Gene TKL1 (Sea Urchin)

TKL1

Species: Sea Urchin
Alias: Spk316, SPU_006901, TKL1, SpTKL1a
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: TKL
Family: TKL-Sp1

Sequence

Name Sequence Type Origin Length Description Download
TKL1.AA Protein None 423 None Fasta, JSON
TKL1.kin_dom Protein Kinase Domain None 261 None Fasta, JSON

Protein domain

Protein domains of TKL1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase TKL1.AA TKL-Sp1 159-419 87 2.2e-245 776.17 In-house 1-263 (263) Show / Hide 
Range on Protein: 159-419
Range on HMM: 1-263/263
Sequence Identity: 87% (229 aa)

LDMGPVVGKGQFGVVHRASWRGTPVAVKKISIMGSRKDEIEKEVAIHRRACHPNIVQMMALGYQEKEAFLVMQFIEGPSLHTVIFPDRDDVKIPLDWAKK
|||||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||||||
LDMGPVVGKGQFGVVHRASWRGTPVAVKKISMMGSRKDEIEKEVAIHRRACHPNIVQMMALGYQGKEAFLVMQFIEGPSLHTVIFPDRDDVKIPLDWAKK

LQISREVLQAVTFMHACNILHLDIKPANILVDSATIRPYICDLGLAHIKNRNLMSQSA--VNIRGTPCFMPPEALGATEPGYRHSNKHDIWSVAGTLVEL
.|||.|||||||||||||||||||||||..|..||.||||||||||||||||.||||.  ||.|||||.||||.....|||.||.|||||||||.|.|||
MQISCEVLQAVTFMHACNILHLDIKPANVMVERATRRPYICDLGLAHIKNRNHMSQSTSMVNMRGTPCHMPPEMVQKQEPGWRHPNKHDIWSVACTFVEL

YSNKRLWGDSMNPLALMARILTGQMSKPESLTAVDPKVQKILEPCFRQKPEKRPSASDLLNQF
||.||||||||...|||.|||||||||||.||.|||||||||||||.|||||||||.|||.||
YSMKRLWGDSMEFMALMRRILTGQMSKPEILTKVDPKVQKILEPCFDQKPEKRPSAEDLLDQF
Kinase TKL1.AA TKL 165-419 19 1.5e-66 227.44 In-house 1-364 (364) Show / Hide 
Range on Protein: 165-419
Range on HMM: 1-364/364
Sequence Identity: 19% (75 aa)

VGKGQFGVVHRASWRG----------TPVAVKKISIMGSRK----------------------------DEIEKEVAIHRRACHPNIVQMMALGYQEKE-
.|.| ||.|... |||          ..|||||.... . .                            ...|.|. ...| .||||||.|.   ...  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------AFLVMQFIEGPS-LHTVIFPDRDDVKIPLDWAKKLQISREVLQAVTFMHACN--------ILHLDIKPANILVDS-------------
             ..||....| | ||...            | ......... ... ..|..|        |.| |.|..|||||.             
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPN

ATIRPYICDLGLAHIKNR---NLMSQSAVN--------------IRGTPCFMPPEALGATEP------------GYRHSNKHDIWSVAGTLVELYSNKRL
|.... |||.||.  ...   . .......              ..|||..|.||.|  ...            |.  | |.|..| .  | |... .| 
ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP

WGDSMNPLAL---------MARILTGQMSKPE----------SLTAVDPKVQKILEPCFRQKPEKRPSASDLLNQF
. | ...  .         | ... |.   .             . ..| . |... |  ..||||||....| ..
YYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase TKL1.AA Pkinase 159-419 22 9.5e-48 169.75 Pfam 1-293 (293) Show / Hide 
Range on Protein: 159-419
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

LDMGPVVGKGQFGVVHRASWRGTP--VAVKKISIMGSRKDEIEK-----EVAIHRRACHPNIVQMMALGYQEKEAFLVMQFIEGP----SLHTVIFPDRD
.  | ..|.| ||.| .. ..||.  ||||.|.  . .... .      |..|..| .|||||..    . ...  .|| . ||     .|...|     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST---

DVKIPL--DWAKKLQISREVLQAVTFMHACNILHLDIKPANILVDSATIRP----YICDLGLAHIKNRNLMSQSAVNIRGTPCFMPPEALGATEPGYRHS
. . ..  ..     . ...|... ..|...|.| |.||.|||.|  .  .     ||| |||  .. .  .. .  . ||| .|.|| .     |  ..
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR---GGQYYG

NKHDIWSVAGTLVELYSNKRLWGDS-----MNPLALMARILTGQMSKPESLT------------------AVDPKVQKILEPCFRQKPEKRPSASDLLNQ
 | |.||.  .| |... . .. ..     ........||. .. . ... .                  ....  ..... |....|.|||.| ..|. 
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--F
  |
PWF
Kinase TKL1.AA S_TKc 159-419 23 1.1e-46 162.34 SMART 1-231 (231) Show / Hide 
Range on Protein: 159-419
Range on HMM: 1-231/231
Sequence Identity: 23% (66 aa)

LDMGPVVGKGQFGVVHRASWRG--TPVAVKKISIMGSRKDEIEKEVAIHRRACHPNIVQMMALGYQEKEAFLVMQFIEG--PSLHTVIFPDRD---DVKI
 ... ..||| ||.|... ...    ||.|.|.      . |..|..|...  |||||..    .  .. ..|| ...|   .|...|   .    ....
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PLDWAKKLQISREVLQAVTFMHACNILHLDIKPANILVDSATIRPYICDLGLAHIKNRNLMSQSAVNIRGTPCFMPPEALGATEPGYRHSN-KHDIWSVA
|  .|..  . .....|. ..|  .|.| |.||.|||.|.   .  ||| ||| .            . ||| .|.|| |        ..  | |.||. 
PE-HARF--YMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL---------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCG

GTLVELYSNKRLWGDSMNPLALMARILTGQMSKPESLTAVDPKVQKILEPCFRQKPEKRPSASDLLN---------QF
 .| |... . ..    .. ... .|.             .| .  ... |..  |||||.| ..|.          |
CILYEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase TKL1.AA STE 159-420 20 3.7e-33 114.48 In-house 1-359 (359) Show / Hide 
Range on Protein: 159-420
Range on HMM: 1-359/359
Sequence Identity: 20% (76 aa)

LDMGPVVGKGQFGVVHRASWR-----------------GTPVAVKKISIMGSR------------------KDEIEKEVAIHRRAC--HPNIVQMMALGY
..   ..||| ||.|..|  .                 |. .|.|....  ..                  ...|.||. |...    |||||.     .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

QE-------KEAFLVMQFIEGPSLHTVIF-----PDRDD------VKIPLDWAKKLQISREVLQA-VTFMHACNILHLDIKPANILVDSATIRPYICDLG
.|        | ...| ...| ||  .|      .....       ..| .. ..  | |..|..   . |  .| | ||||||||.        .|| |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAY--ICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFG

LAHIKNRN--------------LMSQSAVNIRGTPCFMPPEALGATEPGYR---HSNKHDIWSVAGTL-------VEL---YSNKRLWGDSMNP-----L
.. . . .               |.|    . ||| .| || .   . | |   .. | ||||.  |.       ...   .  . ..   .|      .
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQF

ALMARILTGQMSK-PESLTAVD----------------PKVQKILEPCFRQKPEKRPSASDLLN---QFN
 ..  |. |.  . |. |  ..                |. .  .. |..  |.|||.||.||.    | 
EQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase TKL1.AA TKL-Unique 161-419 21 8.4e-31 105.93 In-house 1-290 (290) Show / Hide 
Range on Protein: 161-419
Range on HMM: 1-290/290
Sequence Identity: 21% (62 aa)

