Gene TKL4 (Sea Urchin)
TKL4
Sequence
Protein domains of TKL4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | TKL4.AA | TKL-Sp1 | 157-417 | 86 | 5.4e-245 | 774.93 | In-house | 1-263 (263) | Show / Hide |
Range on Protein: 157-417 Range on HMM: 1-263/263 Sequence Identity: 86% (227 aa) LDMGPVVGKGQFGVVHRASWRGTPVAVKKISMMGSRKDEIEKEVAIHRRACHPNIVQMMALGYQGNEAFLVMQFIEGPSLHTIIFPDRDDVKIPLDWAKK |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||.||||||||||||||||| LDMGPVVGKGQFGVVHRASWRGTPVAVKKISMMGSRKDEIEKEVAIHRRACHPNIVQMMALGYQGKEAFLVMQFIEGPSLHTVIFPDRDDVKIPLDWAKK LQISREVLQAVTFMHACNILHLDIKPANILVESATLRPYLCDLGLAHIKSRNLMSQSS--VNMRGTPCFMPPEALGATEPGYRHSNKHDIWSVAGTLVEL .|||.|||||||||||||||||||||||..||.||.|||.|||||||||.||.||||. ||||||||.||||.....|||.||.|||||||||.|.||| MQISCEVLQAVTFMHACNILHLDIKPANVMVERATRRPYICDLGLAHIKNRNHMSQSTSMVNMRGTPCHMPPEMVQKQEPGWRHPNKHDIWSVACTFVEL YSMKRLWGDSMNPLALMARIFTGQMGNPESLTAVDPKVQKILEPCFKQKPEKRPPASDLLDQF |||||||||||...|||.||.||||..||.||.|||||||||||||.|||||||.|.|||||| YSMKRLWGDSMEFMALMRRILTGQMSKPEILTKVDPKVQKILEPCFDQKPEKRPSAEDLLDQF |
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| Kinase | TKL4.AA | TKL | 163-417 | 19 | 1e-63 | 217.98 | In-house | 1-364 (364) | Show / Hide |
Range on Protein: 163-417
Range on HMM: 1-364/364
Sequence Identity: 19% (73 aa)
VGKGQFGVVHRASWRG----------TPVAVKKISMMGSRK----------------------------DEIEKEVAIHRRACHPNIVQMMALGYQGNE-
.|.| ||.|... ||| ..|||||.... . . ...|.|. ...| .||||||.|. ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------AFLVMQFIEGPS-LHTIIFPDRDDVKIPLDWAKKLQISREVLQAVTFMHACN--------ILHLDIKPANILVES-------------
..||....| | ||... | ......... ... ..|..| |.| |.|..|||| .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPN
ATLRPYLCDLGLAHIKSR---NLMSQSSVN--------------MRGTPCFMPPEALGATEP------------GYRHSNKHDIWSVAGTLVELYSMKRL
|. .. .||.||. .|. . ....... .|||..|.||.| ... |. | |.|..| . | |... .|
ADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP
WGDSMNPLAL---------MARIFTGQMGNPE----------SLTAVDPKVQKILEPCFKQKPEKRPPASDLLDQF
. | ... . | .. |. . . ..| . |... | ...||||| ....|...
YYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | TKL4.AA | S_TKc | 157-421 | 22 | 3.7e-45 | 157.27 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 157-421 Range on HMM: 1-231/231 Sequence Identity: 22% (63 aa) LDMGPVVGKGQFGVVHRASWRG--TPVAVKKISMMGSRKDEIEKEVAIHRRACHPNIVQMMALGYQGNEAFLVMQFIEG--PSLHTIIFPDRD---DVKI ... ..||| ||.|... ... ||.|.|. . |..|..|... |||||.. . .. ..|| ...| .|...| . .... YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF PLDWAKKLQISREVLQAVTFMHACNILHLDIKPANILVESATLRPYLCDLGLAHIKSRNLMSQSSVNMRGTPCFMPPEALGATEPGYRHSN-KHDIWSVA | .|.. . .....|. ..| .|.| |.||.|||. . . .|| ||| . . ||| .|.|| | .. | |.||. PE-HARF--YMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL---------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCG GTLVELYSMKRLWGDSMNPLALMARIFTGQMGNPESLTAVDPKVQKILEPCFKQKPEKRPPASDLLDQF-----NDLI .| |... . .. .. ... .| .| . ... |.. ||||| | ..| . CILYEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | TKL4.AA | Pkinase | 157-417 | 21 | 6.6e-40 | 142.19 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 157-417 Range on HMM: 1-293/293 Sequence Identity: 21% (65 aa) LDMGPVVGKGQFGVVHRASWRGTP--VAVKKISMMGSRKDEIEK-----EVAIHRRACHPNIVQMMALGYQGNEAFLVMQFIEGP----SLHTIIFPDRD . | ..|.| ||.| .. ..||. ||||.|. . .... . |..|..| .|||||.. . ... .|| . || .|...| YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST--- DVKIPL--DWAKKLQISREVLQAVTFMHACNILHLDIKPANILVESATLRP----YLCDLGLAHIKSRNLMSQSSVNMRGTPCFMPPEALGATEPGYRHS . . .. .. . ...|... ..|...|.| |.||.|||. . . .|| ||| .. . .. ||| .|.|| . | .. WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIR---GGQYYG NKHDIWSVAGTLVELYSMKRLWGDS-----MNPLALMARIFTGQMGNPESLT------------------AVDPKVQKILEPCFKQKPEKRPPASDLLDQ | |.||. .| |... . .. .. ........|| .. ... . .... ..... |....|.||| | ..| PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH --F | PWF |
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| Kinase | TKL4.AA | STE | 157-418 | 21 | 5.3e-35 | 121.08 | In-house | 1-359 (359) | Show / Hide |
Range on Protein: 157-418
Range on HMM: 1-359/359
Sequence Identity: 21% (80 aa)
LDMGPVVGKGQFGVVHRASWR-----------------GTPVAVKKISMMGSR------------------KDEIEKEVAIHRRAC--HPNIVQMMALGY
.. ..||| ||.|..| . |. .|.|.... .. ...|.||. |... |||||. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF
QG-------NEAFLVMQFIEGPSLHTIIF-----PDRDD------VKIPLDWAKKLQISREVLQA-VTFMHACNILHLDIKPANILVESATLRPYLCDLG
.. .| ...| ...| || || ..... ..| .. .. | |..|.. . | .| | ||||||||. ||| |
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAY--ICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFG
LAHIKSRN--------------LMSQSSVNMRGTPCFMPPEALGATEPGYR---HSNKHDIWSVAGTLVELYSMKRLW--GDSMNPLALMARIFTGQM--
.. . . . |.| . . ||| .| || . . | | .. | ||||. |..|. | | . | . .... . |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-RDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQF
-------GNPESLT-AVD-------------------PKVQKILEPCFKQKPEKRPPASDLLD---QFN
|.| .| .. |. . .. |.. |.||| ||.|| |
EQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
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| Kinase | TKL4.AA | MOS | 157-287 | 29 | 1.4e-26 | 84.92 | In-house | 1-147 (299) | Show / Hide |
Range on Protein: 157-287 Range on HMM: 1-147/299 Sequence Identity: 29% (45 aa) LDMGPVVGKGQFGVVHRASWRGTPVAVKKIS-----MMGSRKDEIEKEVAIHRRACHPNIVQMMALG---YQGNE--AFLVMQFIEGPSLHTIIF----- . . |.| || | | ..|.||||| . .|. || . .|. |.|||. ||.. . . .. .| . . .|| .| VCLCQMIGRGGFGSVWKAQYCGRPVAVKQVNKCTKNLKAMRR-SFWAEVNY-LRLRHDNIVRVMAVSQRSPEDFNNLGTIIMECGGNQTLHQVIYEPTRH PD--------RDDVKIPLDWAKKLQISREVLQAVTFMHACNILHLDIKPANILV | | | .. . .|. |. |... |..||||||.|||||.| PPGDAGIIHCR-----MLILMHCCKYSLDVVNALQYCHHQNILHLDVKPANIIV |
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| Kinase | TKL4.AA | TKL-Unique | 159-346 | 23 | 1.3e-25 | 87.43 | In-house | 1-213 (290) | Show / Hide |
Range on Protein: 159-346 Range on HMM: 1-213/290 Sequence Identity: 23% (51 aa) MGPVVGKGQFGVVHRASWRGTPVAVKKISM-MGSRKDEIE---KEVAIHRRAC-HPNIVQMMALGY----QGNEAFLVMQFIEGPSLHTIIF-----PDR . ..| | .|.| .. |||.|||.|... .|...... .|| . . |||||. |. . .. ..|| ...| ||. . FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN DDVKIPLDWAKKLQISREVLQAVTFMHACN--ILHLDIKPANILVESAT----LRPYLCDLGLAHIKSRNLMSQSSVNMR---------GTPCFMPPEAL ...|........ . . |. . | |. |.|.|.|. |.|| .. .. .|| ||. ..|. ......|. |.. |.|| | NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSK--INKMTNNEHKGTRNQTRCGSFRWMAPEVL GATEPGYRHSNKHDIWS . . |.| |..| RMNF--CQYSEKSDVYS |
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| Kinase | TKL4.AA | MLK | 157-329 | 22 | 4e-25 | 84.17 | In-house | 1-205 (291) | Show / Hide |
Range on Protein: 157-329 Range on HMM: 1-205/291 Sequence Identity: 22% (47 aa) LDMGPVVGKGQFGVVHRASWRGTP-----VAVKKIS-------MMGSRKDEIEKEVAIHRRACHPN----IVQMMALGYQ-GNEAFLVMQFIEGPSLHTI .. ..|.| ||.|... ||.. ||||.. ... ....|.|. . |. .||| |.| .. | ... ..||...|| ||... IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV I-----------FPDRDDVKIPLDWAKKLQISREVLQAVTFMHACN---ILHLDIKPANILVES-----ATLRPYLCDLGLAHIKSRN---LMSQSSVNM . ... |. ...| | .... . ... . |. | | |.|. |||. . . || |... .... || . LHGARSKWMDANHNQKNDRVYDHDHA--MNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMS-----N RGTPCFMPPEAL .||. .| ||.. AGTYAWMAPEVI |
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| Kinase | TKL4.AA | TAK1 | 157-328 | 27 | 3.5e-23 | 75.09 | In-house | 1-174 (284) | Show / Hide |
Range on Protein: 157-328 Range on HMM: 1-174/284 Sequence Identity: 27% (50 aa) LDMGPVVGKGQFGVVHRASWRGTPVAVKKISMM-----GSRKDEIEKEVAIHRRACHPNIVQMMAL-GYQGNEAFLVMQFIEGPSLHTIIFPDRDDVKIP . .|||| .||| .|.||.. .|||.. . .. . .||.|. |. ||||.. . .. . ||| .... ||| .. .. IQNEHFVGKGTYGVVCKAKWRNKEIAVKRFEFIKYSSEECEQKNIEREIMQWSRVDHPNIIKLYGMYACHRQCQCLVMEYMDCGSLHNFLHGAKPKWEYT LDWAKK--LQISREVLQAVTFMHACN---ILHLDIKPANILVESATLRPYLCDLGLAHIKSRNLMSQSSVNMRGTPCFMPPEA .. | .|.. |.| ..|. . | ||||.| | . . .|| |.. |.|. ..|||. .| ||. HAHAMSWMHQCA----QGVAYLHSMQPKPQIHRDIKPQNMLLCNKHRTLKICDFGTFCD-----MHQMMTCNRGTCRWMAPEV |
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| Kinase | TKL4.AA | Ciliate-E2 | 157-347 | 19 | 2.9e-22 | 73.2 | In-house | 1-282 (365) | Show / Hide |
Range on Protein: 157-347 Range on HMM: 1-282/365 Sequence Identity: 19% (55 aa) LDMGPVVGKGQFGVVHRASWRGTP--------------------VAVKKISMMGSRKDE---IEKEVAIHRRAC----------------HPNIVQMMAL . . |.|.||.| ... . .. |..|.. | .|.. |..| | |. ||||..| YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC GY--QGNEAFLVMQFIEGPSLHT--IIFPDRDDVKIP----LDWAKKLQISREVLQ---------------AVTFMHACN-ILHLDIKPANILVESATLR . . | .||| ...| .| .... . .|. ... . ..|....|| |. ..| | |.| |||| |||. FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------ PYLCDLGLAHIKS-----------RNLMSQSSVNM-------------------RGTPCFMPPEALGATEP-----GYRHSNKHDIWSV . ..|.||. . . .... . .... ||| .|.|| |. . . ... | ||||. IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL |
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| Kinase | TKL4.AA | LISK-DD1 | 162-327 | 28 | 2.8e-21 | 73.84 | In-house | 1-201 (290) | Show / Hide |
Range on Protein: 162-327 Range on HMM: 1-201/290 Sequence Identity: 28% (57 aa) VVGKGQFGVVHRASWRGTPVAVKKISM--MGSRKDEIEK----EVAIHRR---ACHPNIVQMMALGYQ-------------GNEAFLVMQFIEGPSLHTI ||| || | .... |||||.|||. . ... .| |... . |||||| .. . . ..| |||| || . EIGKGSFGKVYKGCYFGTPVAIKKIHKQPNDPNDPDYWKFMQREIKMLKNLLNIRHPNIVQFIGICEHPLASPSLVNRLLNESSLYIVTEFIEGGDLHWY IFP-DRDDV-------KIPLDWAKKLQISREVLQAVTFMHACNILHLDIKPANILVESA---TLRPYLCDLGLAHIKSRN--LMSQSSVNMRGTPCFMPP .. || |||. | ... |.. . .| . |. ||.| | | |||| | .||.|.| . . .. . ||. .|.| LKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFARMFEQKKNQQNNRHMTICGTDNWMAP E | E |
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| Kinase | TKL4.AA | CAMK | 261-327 | 22 | 1.3e-14 | 42.76 | In-house | 186-290 (425) | Show / Hide |
Range on Protein: 261-327 Range on HMM: 186-290/425 Sequence Identity: 22% (24 aa) REVLQAVTFMHACNILHLDIKPANILVESAT----------------LRPYLCDLGLA--HIKSRNLM-------------------SQSSVNMRGTPCF | ...|| ..| .|| |.|.|| |||. . ..| |.| ... |.. | . |||.. RQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEY MP-PE |. || MAAPE |
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| Kinase | TKL4.AA | CAMK | 162-214 | 15 | 2.1e-14 | 42.13 | In-house | 1-103 (425) | Show / Hide |
Range on Protein: 162-214 Range on HMM: 1-103/425 Sequence Identity: 15% (16 aa) VVGKGQFGVVHRASWRGTP--------------VAVKKISM-----------------------------MGSRKDEIEKEVAIHRRAC-------HPNI . |.|.||.|... . |. ||.| |. .. ......|..|... |||| TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VQM ... IKL |
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| Kinase | TKL4.AA | TyrKc | 157-417 | 18 | 4.5e-14 | 4.8 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 157-417 Range on HMM: 1-280/280 Sequence Identity: 18% (54 aa) LDMGPVVGKGQFGVVHRASWRGTPVAVKKISMMGSRKDEIEKEVAIHRRA--CHPNIVQMMALGYQG-------NEAFLVMQFIEGPSLHTIIFPDRDDV . .| . | |.||.|... |. ..||||.. . .. .| | .. |||||.. . |. ..|| . .. .|. . |.. ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK- KIPLDWAKKLQISREVLQAVTFMHACNILHLDIKPANILVESATLRPYLCDLGLAHIKSRN--------LMSQSS-VNMRG-TPCF-MPPEALGATEPGY | ....|... . . . | |. | |. |.|| . . .| ||. .... . .. | |.||.. . ---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYG RHSNKHDIWSVAGTLVELYSM-KRLWGDS----MNPLALMARIFTGQMGNPESLTA------VDPKVQKILEPCFKQKPEKRPPASDLLDQF . . | |.|| .. |... . . . |.. ..... .| . . ... .| . | . .||.|| |.. ..| KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | TKL4.AA | Pkinase_Tyr | 157-238 | 26 | 4.1e-13 | 45.04 | Pfam | 1-96 (270) | Show / Hide |
Range on Protein: 157-238 Range on HMM: 1-96/270 Sequence Identity: 26% (25 aa) LDMGPVVGKGQFGVVHRASWR------GTPVAVKKI--SMMGSR--KDEIEKEVAIHRRA-CHPNIVQMMALGY-QGNE--AFLVMQFIEGPSLHT . .| . |.|.||.|... |. ..|||||.. . | . ... .|..| . |||||.... . || ..|| . .. .|.. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD |
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| Kinase | TKL4.AA | MLK | 394-417 | 29 | 0.023286 | 4.15 | In-house | 268-291 (291) | Show / Hide |
Range on Protein: 394-417 Range on HMM: 268-291/291 Sequence Identity: 29% (7 aa) KILEPCFKQKPEKRPPASDLLDQF | .. | .|.|.||| . . .. KLMKQCWNQDPHKRPSFRQIVQHL |
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| Kinase | TKL4.AA | Pkinase_Tyr | 399-417 | 36 | 0.371565 | 4.54 | Pfam | 252-270 (270) | Show / Hide |
Range on Protein: 399-417 Range on HMM: 252-270/270 Sequence Identity: 36% (7 aa) CFKQKPEKRPPASDLLDQF | ...||.|| |... |. CWHYDPEDRPTFSEIHEQL |
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