Gene HMTK10 (M.brevicollis)

HMTK10

Species: M.brevicollis
Alias: HMTK10
External Links:
Annotation:

Classification

Group: TK
Family: HMTK

Sequence

Name Sequence Type Origin Length Description Download
HMTK10.AA Protein None 1062 None Fasta, JSON
HMTK10.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of HMTK10.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
NUDIX HMTK10.AA NUDIX 314-376 29 1.7e-08 32.12 Pfam 1-54 (129) Show / Hide 
Range on Protein: 314-376
Range on HMM: 1-54/129
Sequence Identity: 29% (19 aa)

RALASSSWAFTPEGDAVYRNGRRVAEFVAIRREDN--GKLAFPGGFVAAGEKVPQALRREFGEEV
. .| . . |...|           ... .|| ..  | ..||||.| .|| . .|.|||. ||.
HHRAVGCVIFNEDG-----------RVLLVRRSRHPPGCWEFPGGKVEPGETPEEAARRELWEET
PID HMTK10.AA PID 617-717 17 1.8e-13 49.06 Pfam 29-153 (153) Show / Hide 
Range on Protein: 617-717
Range on HMM: 29-153/153
Sequence Identity: 17% (22 aa)

DALEEDAEE-------------SGGRTAPMVTIHVTPSKLTVLEDGL---EEPHVNVAVKYISFTGV--DAS-NPKIFAF-IANQPKAASMLCHVFLCKV
.... ....             . ...   ...|.. ...... .     .|. .. ... ||| ..  |   . ..||. |. ...   . |||| |. 
ECIHRVCMQVPAKKINKIRGHRGHWQHWQKIDLHISTDGVKWIDEKTEAEQECMHDHPMRNISFCADGGDPHVDMRYFAYDICRDGPCQRFACHVFWCCK

--KAAAVSDAVAHAFEKA--QELRA
   | ... .|  ||...  | |||
TQQAQDIAQTVGQAFQVCYQQCLRA
PTB HMTK10.AA PTB 591-722 11 2.6e-05 23.94 SMART 1-156 (156) Show / Hide 
Range on Protein: 591-722
Range on HMM: 1-156/156
Sequence Identity: 11% (18 aa)

PRFDADRAVPVGFPTTEGRL-------NEAATPDALEEDAEESGGRTAPMVTIHVTPSKLTVLEDGLEEPHVNVAVKYISFTGVDA-----------SNP
|   . ..  .|   ..           ...  ..... .  .....   ...|.... .... .  ..  .. ... ||| ..|            ...
PWGCCFNVWYLGCVEVPHHRNSMAPGKGMQVCQECMRKIR--QHWKHWQKMHLHISVDGVKLIDPQTKQVIHHHPIHRISFCAHDPYRWNTGGHHCCDDD

KIFAFIANQPKAA-------SMLCHVFLCKVKA-AAVSDAVAHAFEKAQELRALRRVG
..|..|.  | .         . ||||.|. ..  ... .. .||... .... .|  
RCFGYICRHPNDRGSHRMTYWFRCHVFWCEDPHAEDIAQTIGQAFQVCYQQCQKQRCQ
Kinase HMTK10.AA HMTK 749-1013 42 2e-176 592.37 In-house 1-291 (291) Show / Hide 
Range on Protein: 749-1013
Range on HMM: 1-291/291
Sequence Identity: 42% (123 aa)

LHVKMIIGHGQFG-----------------KVYLAEYQPQGLDAARQSVQSSKVAVKLMKADSSSLDIEEFMQEAHMLSVVKHPKCLELIGVCFERLPWL
|.....||.||||                 ||||||......|....|.|....|||....|.|. |.|||..||.......||....|.|||... |||
LKAIKVIGAGQFGMVQCLRLAPPDEGCTSLKVYLAEWSVKDGDGKDDSNQPHHRAVKMLRGDASHEDREEFLREAEVMCQLRHPNLVQLVGVCMQQRPWL

IVVEFMQYKDLGVILRQAKKAKMYFRTHEQLSLMAQVAEGMVFLSSKRLIHRDIAARNIMLHHKSQVKIGDFGLTRQLPPHQDYWRLDKAG-RLPVKYMA
.|.|.|||.||...|............||||....|.|.||....|.|..|.|.||||....|..||||.||||||.|.|.||||.|.|.. .||.|.||
CVLEYMQYGDLRNVLKTCREKNIQLTYHEQLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHLRKHMVKLPIKWMA

IETLT--LKRFGIESDVWAFGVYMWEILAYAETPWESQGIVSKDIRRALIEGKRIAKP------EYIYQLARTCWNKEKSSRPTFPQLHQR
.|...   |.|...||||||||.||||..|.|.|.|||.|..|...|...||.|...|      .....|..|||.|....|||| || ..
PEAMDGKRKIFSEKSDVWAFGVTMWEIWMYGEQPYESQQIKNKEVQRHVREGRRLTQPPPDDCPDDFWDLMCTCWHKDPHQRPTFAQLQKM
Kinase HMTK10.AA TK 749-1014 19 3.2e-92 309.41 In-house 1-486 (486) Show / Hide 
Range on Protein: 749-1014
Range on HMM: 1-486/486
Sequence Identity: 19% (97 aa)

LHVKMIIGHGQFG---KVYLAEYQPQGLDAARQ---------------SVQSSKVAVKLMKADSSSLDIEEFM-------------QEAHMLSVVK----
...   .|.||||   .||..|..... . ...               . .  .|||| .|..... . |.|.             .||..... .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPKCLELIGVCFER------------LPWLIVVEFMQYKD----LGVILRQAKKAKMY-----------------------------------------
 ||  . |.|||..              ||.||.|.|.. |    |   ||. .. ..                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FRTHEQLSLMAQVAEGMVFLSSK------RLIHRDIAARNIMLHHKSQ-----------VKIGDFG---
                               . .|..|  ..|.|.|| .|.||      ...|||.||||...... .           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LTRQLPPHQDYWRLD-----------------------KAGRLPVKYMAIETLT---------LKRFGIESDVWAFGVYMWEILAYAETPWESQG
     |.| .....||.| .                       . |.||...|| |.|.          ..| ..||||.||| ||||. |...|.  . 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

IV--------SKDIRRALIEG--------------KRIAKP------------------EYIYQLARTCWNKEKSSRPTFPQLHQRL
           ... . | .|               | ..|                  | .|.| . ||... . |||| |||..|
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase HMTK10.AA TyrKc 749-1014 31 2.1e-91 310.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 749-1014
Range on HMM: 1-280/280
Sequence Identity: 31% (93 aa)

LHVKMIIGHGQFGKVYLAEYQPQGLDAARQSVQSSKVAVKLMKADSSSLDIEEFMQEAHMLSVV--KHPKCLELIGVCFER-------LPWLIVVEFMQY
.. . ..|.|.||.||....               .|||| .|.|.    .|.||.|| ... .  .||  . |.||| .         | .||.|.| .
ITLGKKLGEGAFGEVYKGTWK-------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH

KDLGVILRQAKKAKMYFRTHEQLSLMAQVAEGMVFLSSKRLIHRDIAARNIMLHHKSQVKIGDFGLTRQLPPH------QDYWRLDK--AGR--LPVKYM
 ||   ||  ..    . . . || . |.|.|| .|.||..||||.||||...... .|||.||||.| .  .      .|| |  .   |.  ||.. |
GDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

AIETLTLKRFGIESDVWAFGVYMWEILAYAETPWES---QGIVSKDIRRALIEGKRIAKPEY------------IYQLARTCWNKEKSSRPTFPQLHQRL
|.|..  ..| ..||||.||| ||||. | ..|..    | .  ..... . .|.|  .|..            .||. ..||. . ..|||| ..|...
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase HMTK10.AA Pkinase_Tyr 749-1014 34 2.6e-87 296.34 Pfam 1-270 (270) Show / Hide 
Range on Protein: 749-1014
Range on HMM: 1-270/270
Sequence Identity: 34% (97 aa)

LHVKMIIGHGQFGKVYLAEYQPQGLDAARQSVQSSKVAVKLMKADSSSLD--IEEFMQEAHMLSVV-KHPKCLELIGVCF-ERLP--WLIVVEFMQYKDL
..    .|.|.||.||.... .       .. .  .|||| .| .... .  .|.||.|| ...   .||. . |.|||  .. |  ..||.|.|.. ||
ITFGKKLGEGAFGEVYKGTWKG------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL

GVILRQAKKAKMYFRTHEQLSLMAQVAEGMVFLSSKRLIHRDIAARNIMLHHKSQVKIGDFGLTRQLPPHQDYW-RLDKAGRLPVKYMAIETLTLKRFGI
   ||. .  |  . ... |.  .|.|.|| .|.||..||||.||||...... .|||.||||.| .  . ||  |  . |.||.| || | .  ..| .
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

ESDVWAFGVYMWEILAYAETP-WESQGIVSKDIRRAL-IEGKRIAKPE----YIYQLARTCWNKEKSSRPTFPQLHQRL
.||||.||| ||||. | |.| .  .|.   .. ...  .| | ..||     ||.| . ||... . |||| ..|..|
KSDVWSFGVLMWEIFTYGEQPTY--PGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase HMTK10.AA UTK 749-1014 29 1.6e-69 236.97 In-house 1-296 (296) Show / Hide 
Range on Protein: 749-1014
Range on HMM: 1-296/296
Sequence Identity: 29% (88 aa)

LHVKMIIGHGQFGKVYLAEYQPQGLDAARQSVQSSKVAVKLMKADSSSLDIEE----FMQEAH---MLSVVK-HPKCLELIGVCFERLPWLIVVEFMQYK
..    .|.|.|| |..|....     ..  .. ..||||  ...... . .|    || ||    |.. .. ||. | |.|||.   ||.||.|.|.  
VQLGRQLGQGAFGEVHKARFTQ-----CSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENG

DLGVILRQAKKAKM----YFRTHEQLSLMAQVAEGMVFLSSKRLIHRDIAARNIMLHHK-------SQVKIGDFG---LTRQLPP--------HQDYWRL
||   || .... .    ... |..|. ....|.|| .|.|....|||.||||. .|.        ...||.|||   ..|...          ..| . 
DLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMA

DKAGRLPVKYMAIETLTLK-RFGIESDVWAFGVYMWEILAYAETPWESQGIVSKDIRRALIEG--KRIAK----PEYIYQLARTCWNKEKSSRPTFPQLH
. ..|.|.. || | ||   || . ||||.||| .|||.... .|..  |.   ..  .. .|   | ..    |. .|.| . ||... . ||.|..| 
QHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYP--GMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLV

QRL
|..
QQM
Kinase HMTK10.AA CTKA 749-1014 32 7.4e-68 227.06 In-house 1-290 (290) Show / Hide 
Range on Protein: 749-1014
Range on HMM: 1-290/290
Sequence Identity: 32% (95 aa)

LHVKMIIGHGQFGKVYLAEYQPQGLDAARQSVQSSKVAVKLMKADSSSLDIEEFMQEAHMLS--VVKHPKCLELIGVCFERLPWLIVVEFMQYKDLGVIL
. .   || |..| |. |   |.  |   |  .   |||| .|..    | ..|  || .||     ||  | |.|||    ||. . |.||| ||  .|
HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCYL

RQAKKAK------------------MYFRTHEQLSLMAQVAEGMVFLSSKRLIHRDIAARNIMLHHKSQVKIGDFGLTRQLPPHQDYWRLDKAGRLPVKY
|    |                   .  ..||| .  .|.| || .|..  ..||| |.||..|     .|| |||. | |     |. . . ...||  
RACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRW

MAIETLTLKRFGIESDVWAFGVYMWEILAYAETPWESQGIVSKDIRRALIEG--KRIAKP----EYIYQLARTCWNKEKSSRPTFPQLHQRL
||.|.|   .|   |||||||| .|||.  .|.||   .   . .  |   .  .|   |    . .| .  .||  |   |||| .|   |
MAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPW--RHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase HMTK10.AA TK-Unique 749-1014 29 2.5e-64 220.02 In-house 1-294 (294) Show / Hide 
Range on Protein: 749-1014
Range on HMM: 1-294/294
Sequence Identity: 29% (89 aa)

LHVKMIIGHGQFGKVYLAEYQPQGLDAARQSVQSSKVAVKLMKADSSSLDIEEFMQEAHMLSVVK-HPKCLELIGVCFERL-PWLIVVEFMQYKDLGVIL
| |. .|| |.|| |. .|. .        . . ..||||. |.... .|  .|..|. |.. .. ||  . ..|.| .   ||.|. |.... .|   |
LEVGDVIGEGAFGQVWRGEVWGIW----KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYL

RQAKKA----------------------KMYFRTHEQLSLMAQVAEGMVFLSS--KRLIHRDIAARNIMLHHKSQVKIGDFGLTRQLPPHQDYWRLDKAG
|. ..|                      . .   .  .. . |.| || .|.|  |. .|||..|||..| .. ..||.|||..| .  ...| . .. |
RTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG

RLPVKYMAIETLT--LKRF-GIESDVWAFGVYMWEILAYAETPWESQGIVSKDIRRALIEGKRIAKPEYI-----YQLARTCWNKEKSSRPTFPQLHQRL
|.|...|| | |    . .  ..||||.||| ||||. . ..|    |. .|||.... .|.|  .||.      |.| ..||..| ..||.| |. .||
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPY--PGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase HMTK10.AA EGFR 749-1015 30 8.4e-56 183.68 In-house 1-258 (258) Show / Hide 
Range on Protein: 749-1015
Range on HMM: 1-258/258
Sequence Identity: 30% (82 aa)

LHVKMIIGHGQFGKVYLAEYQPQGLDAARQSVQSSKVAVKLMKADSSSLDIEEFMQEAHMLSVVKHPKCLELIGVCFERLPWLIVVEFMQYKDLGVILRQ
|    . | | ||.||   . |.|     ..|.   ||.| ..  ..    ||...|| ..  |.||. . |.||| .    . .|   ||  .| .|  
LKKVKVLGSGAFGTVYKGIWIPEG-----ENVKIP-VAIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ--MQLV--TQYMPYGCLLDY

AKKAKMYFRTHEQLSLMAQVAEGMVFLSSKRLIHRDIAARNIMLHHKSQVKIGDFGLTRQLPPHQDYWRLDKAGRLPVKYMAIETLTLKRFGIESDVWAF
 .. |     ...|    |.| ||..|  .|..||| ||||...   ..||| |||| . |.. ..  .  . |..|.| ||.| .  ...  .||||..
VRQHKDNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEYHA-QGGKMPIKWMALECIHHRCYTHQSDVWSY

GVYMWEILAYAETPWESQGIVSKDIRRALIEGKRIAKPEY----IYQLARTCWNKEKSSRPTFPQLHQRLE
|| .||.. . . |..  ||  ..|   | .|.| . |.     .|..   ||   . .|||| .| ....
GVTCWELMTFGQKPYD--GIPAREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDEDMRPTFKELYEEFK
Kinase HMTK10.AA Axl 749-1012 34 1.4e-55 191.01 In-house 1-267 (267) Show / Hide 
Range on Protein: 749-1012
Range on HMM: 1-267/267
Sequence Identity: 34% (95 aa)

LHVKMIIGHGQFGKVYLAEYQPQGLDAARQSVQSSKVAVKLMKAD-SSSLDIEEFMQEAHMLSVVKHPKCLELIGVCF-----ERLPW-LIVVEFMQYKD
. .  ..|.| || |  ..     |.    |..  ||||| ||.| ... .||||..||  .   .||. . |||||.     .|.|  .... ||.. |
FVLGKMLGEGEFGSVMEGQ-----LKQEDGSFV--KVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGD

LGVILRQAK--KAKMYFRTHEQLSLMAQVAEGMVFLSSKRLIHRDIAARNIMLHHKSQVKIGDFGLTRQLPPHQDYWRLDKAGRLPVKYMAIETLTLKRF
|   |  ..  .  .|  .   .  |. .| || .||... ||||.|||| ||.    | . |||| ...    ||.|  .. ..|||..||| |  . .
LHTFLLYSRLGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKI-YSGDYYRQGCIAKMPVKWIAIESLADRVY

GIESDVWAFGVYMWEILAYAETPWESQGIVSKDIRRALIEGKRIAKP----EYIYQLARTCWNKEKSSRPTFPQLHQ
  .|||||||| ||||     ||.   |.  ...   ||.|.|. .|    . .|.|   ||. .   ||.| .| .
TSKSDVWAFGVTMWEIMTRGQTPY--PGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase HMTK10.AA Fer 749-1015 30 2e-55 187.26 In-house 1-283 (283) Show / Hide 
Range on Protein: 749-1015
Range on HMM: 1-283/283
Sequence Identity: 30% (88 aa)

LHVKMIIGHGQFGKVYLAE-----YQPQGLDAARQSVQSSKVAVKLMKADSSSLD-IEEFMQEAHMLSV-VKHPKCLELIGVCFERLPWLIVVEFMQYKD
 . . ..| | ||.||...     . . ...     | . .|.|| .|..... . |.|||.|| ..    .||    ..|||  . | .|| ||.   .
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHV-----VNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGS

LGVILRQAKKAKMYFRTHEQLSLMAQVAEGMVFLSSKRLIHRDIAARNIMLHH-KSQVK--IGDFGLTRQLPPHQDYWRLD-KAGRLPVKYMAIETLTLK
|   |.  |.      . | .   .|.| || .| ||  |||||||||. .|. | ..|  | |||. ||.  ..   ... || ..|....| ||.. .
LDSYLKKNKNK--TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTG

RFGIESDVWAFGVYMWEILAYAETPWES------QGIVSKDIRRALIE-GKRIAKP----EYIYQLAR-TCWNKEKSSRPTFPQLHQRLE
 .  ..|||.||| .||| . ...|..        . | |. |.. |. |..   |    . |.|.   .||.|. . |||. ...|.|.
IYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase HMTK10.AA Abl 749-1014 33 3.2e-55 182.46 In-house 1-252 (252) Show / Hide 
Range on Protein: 749-1014
Range on HMM: 1-252/252
Sequence Identity: 33% (90 aa)

LHVKMIIGHGQFGKVYLAEYQPQGLDAARQSVQSSKVAVKLMKADSSSLDIEEFMQEAHMLSVVKHPKCLELIGVCFERLPWLIVVEFMQYKDLGVILRQ
. .|  .| ||.| || . ..            .  |||| .| |  .....||..|| ..  .|||   .|.|||    |. |. ||| |  |   ||.
IMMKHKLGGGQYGEVYEGVWK----------RHDCTVAVKTLKED--TMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRE

AKKAKMYFRTHEQLSLMAQVAEGMVFLSSKRLIHRDIAARNIMLHHKSQVKIGDFGLTRQLPPHQDYWRLDKAGRLPVKYMAIETLTLKRFGIESDVWAF
... ..       | . .|.| || .| ..  ||||.|||| ..  .  ||. ||||.| .  ..| .      . |.|. | | |  ..| . ||||||
CDREEL--PAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMM--KDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAF

GVYMWEILAYAETPWESQGIVSKDIRRALIEGKRIAKPE----YIYQLARTCWNKEKSSRPTFPQLHQRL
|| .|||  |  .|.   ||  ...   | .| |. .||     .|.| | ||. ... ||.| ..|...
GVLLWEIATYGMSPYP--GIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM
Kinase HMTK10.AA FGFR 867-1014 41 5.4e-45 151.28 In-house 144-293 (293) Show / Hide 
Range on Protein: 867-1014
Range on HMM: 144-293/293
Sequence Identity: 41% (63 aa)

QVAEGMVFLSSKRLIHRDIAARNIMLHHKSQVKIGDFGLTRQLPPHQDYWRLDKAGRLPVKYMAIETLTLKRFGIESDVWAFGVYMWEILAYAETPWESQ
||| || .| |.. |||| ||||.        || |||| |    . || |    ||||.| || | |  . .  .|||| .|| .|||. | ..|    
QVARGMEYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDI-HCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMTYGGQPYP--

GIV-SKDIRRALIEGKRIAKPEY----IYQLARTCWNKEKSSRPTFPQLHQRL
.|    ..   |.||.|. ||.     || . . ||  . . |||| ||   |
HIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase HMTK10.AA S_TKc 749-1018 22 4.7e-32 113.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 749-1018
Range on HMM: 1-231/231
Sequence Identity: 22% (62 aa)

LHVKMIIGHGQFGKVYLAEYQPQGLDAARQSVQSSKVAVKLMKADSSSLDIEEFMQEAHMLSVVKHPKCLELIGVCFERLPWLIVVEFMQY--KDLGVIL
 ..  .||.| |||||..                 .||.| .|        | ...|  .|.  .||    |..|. .     .| |..     ||  ..
YEILRKIGKGAFGKVYKCRHKK----------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI

RQAKKAKMY--FRTHEQLSLMAQVAEGMVFLSSKRLIHRDIAARNIMLHHKSQVKIGDFGLTRQLPPHQDYWRLDKAGRLPVKYMAIETLTLKRFGI-ES
.. .. . .  |   .  ..|.|..... .. |.. ||||.   ||.| .  ..||.|||| |||          .       ||| | |    .|  ..
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKC

DVWAFGVYMWEILAYAETPWESQGIVSKDIRRALIEGKRIAKPEYIYQLARTCWNKEKSSRPTFPQLHQ-----RLEDLL
|.|..|. ..| |.  ..|..    . . ... .        ..   .. | |..|. . |||  .. |     ..   .
DWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HMTK10.AA Pkinase 749-916 22 4.7e-19 68.44 Pfam 1-169 (293) Show / Hide 
Range on Protein: 749-916
Range on HMM: 1-169/293
Sequence Identity: 22% (42 aa)

LHVKMIIGHGQFGKVYLAEYQPQGLDAARQSVQSSKVAVKLMKADSSSLDIEEFMQ-----EAHMLSVVKHPKCLELIGVC--FERLPWLIVVEFMQYK-
.|.. .|| | ||.||..  .  |           .|||| .| .  . . .. ..     |....  ..||  ..|....    ..   .| |...   
YHIGRKIGSGSFGCVYKCHHKGTGK----------IVAVKIIKKR--HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIY--MVMEYCEGGL

---DLGVILRQAKKAKMYFRTHEQLSLMAQVAEGMVFLSSKRLIHRDIAARNIMLHHKSQV----KIGDFGLTRQ--LPPHQDYW
   ||  ...  .. ..||  .|  . | |...|. .. |.. ||||.   ||..... ..    ||.|||| .|  . . . ..
YVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MT
Kinase HMTK10.AA FGFR 749-836 30 1.2e-10 32.45 In-house 1-86 (293) Show / Hide 
Range on Protein: 749-836
Range on HMM: 1-86/293
Sequence Identity: 30% (27 aa)

LHVKMIIGHGQFGKVYLAEYQPQGLDAARQSVQSSKVAVKLMKADSSSLDIEEFMQEAHMLSVV-KHPKCLELIGVCFERLPWLIVVEF
| .  ..| | ||.| .||.   |.| .|.  . ..|||| .|.. .  |.     |  |. .. ||.  . |.|.|    |  ..||.
LTLGKMLGEGCFGQVWMAEAK--GIDCDRPE-KEITVAVKMLKMNHTDKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEY
Kinase HMTK10.AA Pkinase 940-1014 16 0.001374 13.77 Pfam 190-293 (293) Show / Hide 
Range on Protein: 940-1014
Range on HMM: 190-293/293
Sequence Identity: 16% (17 aa)

GIESDVWAFGVYMWEILAYAETPWESQ----GIVSKDIRRALIEGKRIAKP-------------------------EYIYQLARTCWNKEKSSRPTFPQL
| ..|.|..|. ..| |   ..|. ..    . .... . ..| |...  .                         |   .. . |..|  ..|||..|.
GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

HQR--L
 |   .
LQHPWF