MGPVVGKGQFGVVHRASWRGTPVAVKKISI-MGSRKDEIE---KEVAIHRRAC-HPNIVQMMALGY----QEKEAFLVMQFIEGPSLHTVIF-----PDR
 . ..| | .|.| .. |||.|||.|....  .|......   .|| .  .   |||||. |.       .... ..|| ...| ||. |.         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

DDVKIPLDWAKKLQISREVLQAVTFMHACN--ILHLDIKPANILVDSA-TIRPY---ICDLGLAHIKNRNLMSQSA--------VNIRGTPCFMPPEALG
   ...|........ . . |.  . | |.  |.|.|.|. |.|||.. .| ..   ||| ||. ...... . .         ... |..  |.|| | 
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRC-GSFRWMAPEVLR

ATEPGYRHSNKHDIWSVAGTLVELYSNKR-----LWGDSMNPLALMARILTGQMSKPESL-TAVDPKVQKILEPCFRQKPEKRPSASDLLNQF
  .  .  |.| |..| .  | |....|.        ..|.. .. . . .   .... . .   .  ..... |... |..||| .. ..  
MNF--CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase TKL1.AA CAMK 164-329 16 4e-29 90.43 In-house 1-290 (425) Show / Hide 
Range on Protein: 164-329
Range on HMM: 1-290/425
Sequence Identity: 16% (49 aa)

VVGKGQFGVVHRASWRGTP--------------VAVKKISI-----------------------------MGSRKDEIEKEVAIHRRAC-------HPNI
. |.|.||.|...  . |.              ||.| |.                               .. ......|..|...         ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQMMA---------------LGYQ-----EKEAFLVM---QFIEGP----SLHTVI---------FPDRDDVKIPLDWA-------KKL------QISRE
...                    .     .|. ..||    ...|      |   |         |            .       ...      .. | 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF------------DQFDIVERGRFTEREARRYFRQ

VLQAVTFMHACNILHLDIKPANILVDSAT----------------IRPYICDLGLA--HIKNRNLM-------------------SQSAVNIRGTPCFMP
...|| ..| .|| |.|.|| |||.|.                      |.| |.|   ... |..                    |      |||..|.
ICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMA

-PE
 ||
APE
Kinase TKL1.AA MOS 159-293 29 2.1e-27 87.74 In-house 1-151 (299) Show / Hide 
Range on Protein: 159-293
Range on HMM: 1-151/299
Sequence Identity: 29% (47 aa)

LDMGPVVGKGQFGVVHRASWRGTPVAVKKIS----IMGSRKDEIEKEVAIHRRACHPNIVQMMALG---YQEKE--AFLVMQFIEGPSLHTVIF-----P
  .  . |.| || |  | ..|.||||| .     .    .     || . .|. |.|||. ||..       .  .. .| .  . .|| ||      |
VCLCQMIGRGGFGSVWKAQYCGRPVAVKQVNKCTKNLKAMRRSFWAEVNY-LRLRHDNIVRVMAVSQRSPEDFNNLGTIIMECGGNQTLHQVIYEPTRHP

D--------RDDVKIPLDWAKKLQISREVLQAVTFMHACNILHLDIKPANILVDSAT
         |      |  .. . .|. |. |... |..||||||.|||||.||  |
PGDAGIIHCR-----MLILMHCCKYSLDVVNALQYCHHQNILHLDVKPANIIVDEGT
Kinase TKL1.AA MLK 159-331 24 3e-27 91.63 In-house 1-205 (291) Show / Hide 
Range on Protein: 159-331
Range on HMM: 1-205/291
Sequence Identity: 24% (51 aa)

LDMGPVVGKGQFGVVHRASWRGTP-----VAVKKIS-------IMGSRKDEIEKEVAIHRRACHPN----IVQMMALGYQE-KEAFLVMQFIEGPSLHTV
..   ..|.| ||.|... ||..      ||||..        .... ....|.|. . |. .|||    |.| ..   |. .. ..||...|| ||..|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

I-----------FPDRDDVKIPLDWAKKLQISREVLQAVTFMHACN---ILHLDIKPANILVDS-----ATIRPYICDLGLAH-IKNR--NLMSQSAVNI
.            ... |. ...| |  ....  . ... . |.     | | |.|. |||.|      .     ||| |... ....  | ||.     
LHGARSKWMDANHNQKNDRVYDHDHA--MNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSN-----

RGTPCFMPPEAL
.||. .| ||..
AGTYAWMAPEVI
Kinase TKL1.AA Ciliate-E2 159-417 17 1.9e-25 84.29 In-house 1-361 (365) Show / Hide 
Range on Protein: 159-417
Range on HMM: 1-361/365
Sequence Identity: 17% (65 aa)

LDMGPVVGKGQFGVVHRASWRGTP--------------------VAVKK---ISIMGSRKDEIEKEVAIHRRAC----------------HPNIVQMMAL
 .   . |.|.||.| ... . ..                    |..|.    ... . . .|..|  | |.                  ||||..|   
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

GY--QEKEAFLVMQFIEGPSLHT--VIFPDRDDVKIP----LDWAKKLQISREVLQ---------------AVTFMHACN-ILHLDIKPANILVDSATIR
 .  ...  .||| ...| .|     ...   . .|.    ... . ..|....||               |. ..|  | |.| |||| |||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PYICDLGLAHIKN-----------RNLMSQSAVN-------------------IRGTPCFMPPEALGATEP-----GYRHSNKHDIWSVAGTLVELYSNK
. |.|.||. . .           .... .  ..                   | ||| .|.|| |.  .      . ... | ||||.  .| |. ..|
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

RLWGDSMNPLALMARILTGQMSKPESLTA---------------VDPKVQKILEP----CFRQKPEKRPS-ASDLLN
. .         .  |. .. . |.                   ...... ..      ..  .||||.. ....||
PPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILN
Kinase TKL1.AA TK 159-419 13 2.7e-25 81.12 In-house 1-486 (486) Show / Hide 
Range on Protein: 159-419
Range on HMM: 1-486/486
Sequence Identity: 13% (67 aa)

LDMGPVVGKGQFG---VVHRASWRG---------------------------TPVAVKKIS--IMGSRKDEIE----------------KEVAIHR--RA
. .| . |.||||   .|... |||                           |||||| .      | .....                 | .. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

CHPNIVQMMALGYQE------------KEAFLVMQFIEGPS----LHTVIFPDRDDVKI-----------------------------------------
 |||||.. .   |.            .   .|| . .. .    |..     |.. .                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------PLDWAKKLQISREVLQAVTFMHAC------NILHLDIKPANILVDSATIR----------PYICDLGLAH
                              .|. . .| ... . ..  ..|..      |. | |.   |.||..  ..            |.| ||. 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

IKN----RNLM---SQSAVNIRGTPC-------------------------FMPPEALGATEPGYR-----HSNKHDIWSVAGTLVELYS-NKRLWGDSM
 .     | .       ... .||..                          |.||.|   ..        .. | |.||   .. |...  .  ..  |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

NP---------LALMARILTGQ-------------MSKPESLTAVD-------------PKVQKILEPCFRQKPEKRPSASDLLNQF
.            .| .. .|.             | .|    . |             . .. ..  |.. .||.||. |.|..|.
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase TKL1.AA LISK-DD1 164-329 30 3.9e-24 84.29 In-house 1-201 (290) Show / Hide 
Range on Protein: 164-329
Range on HMM: 1-201/290
Sequence Identity: 30% (61 aa)

VVGKGQFGVVHRASWRGTPVAVKKISI--MGSRKDEIEK----EVAIHRR---ACHPNIVQMMALGYQ-------------EKEAFLVMQFIEGPSLHTV
  ||| || | .... |||||.|||..    . ... .|    |... .      ||||||    ..              | . ..|  ||||  ||  
EIGKGSFGKVYKGCYFGTPVAIKKIHKQPNDPNDPDYWKFMQREIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWY

IFP-DRDDV-------KIPLDWAKKLQISREVLQAVTFMHACNILHLDIKPANILVDSA---TIRPYICDLGLAHIKNRNLMSQSA--VNIRGTPCFMPP
..    ||        |||. | ... |.. . .|  . |. ||.| | |  |||||      .|  .||.|.| . .    .|      | ||. .|.|
LKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQNNRHMTICGTDNWMAP

E
|
E
Kinase TKL1.AA TyrKc 159-419 19 3.2e-15 23.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 159-419
Range on HMM: 1-280/280
Sequence Identity: 19% (58 aa)

LDMGPVVGKGQFGVVHRASWRGTPVAVKKISIMGSRKDEIEKEVAIHRRA--CHPNIVQMMALGYQE-------KEAFLVMQFIEGPSLHTVIFPDRDDV
. .| . | |.||.|... |. ..||||..      . .. .|  | ..    |||||.. .   |.       .  ..|| . .. .|.  .   |.. 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

KIPLDWAKKLQISREVLQAVTFMHACNILHLDIKPANILVDSATIRPYICDLGLAHIKNRN--------LMS-----QSA--VNIRGTPCFMPPEALGAT
   | ....|...  . .   . |  |. | |.   |.||..   .  |.| ||.                .     ..   . ||     |.||..   
---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR----WMAPECI---

EPGYRHSNKHDIWSVAGTLVELYSN-KRLWGDS----MNPLALMARILTG-QMSKPES-LTA-----VDPKVQKILEPCFRQKPEKRPSASDLLNQF
   .. . | |.||   .. |.... .  . .     |..  ..... .|  | .|.. .         ... .| . | . .||.||. |..  .|
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase TKL1.AA Pkinase_Tyr 159-240 25 6e-13 44.48 Pfam 1-96 (270) Show / Hide 
Range on Protein: 159-240
Range on HMM: 1-96/270
Sequence Identity: 25% (24 aa)

LDMGPVVGKGQFGVVHRASWR------GTPVAVKKI--SIMGSR--KDEIEKEVAIHRRA-CHPNIVQMMALGY-QEKE--AFLVMQFIEGPSLHT
. .| . |.|.||.|... |.      ..|||||..  . | .   ...  .|..| .    |||||....  . |..    ..|| . .. .|..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD
Kinase TKL1.AA MLK 396-419 33 0.006977 5.99 In-house 268-291 (291) Show / Hide 
Range on Protein: 396-419
Range on HMM: 268-291/291
Sequence Identity: 33% (8 aa)

KILEPCFRQKPEKRPSASDLLNQF
| .. |  |.|.|||| .  . ..
KLMKQCWNQDPHKRPSFRQIVQHL
Kinase TKL1.AA MOS 395-421 29 0.040986 2.56 In-house 273-299 (299) Show / Hide 
Range on Protein: 395-421
Range on HMM: 273-299/299
Sequence Identity: 29% (8 aa)

QKILEPCFRQKPEKRPSASDLLNQFND
...   | ...|| ||||  |.     
RQLIQKCWPKQPEQRPSARQLKHELEM
Kinase TKL1.AA Pkinase_Tyr 401-419 36 0.064745 7.11 Pfam 252-270 (270) Show / Hide 
Range on Protein: 401-419
Range on HMM: 252-270/270
Sequence Identity: 36% (7 aa)

CFRQKPEKRPSASDLLNQF
| ...||.||. |....|.
CWHYDPEDRPTFSEIHEQL