Gene TGFbRII (Sea Urchin)

TGFbRII

Species: Sea Urchin
Alias: Spk326, TGFbRII, SPU_017511
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: STKR
Subfamily: STKR2

Sequence

Name Sequence Type Origin Length Description Download
TGFbRII.AA Protein None 594 None Fasta, JSON
TGFbRII.kin_dom Protein Kinase Domain None 295 None Fasta, JSON

Protein domain

Protein domains of TGFbRII.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TGFbRII.AA Type2 264-565 49 8e-210 699.25 In-house 1-315 (315) Show / Hide 
Range on Protein: 264-565
Range on HMM: 1-315/315
Sequence Identity: 49% (156 aa)

ITLDELIGKGRFGAVWRAHWKINNGTKERTVAVKVFLEYDSASWNVEKELFTDHSVMMRHEHIVQFISAEVRRVSVTSPTRQYWLITKYYKNGSLHDYLR
|.|.|||||||||.||.|.|..|||.| ||||||.| |.|..||..||...... ..|.||.|.|||.||.|||........|||.|.....|||.|||.
IQLMELIGKGRFGCVWKAQWHNNNGEK-RTVAVKIFPEQDKQSWQNEKDIYSLP-YHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLK

QRSVNWIDLCKLCGSAARGLAHLHAETYGSHG--LHKVPVAHRDLKSTNILVKDDGSCAIADFGLAIRLDPQSST--------DHLANSGQVGTPRYMSP
|....|...|....|.||||||||.|......  .||.|.||||.||.|.|||.|..|.|||||||.|..|....        ....|.|||||.|||.|
QHTIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAP

EALECKVNLQD-IESFKQMDTYALALILWEITSRCTLLK---DINEYELPFSRSLGDRRASLEMMKTLVVLRRERPPITDEWLRNPGLT-IIKNTVVDCW
|.||..||.|| ...|||||.||..|.|||..||||...   ...||..||....|....|.|.|..||| .|.||...|.|...||.. ....|..|||
EVLEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRCTDHYPDDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDCW

DEDPEARLTASCVEARF
|.|.||||||.||. |.
DHDAEARLTAQCVQERM
Kinase TGFbRII.AA STKR 264-565 44 1.8e-186 607.3 In-house 1-312 (312) Show / Hide 
Range on Protein: 264-565
Range on HMM: 1-312/312
Sequence Identity: 44% (143 aa)

ITLDELIGKGRFGAVWRAHWKINNGTKERTVAVKVFLEYDSASWNVEKELFTDHSVMMRHEHIVQFISAEVRRVSVTSPTRQYWLITKYYKNGSLHDYLR
|.|.|.|||||.|.||...|. | |.| .|||||.| ..| .||. |.|....  .|||||.|.||| |. .. . .  ..||||||.|..||||.|||.
IQLIECIGKGRYGEVWKGKWRGN-GEK-ETVAVKIFPSRDEQSWFRETEIYQT--PMMRHENILQFIAADMKHTEGS--WTQYWLITEYHENGSLCDYLK

QRSVNWIDLCKLCGSAARGLAHLHAETY--GSHGLHKVPVAHRDLKSTNILVKDDGSCAIADFGLAIRLDPQSSTDHLA-------NSGQVGTPRYMSPE
.. ..| ..|... |.|.||||||.|..  |....|| ..||||.|| |||||.||.|.|||||||.|.||........       ...|||| |||.||
RHTIDWHEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPE

ALECKVNLQDIES-FKQMDTYALALILWEITSRCTLLK------DINEYELPFSRSLGDRRASLEMMKTLVVLRRERPPITDEWL-RNPGLTIIKNTVVD
 |....|.|..|| ||.|| ||..|..|||..|||...      ...||..|| . ....  |.|.|...|. .|.||.|...|. ..|.......|. .
VLDGAMNFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNH-PSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEE

CWDEDPEARLTASCVEARF
|||.|||||||| ||. ..
CWDHDPEARLTALCVKKTM
Kinase TGFbRII.AA Type1 264-558 39 1e-118 323.11 In-house 1-283 (290) Show / Hide 
Range on Protein: 264-558
Range on HMM: 1-283/290
Sequence Identity: 39% (118 aa)

ITLDELIGKGRFGAVWRAHWKINNGTKERTVAVKVFLEYDSASWNVEKELFTDHSVMMRHEHIVQFISAEVR-RVSVTSPTRQYWLITKYYKNGSLHDYL
|.. | |||||.| |||..|      .  .||||.|   | .||  | |..    |||||| | .|| |  . . |.|    | |||| |. .|||.|||
IQMIECIGKGRYGEVWRGKW------RGENVAVKIFFSRDERSWFRETEIY--QTVMMRHENILGFIAADMKDNGSWT----QLWLITDYHEHGSLYDYL

RQRSVNWIDLCKLCGSAARGLAHLHAETYGSHGLHKVPVAHRDLKSTNILVKDDGSCAIADFGLAIRLDPQSSTDHLANSGQVGTPRYMSPEALECKVNL
 .  ..  ....|. |.| ||||||.| .|.    |  .||||.|| ||.|| .|.|.|||.|||.| . .. ......  .||| ||| || |. . | 
NRHTLDTQQMLRLAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNM

QDIESFKQMDTYALALILWEITSRCTLLKDINEYELPFSRSLGDRRASLEMMKTLVVLRRERPPITDEWLRNPGLTIIKNTVVDCWDEDPEARLTA
.. ||.|  | |...|..|||. ||       .|.||.   . ..  | | |.  |  |. ||.|   |  .| .. .     .|| . |.||.||
NCFESYKMADIYSFGLVMWEIARRCEVGGIVEDYQLPY-YDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTA
Kinase TGFbRII.AA TKL 270-565 25 1e-90 307.69 In-house 1-364 (364) Show / Hide 
Range on Protein: 270-565
Range on HMM: 1-364/364
Sequence Identity: 25% (96 aa)

IGKGRFGAVWRAHWKINNGTKE-----RTVAVKVFLEYD-------------------------SASWNVEKELFTD-HSVMMRHEHIVQFISAEVRRVS
||.|.|| |....|. ..| |.     ..||||.| . .                          |||. ..| .   .  . ||..||||. .  .  .
IGSGGFGEVYKGKWRGWGG-KCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPC

VT------SPTRQYWLITKYYKNGSLHDYLRQRSVNWIDLCKLCGSAARGLAHLHAETYGSHGLHKVPVAHRDLKSTNILVKDDGS--------------
 .      .|. |..... |...|||..||      |  .|... ..|||...||... ....  | |..|||||| ||||....               
GCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

CAIADFGLAIRLDPQSSTDHLA---------------NSGQVGTPRYMSPEALECKVNLQD----------IESFKQMDTYALALILWEITSRCTLLKDI
| |.||||. .... ..  . .               .. |.||||.|.||.|. . |...           | ....| |. ...|||| .||.     
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-----

NEYELPFSRSLGDRRASLEMMKTLVVLRRERPPITDEWLR-------NPGLTIIKNTVVDCWDEDPEARLTASCVEARF
 .|..|..  .. .   .|.|  .|.....|||| ..|..       .. .. .|.   ||||.|||.|......  |.
PYYDYPYMPMIFQD-P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase TGFbRII.AA Pkinase 264-565 18 7.5e-41 145.52 Pfam 1-293 (293) Show / Hide 
Range on Protein: 264-565
Range on HMM: 1-293/293
Sequence Identity: 18% (63 aa)

ITLDELIGKGRFGAVWRAHWKINNGTKERTVAVKVFLEYDSASWNVEKELFT----DHSVMMRHEHIVQFISAEVRRVSVTSPTRQYWLITKYYKNG---
... . ||.| || |...|.| ..     .||||..    ...........         ...|..||... .  .        . ..... |  .|   
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-------KDHIYMVMEYCEGGLYV

-SLHDYLR---QRSV--NWIDLCKLCGSAARGLAHLHAETYGSHGLHKVPVAHRDLKSTNILVKDDGSC----AIADFGLAIRLDPQSSTDHLANSGQVG
 .|.||..   ....   . .... .   .|||...|..           . |||||. |||....| .     |.|||||  .|         ... .|
MDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM----------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNS-MTTFCG

TPRYMSPEALECKVNLQ-DIESFKQMDTYALALILWEITSRCTLLKDINEYELPFSRSLGDRRASLEMMKTLVVLRRERPPITDEWLRNPGL--------
||.||.||       .. . .  .  | ... .||.|  ..           .||. . .    .   .. ........|.  |..  ...         
TPWYMAPEV------IRGGQYYGPKVDMWSCGCILYEMLCGR----------PPFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWH

---------TIIKNTVVDCWDEDPEARLTASCVEAR--F
            |  . .|.. ||. |.|| ..     |
FHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase TGFbRII.AA TK 264-460 16 4e-27 87.34 In-house 1-361 (486) Show / Hide 
Range on Protein: 264-460
Range on HMM: 1-361/486
Sequence Identity: 16% (60 aa)

ITLDELIGKGRFG---AVWRAHWKINN---------------------GTKERTVAVKVFLEYDSASWNVEKE-------------LFTDHSVMMR----
||| . .|.| ||    |... |.  |                     . .. .||||.  | |..| . ...              .     ||.    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HEHIVQFISAEVRRVS------VTSPTRQYWLITKYYKNGS----LHDYLRQRS---------------------------------------------
 |..||... . .. ..      | .  . ..... | ..|.    |.||||...                                             
HHPNIVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

--------------------------------VNWIDLCKLCGSAARGLAHLHAE--TYGSHGLHKVPV---AHRDLKSTNILVKDDGS-----------
                                ..  .|.  |  .|.|...||.   . .        .    ||||   |.|| ...            
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-F--------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPV

CAIADFGLA-------IRLDPQSSTDHLANSGQVGTP-----------------------RYMSPEALECKV
| ||||||.        | .....  . ..|. .|.|                       |.|.||.|. .|
CKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRV
Kinase TGFbRII.AA MLK 264-486 23 2.7e-25 84.8 In-house 1-232 (291) Show / Hide 
Range on Protein: 264-486
Range on HMM: 1-232/291
Sequence Identity: 23% (60 aa)

ITLDELIGKGRFGAVWRAHWKINNGTKERTVAVKVFL-------EYDSASWNVEKELFTDHSVMMRHEH----IVQFISAEVRRVSVTSPTRQYWLITKY
|.. | ||.| ||.||.. |. ...   ..|||| .        . .. .|..|.|    |  ...|.     |.||  .       ..|. .. ... |
IQFHEWIGSGSFGKVWKGRWRNKDIVA-KIVAVKRVRARIFDKSDTYCEQWDFEMEC--RHLRILSHPNNHPCIIQFYGV------CLQPPCHFCIVMEY

YKNGSLHDYLRQRSVNWID---------------LCKLCGSAARGLAHLHAETYGSHGLHKVPVAHRDLKSTNILVKD------DGSCAIADFGLAIRLD
  .|||...|. .. .| |               . . .   |||.. ||..        ..|. |||||| |||. .      .| . |.|||..  . 
CEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMA-------PKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDW-

PQSSTDHLA-NSGQVGTPRYMSPEALE-CKVNLQDIESFKQMDTYALALILWEITSR
   .. . .   .. ||...|.||...  . .  .. .    | .  ...|||. .|
---HQMC-TNMMSNAGTYAWMAPEVIQQFRCEKYSEKC----DVWSWGVVLWEMLTR
Kinase TGFbRII.AA Pkinase_Tyr 264-456 23 2.2e-21 73.07 Pfam 1-186 (270) Show / Hide 
Range on Protein: 264-456
Range on HMM: 1-186/270
Sequence Identity: 23% (48 aa)

ITLDELIGKGRFGAVWRAHWKINNGTKERTVAVKVFLEYDSAS-WNVEKELFTDHSVMM---RHEHIVQFISAEVRRVSVTSPTRQ--YWLITKYYKNGS
||... .|.| || |....||   . .. .||||.  |. . .     ....   ..|.   .|..||... . .      .  ..  ..... | ..|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCT------DQGEPNQIYIVMEYMPHGD

LHDYLRQR-----SVNWIDLCKLCGSAARGLAHLHAETYGSHGLHKVPVAHRDLKSTNILVKDDGSCAIADFGLAIRLDPQSSTDHLANSGQVGTPRYMS
|.||||..     ...  ||.. |   |.|...|..              ||||   |.||.... . |.|||||  . . .   . . .|     . |.
LLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN----------CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMA

PEAL
||..
PECI
Kinase TGFbRII.AA S_TKc 264-569 19 3.1e-21 77.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 264-569
Range on HMM: 1-231/231
Sequence Identity: 19% (61 aa)

ITLDELIGKGRFGAVWRAHWKINNGTKERTVAVKVFLEYDSASWNVEKELFTDHSVMMRHEHIVQFISAEVRRVSVTSPTRQYWLITKYYKN--GSLHDY
 .. ..|||| || |.....|       | ||.|.       .   | ..        .|..||... . .           ..... |  .  |.|.||
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK----EHIRREIQILKK-----HHPNIVKLYDVFQD--------DHLYMVMEYCDGDLGDLFDY

LRQRS-------VNWIDLCKLCGSAARGLAHLHAETYGSHGLHKVPVAHRDLKSTNILVKDDGSCAIADFGLAIRLDPQSSTDHLANSGQVGTPRYMSPE
...|         .  . ....   ...|...|             . |||||  |||. .     |.||||| .|           . ..||| ||.||
IKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG----------IIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPE

ALECKVNLQDIESFK--QMDTYALALILWEITSRCTLLKDINEYELPFSRSLGDRRASLEMMKTLVVLRRERPPITDEWLRNPGLTIIKNTVVDCWDEDP
 |          ..     | ...  ||.|  .....                      .|.| ..                      |. .  |.. ||
VL----------GYGKCKCDWWSCGCILYEMLCGYPPFP-----------------QMQMMFKKIG------------------SPEAKDFIRKCLQKDP

EARLTASCVE----ARFQELI
| |.|| . .    ..  . .
EKRPTAEALQDEWDIKCHPWF
Kinase TGFbRII.AA TyrKc 264-565 22 4.6e-17 53.22 SMART 1-280 (280) Show / Hide 
Range on Protein: 264-565
Range on HMM: 1-280/280
Sequence Identity: 22% (74 aa)

ITLDELIGKGRFGAVWRAHWKINNGTKERTVAVKVFLEYDSASWNVEKELFTDHSVMM----RHEHIVQFISAEVRRVSVTSPT------RQYWLITKYY
|||.. .| | || |....||       ..||||.  |.       ....    ..|.    .|..||... .      .|..        ...... | 
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGV------CTQQGRNFMYIEPLMIVMEYM

KNGSLHDYLRQRS--VNWIDLCKLCGSAARGLAHLHAETYGSHGLHKVPVAHRDLKSTNILVKDDGSCAIADFGLAIRLDPQ----SSTDHLANSGQVGT
..|.|.|||| .   ... ||.. |  .|.| ..||            .. ||||   |.||.... . |.||||.  ..       |.|    ..  |.
PHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

P-----RYMSPEALECKVNLQDIESFKQMDTYALALILWEITSRCTLLKDINEYELPFSR---SLGDRRASLEMMKTLVVLRRERPPITDEWLRNP----
      | |.||..  . .   ..|    | ..    .||| ...         . | .             |... .   .| ..|  |.    |    
KTMLPIRWMAPECI--NYGKFTTKS----DVWSFGVCMWEIFTYG---------QQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDY----PMSFV

-GLTIIKNTVVDCWDEDPEARLTASCVEARF
   . . .   .||.|||| | | | .  .|
CCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TGFbRII.AA TKL-Unique 268-487 22 1.3e-16 55.28 In-house 3-225 (290) Show / Hide 
Range on Protein: 268-487
Range on HMM: 3-225/290
Sequence Identity: 22% (56 aa)

ELIGKGRFGAVWRAHWKINNGTKERTVAVKVFLEYDSASWNVEKELFTDHS---VMMR-HEHIVQFISAEVRRVSV--TSPTRQYWLITKYYKNGSLHDY
..|| | .|.| .. |      .   ||.|.| .  . | | ... | ..     . . |. ||... .     ..  . .  .. ... |.  |||.|.
NKIGEGGYGQVYKGKW------RGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGY-----CMDHQVYPPNMCIVMEYCPGGSLYDV

LRQ--------RSVNWIDL---CKLCGSAARGLAHLHAETYGSHGLHKVPVAHRDLKSTNILVKDD-----GSCAIADFGLAIRLDPQSSTDHLANS---
| |        .. . ...    |.   .|.|. .|| .        . |..||||||.|.||  .      .  |.||||.. .. ....  . ..   
LHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHC--------EPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNS-KINKMTNNEHKGT

---GQVGTPRYMSPEALECKVNLQDIESFKQMDTYALALILWEITSRC
   . .|..|.|.|| |.      ..   .. | |. . .|||| .|.
RNQTRCGSFRWMAPEVLRMNF--CQYS--EKSDVYSFGIVLWEIATRK
Kinase TGFbRII.AA STE 396-454 29 2.3e-13 43.69 In-house 168-232 (359) Show / Hide 
Range on Protein: 396-454
Range on HMM: 168-232/359
Sequence Identity: 29% (21 aa)

LHKVPVAHRDLKSTNILVKDDGSCAIADFGLAIRLDPQSS------------TDHLANSGQVGTPRYMSPE
||.  . |||.|. |||.     . ..|||.. .|.. ..            |    .   |||| .|.||
LHSHHIIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPE
Kinase TGFbRII.AA Dicty4 369-456 30 2e-12 37.95 In-house 108-189 (277) Show / Hide 
Range on Protein: 369-456
Range on HMM: 108-189/277
Sequence Identity: 30% (28 aa)

WIDLCK---LCGSAARGLAHLHAETYGSHGLHKVPVAHRDLKSTNILVKDDGSCAIADFGLAIRLDPQSSTDHLA-NSGQVGTPRYMSPEAL
|..  .   .. .||||...||. .        . . |||||| |.|| ..    ..||||. .   .  .|| .  ....||| .|.|| .
WPLIKRAMRMAFDAARGMNWLHCCN--------PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYM--KKHEDHKDNQMTACGTPCWMAPEVM
Kinase TGFbRII.AA STE20 396-454 36 4.4e-12 40.74 In-house 133-192 (288) Show / Hide 
Range on Protein: 396-454
Range on HMM: 133-192/288
Sequence Identity: 36% (23 aa)

LHKVPVAHRDLKSTNILVKDDGSCAIADFGLAIRLDPQSSTDHLANS----GQVGTPRYMSPE
||.  . |||.|. |||. .||.. .||||..  |...  .   ...      |||| .|.||
LHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHG-R-D-TMQFKRNTFVGTPYWMAPE
Kinase TGFbRII.AA STE 264-335 17 2.3e-07 22.18 In-house 1-101 (359) Show / Hide 
Range on Protein: 264-335
Range on HMM: 1-101/359
Sequence Identity: 17% (18 aa)

ITLDELIGKGRFGAVWRAHWK----INNGTKER--------TVAVKVFL--EYDSASWN-------------VEKELFTDHSVMMR----HEHIVQFISA
 .. | |||| || | .|  .    |.  |.|          .|.|.    . .. . .              ....  . ..|..    |..||... .
WEGIEKIGKGAFGTVYKAMNHKNCNIH-KTGEVENNGETGEIMAIKQMNLENCNNKD-ENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

EVR
...
YFK
Kinase TGFbRII.AA STE20 264-298 34 7e-05 14.11 In-house 1-35 (288) Show / Hide 
Range on Protein: 264-298
Range on HMM: 1-35/288
Sequence Identity: 34% (13 aa)

ITLDELIGKGRFGAVWRAHWKINNGTKERT---VAVKV
 .| | ||.| .|.| .|   ... |.|     ||.|.
YELLEKIGQGSYGKVYKA---YHKPTGEYCNQRVAIKK
Kinase TGFbRII.AA Dicty4 264-284 42 0.000154 11.25 In-house 1-21 (277) Show / Hide 
Range on Protein: 264-284
Range on HMM: 1-21/277
Sequence Identity: 42% (9 aa)

ITLDELIGKGRFGAVWRAHWK
|. ...|||| || | .. |.
INIEQRIGKGSFGEVYKGTWR
Kinase TGFbRII.AA TK 546-565 40 0.009529 4.18 In-house 467-486 (486) Show / Hide 
Range on Protein: 546-565
Range on HMM: 467-486/486
Sequence Identity: 40% (8 aa)

DCWDEDPEARLTASCVEARF
.||..||| | | | .  ..
QCWHYDPEDRPTFSQLHEQL
Kinase TGFbRII.AA Dicty4 544-555 50 0.042526 2.99 In-house 252-263 (277) Show / Hide 
Range on Protein: 544-555
Range on HMM: 252-263/277
Sequence Identity: 50% (6 aa)

VVDCWDEDPEAR
...|||.||. |
IQWCWDHDPQHR
Kinase TGFbRII.AA Pkinase_Tyr 546-565 40 0.059672 7.23 Pfam 251-270 (270) Show / Hide 
Range on Protein: 546-565
Range on HMM: 251-270/270
Sequence Identity: 40% (8 aa)

DCWDEDPEARLTASCVEARF
.||..||| | | | .  ..
QCWHYDPEDRPTFSEIHEQL