range on Protein: 1658-1699
Range on HMM: 1-45/294
Sequence Identity: 26% (12 aa)

LEIQRLLGSGTFGLVFQGVMARAS---EHRRPIAAKMLQPYPPGQ
||.....|.| || |. | . . .   .... .| |||. .  ..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDT
Kinase LRRKa.AA Pkinase_Tyr 1658-1694 31 1.3e-05 19.67 Pfam 1-38 (270) Show / Hide 
Range on Protein: 1658-1694
Range on HMM: 1-38/270
Sequence Identity: 31% (12 aa)

LEIQRLLGSGTFGLVFQGVMA-RASEHRRPIAAKMLQP
... . ||.| || |..|..    .... | | ||| .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE
Kinase LRRKa.AA MLK 1658-1677 35 0.000825 9.25 In-house 1-20 (291) Show / Hide 
Range on Protein: 1658-1677
Range on HMM: 1-20/291
Sequence Identity: 35% (7 aa)

LEIQRLLGSGTFGLVFQGVM
..... .|||.|| |. |..
IQFHEWIGSGSFGKVWKGRW
Kinase LRRKa.AA Pkinase_Tyr 1862-1894 36 0.002147 12.12 Pfam 181-210 (270) Show / Hide 
Range on Protein: 1862-1894
Range on HMM: 181-210/270
Sequence Identity: 36% (12 aa)

MAPEIVQYDGKETYNEKVDCFSFGMFMFELMSL
||||  .|     ...| |  |||  |.|....
MAPECINYGK---FTTKSDVWSFGVLMWEIFTY
Kinase LRRKa.AA STE 1658-1676 31 0.003507 7.23 In-house 1-19 (359) Show / Hide 
Range on Protein: 1658-1676
Range on HMM: 1-19/359
Sequence Identity: 31% (6 aa)

LEIQRLLGSGTFGLVFQGV
.|... .|.|.|| |....
WEGIEKIGKGAFGTVYKAM
Kinase LRRKa.AA Ciliate-E2 1658-1675 27 0.009453 5.25 In-house 1-18 (365) Show / Hide 
Range on Protein: 1658-1675
Range on HMM: 1-18/365
Sequence Identity: 27% (5 aa)

LEIQRLLGSGTFGLVFQG
 ......|.|.|| |...
YKFIKKIGQGNFGSVYKC
Kinase LRRKa.AA Pkinase_Tyr 1938-1957 45 0.042188 7.74 Pfam 247-266 (270) Show / Hide 
Range on Protein: 1938-1957
Range on HMM: 247-266/270
Sequence Identity: 45% (9 aa)

DLLSWCWAQDSRDRPSMEQI
||.  ||..|  |||....|
DLMKQCWHYDPEDRPTFSEI
Kinase LRRKa.AA CAMK-Unique 1658-1673 37 0.046813 2.35 In-house 1-16 (363) Show / Hide 
Range on Protein: 1658-1673
Range on HMM: 1-16/363
Sequence Identity: 37% (6 aa)

LEIQRLLGSGTFGLVF
 .  |..|.|.||.|.
YKMHRIIGHGNFGHVY
Kinase LRRKa.AA TKL-Unique 1660-1676 29 0.088275 2.28 In-house 1-17 (290) Show / Hide 
Range on Protein: 1660-1676
Range on HMM: 1-17/290
Sequence Identity: 29% (5 aa)

IQRLLGSGTFGLVFQGV
.  ..|.|..| |..|.
FWNKIGEGGYGQVYKGK