Gene HMTK01 (M.brevicollis)

HMTK01

Species: M.brevicollis
Alias: HMTK01
External Links:
Annotation:

Classification

Group: TK
Family: HMTK

Sequence

Name Sequence Type Origin Length Description Download
HMTK01.AA Protein None 784 None Fasta, JSON
HMTK01.kin_dom Protein Kinase Domain None 269 None Fasta, JSON

Protein domain

Protein domains of HMTK01.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PTB HMTK01.AA PTB 18-147 20 7.8e-14 53.2 SMART 1-156 (156) Show / Hide 
Range on Protein: 18-147
Range on HMM: 1-156/156
Sequence Identity: 20% (32 aa)

TEIDSFNVKYVGSVPVKAGT-------GNDVCRNAVERLRSLHLKEKPIHLKVTTLGLYLIDAKTCDVVKEVNIEEVSFVAQDA-----------YDQQL
 .  .|||.|.|.|.|.. .       |..||... ...|.   . ...||...  |. |||..| .|. . .|. .||.|.|             |  .
PWGCCFNVWYLGCVEVPHHRNSMAPGKGMQVCQECMRKIRQHWKHWQKMHLHISVDGVKLIDPQTKQVIHHHPIHRISFCAHDPYRWNTGGHHCCDDDRC

VSFFENDKSMR-------LITCHTVRIARDG-HAIPVAINEAFKALKGEITVEPKP
...   ... |          ||  . . .   .|. .| .||.    . ... ..
FGYICRHPNDRGSHRMTYWFRCHVFWCEDPHAEDIAQTIGQAFQVCYQQCQKQRCQ
PID HMTK01.AA PID 23-93 22 9.3e-11 39.55 Pfam 1-98 (153) Show / Hide 
Range on Protein: 23-93
Range on HMM: 1-98/153
Sequence Identity: 22% (22 aa)

FNVKYVGSVPVKAG-------TGNDVCRNAVERLRSL--------------HLKEK-PIHLKVTTLGLYLIDAKT---CDVVKEVNIEEVSFVAQ--D
|.|.|.|.|.|          |. ..|.....|..                | ... .|.|...| |. .||.||    ... . ... .||.|.  |
FEVRYLGCVEVPCHMRRPDKNTRMMQCQECIHRVCMQVPAKKINKIRGHRGHWQHWQKIDLHISTDGVKWIDEKTEAEQECMHDHPMRNISFCADGGD
PTB HMTK01.AA PTB 176-309 17 6.6e-05 18.76 SMART 1-156 (156) Show / Hide 
Range on Protein: 176-309
Range on HMM: 1-156/156
Sequence Identity: 17% (27 aa)

NLQQSYSVKLIGIVNVSSPK-------GDEVILEAASRIRKLNSKPMEVNLNIYDKAFALESSKHELPLQICHIREISFAKRLE----------DDTPPL
.  ....|. .|.| |....       |..|. |. ..||. . .. ...|.| ...  | . . .  .  ..|. |||. .             |.. .
PWGCCFNVWYLGCVEVPHHRNSMAPGKGMQVCQECMRKIRQHWKHWQKMHLHISVDGVKLIDPQTKQVIHHHPIHRISFCAHDPYRWNTGGHHCCDDDRC

FTYIIHDRRLD-------KMSCTAVTLPENLADDQPSIRRSIDAAQKAFVAEIKAKEQ
| ||. .   .       ...| .    .  |.|... ..  .| |...    |...|
FGYICRHPNDRGSHRMTYWFRCHVFWCEDPHAEDIAQTIG--QAFQVCYQQCQKQRCQ
PID HMTK01.AA PID 181-273 15 0.010335 11.31 Pfam 1-121 (153) Show / Hide 
Range on Protein: 181-273
Range on HMM: 1-121/153
Sequence Identity: 15% (19 aa)

YSVKLIGIVNVSSP--KGDEV-----ILEAASRIRKL---------------NSKPMEVNLNIYDKAFALESSKH---ELPLQICHIREISFAKR-LEDD
. |...|.| | ..   .|.        |. .|...                  ..... |.| ...  .   |    . ..  ...| |||.      .
FEVRYLGCVEVPCHMRRPDKNTRMMQCQECIHRVCMQVPAKKINKIRGHRGHWQHWQKIDLHISTDGVKWIDEKTEAEQECMHDHPMRNISFCADGGDPH

-TPPLFTY-IIHDRRLDKMSC
 .   | | |..|... .. |
VDMRYFAYDICRDGPCQRFAC
PID HMTK01.AA PID 345-467 20 3.1e-15 55.27 Pfam 1-153 (153) Show / Hide 
Range on Protein: 345-467
Range on HMM: 1-153/153
Sequence Identity: 20% (32 aa)

FEATYLGAIVVDQL-------KGIDVVQNAANQALKL---------------KAAPQGVFVHVATEGIKIFESLS---HEVLGAFVLKDVSFTTVVGKRK
||. ||| . |..         . ...|.. ... .                . ..| ...|..|.|.|..   .   .|..  . .. .||  . | ..
FEVRYLGCVEVPCHMRRPDKNTRMMQCQECIHRVCMQVPAKKINKIRGHRGHWQHWQKIDLHISTDGVKWIDEKTEAEQECMHDHPMRNISFCADGGDPH

---DQFAF-IQKDDTLNLINCHVFLCAG-ERAFDIATAVNEAFKAFAEEQKKT
   . ||. |..|....   |||| |     | |||..| .||  . .. .. 
VDMRYFAYDICRDGPCQRFACHVFWCCKTQQAQDIAQTVGQAFQVCYQQCLRA
PTB HMTK01.AA PTB 341-470 19 1.7e-11 45.4 SMART 1-156 (156) Show / Hide 
Range on Protein: 341-470
Range on HMM: 1-156/156
Sequence Identity: 19% (30 aa)

IMGV-FEATYLGAIVVDQLK-------GIDVVQNAANQALKLKAAPQGVFVHVATEGIKIFESLSHEVLGAFVLKDVSFTTVVG-----------KRKDQ
. |. |...||| . |.. .       | .|.|.. ..  . . ..|.. .|.   |.|.    ...|.  . .. .||  .             . .. 
PWGCCFNVWYLGCVEVPHHRNSMAPGKGMQVCQECMRKIRQHWKHWQKMHLHISVDGVKLIDPQTKQVIHHHPIHRISFCAHDPYRWNTGGHHCCDDDRC

FAFIQKDDTLN-------LINCHVFLCAGERAFDIATAVNEAFKAFAEEQKKTGGN
|..| ....           .||||.|. . | ||| .. .||.  .....|    
FGYICRHPNDRGSHRMTYWFRCHVFWCEDPHAEDIAQTIGQAFQVCYQQCQKQRCQ
Kinase HMTK01.AA HMTK 495-760 58 9.3e-204 683.2 In-house 1-291 (291) Show / Hide 
Range on Protein: 495-760
Range on HMM: 1-291/291
Sequence Identity: 58% (171 aa)

LIPRKAIGAGQFG-----------------QVYLADQIVKDGDGKDGGNRVS-RAVKMLRGGASAEDKTDFESEATVMLELEHENLVQLIGVSMQQRPWL
|...|.|||||||                 .||||...||||||||..|... ||||||||.||.||...|..||.||..|.|.|||||.||.|||||||
LKAIKVIGAGQFGMVQCLRLAPPDEGCTSLKVYLAEWSVKDGDGKDDSNQPHHRAVKMLRGDASHEDREEFLREAEVMCQLRHPNLVQLVGVCMQQRPWL

MVLEYLQYGDLRNVLKGCASKNIELQYEDQLNFAVQIAKGMAYIAAQGMVHMDLAARNCLVAENNLVKVADFGLTRKIPEGQDYWQSKTVM-KLPVKWCA
.||||.||||||||||.|..|||.|.|..||.|.||.|.||||||.|.|||||||||||||..||.||.|||||||....|||||.....| |||.||.|
CVLEYMQYGDLRNVLKTCREKNIQLTYHEQLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHLRKHMVKLPIKWMA

IEALD--DRIFSEKSDVWAYGVVMWEISSYGAMPYE--DVKTQEVQRRVREGLRLE-PVPN-TNPDYFALAKSCWRLDRHERPSFANMAQE
.||.|  ..||||||||||.||.||||..||..|||  ..|..||||.||||.||. |.|. ...|...|...||. |.|.||.||.....
PEAMDGKRKIFSEKSDVWAFGVTMWEIWMYGEQPYESQQIKNKEVQRHVREGRRLTQPPPDDCPDDFWDLMCTCWHKDPHQRPTFAQLQKM
Kinase HMTK01.AA TK 495-761 22 2e-110 371.56 In-house 1-486 (486) Show / Hide 
Range on Protein: 495-761
Range on HMM: 1-486/486
Sequence Identity: 22% (111 aa)

LIPRKAIGAGQFG---QVYLADQIVKDGDGKDG----------------GNRVSRAVKMLRGGASAEDKTDFE-------------SEATVMLELE----
..  | .|.||||   .||..  . ..... ..                |...  |||||. |......  |.             .|| .|  .     
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HENLVQLIGVSMQQ------------RPWLMVLEYLQYGD----LRNVLKGCASKNIE-----------------------------------------
 |.|.|.|.||..|.            .||..|.|| ..||    ||. |. |  | ..                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LQYEDQLNFAVQIAKGMAYIAAQ------GMVHMDLAARNCLVAENNL-----------VKVADFG---
                               |  ...| ...|||.||.|....      ..||.|||||||||.|||            .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LTRKIPEGQDYWQSK-----------------------TVMKLPVKWCAIEALDDRI---------FSEKSDVWAYGVVMWEISSYGAMPYEDVK
     |.|.|....||. ..                       . .|||..|.| |.|.||.         |..|||||..||.|||| .||..||    
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

T----------QEVQRRVREG--------------LRLEPVPNTN--------------PDYFALAKSCWRLDRHERPSFANMAQEL
.          ||| ...|.|              .|... |.                ..|. | ..||..|  .||.|. . ..|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase HMTK01.AA TyrKc 495-761 35 7.29999999999e-108 365.57 SMART 1-280 (280) Show / Hide 
Range on Protein: 495-761
Range on HMM: 1-280/280
Sequence Identity: 35% (106 aa)

LIPRKAIGAGQFGQVYLADQIVKDGDGKDGGNRVSRAVKMLRGGASAEDKTDFESEATVMLEL--EHENLVQLIGVSMQQ-------RPWLMVLEYLQYG
.   | .| |.||.||..  .            .  |||||. .|    . || .|| .| .|  .|.|.|.|.|| .||        | ..|.||  .|
ITLGKKLGEGAFGEVYKGTWK------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG

DLRNVLKGCASKNIELQYEDQLNFAVQIAKGMAYIAAQGMVHMDLAARNCLVAENNLVKVADFGLTRKIPEG------QDYWQSKT--VMK--LPVKWCA
||.. |. .  |   |. .| |.|..|||.||.|.. .. .| |||||||||.||. ||..||||.|.| ..      .||  .|.    |  ||..|.|
DLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

IEALDDRIFSEKSDVWAYGVVMWEISSYGAMPYED-----VKTQEVQRRVREGLRLEPVPN--------TNPDYFALAKSCWRLDRHERPSFANMAQEL
.|......|..|||||..||.|||| .||..||..     .. ||| ..|..| |... ||          .. . . |.||. | ..||.|..  ...
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase HMTK01.AA Pkinase_Tyr 495-761 38 4.8e-105 356.38 Pfam 1-270 (270) Show / Hide 
Range on Protein: 495-761
Range on HMM: 1-270/270
Sequence Identity: 38% (106 aa)

LIPRKAIGAGQFGQVYLADQIVKDGDGKDGGNRVSRAVKMLRGGASAED--KTDFESEATVMLEL-EHENLVQLIGVSM-QQRP--WLMVLEYLQYGDLR
..  | .|.|.||.||..         .......  |||||. ||. |.  . || .|| .| .|  |.|.|.|.|| . |..|  ...|.|| ..|||.
ITFGKKLGEGAFGEVYKGTWKG-----DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLL

NVLKGCASKNIELQYEDQLNFAVQIAKGMAYIAAQGMVHMDLAARNCLVAENNLVKVADFGLTRKIPEGQDYW-QSKTVMKLPVKWCAIEALDDRIFSEK
. |.   . .  |  .| |....||||||.| ......| |||||||||.||| ||..||||.| | .  ||  ....  |||.||.| |.. ...|..|
DYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTK

SDVWAYGVVMWEISSYGAMP-YEDVKTQEVQRRV-REGLRLEPVPNTNPDYFALAKSCWRLDRHERPSFANMAQEL
||||..||.|||| .||..| |.... .|| ... ..| |... .|. ..   | |.||. |  .||.|.   ..|
SDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase HMTK01.AA UTK 495-761 30 9.4e-86 291.2 In-house 1-296 (296) Show / Hide 
Range on Protein: 495-761
Range on HMM: 1-296/296
Sequence Identity: 30% (91 aa)

LIPRKAIGAGQFGQVYLADQIVKDGDGKDGGNRVSRAVKMLRGGASAEDKTD----FESEAT---VMLELE-HENLVQLIGVSMQQRPWLMVLEYLQYGD
..... .|.|.||.|..|.      . .. .  . .||| .. .|.|... .    |  ||.   .|  .. |.|...|.|| .|. ||..|.|| . ||
VQLGRQLGQGAFGEVHKARFT----QCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGD

LRNVLKGCAS-KNIELQYED---QLNFAVQIAKGMAYIAAQGMVHMDLAARNCLVAEN-------NLVKVADFG---LTRKIPE--------GQDYWQSK
||..|  ..   ...  . .   .| .|..|| ||.|.. .| || |||||||||...       ...|.||||   ..| ..         ...| .. 
LRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQ

TVMKLPVKWCAIEALDDR-IFSEKSDVWAYGVVMWEISSYGAMPYEDVKTQEVQRRVREG--LRLEPVPNTNPDYFALAKSCWRLDRHERPSFANMAQEL
 . ..|..|.| |||...  |..|||||..|||.||| ..|..||..  ...|  .|..|  .|... .    . . | ..||. |  |||.|  . |..
HQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase HMTK01.AA TK-Unique 495-761 32 2e-85 290.09 In-house 1-294 (294) Show / Hide 
Range on Protein: 495-761
Range on HMM: 1-294/294
Sequence Identity: 32% (96 aa)

LIPRKAIGAGQFGQVYLADQIVKDGDGKDGGNRVSRAVKMLRGGASAEDKTDFESEATVMLELE-HENLVQLIGVSMQQR-PWLMVLEYLQYGDLRNVLK
|   . || |.||||. ..   ..   |. . ... |||||. .|. .|| || .|. .| ||  |.|.||..|...    ||....||...|.|.. |.
LEVGDVIGEGAFGQVWRGEVWGIW---KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

GCASK--------NIE--------------LQYEDQLNFAVQIAKGMAYIAA--QGMVHMDLAARNCLVAENNLVKVADFGLTRKIPEGQDYWQSKTVMK
 |. .        |.               ....| ..||.|||.||.|.|   .. ||.||.|||.|..|.. .|..|||..|..  ...|  ...  .
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGR

LPVKWCAIEALD--DRIF-SEKSDVWAYGVVMWEISSYGAMPYEDVKTQEVQRRVREGLRLEPVPNT-NPDYFALAKSCWRLDRHERPSFANMAQEL
.|..|.| |.|   .... ..|||||..||.|||| ..||.|| ...  ......|.| |..  ..  ... . | ||||.....|||||.  ...|
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase HMTK01.AA CTKA 495-761 36 2.4e-74 249.19 In-house 1-290 (290) Show / Hide 
Range on Protein: 495-761
Range on HMM: 1-290/290
Sequence Identity: 36% (107 aa)

LIPRKAIGAGQFGQVYLADQIVKDGD----GKDGGNRVSRAVKMLRGGASAEDKTDFESEATVML--ELEHENLVQLIGVSMQQRPWLMVLEYLQYGDLR
.     || |..|||. |     | |     .  |  |  |||||.  |  ||   |  || |     ..| | . |.||  |  ||.|. |..|||||.
HCIMFKIGEGHYGQVFRA-WLMPDPDDFKAQRKKGKDV--AVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLH

NVLKGCASKN------------------IELQYEDQLNFAVQIAKGMAYIAAQGMVHMDLAARNCLVAENNLVKVADFGLTRKIPEG-QDYWQSKTVMKL
 .|. |..                    ||..   |   | ||| || | |. |.|| |||.||||.   . .|.||||. |    . |.|  |.  . .
CYLRACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRV-M

PVKWCAIEALDDRIFSEKSDVWAYGVVMWEISSYGAMPYEDVKTQEVQRRVREG--LRLEPVPNTNPDY-FALAKSCWRLDRHERPSFANMAQEL
|| | |.|||    ||  |||||.||..||| | |  |.    .|||   .  .   || ||| . |.    . . ||.    .||.|. .  .|
PVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRL-PVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase HMTK01.AA Src 495-761 36 2.7e-68 231.14 In-house 1-255 (255) Show / Hide 
Range on Protein: 495-761
Range on HMM: 1-255/255
Sequence Identity: 36% (99 aa)

LIPRKAIGAGQFGQVYLADQIVKDGDGKDGGNRVSRAVKMLRGGASAEDKTDFESEATVMLELEHENLVQLIGVSMQQRPWLMVLEYLQYGDLRNVLKGC
.   . .|.|||| |. .             ...  ||| |. |    . ..|  || .| .| ||.||||  |  |  | . | || . | |   ||  
IKLCRKLGQGQFGEVWMGYWN----------GNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-

ASKNIELQYEDQLNFAVQIAKGMAYIAAQGMVHMDLAARNCLVAENNLVKVADFGLTRKIPEGQDYWQSKTVMKLPVKWCAIEALDDRIFSEKSDVWAYG
 ..  .|. .... .| |.|.||||. .. ..| |||||| || |||..||||||| | | |. |   ...  |.|.|| | ||.. . |. ||||| .|
DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFG

VVMWEISSYGAMPYEDVKTQEVQRRVREGLRLEPVPNTNPDYFA--LAKSCWRLDRHERPSFANMAQEL
. ..|| .|| .||.  . .|| ..|  | |. | | . ||..   . . ||. |  .|| |. . . |
ILLTEIVTYGRVPYPGMTNHEVLQQVERGYRM-PCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase HMTK01.AA Abl 495-761 36 1.9e-67 223.88 In-house 1-252 (252) Show / Hide 
Range on Protein: 495-761
Range on HMM: 1-252/252
Sequence Identity: 36% (97 aa)

LIPRKAIGAGQFGQVYLADQIVKDGDGKDGGNRVSRAVKMLRGGASAEDKTDFESEATVMLELEHENLVQLIGVSMQQRPWLMVLEYLQYGDLRNVLKGC
.. .. .| ||.|.|| .  . |  |          ||| |.  . . .  .|  || .| |..|.|||||.||  .  |. .. |.. || | . |. |
IMMKHKLGGGQYGEVYEG--VWKRHD-------CTVAVKTLKEDTMEVH--EFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLREC

ASKNIELQYEDQLNFAVQIAKGMAYIAAQGMVHMDLAARNCLVAENNLVKVADFGLTRKIPEGQDYWQSKTVMKLPVKWCAIEALDDRIFSEKSDVWAYG
  ....      |  | ||| || |. ..  .| |||||||||.|...||||||||.| . .  | .  .   | |.|| | |.|    || ||||||.|
DREELPAVV--LLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKD--DTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFG

VVMWEISSYGAMPYEDVKTQEVQRRVREGLRLEPVPNTNPDYFALAKSCWRLDRHERPSFANMAQEL
|..|||  ||  ||  .  ..|  .. .| |.|  .   |. . | . ||. .  .||||... ...
VLLWEIATYGMSPYPGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase HMTK01.AA Fer 493-762 29 2.6e-65 221.39 In-house 1-283 (283) Show / Hide 
Range on Protein: 493-762
Range on HMM: 1-283/283
Sequence Identity: 29% (86 aa)

VDLIPRKAIGAGQFGQVYLA-DQIVKDGDGKDGG-NRVSRAVKMLRGG-ASAEDKTDFESEATVMLE-LEHENLVQLIGVSMQQRPWLMVLEYLQYGDLR
|.|.  | .| | || ||..    .| ..||    | |  .||....  |..| . .|  || .|.  . | | |...||. .. | . |.|.   |.|.
VTLG--KKLGEGAFGEVYKGRR-TLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLD

NVLKGCASKNIE--LQYEDQLNFAVQIAKGMAYIAAQGMVHMDLAARNCLVAENNLVK---VADFGLTRKIPEGQDYWQSK-TVMKLPVKWCAIEALDDR
. ||    || .  .   . .... |.|.||.|. .....| |.||||||. .....|   ..|||. |.  ...   . | . .|.|..| | |.....
SYLK----KNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTG

IFSEKSDVWAYGVVMWEISSYGAMPYED----VKTQEV----QRR-VREGLRLEPVPNTNPDYFALAK-SCWRLDRHERPSFANMAQELQ
|.|.|.|||..||..||| . || ||..    .|  .|    ... ...| .. . ... |.   . . .||  |  .||...   |.| 
IYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase HMTK01.AA Frk 493-765 35 8.8e-65 221.53 In-house 1-260 (260) Show / Hide 
Range on Protein: 493-765
Range on HMM: 1-260/260
Sequence Identity: 35% (96 aa)

VDLIPRKAIGAGQFGQVYLADQIVKDGDGKDGGNRVSRAVKMLRGGASAEDKTDFESEATVMLELEHENLVQLIGVSMQQRPWLMVLEYLQYGDLRNVLK
. ||  . .|.||||.|.               | .  ||| |. |.   | .||  || .| .| |  |.||  |   . | ... | .. | | . |.
IQLI--RRLGSGQFGEVWEGLWN----------NTTPVAVKTLKPGTM--DPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQ

GCASKNIELQYEDQLNFAVQIAKGMAYIAAQGMVHMDLAARNCLVAENNLVKVADFGLTR-KIPEGQDYWQSKTVMKLPVKWCAIEALDDRIFSEKSDVW
  . |  ..| . ... | |.| ||||.  |  .| |||||| || |.| .|.||||| |  . . .| . |.. ...|.|| | ||     |. |||||
AINDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVW

AYGVVMWEISSYGAMPYEDVKTQEVQRRVREGLRLEPVPNTNPDYFALAKSCWRLDRHERPSFANMAQELQTYL
..|... ||  || |||  .  .||   | .| |.   || .. .. .   ||. | ..|| |  .   |. |.
SFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase HMTK01.AA Tec 495-763 38 1.1e-64 221.23 In-house 1-254 (254) Show / Hide 
Range on Protein: 495-763
Range on HMM: 1-254/254
Sequence Identity: 38% (104 aa)

LIPRKAIGAGQFGQVYLADQIVKDGDGKDGGNRVSRAVKMLRGGASAEDKTDFESEATVMLELEHENLVQLIGVSMQQRPWLMVLEYLQYGDLRNVLKGC
|   | .| ||||       .|. |  .     |  |.||.. |.  |.  ||  || || .| |..|||| || .||||  .| ||.. | | | |.  
LTFMKELGSGQFG-------VVHLGKWRH-QYDV--AIKMIKEGSMSEE--DFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLR--

ASKNIELQYED--QLNFAVQIAKGMAYIAAQGMVHMDLAARNCLVAENNLVKVADFGLTRKIPEGQDYWQSKTVMKLPVKWCAIEALDDRIFSEKSDVWA
 ..  ..| .    |    .. .||||   .. .| ||||||||| ... |||.|||.|| .    |   | .  | |||||. | .    .| ||||||
-EHKHHFQKNMAILLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLD--DQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWA

YGVVMWEISSYGAMPYEDVKTQEVQRRVREGLRLEPVPNTNPDY-FALAKSCWRLDRHERPSFANMAQELQT
.|| |||. | | ||||  .  ||  .| .|.||.  |   ... .   ..||.    |||.|... .... 
FGVLMWEVFSCGKMPYENMSNSEVVEHVSQGHRLY-RPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase HMTK01.AA S_TKc 495-765 20 2.5e-32 114.64 SMART 1-231 (231) Show / Hide 
Range on Protein: 495-765
Range on HMM: 1-231/231
Sequence Identity: 20% (57 aa)

LIPRKAIGAGQFGQVYLADQIVKDGDGKDGGNRVSRAVKMLRGGASAEDKTDFESEATVMLELEHENLVQLIGVSMQQRPWLMVLEYLQY--GDLRNVLK
    . || | ||.||..  .               |.|...         ....|  .. .  |.|.|.|..|        ||.||.    |||. ..|
YEILRKIGKGAFGKVYKCRHKK---------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIK

GCAS--KNIELQYEDQLNFAVQIAKGMAYIAAQGMVHMDLAARNCLVAENNLVKVADFGLTRKIPEGQDYWQSKTVMKLPVKWCAIEALDDRIFSE-KSD
 . .  ..  .   .   .. ||.....|.  .| .| ||   | |. |   .|..|||| |..          | .     ..| | |    ..  |.|
KRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCD

VWAYGVVMWEISSYGAMPYEDVKTQEVQRRVREGLRLEPVPNTNPDYFALAKSCWRLDRHERPSFANMAQ-----ELQTYL
.|. |....|  . |  |..    |.. ....            |.   . . |.. |  .||.     |      .  ..
WWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HMTK01.AA Pkinase 495-661 23 8.2e-18 64.06 Pfam 1-169 (293) Show / Hide 
Range on Protein: 495-661
Range on HMM: 1-169/293
Sequence Identity: 23% (44 aa)

LIPRKAIGAGQFGQVYLADQIVKDGDGKDGGNRVSRAVKMLRGGASAEDKTDFES-----EATVMLELEHENLVQLIGVSM-QQRPWLMVLEYLQYG---
.   . ||.| ||.||..   .. |.||        ||| ..   . |..   ..     |. .|..| |.| |.|... .  .... ||.||.. |   
YHIGRKIGSGSFGCVYKC---HHKGTGK------IVAVKIIK--KRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY-MVMEYCEGGLYV

-DLRNVLKGCASKNIEL--QYEDQLNFAVQIAKGMAYIAAQGMVHMDLAARNCLVAENNLV----KVADFGLTRK--IPEGQDYW
 ||  ....  ...  .  ....  ... ||..|..|. ..| .| ||   |.|. .|. .    |..|||| ..  .  .. ..
MDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MT
Kinase HMTK01.AA Pkinase 685-765 12 3.1e-05 19.59 Pfam 190-293 (293) Show / Hide 
Range on Protein: 685-765
Range on HMM: 190-293/293
Sequence Identity: 12% (14 aa)

SEKSDVWAYGVVMWEISSYGAMPYEDV----KTQEVQRRVREGLR---LEPVPNTN--------------------PDYFALAKSCWRLDRHERPSFANM
. |.|.|..|....|  . |  |. .     .  . . .... ..    .. |...                    ..   . |.|...| ..||.    
GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT----

AQELQTY--L
|...     .
AEQILQHPWF