Gene Abl2 (M.brevicollis)

Abl2

Species: M.brevicollis
Alias: Abl2
External Links:
Annotation:

Classification

Group: TK
Family: SFK-Abl

Sequence

Name Sequence Type Origin Length Description Download
Abl2.AA Protein None 575 None Fasta, JSON
Abl2.kin_dom Protein Kinase Domain None 250 None Fasta, JSON

Protein domain

Protein domains of Abl2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 Abl2.AA SH3 8-67 38 7.8e-17 63.17 SMART 1-58 (58) Show / Hide 
Range on Protein: 8-67
Range on HMM: 1-58/58
Sequence Identity: 38% (23 aa)

DIFVALDDYASQHKGELSFSKGDNFKILKNAAPDDGWWNAQNLNTKKKGWIPCSLVALDG
  ..|| || .|. .||||.||| . .|.    ||||| ... .| ..||.|.. |..  
PYVRALYDYQAQNPDELSFKKGDIITVLEKD--DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 Abl2.AA SH3_1 11-60 40 4.1e-16 57.33 Pfam 1-49 (49) Show / Hide 
Range on Protein: 11-60
Range on HMM: 1-49/49
Sequence Identity: 40% (20 aa)

VALDDYASQHKGELSFSKGDNFKILKNAAPDDGWWNAQNLNTKKKGWIPC
||| ||. |. .|||| ||| .....     ..|| ....||...||.|.
VALYDYQAQQPDELSFKKGDIIHVIEKSDD-WDWWKGRCNNTGQEGWFPS
SH3_2 Abl2.AA SH3_2 9-66 23 3.3e-10 38.64 Pfam 1-68 (68) Show / Hide 
Range on Protein: 9-66
Range on HMM: 1-68/68
Sequence Identity: 23% (16 aa)

IFVALDDYAS-QHKGE-----LSFSKGDNFKIL--KNAAPDDGWWNA-QNLNTKKK--GWIPCSLVALD
 .... || . . ..|     |.| ||| .|..  ..  .| .|| .  .......  ||.| . |. .
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWD-NWWWCWETIWGGRRMRGWFPSQWVEEC
SH2 Abl2.AA SH2 74-149 43 1.9e-29 88.3 Pfam 1-81 (81) Show / Hide 
Range on Protein: 74-149
Range on HMM: 1-81/81
Sequence Identity: 43% (35 aa)

WCHGAISRNGADYLLKQ-HGIDGMYLVRESQSQPGQYTLDVWKEG---KSVHYRITKGDEG-YFFRQGVCFPTIPELIQHH
| || |||. |  ||..  . || .|||||.|.||.||| |. .|   .  |||| . |.| |.   ...|....||..|.
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 Abl2.AA SH2 72-155 42 4.7e-29 103.75 SMART 1-87 (87) Show / Hide 
Range on Protein: 72-155
Range on HMM: 1-87/87
Sequence Identity: 42% (37 aa)

FDWCHGAISRNGADYLLKQH-GIDGMYLVRESQSQPGQYTLDVWKEGKSVHYRITKGDEGYFFRQG---VCFPTIPELIQHHQTRSDG
  |.|| |||  |. |||.. . || .|||.|.|.||.|.| |. .||  |||| . |.| .. ..   ..||.. ||..|.|. ..|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase Abl2.AA SFK-Abl 189-438 74 1.2e-238 787.0 In-house 1-251 (251) Show / Hide 
Range on Protein: 189-438
Range on HMM: 1-251/251
Sequence Identity: 74% (188 aa)

VILGDRLGGGNYGEVFKGIYNNKTVAIKTIKEESMETVEFMKEAHVMKKLQHPNLVKLIGVCSTELPMYIVQEFVPYGDLLSYLRLPQSRIQLDHVSMLY
.|||.|||.|.||||.|||.||..|||||||.|||||..||||||.||..||||||.|||||..|.||||||||..||.||.||..||||||.|||||..
IILGHRLGEGQYGEVYKGIWNNHRVAIKTIKDESMETKDFMKEAHIMKRMQHPNLVRLIGVCTREGPMYIVQEFMNYGNLLDYLQSPQSRIQIDHVSMMH

IAQQIADGMSALEAQNTIHRDLAARNCLVGENLSVKVADFGMGRVVD-DLYTARTGTKMPIKWTAPEALCYDAFSVKSDVWSFGITLWEIATFGDVPYPG
.|||||||||.||.|..|||||||||||||.||..|||||||.|.|| |.|.||.||||||||||||.||||.|..||||||||||||||||.|||||||
CAQQIADGMSFLEEQHFIHRDLAARNCLVGDNLQIKVADFGMARFVDSDFYEARIGTKMPIKWTAPESLCYDIFTIKSDVWSFGITLWEIATYGDVPYPG

LEARDVINQLEGGYRMPEPQDCPAGLYEIMTQCWALESRERPSFFDLQHQL
...|||||||..||||..|||||...|.||||||.....|||||.||||||
IHHRDVINQLMMGYRMQRPQDCPMEIYNIMTQCWDVNPDERPSFHDLQHQL
Kinase Abl2.AA SFK-Src 189-442 51 2.8e-133 397.6 In-house 1-259 (259) Show / Hide 
Range on Protein: 189-442
Range on HMM: 1-259/259
Sequence Identity: 51% (133 aa)

VILGDRLGGGNYGEVFKGIYNNKT-VAIKTIKEESMETVEFMKEAHVMKKLQHPNLVKLIGVCSTELPMYIVQEFVPYGDLLSYLRLPQSRIQLDHVSML
. |  .|| | .|.|.||  ||.| ||.|| |  .|   ||..|| |||||.||||..|  ||    |.||. | . || || ||. |. |  |    . 
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGR-SLRMPQLV

YIAQQIADGMSALEAQNTIHRDLAARNCLVGENLSVKVADFGMGRVV--DDL-YTARTGTKMPIKWTAPEALCYDAFSVKSDVWSFGITLWEIATFGDVP
  | |.| ||  ||||| .|||||||| |||.|  .||.|||| ||.  ||  |||..| | |||||||||  .  ||.||||||||| . || |.| .|
DMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIP

YPGLEARDVINQLEG--GYRMPEPQDCPAGLYEIMTQCWALESRERPSFFDLQHQLDDLH
|||.    |. |..   ||||| |. ||  .|.|| .||  |  .|| |  |. |..|  
YPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase Abl2.AA Pkinase_Tyr 189-438 46 6.1e-133 450.86 Pfam 1-270 (270) Show / Hide 
Range on Protein: 189-438
Range on HMM: 1-270/270
Sequence Identity: 46% (125 aa)

VILGDRLGGGNYGEVFKGIYN------NKTVAIKTIKEESMET----VEFMKEAHVMKKL-QHPNLVKLIGVCS-TELP--MYIVQEFVPYGDLLSYLRL
...|  || |..|||.||...      . .||.|..|| .|.      .||.|| .||.| .|||.|.|.|||.  . |  .||| |..|.||||.||| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

P-QSRIQLDHVSMLYIAQQIADGMSALEAQNTIHRDLAARNCLVGENLSVKVADFGMGRVV--DDLY-TARTGTKMPIKWTAPEALCYDAFSVKSDVWSF
.  .. .|..  .| ...|||.||. ||..| ||||||||||||.||. ||..|||. | .  || | ..|.|.|.||||.|||.. |  |..|||||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GITLWEIATFGDVP-YPGLEARDVINQL-EGGYRMPEPQDCPAGLYEIMTQCWALESRERPSFFDLQHQL
|...||| |.|. | |||.   .|.... | ||||| |..||. .|..|.|||. .  .||.| ....||
GVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Abl2.AA Src 189-438 51 7.89999999999e-131 440.93 In-house 1-255 (255) Show / Hide 
Range on Protein: 189-438
Range on HMM: 1-255/255
Sequence Identity: 51% (132 aa)

VILGDRLGGGNYGEVFKGIYNNKT-VAIKTIKEESMETVEFMKEAHVMKKLQHPNLVKLIGVCSTELPMYIVQEFVPYGDLLSYLRLPQSRIQLDHVSML
. | ..|| |..|||..|..|..| ||.||.|. .|..  | .|| .||||.|..||.|  |||.| | |||.|.   | || ||.  .   .|     .
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

YIAQQIADGMSALEAQNTIHRDLAARNCLVGENLSVKVADFGMGRVVD--D-LYTARTGTKMPIKWTAPEALCYDAFSVKSDVWSFGITLWEIATFGDVP
..| |.|.||. ||..| ||||||||| |||||. .||||||  |...  |  |.||.| |.|||||||||. |  |..||||||||| |.|| |.| ||
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP

YPGLEARDVINQLEGGYRMPEPQDCPAGLYE-IMTQCWALESRERPSFFDLQHQL
||| . ..|. |.| ||||| |. ||. ||| ||.|||  . ..|| |  ||. |
YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Abl2.AA TyrKc 189-438 41 3e-128 433.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 189-438
Range on HMM: 1-280/280
Sequence Identity: 41% (119 aa)

VILGDRLGGGNYGEVFKGIYNNKTVAIKTIKEESMETVEFMKEAHVMKKL--QHPNLVKLIGVCSTE-------LPMYIVQEFVPYGDLLSYLRLPQSRI
. ||. || |..|||.||...  .||.|..||..    .||.|| .|.||  .|||.|.|.|||...        |..|| |..|.|||..||| .. . 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

QLDHVSMLYIAQQIADGMSALEAQNTIHRDLAARNCLVGENLSVKVADFGMGRVVD---------DLYTART--GTK--MPIKWTAPEALCYDAFSVKSD
 | .  .|... |||.||. |. .| |||||||||||||||. ||..|||. | ..         | |....  |.|  .||.|.|||.. |  |. |||
-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSD

VWSFGITLWEIATFGDVPYPG-----LEARDVINQLEGGYRMPEPQD--------CPAGLYEIMTQCWALESRERPSFFDLQHQL
|||||...||| |.|. ||||     .....||.... ||||| |..        ||. .|.||.|||. .  .||.| .. ...
VWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Abl2.AA Abl 189-438 55 7.69999999999e-122 408.44 In-house 1-252 (252) Show / Hide 
Range on Protein: 189-438
Range on HMM: 1-252/252
Sequence Identity: 55% (141 aa)

VILGDRLGGGNYGEVFKGIYN--NKTVAIKTIKEESMETVEFMKEAHVMKKLQHPNLVKLIGVCSTELPMYIVQEFVPYGDLLSYLRLPQSRIQLDHVSM
... ..|||| ||||..|..   ..|||.||.||..||  ||.||| .||...|||||.|.|||  | | ||. ||..|| || |||   .| .|. | .
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRE-CDREELPAVVL

LYIAQQIADGMSALEAQNTIHRDLAARNCLVGENLSVKVADFGMGRVV-DDLYTARTGTKMPIKWTAPEALCYDAFSVKSDVWSFGITLWEIATFGDVPY
||.| ||| ||| ||... ||||||||||||||.  |||||||. |.. || |||. | | ||||||||.| |  ||.||||| ||. ||||||.|  ||
LYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPY

PGLEARDVINQLEGGYRMPEPQDCPAGLYEIMTQCWALESRERPSFFDLQHQL
||..  .| ..|| |||| .|. ||   ||.| |||  .  .|||| .. |..
PGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase Abl2.AA TK 189-438 24 4.90000000001e-116 390.67 In-house 1-486 (486) Show / Hide 
Range on Protein: 189-438
Range on HMM: 1-486/486
Sequence Identity: 24% (119 aa)

VILGDRLGGGNYG---EVFKGIYNNK---------------------------TVAIKTIKEE-SMETVEFMK--------------EAHVMKKLQ----
..||. || |..|   ||.||.....                           .||.|..||. .|.  ||.               ||..||...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNLVKLIGVCSTE------------LPMYIVQEFVPYGD----LLSYLRL-PQSRIQ-----------------------------------------
 |||.|.|.|||. .             |..|| |..|.||    |..|||  .  ...                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LDHVSMLYIAQQIADGMSALEAQ------NTIHRDLAARNCLVGENLS-----------VKVADFG---
                               |.   .| ...|||.||. |...      | .||||||||||||||.            .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----MGRVV--------------------------DDLYTARTGTKMPIKWTAPEALC---------YDAFSVKSDVWSFGITLWEIATFGDVPYPGLE
     . | .                          .| | ...|.|.||.|.|||.|          |  |. ||||||||...||| |.|..||.|  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

A----------RDVINQLEGG--------------YRMPEPQDCP--------------AGLYEIMTQCWALESRERPSFFDLQHQL
           ..|...|. |              .||| |..||              . .|..|.|||... ..||.| .|..||
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Abl2.AA Src-Unclassified 189-438 42 1.1e-110 373.99 In-house 1-284 (284) Show / Hide 
Range on Protein: 189-438
Range on HMM: 1-284/284
Sequence Identity: 42% (122 aa)

VILGDRLGGGNYGEVFKGIYNN-KTVAIKTIKEE---SMETVEFM--------KEAHVMKKLQHPNLVKLIGVCSTELPMYIVQEFVPYGDLLSYLRLPQ
| | . || |. |||..|.. .   ||.|| ..     | .  |         .|| .|||..|.|||.| .|||.| | ||..|.   | || .||   
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

SRIQLDHVSM------------LYIAQQIADGMSALEAQNTIHRDLAARNCLVGENLS-----VKVADFGMGR---VVDDLYTARTGTKMPIKWTAPEAL
 .  |    |             .|| |.| ||  ||.   .|||||||| |.|.| |     |||.|||  |   . || | .||| . |.||.|||. 
GQY-LHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECF

CYDAFSVKSDVWSFGITLWEIATFGDVPYPGLEARDVINQLEGGYRMPEP--QDCPAGLYE-IMTQCWALESRERPSFFDLQHQL
 |  ||.||||||.|| ||||.| | .||||   | |. ..| ||||| |  . ||  .|| ||..|| .  . || |  | | .
IYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase Abl2.AA UTK 189-438 39 5.4e-105 355.11 In-house 1-296 (296) Show / Hide 
Range on Protein: 189-438
Range on HMM: 1-296/296
Sequence Identity: 39% (116 aa)

VILGDRLGGGNYGEVFKGIYNN-------KTVAIKTIKEESM-ETV-----EFMKEAH---VMKKLQ-HPNLVKLIGVCSTELPMYIVQEFVPYGDLLSY
|.||..|| |..|||.|. ...         ||.|. ..... ..      .||.||    .||... |||...|.|||. | |..|| |. . |||.||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR-----LPQSRIQLDHVSMLYIAQQIADGMSALEAQNTIHRDLAARNCLVGEN-------LSVKVADFG---MGRVVDD-----------LYTARTGTK
||     .|. . .|.  ..|. | .||.||. |. .. .|||||||||||...       ...|.||||   | | | .           .|.|.  ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

MPIKWTAPEALCYD-AFSVKSDVWSFGITLWEIATFGDVPYPGLEARDVINQLEGG--YRMPEPQDCPAGLYEIMTQCWALESRERPSFFDLQHQL
.||.|.|||||..   |. ||||||||...||| |.| .||||. ...|. |.. |  |||| |.|||. .|..|..||. . .|||.| ||  |.
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase Abl2.AA Frk 189-442 48 3.6e-104 352.39 In-house 1-260 (260) Show / Hide 
Range on Protein: 189-442
Range on HMM: 1-260/260
Sequence Identity: 48% (125 aa)

VILGDRLGGGNYGEVFKGIYNNKT-VAIKTIKEESMETVEFMKEAHVMKKLQHPNLVKLIGVCSTELPMYIVQEFVPYGDLLSYLR-LPQSRIQLDHVSM
. |  ||| | .|||. | .||.| ||.||.|  .|.  .|..|| .||||.|| |..|  ||  | |.||. | .  | |. ||. . .   |.    .
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

LYIAQQIADGMSALEAQNTIHRDLAARNCLVGENLSVKVADFGMGR--VVDDL--YTARTGTKMPIKWTAPEALCYDAFSVKSDVWSFGITLWEIATFGD
. .| |.| ||  || || ||||||||| ||||....|.||||. |  ..|.   | .|.| ..|||||||||  |. |..||||||||| | || |.| 
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR

VPYPGLEARDVINQLEGGYRMPEPQDCPAGLYEIMTQCWALESRERPSFFDLQHQLDDLH
.||||.  ..|..... |||||.| .||  ||||| .||  ....|| |  || .|.|  
MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase Abl2.AA SrcB 189-439 49 8.6e-100 337.83 In-house 1-251 (251) Show / Hide 
Range on Protein: 189-439
Range on HMM: 1-251/251
Sequence Identity: 49% (125 aa)

VILGDRLGGGNYGEVFKGIYNNKT-VAIKTIKEESMETVEFMKEAHVMKKLQHPNLVKLIGVCSTELPMYIVQEFVPYGDLLSYLRLPQSRIQLDHVSML
. |  .|| | .|||. | |||.. ||.||.|. .|    |..|| |||.|||  ||.|  | . | |.||. |..  | || .|. ..  ..|    ..
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEG-SKLSLPKLI

YIAQQIADGMSALEAQNTIHRDLAARNCLVGENLSVKVADFGMGRVVDD-LYTARTGTKMPIKWTAPEALCYDAFSVKSDVWSFGITLWEIATFGDVPYP
 .. |||.||  .| .| ||||| | | || | |. |.||||. |...|  |||| | | |||||||||. . .| .||||||||| | || |.| .|||
DMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYP

GLEARDVINQLEGGYRMPEPQDCPAGLYEIMTQCWALESRERPSFFDLQHQLD
|    .||..|| ||||| |. ||  ||.||..||   . ||| |  ||  ||
GMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase Abl2.AA Tec 189-440 44 5.9e-99 335.05 In-house 1-254 (254) Show / Hide 
Range on Protein: 189-440
Range on HMM: 1-254/254
Sequence Identity: 44% (113 aa)

VILGDRLGGGNYGEVFKGIY-NNKTVAIKTIKEESMETVEFMKEAHVMKKLQHPNLVKLIGVCSTELPMYIVQEFVPYGDLLSYLRLPQSRIQLDHVSML
  .   || | .| |  | . ..  ||||.||| ||   .|. || ||.||.||.||.| |||| . |.||| |..  | ||.|||  . . | .    |
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

YIAQQIADGMSALEAQNTIHRDLAARNCLVGENLSVKVADFGMGR-VVDDLYTARTGTKMPIKWTAPEALCYDAFSVKSDVWSFGITLWEIATFGDVPYP
.. |..  ||  || .. |||||||||||||..  |||.|||| | | || ||  .||| |.|| .|| . |  .| |||||.||.  ||. . | .||.
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE

GLEARDVINQLEGGYRMPEPQDCPAGLYEIMTQCWALESRERPSFFDLQHQLDD
 ..  .|. .   |.|.  |. |.  .|.|| .||  .  |||.| .|  |. .
NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase Abl2.AA S_TKc 189-445 23 1.6e-48 168.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 189-445
Range on HMM: 1-231/231
Sequence Identity: 23% (63 aa)

VILGDRLGGGNYGEVFKGIYNN--KTVAIKTIKEESMETVEFMKEAHVMKKLQHPNLVKLIGVCSTELPMYIVQEFVPY--GDLLSYLRLPQS---RIQL
  ... .| | .|.|.|.. ..  . |||| ||        ...|  ..|| .|||.|||..|. .   .|.| |...   |||..|..  ..   | ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

DHVSMLYIAQQIADGMSALEAQNTIHRDLAARNCLVGENLSVKVADFGMGRVVDDLYTARTGTKMPIKWTAPEALCYDAFSV-KSDVWSFGITLWEIATF
.     ....||....  .  .. |||||   | |. |   .|..|||. |..       |       . ||| |    ..  |.|.||.|..|.| .. 
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-

GDVPYPGLEARDVINQLEGGYRMPEPQDCPAGLYEIMTQCWALESRERPSFFDLQH--QLDDLHKNT
|  |.|  .   .....            .  . ... .|.  . ..||.  .. .  ..  .|   
GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Abl2.AA Pkinase 189-438 21 2e-41 147.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 189-438
Range on HMM: 1-293/293
Sequence Identity: 21% (65 aa)

VILGDRLGGGNYGEVFKGIYNNKT--VAIKTIKEESMETVEFMK-----EAHVMKKLQHPNLVKLIGVCSTELPMYIVQEFVPYG----DLLSYLRLPQS
  .| ..| |..|.|.|..  .    ||.|.|| .. .  . .      |...||.|.||| |.|.... ..  .|.|.|... |    || .|..  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-WR

RIQL--DHVSMLYIAQQIADGMSALEAQNTIHRDLAARNCLVGENLSV----KVADFGMGRV---VDDLYTARTGTKMPIKWTAPEALC-YDAFSVKSDV
.  .  .      .. ||. |.  . ... |||||   |.|. .|  .    |..|||  ..    .  .| ..||   . . ||| .  .   . |.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDYNNS-MTTFCGT---PWYMAPEVIRGGQYYGPKVDM

WSFGITLWEIATFGDVPYPGL-----EARDVINQLEGG--YRMPEPQDCP-------------------AGLYEIMTQCWALESRERPSFFDLQHQ--L
||.|..|.| .. |  |.||         ... .. .|  .. ..|..|.                     . .... |...   .||.. .. .   .
WSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF