Gene MLKL (Sea Urchin)
MLKL
Group:
TKL
Family:
TKL-Unique
Sequence
Protein domains of MLKL.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | MLKL.AA | TKL-Unique | 257-473 | 32 | 8.4e-100 | 337.86 | In-house | 1-240 (290) | Show / Hide |
Range on Protein: 257-473 Range on HMM: 1-240/290 Sequence Identity: 32% (79 aa) DLETLQQGTYGPIIKTKHRFEDKLLVRKAF-EDKELSSTRELKEQLNLWKNLQYSAFIVQLYGYTMD---YESRMCFVVEYMSHGTLRSVLQD------- .......|.||...|.|.|.... ...... ||.......|.....|..|.|.|...||...||.|| |...||.|.||...|.|..||.. FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN -KENHPLPWEQRVTLARDCAQGLYTIHFCQKKTMLHRAITSTRFLVDER-----YRAKISDNGFVKSASKISKSKSTMLSGGRGSVEQDEINYLCPEETS ..|..|...|||..|.|.|||.|..|.|... ..||...|..||||.. ...||.|.|..|..|||.|.......|.|............||... NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR MS-FKRSIKSEVYKFGVILYEIASRMQ------PFQAMEQQ |. ...|.||.||.||..|.|||.|.. |.|.|.|. MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQE |
|||||||||
| Kinase | MLKL.AA | TKL | 261-468 | 20 | 6.2e-46 | 158.91 | In-house | 1-290 (364) | Show / Hide |
Range on Protein: 261-468
Range on HMM: 1-290/364
Sequence Identity: 20% (62 aa)
LQQGTYGPIIKTKHRFED--------KLLVRKAFE--------------------------DKELSSTRELKEQLNLWKNLQYSAFIVQLYGYTMDYESR
. .|..| . | |.| .. | . | | |.|.| |. .|. . .. |||..|| .. ...
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG
------------MCFVVEYMSHGTLRSVLQDKENHPLPWEQRVTLARDCAQGLYTIHFCQ-----KKTMLHRAITSTRFLVDERYR--------------
.|.| ||...|.|...|. |.||. .|.|.|.|.. | .. |. ..|| ..| |||| ..
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC
AKISDNGFVKSASKISKSKSTMLSGG----------RGSVEQDEINYLCPEETSMS---------------FKRSIKSEVYKFGVILYEIASRMQPFQ
.||.| |. .. |. .... || ... . . . .... || .. |. | |. || ||..|.||..| .|..
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY
|
|||||||||
| Kinase | MLKL.AA | TESK | 330-393 | 39 | 1.1e-11 | 32.66 | In-house | 71-130 (292) | Show / Hide |
Range on Protein: 330-393 Range on HMM: 71-130/292 Sequence Identity: 39% (25 aa) VVEYMSHGTLRSVLQDKENHPLPWEQRVTLARDCAQGLYTIHFCQKKTMLHRAITSTRFLVDER ..||.. |.| .| |.| | |.| |.. || | |.|. .|. | || || || .| LTEYINGGCLEQLLADSELH-LSWTQKIHLAYDIARGMSYLHS---KGVFHRDLTSKNCLVRQR |
|||||||||
| Kinase | MLKL.AA | MLK | 255-400 | 20 | 3.2e-11 | 35.31 | In-house | 1-176 (291) | Show / Hide |
Range on Protein: 255-400 Range on HMM: 1-176/291 Sequence Identity: 20% (36 aa) FTDLETLQQGTYGPIIKTKHRFED----KLLVRKAF--------EDKELSSTRELKEQLNLWKNLQYSAFIVQLYGYTMDYESRMCFVVEYMSHGTLRSV .. .| .. |..| |.. | .| . |.... .. | .. ..|. . . . |.|.|| .... | | ||...| | .| IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV LQDKENHPL------------PWEQRVTLARDCAQGLYTIHFCQKKTMLHRAITSTRFLVDE------RYRAKISD | ...... . .. .. | .||.|. | ..|. || . | |.|| .||.| LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICD |
|||||||||
| Kinase | MLKL.AA | Dicty5 | 330-402 | 31 | 1.4e-10 | 32.6 | In-house | 77-149 (260) | Show / Hide |
Range on Protein: 330-402 Range on HMM: 77-149/260 Sequence Identity: 31% (24 aa) VVEYMSHGTLRSVLQDKEN---HPLPWEQRVTLARDCAQGLYTIHFCQKKTMLHRAITSTRFLVDERYRAKISDNG | || . |.|.. | |... |. . |.. .| | ||.. .| . || . | ||. |.. .|| | | VTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHS---MNIIHRDLKSMNFLITENWKIKIIDFG |
|||||||||
| Kinase | MLKL.AA | S_TKc | 255-535 | 16 | 4.9e-10 | -29.76 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 255-535 Range on HMM: 1-231/231 Sequence Identity: 16% (50 aa) FTDLETLQQGTYGPIIKTKHRFEDKLLVRKAFEDKELSSTRELKEQLNLWKNLQYSAFIVQLYGYTMDYESRMCFVVEYMSH--GTLRSVLQDKENHPLP .. |... .|..| | .|. ... | . .. ... |. .||.||.. | .....| ||... |.|....... |.|. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR -WEQRVTLARDCAQGLYTIHFCQKKTMLHRAITSTRFLVDERYRAKISDNGFVKSASKISKSKSTMLSGGRGSVEQDEI---NYLCPEETSMSFKRSI-K . . .. ..| . . .| .. .|| . |.|| . ||.| |. . . .|. || . . | FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------------TTFCGTPWYMAPEVL----GYGKCK SEVYKFGVILYEIASRMQPFQAMEQQGKVVRNMSAGDILSCIVKVIKISKQIHDAVRDVQSFKEK---SKTLARNIELLVEPLEVLE-------KRCT . .. .|.|||| ... ||. . . |.|. | | .| | .. | |.|. CDWWSCGCILYEMLCGYPPFP----------------QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
|||||||||
| Kinase | MLKL.AA | LISK | 332-448 | 28 | 7e-10 | 28.08 | In-house | 77-187 (296) | Show / Hide |
Range on Protein: 332-448 Range on HMM: 77-187/296 Sequence Identity: 28% (35 aa) EYMSHGTLRSVLQDKE--NHPLPWEQRVTLARDCAQGLYTIHFCQKKTMLHRAITSTRFLVDER----YRAKISDNGFVKSASKISKSKSTMLSGGRGSV ||.. |.|. | |.. ||||.||| .|.| |.|. |. . .|| .|. ||.|. .|.|. | || . ... ..| | ... .. EYINGGDLHQYLKDMDKHKIPLPWPQRVKIALDIACGMSYLHS---MNIIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPREDESD- EQDEINYLCPEETSMSFKRSIKS . . .|. ||.|.. PC--------MDNDMPMKRKIPK |
|||||||||
| Kinase | MLKL.AA | DRK | 328-402 | 34 | 7.3e-10 | 29.62 | In-house | 73-145 (258) | Show / Hide |
Range on Protein: 328-402 Range on HMM: 73-145/258 Sequence Identity: 34% (26 aa) CFVVEYMSHGTLRSVLQDKENHPLPWEQRVTLARDCAQGLYTIHFCQKKTMLHRAITSTRFLVDERYRAKISDNG | . |||. | | ..| | | . | . .. ||| |. | | .|| | |||| .. |..| | CICMEYMPRGSLYNILHD-ESIEMDWPLMKQMMFDCAKGMIYLH-CCNPIIIHRDLKSHNLLVDEHWQVKVADFG |
|||||||||
| Kinase | MLKL.AA | TKL-ciliate1 | 329-407 | 26 | 4.3e-09 | 27.26 | In-house | 76-155 (279) | Show / Hide |
Range on Protein: 329-407 Range on HMM: 76-155/279 Sequence Identity: 26% (22 aa) FVVEYMSHGTLRSVLQDKEN--HPLPWEQRVTLARDCAQGLYTIHFCQKK-TMLHRAITSTRFLVDERYRAKISDNGFVKSA ...|. ||. . . | ...| .|. .| |||. .| ... . || ... | || |. || . . || | IIMEHCHKGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLH--MRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIA |
|||||||||
| Kinase | MLKL.AA | TyrKc | 255-516 | 20 | 6.2e-09 | -78.2 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 255-516 Range on HMM: 1-280/280 Sequence Identity: 20% (60 aa) FTDLETLQQGTYGPIIKTKHRFED---KLLVRKAFEDKELSSTRELKEQLNLWKNL-QYSAFIVQLYGYTMDYE------SRMCFVVEYMSHGTLRSVLQ | ...| | .| . | . . .. | | | ... . ... ..| ||.|||. .. . .. |.|||.|| |.. |. ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR DKENHPLPWEQRVTLARDCAQGLYTIHFCQKKTMLHRAITSTRFLVDERYRAKISDNGFVKSASKI------SKSKSTML-SGGR--GSVEQDEINYLCP ..... |.... . . . |.| .| || . ||.|....|||| | . .. .... .||. . .. KHRPK-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI------RWMA EETSMSFKRSIKSEVYKFGVILYEIASR-MQPFQA-----MEQQGKVVRNMSAGDILSCIVK------------VIKISKQIHDA-VRDVQSFKEKSKTL |. . | ..|| |. ||| ..|| .. .|| |. | |... .|. . . . .| || .. | .|.| . . PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQ-EVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
|||||||||
| Kinase | MLKL.AA | Dicty4 | 313-403 | 29 | 1.7e-08 | 24.67 | In-house | 60-160 (277) | Show / Hide |
Range on Protein: 313-403 Range on HMM: 60-160/277 Sequence Identity: 29% (31 aa) IVQLYGYTM---DYESRMCFVVEYMSHGTLRSVLQD-----KENHPLPWEQRVT---LARDCAQGLYTIHFCQKKT--MLHRAITSTRFLVDERYRAKIS |....|. ..|| | |||. |.| |.| | ... .|.|. . .|.|.|.|. | | . .|| . | |||. .|.|.. ICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCC---NPVIIHRDLKSHNLLVDKNWRVKVC DNGF | |. DFGL |
|||||||||
| Kinase | MLKL.AA | LRRK | 313-371 | 27 | 7.7e-08 | 23.81 | In-house | 119-181 (351) | Show / Hide |
Range on Protein: 313-371 Range on HMM: 119-181/351 Sequence Identity: 27% (18 aa) IVQLYGYTMDYESRMCFVVEYMSHGTLRSVLQDKENHP-------LPWEQRVTLARDCAQGLYTIH ||.|.|.... .|.| ||..||.| ..|..|.... ..| . .| . | |. | IVSLKGFCIHP---LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH |
|||||||||
| Kinase | MLKL.AA | Pkinase_Tyr | 313-367 | 30 | 4e-07 | 24.74 | Pfam | 66-124 (270) | Show / Hide |
Range on Protein: 313-367 Range on HMM: 66-124/270 Sequence Identity: 30% (18 aa) IVQLYGYTM-DYES-RMCFVVEYMSHGTLRSVLQDK--ENHPLPWEQRVTLARDCAQGL ||.||| . . |. ... |.||| || |.. |... ...||. .. . ... |.|. IVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGM |
|||||||||
| Kinase | MLKL.AA | Pkinase | 255-371 | 16 | 8.3e-07 | 25.15 | Pfam | 1-125 (293) | Show / Hide |
Range on Protein: 255-371 Range on HMM: 1-125/293 Sequence Identity: 16% (22 aa) FTDLETLQQGTYGPIIKTKHRFEDKLLVRKAFEDKELSSTR--------ELKEQLNLWKNLQYSAFIVQLYGYTMDYESRMCFVVEYMSHG----TLRSV .. .... .|..| | .|. . |. . | .. .. .| |.. ..| . . .||.||.. .| ......| ||. .| | .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-N----HPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDY LQDKENHPL--PWEQRVTLARDCAQGLYTIH .. ... .. .... .. ..||. .| ISTWRHGCFYFSEWECKFYMYQILRGLEYCH |
|||||||||
| Kinase | MLKL.AA | TKL-ciliate1 | 445-468 | 33 | 0.000448 | 9.84 | In-house | 197-220 (279) | Show / Hide |
Range on Protein: 445-468 Range on HMM: 197-220/279 Sequence Identity: 33% (8 aa) SIKSEVYKFGVILYEIASRMQPFQ ..| .| .|...|. ..| ||| NEKIDIYAYGIVMYILCFRKTPFQ |
|||||||||
| Kinase | MLKL.AA | LRRK | 447-468 | 43 | 0.008819 | 5.65 | In-house | 262-284 (351) | Show / Hide |
Range on Protein: 447-468 Range on HMM: 262-284/351 Sequence Identity: 43% (10 aa) KSEVYKFGVILYEIASRM-QPFQ |. .| ||.||.|. .| .||. KVDCYSFGMILWELLTRQHHPFD |
|||||||||
| Kinase | MLKL.AA | DRK | 447-470 | 37 | 0.01894 | 4.15 | In-house | 182-205 (258) | Show / Hide |
Range on Protein: 447-470 Range on HMM: 182-205/258 Sequence Identity: 37% (9 aa) KSEVYKFGVILYEIASRMQPFQAM | || |...| |.. | |.. | KADVYSFAIVLWECVTRQDPYFGM |
|||||||||
| Kinase | MLKL.AA | MLK | 445-472 | 31 | 0.024378 | 4.08 | In-house | 214-242 (291) | Show / Hide |
Range on Protein: 445-472 Range on HMM: 214-242/291 Sequence Identity: 31% (9 aa) SIKSEVYKFGVILYEIASRMQPFQ-AMEQ |.|. |. .||.|.|. .| |.. ... SEKCDVWSWGVVLWEMLTREVPYKQHYDP |
|||||||||
| Kinase | MLKL.AA | Dicty4 | 447-468 | 50 | 0.028075 | 3.6 | In-house | 197-218 (277) | Show / Hide |
Range on Protein: 447-468 Range on HMM: 197-218/277 Sequence Identity: 50% (11 aa) KSEVYKFGVILYEIASRMQPFQ |. || || .|.||. | |.| KADVYSFGIVLWEILTRQEPYQ |
|||||||||
| Kinase | MLKL.AA | Dicty5 | 450-467 | 44 | 0.075494 | 2.14 | In-house | 186-203 (260) | Show / Hide |
Range on Protein: 450-467 Range on HMM: 186-203/260 Sequence Identity: 44% (8 aa) VYKFGVILYEIASRMQPF || ||..|.|. | |. VYSFGIVLWEMFTRKEPY |
|||||||||