Gene MLK (Sea Urchin)

MLK

Species: Sea Urchin
Alias: MLK, Spk226, SPU_018191
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK

Sequence

Name Sequence Type Origin Length Description Download
MLK.AA Protein None 1112 None Fasta, JSON
MLK.kin_dom Protein Kinase Domain None 115 None Fasta, JSON

Protein domain

Protein domains of MLK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 MLK.AA SH3 91-151 36 1.1e-19 72.61 SMART 1-58 (58) Show / Hide 
Range on Protein: 91-151
Range on HMM: 1-58/58
Sequence Identity: 36% (23 aa)

SLCTAMHDYESTADDELTIHRGDLVEIISKDHAVSGDDGWWMGKVG--DQQGIFPNNYVSDSQ
  . |..||... .|||....|| .....||     ||||| |...   |.|.|| |||   .
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-----DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 MLK.AA SH3_1 94-144 32 4.6e-13 47.07 Pfam 1-49 (49) Show / Hide 
Range on Protein: 94-144
Range on HMM: 1-49/49
Sequence Identity: 32% (17 aa)

TAMHDYESTADDELTIHRGDLVEIISKDHAVSGDDGWWMGKVGD--QQGIFPN
.| .||. . .|||.. .|| ...|.|...    ..|| |.. .  |.|.|| 
VALYDYQAQQPDELSFKKGDIIHVIEKSDD----WDWWKGRCNNTGQEGWFPS
SH3_2 MLK.AA SH3_2 92-150 22 1.3e-08 33.01 Pfam 1-68 (68) Show / Hide 
Range on Protein: 92-150
Range on HMM: 1-68/68
Sequence Identity: 22% (16 aa)

LCTAMHDYES-TADDE-----LTIHRGDLVEIISKDHAVS--GDDGWWMG-KV--GDQQ--GIFPNNYVSDS
.. .. ||.. |  .|     |....||....|.    ..   .|.|| .  .  | .   | ||...|.  
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVID----NGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
Kinase MLK.AA MLK 170-433 65 4.8e-182 606.75 In-house 1-280 (280) Show / Hide 
Range on Protein: 170-433
Range on HMM: 1-280/280
Sequence Identity: 65% (186 aa)

IQLNELIGVGGFGKVFRGSWRGEEVAVKAAKHDPEEDDNVR-STIDNVRQEAKLFSLLSHPNIISLRGACLREPHVCIVMEYARGGSLNRLLFGKKMAMP
... |.||.||||||.|..|.||||||||...|||.|  .    ...|||||.||  |.||||| |||.||..|| |.||||.||||||| . ||  . |
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGK--RIP

PNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVE-----------------HSNMYNIQLKITDFGLAREMYKTTRMSAAGTYAWMAPEVI
|.|||||| ||| |||||| |||.|.|||||||||||. .|..                 | .| | ||||||||||||..|||||||||||||||||||
PHVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHKTTRMSAAGTYAWMAPEVI

KSSLFSKSSDVWSFGILLWELLTGEVPYKGIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQL
|.|..||.|||||.|.||||||||||||.|||.||||||.|.|||||||||||||...|.. ||||.|||.||.||||.|||
KESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL
Kinase MLK.AA MLK 170-433 45 3.7e-150 505.13 In-house 1-291 (291) Show / Hide 
Range on Protein: 170-433
Range on HMM: 1-291/291
Sequence Identity: 45% (133 aa)

IQLNELIGVGGFGKVFRGSWRGEE-----VAVKAAKHDPEEDDNV-RSTIDNVRQEAKLFSLLSHPN----IISLRGACLREPH-VCIVMEYARGGSLNR
||. | ||.|.||||..| ||...     ||||....... |  .  . ......|..... |||||    || ..|.||..|. .||||||..||||..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

LLFGKK-------------MAMPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAREMYKT-T-RMSAAGTY
.| |..               ... ...|||.|.| ||.||| .|| |.|||||||.|||.|. ..| .| . .|||.|||..|..... | .||.||||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTY

AWMAPEVI---KSSLFSKSSDVWSFGILLWELLTGEVPYK-GIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQL
||||||||   ... .|...||||.|..|||.||.||||| ..| .|.|...|.|.|..||||||||...|.. .||| |||.||.|..|.|.|
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK.AA TKL 176-433 29 7.89999999999e-108 364.53 In-house 1-364 (364) Show / Hide 
Range on Protein: 176-433
Range on HMM: 1-364/364
Sequence Identity: 29% (111 aa)

IGVGGFGKVFRGSWRG----------EEVAVKAAKHDPEEDDNVRS---------------------TIDNVRQEAKLFSLLSHPNIISLRGACLREPH-
|| ||||.|..| |||          ..||||  | . .  ..  |                       .  ..|... | |.||||... |.|...|. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------VCIVMEYARGGS-LNRLLFGKKMAMPPNVLVNWAYQIADGMNYLHWEAP-----IPLIHRDLKSSNILLDQKVEH------SNMYNIQ
             ||||||. ||| |..|.        ......||..|| |||||| . |      |.|||||||.|||.|.. ..      .  ... 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

LKITDFGLAREM---------------------YKTTRMSAAGTYAWMAPEVIKSS----------------LFSKSSDVWSFGILLWELLTGEVPYKGI
.||.||||.|.|                     ...|.|.  ||..||||||.. .                 .|...||.||||.|||.||...||...
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

DTLAVA---------YGIAVNKLTLPIP------------STCPEIFSKMLLDCWNYDPHERPTFSEIMQQL
.   .          .......| .|||            ..||. ..| . |||..||..||.|.||...|
PYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK.AA TyrKc 170-433 31 9.9e-90 305.32 SMART 1-280 (280) Show / Hide 
Range on Protein: 170-433
Range on HMM: 1-280/280
Sequence Identity: 31% (94 aa)

IQLNELIGVGGFGKVFRGSWRGEEVAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLL--SHPNIISLRGACLRE-------PHVCIVMEYARGGSLNRLL
|.|.. .| | ||.|..| |. ..||||  |.|          .   ..||.. . |  .||||. | |.|. .       . ..|||||. .|.|.  |
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

FGKKMAMPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAREMYKT---------TRM----SAA--GTYAW
  ..   ..  |.....|||.||.|||     ..|||||   |.|.. .         . ||.||||.|. |            |.    ..     . |
RKHRPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MAPEVIKSSLFSKSSDVWSFGILLWELLT-GEVPYKGI----DTLAVAYGIAVNKLTLPIPST--------CPEIFSKMLLDCWNYDPHERPTFSEIMQQ
||||.|. . |.  |||||||...||..| |. || |.     . . ..    .   .|.|          ||.   .. ..||..||..||||||| ..
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase MLK.AA TKL-Unique 172-433 35 5.1e-84 285.44 In-house 1-290 (290) Show / Hide 
Range on Protein: 172-433
Range on HMM: 1-290/290
Sequence Identity: 35% (104 aa)

LNELIGVGGFGKVFRGSWRGEEVAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLLS-HPNIISLRGACL----REPHVCIVMEYARGGSLNRLLF-----
  ..|| ||.|.|..| |||..||.|  .  | . |   . ... . | .. . |  ||||  . |.|      .|. ||||||  ||||. .|      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFH--P-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN

----GKKMAMPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAREMYKTTRMSAA-----------GTYAWM
     ... ..... |. | .||.||.||| . |   |||||||||.|.|..   ||   .. || ||||..   | ..|..            |.. ||
NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNN---SNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWM

APEVIKS--SLFSKSSDVWSFGILLWELLTGEV------PYKGIDTLAVAYGIAV--NKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQL
||||...  ...|..|||.|||| |||..|...      ||.|.|  ...  ...   .. .|||. ||..... . .||. || .||.|.||   |
APEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLK.AA Dicty4 170-435 35 1e-83 279.09 In-house 1-277 (277) Show / Hide 
Range on Protein: 170-435
Range on HMM: 1-277/277
Sequence Identity: 35% (101 aa)

IQLNELIGVGGFGKVFRGSWRGEEVAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLLSHPNIISLRGACL----REPHVCIVMEYARGGSLNRLLFG---
|.  ..|| |.||.|..|.||| ||||| .. . . .|   ...   |.|... . ..||||. . |||.      . .|||.||   |.| .||     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFD--ENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

---KKMAMP-PNVLV--NWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAR----EMYKTT-RMSAAGTYAWMAPEVI
   ..  .. | ..     |  .| |||.||   |.  |||||||.|.| |.        | . |..||||..    .  ...  |.|.|| .|||||| 
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDK--------NWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVM

KSSLFSKSSDVWSFGILLWELLTGEVPYK--GIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQ--LKD
 .  .  ..|| ||||.|||.||.. ||   ....  .. ...  || .|||. ||  ... . .||. ||  ||.|.|| |.  |  
MHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK.AA Pkinase_Tyr 170-433 35 6.1e-80 271.36 Pfam 1-270 (270) Show / Hide 
Range on Protein: 170-433
Range on HMM: 1-270/270
Sequence Identity: 35% (102 aa)

IQLNELIGVGGFGKVFRGSWR------GEEVAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLL-SHPNIISLRGACL-REPH--VCIVMEYARGGSLNRL
|.... .| | ||.|..| |.      . .||||  |..  ...|    ..   .|||. . | .||||..| |.|. .. .  ..|||||. .|.|   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN---CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LFGK---KMAMPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAREM-----Y-KTTRMSAAGTYAWMAPEV
|  .   | . ..  |.....|||.||.||.    ...|||||   |.|..         | . ||.|||||| .     | ...  .      |||||.
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTE--------NNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPEC

IKSSLFSKSSDVWSFGILLWELLT-GEVP-YKGIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQL
|. . |.  |||||||.|.||..| || | |.|..   |   |. .   .|.|  ||.   .....||.||| .||||||| .||
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK.AA LZK 170-433 41 8.2e-79 265.34 In-house 1-241 (241) Show / Hide 
Range on Protein: 170-433
Range on HMM: 1-241/241
Sequence Identity: 41% (111 aa)

IQLNELIGVGGFGKVFRGSWRGEEVAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLLSHPNIISLRGACLREPHVCIVMEYARGGSLNRLLFGKKMAMPP
|.  . .| |  | |||| .|.|.||||  .   | |      |   |.       | ||||| ..| | . |  ||.|||   | |   |  ..  ..|
ISELQWLGSGAQGAVFRGWFRNETVAVKKVRDLKETD------IKHLRK-------LKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVL-RERRTITP

NVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAREMYKT--TRMSAAGTYAWMAPEVIKSSLFSKSSDVWSFGI
. .|.|  |||.||.|||       ||||||| |||          .|  .|| |||  ... .   |.|| .|| ||||||||.    |   |.||||.
QLMVDWSKQIAQGMHYLHQHK---IIHRDLKSPNILI--------SHNDVVKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGV

LLWELLTGEVPYKGIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQL
 |||.||.|.||| .|  |. .|.  | | ||.|||||| |  ..  ||.  |  || |. |.. .
VLWEMLTCEIPYKDVDSMAIIWGVGSNSLHLPMPSTCPEGFKLLMKQCWSQKPRNRPSFRQILMHW
Kinase MLK.AA Pkinase 170-433 27 3e-77 267.74 Pfam 1-293 (293) Show / Hide 
Range on Protein: 170-433
Range on HMM: 1-293/293
Sequence Identity: 27% (84 aa)

IQLNELIGVGGFGKVFRGSWRGEE--VAVKAAKHDPEEDDNVRST---IDNVRQEAKLFSLLSHPNIISLRGACLREPHVCIVMEYARGG----SLNRLL
... . || |.||.|... ..|..  ||||  | . .|..... |   .    .|...   |.||||. |.... ...|...||||..||    .| ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL----SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

F---GKKMAMPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAR---EMYKTTRMSAAGTYAWMAPEVIK-S
    .... ...... ...|||. |..|.| .     ||||||..|||.|.. . .      .||.|||||.   .  ..  .. .||. .||||||. .
STWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGG

SLFSKSSDVWSFGILLWELLTGEVPYKGI------DTLAVAYGIAVNKLTLPIPSTCP-------------------EIFSKMLLDCWNYDPHERPTFSE
.  ....|.||.|..|.|.|.|. |..|       | ... . |   .|  ..| .|.                   | . . . .|...||..|||. .
QYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

IMQQ--L
|.|   .
ILQHPWF
Kinase MLK.AA DRK 170-435 36 3.2e-77 261.07 In-house 1-258 (258) Show / Hide 
Range on Protein: 170-435
Range on HMM: 1-258/258
Sequence Identity: 36% (98 aa)

IQLNELIGVGGFGKVFRGSWRGEEVAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLLSHPNIISLRGACLREPHVCIVMEYARGGSLNRLLFGKKMAMPP
|     || |..| ||||.||| .|||| .. . ..| |    .   ..|. | . | ||||.   |.|.  | .||.|||   ||| . |   .. |  
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENF---LNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDW

NVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAR----EMYKTTRMSAAGTYAWMAPEVIKSSLFSKSSDVWSF
  .   .  .| ||.|||   ||  ||||||| | | |         . | |. ||||.        ... | . ||  | ||||  .  .    ||.||
PLMKQMMFDCAKGMIYLHCCNPI-IIHRDLKSHNLLVDE--------HWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSF

GILLWELLTGEVPYKGIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQLKD
.| |||..| . || |. |. |   .   .. .|.|  ||  . . . |||| ||  ||.. |... |  
AIVLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase MLK.AA LRRK 170-435 29 1.2e-73 250.96 In-house 1-351 (351) Show / Hide 
Range on Protein: 170-435
Range on HMM: 1-351/351
Sequence Identity: 29% (106 aa)

IQLNELIGVGGFG-KVFRGSWRG----------------------------EEVAVKAAKHDP-----------------------------EEDDNVRS
.  .|.||.|||| .|.|. |||                            ..||.|  . ||                             ...|  |.
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

TIDNVRQEAKLFSLLSHPNIISLRGACLREPHVCIVMEYARGGSLNRLLFGKK-MA-------MPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSN
     |.|. . | | ||||.|| | |..  . |.|||||. |.|...|. || ..       ......   |.|||.||.|||   | |.||||||| |
-FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPN

ILL-DQKVEHSNM---YNIQLKITDFGLAR--EMYKTT-RMSAAGTYAWMAPEVIK---SSLFSKSSDVWSFGILLWELLTGE-VPYKGID---TLAVAY
|||   . .||      ..  || |||. |    .... ..   |.  |||||...    . ..  .|. |||..||||||..  |. ..|    .   .
ILLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWME

GIAV---NKLTLPIPST-CPE-----IFSKMLLDCWNYDPHERPTFSEIMQQLKD
 |     ..|  .||.. ||.      ... . .||. || .||.||.| ..|..
QIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK.AA TK 170-433 19 3.4e-73 244.51 In-house 1-486 (486) Show / Hide 
Range on Protein: 170-433
Range on HMM: 1-486/486
Sequence Identity: 19% (97 aa)

IQLNELIGVGGFG---KVFRGSWRG---------------------------EEVAVKAAKHDPEEDDNVRST--ID---------NVRQEAKLFS--LL
|.| . .| | ||   .|..| |||                           ..||||  | . ..... .    ..         .  .|.|...  |.
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHPNIISLRGACLRE------------PHVCIVMEYARGGS----LNRLLFGKKMA--------------------------------------------
 ||||..| |.|...            ....|||||. .|.    |   |  ..                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------MPPNVLVNWAYQIADGMNYLHWEAPI----PLIHRDLKSSNILLDQKVEHS---NMYNIQLKITDFG--
                               ...  |. ...|||.|| ||| . ..     ..||||   |.|....        ..  . ||.|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH-SKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAREMYKTTRMSAAGTYA----------------------------WMAPEVIKSSL---------FSKSSDVWSFGILLWELLT-GEVPYKGI
      |||..|. .   ....|                             |||||....           |.  |||||||.|.||..| |..|| | 
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

DTL---------AVAYGIAVN--------------KLTLPIPSTCP--------------EIFSKMLLDCWNYDPHERPTFSEIMQQL
 .          .  .   ..              .. .| |  ||              |..  ....||.||| .|||||.. .||
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK.AA S_TKc 170-442 27 3.7e-70 240.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 170-442
Range on HMM: 1-231/231
Sequence Identity: 27% (79 aa)

IQLNELIGVGGFGKVFRGSWRG--EEVAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLLSHPNIISLRGACLREPHVCIVMEYARG--GSLNRLLFGKKM
 .. ..|| |.||||... ...  ..||.|  |             ...|.| .. .   ||||. | ...    |...||||. |  |.| ...  .. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

A-----MPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAREMYKTTRMSAAGTYAWMAPEVIKSSLFSK-S
      .|. .   ..|||.....|.|       |||||| .|||||.          ..||.||||||..     ..  ||  .|||||.    ..| .
HGLRFPFPE-HARFYMYQICCALEYCH---SHGIIHRDLKPENILLDE----------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCK

SDVWSFGILLWELLTGEVPYKGIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQLKDISESPFI
.|.||.|..|.|.|.|. |.    .... . . .           .. .  ..  |...|| .|||  |..|   ||   |..
CDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK.AA ZAK 170-432 36 1.7e-67 230.57 In-house 1-257 (257) Show / Hide 
Range on Protein: 170-432
Range on HMM: 1-257/257
Sequence Identity: 36% (102 aa)

IQLNELIGVGGFGKVFRGSWRGEE-----VAVKAAKHDPEEDDNVRSTIDNVRQEAKLFSLLSHPNIISLRGACLREPH-VCIVMEYARGGSLNRLLFGK
||. . .||| || |.|. |         .|||               .  .  ||   | ..| |||   | |.  |    || |||  |||       
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKK--------------VFKIEKEAEILSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSN

K---MA-------MPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQKVEHSNMYNIQLKITDFGLAR-EMYKTTRMSAAGTYAWMAPEVI-
.   |.       |  .. . || ||| || ||| .||   ||||||| |. .|         |  .|| |||  |     .| ||  || .|||||.| 
RSQEMDSSSGGNSM--DHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVIDK--------NGVCKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMIL

KSSLFSKSSDVWSFGILLWELLTGEVPYKGIDTLAVAYGIAVNKLTLPIPSTCPEIFSKMLLDCWNYDPHERPTFSEIMQQ
 |   .   ||||.|. |||.|| |||||. . . ..  |     .| ||. ||  | ... .||  || .|| .  |   
QSEPVTETCDVWSYGVVLWEMLTREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI