Gene ANKK6 (Sea Urchin)

ANKK6

Species: Sea Urchin
Alias: Spk365, ANKK6, SPU_006622
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: RIPK

Sequence

Name Sequence Type Origin Length Description Download
ANKK6.AA Protein None 1220 None Fasta, JSON
ANKK6.kin_dom Protein Kinase Domain None 277 None Fasta, JSON

Protein domain

Protein domains of ANKK6.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase ANKK6.AA RIPK 29-56 53 1.3e-14 46.22 In-house 1-28 (290) Show / Hide 
Range on Protein: 29-56
Range on HMM: 1-28/290
Sequence Identity: 53% (15 aa)

LGGGSFGEVFKATHKVHGEVAVKLAKPG
.|||.|||||||.|...|....|..||.
VGGGGFGEVFKARHRHWGDWVAKKCKPC
Kinase ANKK6.AA TKL 29-54 37 8.8e-08 24.11 In-house 1-35 (364) Show / Hide 
Range on Protein: 29-54
Range on HMM: 1-35/364
Sequence Identity: 37% (13 aa)

LGGGSFGEVFKATHKVHG---------EVAVKLAK
.| |.||||.|.... .|         .||||  |
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFK
Kinase ANKK6.AA Src 29-56 50 8e-06 15.76 In-house 7-34 (255) Show / Hide 
Range on Protein: 29-56
Range on HMM: 7-34/255
Sequence Identity: 50% (14 aa)

LGGGSFGEVFKATHKVHGEVAVKLAKPG
|| | ||||.... . . .||||  |||
LGQGQFGEVWMGYWNGNTKVAVKTLKPG
Kinase ANKK6.AA LISK 28-48 47 3.5e-05 12.58 In-house 1-21 (296) Show / Hide 
Range on Protein: 28-48
Range on HMM: 1-21/296
Sequence Identity: 47% (10 aa)

HLGGGSFGEVFKATHKVHGEV
 .| |.||.|.| ||.  |.|
EIGKGFFGKVYKGTHRQTGQV
Kinase ANKK6.AA TK 23-56 23 6e-05 11.7 In-house 1-63 (486) Show / Hide 
Range on Protein: 23-56
Range on HMM: 1-63/486
Sequence Identity: 23% (15 aa)

EHEGCHLGGGSFG---EVFKATHKVHG--------------------------EVAVKLAKPG
 . |  || | ||   ||.|.. . ..                          .||||  |.|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEG
Kinase ANKK6.AA SrcB 24-56 42 6.4e-05 12.48 In-house 2-34 (251) Show / Hide 
Range on Protein: 24-56
Range on HMM: 2-34/251
Sequence Identity: 42% (14 aa)

HEGCHLGGGSFGEVFKATHKVHGEVAVKLAKPG
.   .|| | ||||. .. . |  ||||  |.|
KLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQG
Kinase ANKK6.AA Pkinase_Tyr 24-56 44 7e-05 17.15 Pfam 2-39 (270) Show / Hide 
Range on Protein: 24-56
Range on HMM: 2-39/270
Sequence Identity: 44% (17 aa)

HEGCHLGGGSFGEVFKATHK-----VHGEVAVKLAKPG
. |  || |.||||.|.| |      . .||||  |.|
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEG
Pkinase ANKK6.AA Pkinase 23-51 53 0.001287 13.87 Pfam 1-30 (293) Show / Hide 
Range on Protein: 23-51
Range on HMM: 1-30/293
Sequence Identity: 53% (16 aa)

EHEGCHLGGGSFGEVFKATHKVHGE-VAVK
 | |  .| ||||.|.|..||  |. ||||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVK
Kinase ANKK6.AA Dicty4 29-54 53 0.003821 6.53 In-house 7-31 (277) Show / Hide 
Range on Protein: 29-54
Range on HMM: 7-31/277
Sequence Identity: 53% (14 aa)

LGGGSFGEVFKATHKVHGEVAVKLAK
.|.||||||.|.| .   |||||...
IGKGSFGEVYKGTWRGK-EVAVKKLN
Kinase ANKK6.AA LRRK 23-41 30 0.016541 4.67 In-house 1-20 (351) Show / Hide 
Range on Protein: 23-41
Range on HMM: 1-20/351
Sequence Identity: 30% (6 aa)

EHEGCHLGGGSFG-EVFKAT
  ..  .| |.|| .|..|.
LKIEEQIGRGGFGTFVYRAK
Kinase ANKK6.AA MLK 23-51 33 0.016893 4.64 In-house 1-33 (291) Show / Hide 
Range on Protein: 23-51
Range on HMM: 1-33/291
Sequence Identity: 33% (11 aa)

EHEGCHLGGGSFGEVFKATHKVHG----EVAVK
  .  ..| ||||.|.|.. .       .||||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVK
Kinase ANKK6.AA RIPK 99-287 49 7.69999999999e-123 414.39 In-house 76-290 (290) Show / Hide 
Range on Protein: 99-287
Range on HMM: 76-290/290
Sequence Identity: 49% (107 aa)

LFGIVMKYMENGSLWDFRKRRW--QDHPDLWPLTNR-VYEISCGMHFLHSND--IIHRDLKLENVLVDGNLHAKIADLGLAADLRTS--FGDRC------
|.||||.||||||||.|....|  |.|||.|||..| ..||||||..|||..  |||||||.||.|||.|.|.||||.|||.....|  ..|||      
LYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVY

-------WGTDSHKPPEAFRTDLSKSIKVVNPKYDVYSFAMTLYELLTGIHPYAERGLEMVKVFKLS-DQAPCLKPVPVNTPTP-----LIKVMTDSWRY
       |||.|..|||.||||..|.||||.|||||||||....|.||..|||..|...|....... ...|||.|||...|.|     .|..|...|..
SMKSKNRWGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHPYEDRKCMMMIMMCCKQGHRPCLQPVPEYWPEPPHCEQMIELMQRCWQQ

AANSRPAFIEITDWV
..|.||.|.|...|.
DPNDRPCFQECEEWT
Kinase ANKK6.AA TKL 100-287 25 1.5e-54 187.59 In-house 113-364 (364) Show / Hide 
Range on Protein: 100-287
Range on HMM: 113-364/364
Sequence Identity: 25% (67 aa)

FGIVMKYMENGSLWDFRKRRWQDHPDLWPLTNR-VYEISCGMHFLHSND--------IIHRDLKLENVLVDGNLH--------------AKIADLGLAAD
..||| |...|||...           |... | ...|..||..|||..        ||||||| .|.||| |..              .||.|.||. .
LCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRF

LRTSFGDRCW---------------------GTDSHKPPEAFRTDLSKSIKV----------VNPKYDVYSFAMTLYELLTGIHPYAERGL---------
. .|... ..                     ||  . .||..| ..  . ||           ..| |||||.. |.|.||. .||.. .          
MSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPF

-EMVKVFKLSDQAPCLKPVPVN---------TPTPLIKVMTDSWRYAANSRPAFIEITDWV
 || ..  .  . | ..|.. |         .|....| |.| | . ...|| | ||... 
EEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase ANKK6.AA MLK 100-287 27 3.9e-25 84.21 In-house 85-291 (291) Show / Hide 
Range on Protein: 100-287
Range on HMM: 85-291/291
Sequence Identity: 27% (59 aa)

FGIVMKYMENGSLWDFR---KRRWQDH---------PDLWPLTNRVYEISCGMHFLHSND---IIHRDLKLENVLVD------GNLHAKIADLGLAADLR
|.||| |.|.||| ..    .  | |           |.  . |  . .. |||.|||..   |||||||  |.|.|      .....||.| |.. |. 
FCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWH

TSFGD---RCWGTDSHKPPEAF-RTDLSKSIKVVNPKYDVYSFAMTLYELLTGIHPYAERGLEMVKVFKLSDQAPCLKPVPVNTPTPLIKVMTDSWRYAA
..  .      ||     ||.. .    .    .. | ||.|... |.|.||. .||..   .|   ..       . |.| . | .. | |.. |   .
QMC-TNMMSNAGTYAWMAPEVIQQ----FRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRP-PIPSTCPEHWKKLMKQCWNQDP

NSRPAFIEITDWV
..|| | .|    
HKRPSFRQIVQHL
Kinase ANKK6.AA Dicty4-Unclassified 139-287 33 3.2e-22 72.89 In-house 121-263 (263) Show / Hide 
Range on Protein: 139-287
Range on HMM: 121-263/263
Sequence Identity: 33% (50 aa)

GMHFLHSNDIIHRDLKLENVLVDGNLHAKIADLGLAADLRTSFGDRCWG-TDSHKPPEAFRTDLSKSIKVVNPKYDVYSFAMTLYELLTGIHPYAERGLE
|| .||. ..||||.|  |.|.| .  .||||.|..      |     . |     ||  .          | | ||||.|| ||||.||  || |    
GMQHLHTRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHE------SYNQKSDVYSYAMMLYELATGDEPYQEIQSI

MVKVFKLSDQAPCLKP-VPVNTPTPLIKVMTDSWRYAANSRPAFIEITDWV
|       |    |.| .| | .  . |   . |    | || . .|..  
MNAARSVCDKK--LRPKIPDNCDNFWKKLIKWCWHNDPNKRPTMNQIIQYL
Kinase ANKK6.AA Pkinase 133-231 37 1.7e-20 73.54 Pfam 114-212 (293) Show / Hide 
Range on Protein: 133-231
Range on HMM: 114-212/293
Sequence Identity: 37% (40 aa)

VYEISCGMHFLHSNDIIHRDLKLENVLVDGNLHA----KIADLGLA----ADLRTSFGDRCWGTDSHKPPEAFRTDLSKSIKVVNPKYDVYSFAMTLYEL
.|.| .|. ..||. |||||||.||.|.| | |     ||.| |||        . . ..| ||    .||  |     . .   || |..|.  .|||.
MYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFC-GTPWYMAPEVIR-----GGQYYGPKVDMWSCGCILYEM

LTGIHPY
|.|  |.
LCGRPPF
Kinase ANKK6.AA LISK 136-174 51 1.8e-15 46.52 In-house 110-152 (296) Show / Hide 
Range on Protein: 136-174
Range on HMM: 110-152/296
Sequence Identity: 51% (22 aa)

ISCGMHFLHSNDIIHRDLKLENVLVDGN----LHAKIADLGLA
|.||| .|||..|||||||  |.||. |      .|..|.|.|
IACGMSYLHSMNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFA
Kinase ANKK6.AA Src 102-174 43 1.3e-14 46.06 In-house 71-144 (255) Show / Hide 
Range on Protein: 102-174
Range on HMM: 71-144/255
Sequence Identity: 43% (32 aa)

IVMKYMENGSLWDFRK-RRWQDHPDLWPLTNRVYEISCGMHFLHSNDIIHRDLKLENVLVDGNLHAKIADLGLA
||  ||..||| |. | ..   |  |  |      .. || .| |. .|||||   ||||. |. .|.|| |||
IVTEYMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLA
Kinase ANKK6.AA Pkinase_Tyr 102-174 38 1.5e-14 49.87 Pfam 84-158 (270) Show / Hide 
Range on Protein: 102-174
Range on HMM: 84-158/270
Sequence Identity: 38% (29 aa)

IVMKYMENGSLWDFRKRR--WQDHPDLWPLTNRVYEISCGMHFLHSNDIIHRDLKLENVLVDGNLHAKIADLGLA
||| ||..|.| |. ...  .......  | .  ..|..|| .|.|. .|||||   |.||. |...||.| |||
IVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase ANKK6.AA Dicty4 139-175 53 3.7e-14 43.8 In-house 124-162 (277) Show / Hide 
Range on Protein: 139-175
Range on HMM: 124-162/277
Sequence Identity: 53% (21 aa)

GMHFLHS-N-DIIHRDLKLENVLVDGNLHAKIADLGLAA
||  ||. | .|||||||  | ||| |. .|..|.||..
GMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQ
Kinase ANKK6.AA SrcB 102-174 39 6.9e-14 43.27 In-house 70-142 (251) Show / Hide 
Range on Protein: 102-174
Range on HMM: 70-142/251
Sequence Identity: 39% (29 aa)

IVMKYMENGSLWDFRKRRWQDHPDLWPLTNRVYEISCGMHFLHSNDIIHRDLKLENVLVDGNLHAKIADLGLA
|.  ||..|.| || |     .  |  |      |. || ..     |||||.  |.||   |  |||| |||
IITEYMAKGCLLDFLKTDEGSKLSLPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLA
Kinase ANKK6.AA TK 134-174 36 9.2e-13 38.34 In-house 241-298 (486) Show / Hide 
Range on Protein: 134-174
Range on HMM: 241-298/486
Sequence Identity: 36% (21 aa)

YEISCGMHFLHSNDI------IHRDLKLENVLVDGNLH-----------AKIADLGLA
. |.||| .|||. .      .||||   |.||. |..           .|||| ||.
WQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS
Kinase ANKK6.AA LRRK 211-289 23 1.3e-11 37.35 In-house 262-351 (351) Show / Hide 
Range on Protein: 211-289
Range on HMM: 262-351/351
Sequence Identity: 23% (21 aa)

KYDVYSFAMTLYELLTGI-HPYAERG----LEMVKVFKL---SDQAPCLK---PVPVNTPTPLIKVMTDSWRYAANSRPAFIEITDWVKN
| |.|||.| |.||||.  ||. |      ...   ...   . . | ..     |. ... . . ... |    ..|| |..|..  . 
KVDCYSFGMILWELLTRQHHPFDEHDFFDHMQWMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase ANKK6.AA TyrKc 99-287 17 9.2e-11 -48.65 SMART 1-280 (280) Show / Hide 
Range on Protein: 99-287
Range on HMM: 1-280/280
Sequence Identity: 17% (51 aa)

L---------------------------------------------F-----------GIVMK----------------YMENGSLWDFRKRRWQDHPDL
.                                             .           |....                ||..|.| |. ...  .   .
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-LCM

WPLTNRVYEISCGMHFLHSNDIIHRDLKLENVLVDGNLHAKIADLGLAADLRTS-------FGDRCWGTDSHK--------PPEAFRTDLSKSIKVVNPK
  | .  . |.||| .|||. .|||||   |.||. |...||.| ||. |.             |  .... |        .||..        .. ..|
KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI------NYGKFTTK

YDVYSFAMTLYELLTGIHPYAERG----LEMVKVFKLSDQAPCLKPVPVN-------TPTPLIKVMTDSWRYAANSRPAFIEITDWV
 ||.||  ...|..|   .  .      ..   |... .|   ... | .        |. . ..|.. |.. ...|| | || .  
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase ANKK6.AA LRRK 133-173 38 2.2e-10 32.92 In-house 170-224 (351) Show / Hide 
Range on Protein: 133-173
Range on HMM: 170-224/351
Sequence Identity: 38% (21 aa)

VYEISCGMHFLHSND--IIHRDLKLENVLV---D---------GNLHAKIADLGL
...|. || .|||..  ||||||| .|.|.   .          . .||||| |.
ALQIAKGMEYLHSHNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGI
Kinase ANKK6.AA S_TKc 100-287 21 4.2e-10 -28.83 SMART 12-231 (231) Show / Hide 
Range on Protein: 100-287
Range on HMM: 12-231/231
Sequence Identity: 21% (54 aa)

FGIVMK--------------------------------------------------YMEN--GSLWDFRKRRW-------QDHPDLWPLTNRVYEISCGM
|| |.|                                                  |...  |.| |. |.|         .  . . .   .|.| |..
FGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFY---MYQICCAL

HFLHSNDIIHRDLKLENVLVDGNLHAKIADLGLAADLRTSFGDRCWGTDSHKPPEAFRTDLSKSIKVVNP-KYDVYSFAMTLYELLTGIHPYAERGLEMV
 ..||. ||||||| ||.|.|   | ||.| |||. |     . . ||    .|| .           .. | |..|.  .|||.|.|  |.     .| 
EYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---------GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQ

KVFKLSDQAPCLKPVPVNTPTPLIKVMTDSWRYAANSRPAFIEITD---------WV
..||.              . ...  .   ...  . ||   |.           |.
MMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase ANKK6.AA TK 213-287 15 6.1e-10 28.72 In-house 376-486 (486) Show / Hide 
Range on Protein: 213-287
Range on HMM: 376-486/486
Sequence Identity: 15% (18 aa)

DVYSFAMTLYELLT-G-IHPYAERG-------------LEMVKV---------------FKLS--DQAPC-----LKPVPVNTPTPLI-KVMTDSWRYAA
||.||  ...|..| |   .| .               .|...                . .   ...|        . | ..| ...  .|.. |.| .
DVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM-H-PPHCPPEEYYDLMQQCWHYDP

NSRPAFIEITDWV
. || | .. .  
EDRPTFSQLHEQL
Kinase ANKK6.AA Dicty4 213-284 27 4.6e-07 19.8 In-house 199-270 (277) Show / Hide 
Range on Protein: 213-284
Range on HMM: 199-270/277
Sequence Identity: 27% (20 aa)

DVYSFAMTLYELLTGIHPYAERGLEMVKVFKLSDQAPCLKPVPVNTPTPLIKVMTDSWRYAANSRPAFIEIT
|||||.. |.|.||.  ||.  . . .... . ..     |.| ..|..... ... |    ..|| | ||.
DVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEII
Kinase ANKK6.AA LISK 257-287 32 0.000662 8.35 In-house 266-296 (296) Show / Hide 
Range on Protein: 257-287
Range on HMM: 266-296/296
Sequence Identity: 32% (10 aa)

NTPTPLIKVMTDSWRYAANSRPAFIEITDWV
. | |..... |  .|  ..|| | ||..| 
DCPPPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase ANKK6.AA Pkinase_Tyr 213-291 30 0.000823 13.53 Pfam 196-270 (270) Show / Hide 
Range on Protein: 213-291
Range on HMM: 196-270/270
Sequence Identity: 30% (25 aa)

DVYSFAMTLYELLT-GIHP-YAERGLEMVKVFKLSDQAPCLKPVPVNTPTPLIKVMTDSWRYAANSRPAFIEITDWVKNQL
||.||  ...|..| |  | |..   | |. .   |     .  | |.| .. ..|.. |.| .. || | ||     .||
DVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC--PENCPDEIYDLMKQCWHYDPEDRPTFSEI----HEQL
Kinase ANKK6.AA SrcB 211-292 30 0.006847 5.5 In-house 176-251 (251) Show / Hide 
Range on Protein: 211-292
Range on HMM: 176-251/251
Sequence Identity: 30% (25 aa)

KYDVYSFAMTLYELLT-GIHPYAERGLEMVKVFKLSDQAPCLKPVPVNTPTPLIKVMTDSWRYAANSRPAFIEITDWVKNQLN
| ||.|| . |.|. | |  ||   |     | .  ..   . | | | |  | ..|.  |.  .  || |    |...  |.
KSDVWSFGILLMEIVTYGRIPYP--GMTNPEVIRNLERGYRM-PRPDNCPEELYNIMMMCWKERPEERPTF----DYLQSVLD
Kinase ANKK6.AA Src 253-287 27 0.114795 1.38 In-house 220-255 (255) Show / Hide 
Range on Protein: 253-287
Range on HMM: 220-255/255
Sequence Identity: 27% (10 aa)

PVPVNTPTPLIK-VMTDSWRYAANSRPAFIEITDWV
| | | |  | . .|.  |.  .  || |  . .  
PCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL