Gene TNNI3K (Sea Urchin)
TNNI3K
Sequence
Protein domains of TNNI3K.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Ank | TNNI3K.AA | Ank | 174-206 | 54 | 1.7e-09 | 38.54 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 174-206 Range on HMM: 1-33/33 Sequence Identity: 54% (18 aa) VKFTPLHIACYFGHEKVVKCLINHGADINLSGE |||||.||. ||..|||.|..||||.|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | TNNI3K.AA | Ank | 141-173 | 36 | 2.2e-09 | 38.09 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 141-173 Range on HMM: 1-33/33 Sequence Identity: 36% (12 aa) SSVTALHIASLNGNEEIVEHLIKCGANIHARDT |.||.|...|..|.|. |...||...|.| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | TNNI3K.AA | Ank | 108-140 | 45 | 4.4e-07 | 29.79 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 108-140 Range on HMM: 1-33/33 Sequence Identity: 45% (15 aa) NGFSPLHLACFQGDVDLVKDLLLEEADPTVIGY .||.||||||. |... ||.|| ||. . DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | TNNI3K.AA | Ank | 207-243 | 43 | 3e-06 | 26.89 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 207-243 Range on HMM: 1-33/33 Sequence Identity: 43% (16 aa) VGDVPLHLTCVKGHQSITELLVKGRRNNKADVNAQDN |. |||| | .|| .. ..|.. . |||||||. DGFTPLHLACRCGHTEVVKMLLQ----HGADVNAQDD |
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| Ank | TNNI3K.AA | Ank | 279-313 | 34 | 1e-05 | 24.85 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 279-313 Range on HMM: 1-33/33 Sequence Identity: 34% (12 aa) YGDTPLHLACYTGRLDIVKSLITKTGPTSLLVENI .|.|||||||. |....|| |. .. . . DGFTPLHLACRCGHTEVVKMLLQ--HGADVNAQDD |
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| Ank | TNNI3K.AA | Ank | 74-107 | 35 | 0.034984 | 12.13 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 74-107 Range on HMM: 1-33/33 Sequence Identity: 35% (12 aa) TGLTLLHLSCISTGSKPFVKLLVHAGARVSSLSR | | ||| |.. .. ||.|. .|| | . DGFTPLHLACRCG-HTEVVKMLLQHGADVNAQDD |
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| Ank | TNNI3K.AA | Ank | 244-278 | 34 | 0.846048 | 7.14 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 244-278 Range on HMM: 1-33/33 Sequence Identity: 34% (12 aa) EQHMPLHFSCRAGHLTTVDYLLQPNLGTKAHEVNI . ||| || ||. | .||| | . .. DGFTPLHLACRCGHTEVVKMLLQ--HGADVNAQDD |
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| Ank | TNNI3K.AA | Ank | 349-381 | 48 | 1e-09 | 39.34 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 349-381 Range on HMM: 1-33/33 Sequence Identity: 48% (16 aa) DGHTALHSACYHGHYHLVQLLLDQGADMNLVAT || |.|| ||..||. |..||..||| |.. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | TNNI3K.AA | Ank | 318-348 | 45 | 0.00089 | 17.88 | Pfam | 5-33 (33) | Show / Hide |
Range on Protein: 318-348 Range on HMM: 5-33/33 Sequence Identity: 45% (14 aa) PLHSACTYGKNIELVKYLLSQEGVNINTQGR ||| || .| ..| ||.||. | ..| | . PLHLACRCG-HTEVVKMLLQ-HGADVNAQDD |
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| Ank | TNNI3K.AA | Ank | 391-411 | 33 | 2.148699 | 5.68 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 391-411 Range on HMM: 1-21/33 Sequence Identity: 33% (7 aa) QEQTCLVWAYQRGHDAIVTLL .|.| .| ..|| .|..| DGFTPLHLACRCGHTEVVKML |
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| Kinase | TNNI3K.AA | HH498 | 473-729 | 65 | 4.90000000001e-218 | 698.44 | In-house | 1-284 (284) | Show / Hide |
Range on Protein: 473-729
Range on HMM: 1-284/284
Sequence Identity: 65% (186 aa)
IEFLETIGSGSFGNVYKGYCRGKIVAIKRYRSSAFSAKSD-----VDMFCREVSILCRLDSPYVIRFVGACIEDPSHFAIVTQYVAGGSLFSLL------
|||.|.|||||||.||||..|.||||.||||..||..||| ||||||||||.|||..|.|..||.||..|||.|||||||...|||||.|
IEFHEKIGSGSFGKVYKGEWRNKIVAVKRYRAMAFCCKSDSYQWIVDMFCREVSIMCRLNHPCVVQFVYACCDDPSQFAIVTQYCDNGSLFSILNTIPIG
--------HVQK---RNIDLQSKMTIAVDVAHGMDYLHN-LPHPIIHRDLNSHNILLDEFGHAEVADFGESRFVKSMHEDNMTKQPGNLRWMAPEVFSQN
|.|| |..||||||||.|||||||.|||| |.||||||||||||||..|.|||.||||||||||..||.||||||||||||||||||||.
GAGANNNNHNQKNNYRIMDLQSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHAVVADFGESRFVCDMHDDNMTKQPGNLRWMAPEVFSQC
TQYSIKADIFSYALCIWELLSGELPFAHLKPAAAAAEMAYRSTRPPIAIT----IPKSIVNILQMMWSPNPEERPTFAQIIPML
..||||.|.||||.||||....|.||.|.|||||||||||...||||..| ||....|..||.|.|.||.||.|.||. .|
QKYSIKVDVFSYAMCIWEMHTREVPFHHYKPAAAAAEMAYHHIRPPIPQTPTAQIPHHWSNLIQMCWHPCPENRPDFDQIVTIL
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| Kinase | TNNI3K.AA | MLK | 473-729 | 39 | 2.4e-138 | 465.93 | In-house | 1-291 (291) | Show / Hide |
Range on Protein: 473-729 Range on HMM: 1-291/291 Sequence Identity: 39% (117 aa) IEFLETIGSGSFGNVYKGYCRGKI-----VAIKRYRSSAFSAKSD-------VDMFCREVSILCRLD-SPYVIRFVGACIEDPSHFAIVTQYVAGGSLFS |.|.| ||||||| |.||..|.|. ||.||.|...| .||| ..|.||...||... .|..|.|.|.|...|.||.||..|..||||.. IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN LLHVQK-------------RNIDLQSKMTIAVDVAHGMDYLHN-LPHPIIHRDLNSHNILLDE------FGHAEVADFGESRFVKSMHEDNMTKQPGNLR .|| .. |..|....|..|...|.||.|||. .|.|||||||.|||||.|| |.. ..|||.||....|. .||....|... VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGTYA WMAPEVF--SQNTQYSIKADIFSYALCIWELLSGELPFA-HLKPAAAAAEMAYRSTRPPIAITIPKSIVNILQMMWSPNPEERPTFAQIIPML ||||||. .....||.|.|..|.....||.|..|.|.. |..|.|.|...|| ..|||| .|.|... . ....|...|..||.|.||.. | WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | TNNI3K.AA | TKL | 479-729 | 26 | 2.8e-95 | 322.83 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 479-729
Range on HMM: 1-364/364
Sequence Identity: 26% (99 aa)
IGSGSFGNVYKGYCRG----------KIVAIKRYRS--SAFSAKSDVD--------------------MFCREVSILC--RLDSPYVIRFVGACIEDPS-
||||.|| ||||..|| | ||.|...| . .. |.. . .|..|. |.. ||. | ...|.|.|.. |.
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
-----------HFAIVTQYVAGGSLFSLLHVQKRNIDLQSKMTIAVDVAHGMDYLHN--L----PHPIIHRDLNSHNILLDEFGH--------------A
...||..|. ||||...|| .. .. .| |.| ||.|||. . |||||||.|.|||.|| .. .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC
EVADFGESRFVKSMHEDNMTK------------------QPGNLRWMAPEVFSQNT---------------QYSIKADIFSYALCIWELLSGELPFAHLK
..||| |||.. . ..|.|. | |..|||||||. ... .|| |.|..|.....||.|....|.....
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYP
PA---------AAAAEMAYRSTRPPIA------------ITIPKSIVNILQMMWSPNPEERPTFAQIIPML
. . .. .... |||| ..|.|. ...|. |...||.||.| .|. |
YMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
|
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| Kinase | TNNI3K.AA | TKL-Unique | 475-729 | 31 | 3.7e-82 | 279.25 | In-house | 1-290 (290) | Show / Hide |
Range on Protein: 475-729 Range on HMM: 1-290/290 Sequence Identity: 31% (92 aa) FLETIGSGSFGNVYKGYCRGKIVAIKRYRSSAFSAKSDVDMFCREVSILCRLD-SPYVIRFVGACIE---DPSHFAIVTQYVAGGSLFSLLH-------- |...||.|..|.|||| ||..||||. . | .. .. | .||... .|. .| . ...|.|. .|... ||. |. |||| ..|| FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN -VQKRNIDLQSKMTIAVDVAHGMDYLHNLPHPIIHRDLNSHNILLDEF-----GHAEVADFGESRFVKSMHEDNMT--------KQPGNLRWMAPEVFSQ .. ....| ....| |.| ||.|||.. ||||||| | |.|.|.. . ..||| |.| ... . . . |..|||||||... NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRM N-TQYSIKADIFSYALCIWELLSGEL------PFAHLKPAAAAAEMAY--RSTRPPIAITIPKSIVNILQMMWSPNPEERPTFAQIIPML | .|||.|.|..|.. . ||...... |. .. . . .. .| .. |||| .||.. ...|. | ..|..||.| .|| | NFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL |
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| Kinase | TNNI3K.AA | CZAK | 473-729 | 36 | 2.9e-65 | 223.12 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 473-729 Range on HMM: 1-279/279 Sequence Identity: 36% (104 aa) IEFLETIGSGSFGNVYKGYCRGKIVAIKRYRSSAFSAKSD---VDMFCREVSILCRLDSPYVIRFVGACIEDP-SHFAIVTQYVAGGSLFSLLHVQKRNI .| ||| | || |||.| ||| |||| | |. || .||||. | | .. |.||| || | ||. . |||| || . . LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLT-DHYFY DLQ---SKMTIAVDVAHGMDYLHN--LPHPIIHRDLNSHNILLDEFGH-------------AEVADFGESRFVKSMHEDNMTKQPGNLRWMAPEVFSQNT .| .. .|.|.| || ||| | ||.|||| | |||||. . ..||| || . . || | | |||||.| HKQNPHLQWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFE-MTQTMGCLCWMAPECF-KGE QYSIKADIFSYALCIWELLSGELPFAHLKPAAAAAEMAYRSTRPPIAITIPKSIV---NILQMMWSPNPEERPTFAQIIPML |. |.|..|... .|... .. | ..| | || . |||. ... . .. | | ||.|||.| ||. | NYTEKVDVYSFGMILWCIITCDQPYQNMQPMKMAHLAAYENYRPPMPQPMDPMWKNLGELIEMCWNKNPDERPSFKQILQHL |
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| Kinase | TNNI3K.AA | Pkinase_Tyr | 473-729 | 27 | 6.1e-65 | 220.56 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 473-729 Range on HMM: 1-270/270 Sequence Identity: 27% (76 aa) IEFLETIGSGSFGNVYKGYCR------GKIVAIKRYRSSAFSAKSD--VDMFCREVSILCRL-DSPYVIRFVGACI--EDPSHFAIVTQYVAGGSLFSLL |.|....|.|.||.||||... . ||.| . . ... ..| ||..|.. | . | ..|..|.|. ..|.. ||. |...|.| . | ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL HVQ---KRNIDLQSKMTIAVDVAHGMDYLHNLPHPIIHRDLNSHNILLDEFGHAEVADFGESRFVKSMHEDNM-TKQP---GNLRWMAPEVFSQNTQYSI . . |...... . .....| ||.||.. . .||||| |.|..| ... ..||| .| . ...|. .|. .|||||... . ... RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTENNVVKICDFGLARDI--YNDDYYYRKRGGGKLPIKWMAPECINYGK-FTT KADIFSYALCIWELLS-GELP-FAHLKPAAAAAEMA-YRSTRPPIAITIPKSIVNILQMMWSPNPEERPTFAQIIPML | |. |. ..||... || | .. . . . |. . | |. |. | ..... | ..||.||||..|. .| KSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | TNNI3K.AA | TK | 473-729 | 15 | 2.4e-62 | 207.5 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 473-729
Range on HMM: 1-486/486
Sequence Identity: 15% (75 aa)
IEFLETIGSGSFG---NVYKGYCRGK---------------------------IVAIKRYRS-SAFSAKSDVD-------------MFCREVSILC--RL
|......|.| || |||| ||. ||.| .. .| |.. | ....| ...| .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
DSPYVIRFVGACIEDP-----------SHFAIVTQYVAGGS----LFSLLHVQKRN--------------------------------------------
. | ..|..|.| .. .. ||. |...|. | . |. ...
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
-------------------------------IDLQSKMTIAVDVAHGMDYLHNLPH----PIIHRDLNSHNILLDEFGH-----------AEVADFG---
.... .. .....| || ||| .. ..|||| .|.|..| .. . .||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR
-----ESRFVKSMHEDNMTKQPGN-------------------------LRWMAPEVFSQNT--------QYSIKADIFSYALCIWELLS-GELPFAHLK
.| . | .. ....| .||||||.. .. ...| |..|. ..||... |. |..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM
PA------------AAAAEM------------AYRSTRPPIAITIP-------------KSIVNILQMMWSPNPEERPTFAQIIPML
. .. || .|. . . . . ..|. |...||.||||.|. .|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
|
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| Kinase | TNNI3K.AA | TyrKc | 473-729 | 25 | 2.4e-61 | 211.01 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 473-729 Range on HMM: 1-280/280 Sequence Identity: 25% (74 aa) IEFLETIGSGSFGNVYKGYCRGKIVAIKRYRSSAFSAKSDVDMFCREVSILCRL--DSPYVIRFVGACIEDP------SHFAIVTQYVAGGSLFSLLHVQ |......|.| || |||| . ||.| ...| . .|.|| .|.|.| . | ..|..|.|... ||. |...|.| . |. ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH KRNIDLQSKMTIAVDVAHGMDYLHNLPHPIIHRDLNSHNILLDEFGHAEVADFGESRFVKSM------HEDNM------TKQPGNLRWMAPEVFSQNTQY .... .. . .....| ||.||| ..||||| |.|..| ... ..||| ||.... .. . .| . .||||||.. . . RPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-NYGKF SIKADIFSYALCIWELLS-GELPFAH-----LKPAAAAAEMAYRSTRPPIAI-------TIPKSIVNILQMMWSPNPEERPTFAQIIPML ..| |..|. |.||... |. | .... . . . .|. . . |. . .| .. | .||.||||..|. . TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | TNNI3K.AA | Dicty4 | 473-731 | 36 | 7.9e-60 | 198.27 | In-house | 1-277 (277) | Show / Hide |
Range on Protein: 473-731 Range on HMM: 1-277/277 Sequence Identity: 36% (103 aa) IEFLETIGSGSFGNVYKGYCRGKIVAIKRY--RSSAFSAKSDVDMFCREVSILCRLDSPYVIRFVGACI---EDPSHFAIVTQYVAGGSLFSLLHV---- | . . ||.|||| |||| .|||.||.| . |... | .||.|.| . | .. | |||. |. . ||| |. |.|.|||| INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENM-LNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE --QKRNID--LQSK-MTIAVDVAHGMDYLHN-LPHPIIHRDLNSHNILLDEFGHAEVADFGESRFVKSMH--EDNMTKQPGNLRWMAPEVFSQNTQYSIK |. .| | . | .| |.| || .||. | |||||| |||.| |. . |.||| |. | ||.. . | |||||| .. | | QQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVM-MHQPYNEK ADIFSYALCIWELLSGELPFA-HLKPAAAAAEMAYR-STRPPIAITIPKSIVNILQMMWSPNPEERPTFAQIIPM--LDD || .|... ||.| .. |.. | .| ... . |||| |.|. .| |...|. ||.|..||. |. ADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH |
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| Kinase | TNNI3K.AA | Dicty4-Unclassified | 473-729 | 32 | 7.7e-52 | 175.81 | In-house | 1-263 (263) | Show / Hide |
Range on Protein: 473-729 Range on HMM: 1-263/263 Sequence Identity: 32% (87 aa) IEFLETIGSGSFGNVYKGYCRGKIVAIKRYRSSAFSAK-SDVDMFCREVSILCRLDSPYVIRFVGACIEDP----SHFAIVTQYVAGGSLFSLLH----V | . || | | |.|| .|| ||.| . |.. .. | .|| || . | .. |.|| | | . ||. | || . | IQIDQFIGKGHFSKVHKGNWKGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCIN-PRSHKSTMCIVMEFMHKGNLFEVIHSKPSE QKRNIDLQS--KMTIAVDVAHGMDYLHNLPHPIIHRDLNSHNILLDEFGHAEVADFGESRFVKSMHEDNMTKQPGNLRWMAPEVFSQNTQYSIKADIFSY |.. | | . . .| |.| || .|| .||||. | |||.| . .|||| || . ||| | .| .||. | |.|..|| QQQPIKLDDTLIIKYAFDIAQGMQHLHTR--NFIHRDIKSSNILMDKHFNIKIADFGISRVID--FNFNMTTIAGTPKWESPECLMHES-YNQKSDVYSY ALCIWELLSGELPFAHLK-PAAAAAEMAYRSTRPPIAITIPKSIVNILQMMWSPNPEERPTFAQIIPML |. .||. |. |. . || . . || | .. . |. | |||. ||| | AMMLYELATGDEPYQEIQSIMNAARSVCDKKLRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL |
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| Kinase | TNNI3K.AA | STE | 473-724 | 20 | 1.6e-51 | 177.45 | In-house | 1-350 (359) | Show / Hide |
Range on Protein: 473-724
Range on HMM: 1-350/359
Sequence Identity: 20% (72 aa)
IEFLETIGSGSFGNVYKGYCR-----------------GKIVAIKRYRSSAFSA--------------KSDVDMFCREVSILCRLD--SPYVIRFVGACI
|..| ||.|.|| |||.... |.|.|||. . . .. ..... . .|..|. ... .|..... |...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
EDP------SHFAIVTQYVAGGSLFSLLH-VQKRNIDL-----------QSKM-TIAVDVAHG-MDYLHNLPHPIIHRDLNSHNILLDEFGHAEVADFGE
. .. |. |..|||| .... . ... .| | .|.... .| ..|||.. |||||. . |||| . .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCDFGV
SR-FVKSMHED--------------NMTKQPGNLRWMAPEVFSQ-----NTQYSIKADIFSYALCIWELLSGELPFAHLKPAAAAAEMAYR---------
. ...|| .. . . | |||||| .| . .|..|.|| | ..|.|.. |. |.. ..| | ...
CGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQ
-----STRPPIAITIP-------------------KSIVNILQMMWSPNPEERPTFAQ
. ||. .. .. . .. .|..||| |
LCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
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| Kinase | TNNI3K.AA | LRRK | 473-731 | 25 | 3.7e-50 | 172.94 | In-house | 1-351 (351) | Show / Hide |
Range on Protein: 473-731 Range on HMM: 1-351/351 Sequence Identity: 25% (92 aa) IEFLETIGSGSFG-NVYKGYCRG-----KIVAIKRYRS--------SAFSA------KSDVD-------------------------------------- ... | ||.|.|| .||.. .|| . ...|. |. .. | ..| LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA --MFCREVSILCRLDSPYVIRFVGACIEDPSHFAIVTQYVAGGSLFSLLHVQKRN--------IDLQSKMTIAVDVAHGMDYLHNLPHPIIHRDLNSHNI | .||.|...|. |... .| ||. ....|. |. |.| ..|| |.. |. . | ||...| ||.|||. ||||||| |.|| FREFRHEVWIMSHLNHPNIVSLKGFCIH---PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNPPIIHRDLKSPNI LL---D---------EFGHAEVADFGESR-FVKSMHEDNMTKQPGNLRWMAPEVFSQN--TQYSIKADIFSYALCIWELLSGE-LPFAHLK-PAAA--AA || . .. .| .|||| || | .. |. . || .|||||. | .|. |.|..|... .||||... .|| ... .. LLWSSPQNHSPNYPNAHVCAKIADFGISRMF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWME EMAY---RSTRPPIAIT-IPK-----SIVNILQMMWSPNPEERPTFAQIIPMLDD . . ||.| . | . . .| |. .|..||.| ||. | . QIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ |
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| Kinase | TNNI3K.AA | S_TKc | 473-729 | 25 | 1e-49 | 172.43 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 473-729
Range on HMM: 1-231/231
Sequence Identity: 25% (70 aa)
IEFLETIGSGSFGNVYKGYCRG--KIVAIKRYRSSAFSAKSDVDMFCREVSILCRLDSPYVIRFVGACIEDPSHFAIVTQYVAG--GSLFSLLHVQKRN-
|.|..||.|.|| |||.. .. .|||||. . ....||..|| . . |..... ... . .|. .|. |. | |.||.... ..|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHG
----IDLQSKMTIAVDVAHGMDYLHNLPHPIIHRDLNSHNILLDEFGHAEVADFGESRFVKSMHEDNMTKQPGNLRWMAPEVFSQNTQYSI-KADIFSYA
.. .. .. ...|.|.. |||||| |||||| | ..||| .|.. | . | . .|||||. .|. |.|. |
LRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL----GYGKCKCDWWSCG
LCIWELLSGELPFAHLKPAAAAAEMAYRSTRPPIAITIPKSIVNILQMMWSPNPEERPTFAQII---------PML
...|.|.|. || .| .. . ... .... .. .||.||| .. | .
CILYEMLCGYPPFP-------QMQMMFKKIG-------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
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| Kinase | TNNI3K.AA | Pkinase | 473-729 | 25 | 6e-44 | 156.48 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 473-729 Range on HMM: 1-293/293 Sequence Identity: 25% (75 aa) IEFLETIGSGSFGNVYKGYCRGK--IVAIKRYRSSAFSAKSDVDMFCR--EVSILCRLDSPYVIRFVGACIEDPSHFAIVTQYVAGG----SLFSLLH-V ......||||||| |||.. .| |||.|. . . .. | |..|. ||..|...|. ... . ..| .|. |. || .||.... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYISTW QKRNI--DLQSKMTIAVDVAHGMDYLHNLPHPIIHRDLNSHNILLDEFGHA----EVADFGESRFVKSMHEDNMTKQPGNLRWMAPEVFSQNTQYSIKAD ..... . . .. .. |..|.|. |||||| . |||.|. || ..||| ..... . || | ...||||| .. |. |.| RHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD IFSYALCIWELLSGELPFAHL---KPAAAAAEMAYRSTRPPIAITIP-----------------------KSIVNILQMMWSPNPEERPTFAQIIPM--L ..|. . ..|.|.|..|| . .. . .| .| .||. .| .. .. .. ..|..|||..|| . MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | TNNI3K.AA | RIO1 | 486-506 | 41 | 0.000933 | 12.18 | Pfam | 1-24 (200) | Show / Hide |
Range on Protein: 486-506 Range on HMM: 1-24/200 Sequence Identity: 41% (10 aa) NVYKGYC--RGK-IVAIKRYRSSA |||..|. .|| .|.| || .. NVYHAYSMEDGKDECAVKIYRTGT |
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