RTKA3

Species: M.brevicollis
Alias: RTKA3
External Links:
Annotation:

Classification

Group: TK
Family: RTKA

Sequence

Name Sequence Type Origin Length Description Download
RTKA3.AA Protein None 888 None Fasta, JSON
RTKA3.kin_dom Protein Kinase Domain None 238 None Fasta, JSON

Protein domain

Protein domains of RTKA3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LDLa RTKA3.AA LDLa 369-409 27 2.3e-05 22.07 SMART 1-47 (47) Show / Hide
Range on Protein: 369-409
Range on HMM: 1-47/47
Sequence Identity: 27% (13 aa)

FCPKP-AQNVVCPSSGSALEIVQICDGVADCPNGEDE------ASCHG
 ||        |. .|  .   . |||. ||..|.||      . |. 
TCPPDHPNQFQCG-NGRCIPKSWVCDGDNDCGDGSDEWPFFDPENCPQ

Ldl_recept_a RTKA3.AA Ldl_recept_a 392-407 50 0.000122 16.9 Pfam 24-41 (41) Show / Hide
Range on Protein: 392-407
Range on HMM: 24-41/41
Sequence Identity: 50% (9 aa)

CDGVADCPNGEDE--ASC
||| .|| .|.||  ..|
CDGDPDCHDGSDEWPENC

Kinase RTKA3.AA RTKA 644-885 52 3.1e-182 611.69 In-house 1-314 (314) Show / Hide
Range on Protein: 644-885
Range on HMM: 1-314/314
Sequence Identity: 52% (166 aa)

IKVEHAVGHGNFSDVYQASLLRGE----QAPWCVAIKKCH----ADKTTLLAWLREIMLLHSFRDQPNIIGLHGVLLSVAK---LSNLSAVLEWAPHGNL
..|.| ||||.||.||||||...|    |.|.|||||.|.    .|||||.||.||||||||.||.|.|||||||.|....    |....|.||.|||||
MQVRHVVGHGHFSQVYQASLQDMEDEMRQGPQCVAIKECDDLMLNDKTTLSAWMREIMLLHSMRDCPHIIGLHGVCLPREDKHHQSHCGMVCEWCPHGNL

RDFVRRHP------------------------LSEAQLHQALHQTV-------SALAYLAKLDIVHRDVAARNVLVMAASPTFVCKLGDFGLSRIMPSSE
|||||.||                        |||||.||||.|..       .|.|||||..||||||||||||||...|.|.|||.||||||.||||.
RDFVRQHPHFSAPVVATIAMQHSGEPNASPKLLSEAQCHQALLQMCPCWAQVAQAMAYLAKCGIVHRDVAARNVLVMSLQPAFHCKLADFGLSRVMPSSD

YYKSTADSEMPFRWMALECLVARRYSEHSDVWAFGVLVWELVTAGATPWQ------------------------------GMELPAIIQQLKAGAALPLP
||||.||.||||||||.||...||||||||||.||||||||.|.|.||||                              |..|..|||.||.|..||.|
YYKSRADDEMPFRWMAPECIMERRYSEHSDVWSFGVLVWELLTHGQTPWQNCESHQIVALLMRGERLTFAPTINAALRDSGCDLHHIIQMLKQGQTLPMP

PGAPSIAQRFALPL
|..|...|||..  
PCCPPCLQRFCFWC

Kinase RTKA3.AA TK 644-875 18 9.7e-74 246.37 In-house 1-444 (486) Show / Hide
Range on Protein: 644-875
Range on HMM: 1-444/486
Sequence Identity: 18% (83 aa)

IKVEHAVGHGNFS---DVYQASLLR----------------------GEQAPWCVAIKKCHADKTTLLAW------------------LREIMLLHS-FR
|....  |.|.|    .||.. . .                      .|...  ||.| .... ..  .                   ..|......   
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DQPNIIGLHGVLLSVAKL---------SNLSAVLEWAPHGN----LRDFVRRH-----------------------------------------------
. |||. |.|| . ..             .  |.|..|||.    |||. |..                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------PLSEAQLHQ-------------------ALHQTVSALAYLAKLDI------VHRDVAARNVLVMAASP--------TFVCKLGDFG----
          ||....|.|                     .|  ....||... .      ||||.||||.||    .        ..|||..|||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LSRIMPS------------------------SEYYKSTADSEMPFRWMALECLV---------ARRYSEHSDVWAFGVLVWELVTAGATPWQG-ME
    |.| ..|                        ..||... .  .|.|||| |||           ..... ||||.||||.||..| |..|. | | 
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

L---------PAIIQQLKAG--------------AALPLPPGAP
            ....|..|                .| ||..|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCP

Kinase RTKA3.AA Pkinase_Tyr 644-875 31 1.4e-64 219.39 Pfam 1-242 (270) Show / Hide
Range on Protein: 644-875
Range on HMM: 1-242/270
Sequence Identity: 31% (77 aa)

IKVEHAVGHGNFSDVYQASLL-RGEQAPWCVAIKKC--HADKTT--LLAWLREIMLLHSFRDQPNIIGLHGVLLSVAKLSNLSAVLEWAPHGNLRDFVRR
|.  .  |.|.| .||.. .   ...    ||.|..  .|..    . . .||. ..... . |||. |.|| ..  . ...  |.| .|||.|.|. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H-----PLSEAQLHQALHQTVSALAYLAKLDIVHRDVAARNVLVMAASPTFVCKLGDFGLSRIMPSSEYY-KSTADSEMPFRWMALECLVARRYSEHSDV
|     ||.  .| |  .|  ....||.   ..|||.||||.||     ..|.| .||||.| . . .|| ... .. .| .|||.||.  ..... |||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WAFGVLVWELVTAGATP-WQGMELPAIIQQL-KAGAALPLPPGAP
|.|||| ||..| |..| ..||    ..... . |  .| |...|
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCP

Kinase RTKA3.AA RTKF 644-882 35 8.8e-64 204.24 In-house 1-245 (272) Show / Hide
Range on Protein: 644-882
Range on HMM: 1-245/272
Sequence Identity: 35% (87 aa)

IKVEHAVGHGNFSDVYQASLLRGEQAPWCVAIKKCHADKTTLLAW----LREIMLLHSFRDQPNIIGLHGVLLSVAKLSNLSAVLEWAPHGNLRDFVRRH
| ..  .|||.|  | ..   .       ||||  |     .  |    |||  ..    . | || ..|.| ..     .. |.| |||| .| .  .|
IMLGEQLGHGHFGRVHHGYWRQQKGQRQPVAIKHIHT--QDMMNWRRQMLRECCAMNRVGQHPHIIQFFGILMTPFEQNEMAFVMEFAPHGDMRRYLQQH

P--LSEAQLHQALHQ-TVSALAYLAKLDIVHRDVAARNVLVMAASPTFVCKLGDFGLSRIMPSS-EYYKSTADSEMPFRWMALECLVARRYSEHSDVWAF
   |  |.. .| ||   .|...  .   |||||||||||| .  |.   || |||| |.   . .|| |  . | |||||| |   .||... |||| |
DVDLGRAHMLDAAHQVVAEAMVFISRQGLVHRDVAARNVLVFEDQPRMYVKLTDFGLARVLSQHQDYYRSMQNEELPFRWMAPEAIMHRRFTQKSDVWSF

GVLVWELVTAGATPWQGMELPAIIQQLKAGAALPLPPGAPSIAQRFA
|.. .||.| |  |. .|. |...|    |  | .|. .|    ||.
GMMLFELFTRGDVPYGNMPHPVVLQFIRRGKTLQMPDSCPPDVCRFV

Kinase RTKA3.AA RTKL 646-875 37 2.3e-59 155.39 In-house 3-231 (259) Show / Hide
Range on Protein: 646-875
Range on HMM: 3-231/259
Sequence Identity: 37% (90 aa)

VEHAVGHGNFSDVYQASLLRGEQAPWCVAIKKCHADKTTL--LAWLREIMLLHSFRDQPNIIGLHGVLLSVAKLSNLSAVLEWAPHGNLRDFVRRHPLSE
 |   | |.|| ||||. . .   |  ||||  |  .      | |.| .|||   . |.|| .||. .   .   .  .|| || |||| . |      
LENELGRGQFSRVYQAR-SCSRMVPTQVAIKIAHEQQSKNQMDAVLYEAVLLHQL-HHPHIIQMHGCTAVPQR---MAMILELAPNGNLREYLRHDDAPS

AQLHQA-----LHQTVSALAYLAKLDIVHRDVAARNVLVMAASPTFVCKLGDFGLSRIMPSS-EYYKSTADSEMPFRWMALECLVARRYSEHSDVWAFGV
.   |.     | |  .||||.    ..||| |.||||     |  |||| |||||| .    .||    . ..||||| .| |.       ||||||||
SSWPQRQRLQWLCQVAQALAYIHQRRMIHRDLASRNVLLV---PMMVCKLSDFGLSRRLQNEQDYYRPQQNDHVPFRWMSPETLNGKPHTMASDVWAFGV

LVWELVTAGATPWQGMELPAIIQQLKAGAALPLPPGAP
. .| .| |  |. ..  | ..  ||    | || | |
VCYEVIT-GQVPYADTDMPQVVALLKNEGRLALPAGTP

Kinase RTKA3.AA UTK 644-875 28 3.4e-57 194.23 In-house 1-268 (296) Show / Hide
Range on Protein: 644-875
Range on HMM: 1-268/296
Sequence Identity: 28% (78 aa)

IKVEHAVGHGNFSDVYQASLLR-GEQAPW-CVAIKKCH--ADKTTLLA----WLREIM---LLHSFRDQPNIIGLHGVLLSVAKLSNLSAVLEWAPHGNL
..     |.|.| .|. |.. .  |...   ||.|.|   ||...  .    ...|     ..  |.  ||...| ||   . . . .  |.| .. |.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGV---CTQEEPWMIVTEYMENGDL

RDFVRRHPL---------SEAQLHQALHQTVSALAYLAKLDIVHRDVAARNVLVMAAS----PTFVCKLGDFG---LSRIMP---------SSEYYKSTA
|...|||.          .. |. .   .  ....||.   .||||.||||.|| . .       |||..|||   .|| ..         .|.||... 
RSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQH

DSEMPFRWMALECLVAR-RYSEHSDVWAFGVLVWELVTAGATPWQGMELPAIIQQLKAG--AALPLPPGAP
. ..|.|||| |.|. . |....||||.|||..||..| |..|. ||  .....|. .|  . .| |.. |
QDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCP

Kinase RTKA3.AA TyrKc 644-881 27 5.5e-53 183.26 SMART 1-280 (280) Show / Hide
Range on Protein: 644-881
Range on HMM: 1-280/280
Sequence Identity: 27% (81 aa)

IKVEHAVGHGNFSDVYQASLLRGEQAPWCVAIKKCHADKTTLLAWLREIMLLHSF-RDQPNIIGLHGVLLSV----AKLSNLSAVLEWAPHGNLRDFVRR
|. ..  |.|.|  ||.. .         ||.|....|.  . . .||. .....  . |||. |.|| ..          |  |.| .|||.|.|. |.
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

HP--LSEAQLHQALHQTVSALAYLAKLDIVHRDVAARNVLVMAASPTFVCKLGDFGLSRIMPSS-------EYYKSTA--DSE--MPFRWMALECLVARR
|   |. ..|..  .|  .  .||..  ..||| ||||.||   .  ...| .||||||   .        .||...   ..   .| ||||.||.  ..
HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLV---GENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

YSEHSDVWAFGVLVWELVTAGATPWQG-----MELPAIIQQLKAGAALPLPPG--------APS----------------------IAQRF
... ||||.|||. ||. | |..|. |     |.   .|...|.|  .| ||         .|.                      | ..|
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase RTKA3.AA TK-Unique 644-873 29 1.5e-49 169.0 In-house 1-263 (294) Show / Hide
Range on Protein: 644-873
Range on HMM: 1-263/294
Sequence Identity: 29% (79 aa)

IKVEHAVGHGNFSDVYQASLLRGE---QAPWCVAIKKCH--ADKTTLLAWLREIMLLHSFRDQPNIIGLHGVLLSVAKLSNLSAVLEWAPHGNLRDFVR-
..|.  .| |.|. |. . . ..     .. |||.|...  |..|.  . |.|| .. .  |.|||. . |.  .. .  .   ..|..| |||... | 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGC--CTKSDEPWMIIMEYCPCGNLQHYLRT

------RH--------------------PLSEAQLHQALHQTVSALAYLAK--LDIVHRDVAARNVLVMAASPTFVCKLGDFGLSR-IMPSSEYYKSTAD
      .|                    |.|. .| . . |  ....|||.    |||||..|||||.      .|||..|||..| ..   .| ...  
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE---DKVCKICDFGMARDVYTNGVYSMMCSQ

SEMPFRWMALECLV--ARRY-SEHSDVWAFGVLVWELVTAGATPWQGMELPAIIQQLKAGAALPLPPG
...| ||||.| |    . | .. ||||.|||| ||..| ||.|  ||  . |......|  .|.|..
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEH

Kinase RTKA3.AA FAK 644-875 32 3.4e-41 135.7 In-house 1-252 (285) Show / Hide
Range on Protein: 644-875
Range on HMM: 1-252/285
Sequence Identity: 32% (85 aa)

IKVEHAVGHGNFSDVYQASLLRGEQ------------------------APWCVAIKKCHADKTTLLA--WLREIMLLHSFRDQPNIIGLHGVLLSVAKL
|.    .| | | ||||   .  ..                            |||| | .. .       . | . .. | | | |. | |.     . 
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQF-DHPHIVKLIGIC----EE

SNLSAVLEWAPHGNLRDFVRRH--PLSEAQLHQALHQTVSALAYLAKLDIVHRDVAARNVLVMAASPTFVCKLGDFGLSRIMPSSEYYKSTADSEMPFRW
     ..| .. | || . .|.   |. | |     |   |.|||     ||||.|||||||  .||. | ||||||||| |  ..|||..    .| .|
MPIWIIMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLV--SSPDCV-KLGDFGLSRWMHDHSYYKASPKGKLPIKW

MALECLVARRYSEHSDVWAFGVLVWELVTAGATPWQGMELPAIIQQLKAGAALPLPPGAP
|. |    ||.   |||| ||| .||    |  | |...   .| ..  |  ||.||  |
MSPESINFRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCP

Kinase RTKA3.AA CTKA 759-877 38 4.8e-41 135.58 In-house 146-264 (290) Show / Hide
Range on Protein: 759-877
Range on HMM: 146-264/290
Sequence Identity: 38% (47 aa)

YLAKLDIVHRDVAARNVLVMAASPTFVCKLGDFGLSRIMPSS-EYYKSTADSEMPFRWMALECLVARRYSEHSDVWAFGVLVWELVTAGATPWQGMELPA
||| ...|||| |.||.|.       . |. |||..|   .   || .   . ||.|||| | |   ..|  |||||||||.||. . | .|| .|    
YLAEMGFVHRDLACRNCLLGQYC---HIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQE

IIQQLKAG--AALPLPPGAPSI
. |   ..   .||.|. .|..
VCQAYTSHGMRRLPVPRNCPQV

Kinase RTKA3.AA EGFR 644-872 35 2.9e-40 131.28 In-house 1-226 (258) Show / Hide
Range on Protein: 644-872
Range on HMM: 1-226/258
Sequence Identity: 35% (83 aa)

IKVEHAVGHGNFSDVYQASLL-RGEQAPWCVAIKKC--HADKTTLLAWLREIMLLHSFRDQPNIIGLHGVLLSVAKLSNLSAVLEWAPHGNLRDFVRRH-
.|     | | |  ||       ||.    ||||    . ..    . |.| . . |  | |... | || ..    |..  |    |.|.| |.|| | 
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASV-DHPHLVRLLGVCMH----SQMQLVTQYMPYGCLLDYVRQHK

-PLSEAQLHQALHQTVSALAYLAKLDIVHRDVAARNVLVMAASPTFVCKLGDFGLSRIMPSSEYYKSTADSEMPFRWMALECLVARRYSEHSDVWAFGVL
  .   .|     |  . . || .  .|||| |||||||   ||  | |  ||||...... |     ..  || .||||||.  |.|   ||||..|| 
DNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVK--SPNHV-KITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVT

VWELVTAGATPWQGMELPAIIQQLKAGAALPLPP
.|||.| |. |..|...  | . |. |  || ||
CWELMTFGQKPYDGIPAREIPDLLEKGERLPQPP

Kinase RTKA3.AA Abl 644-875 32 3.4e-38 124.7 In-house 1-224 (252) Show / Hide
Range on Protein: 644-875
Range on HMM: 1-224/252
Sequence Identity: 32% (77 aa)

IKVEHAVGHGNFSDVYQASLLRGEQAPWCVAIKKCHADKTTLLAWLREIMLLHSFRDQPNIIGLHGVLLSVAKLSNLSAVLEWAPHGNLRDFVR---RHP
| ..| .| | . .||..   | ..    ||.|  . |   .  .|.|  ..   .  ||.. | ||     . .    . |. ..||| |..|   |. 
IMMKHKLGGGQYGEVYEGVWKRHDC---TVAVKTLKEDTMEVHEFLKEAAIMKEMK-HPNLVQLLGV---CTREPPFYIITEFMCYGNLLDYLRECDREE

LSEAQLHQALHQTVSALAYLAKLDIVHRDVAARNVLVMAASPTFVCKLGDFGLSRIMPSSEYYKSTADSEMPFRWMALECLVARRYSEHSDVWAFGVLVW
|.   | .   |  |.. || | . .|||.|||| ||       . |. ||||.|.|   . |   |    | .| | | |   ..|  |||||||||.|
LPAVVLLYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHH---IVKVADFGLARMM-KDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLW

ELVTAGATPWQGMELPAIIQQLKAGAALPLPPGAP
|. | | .|. |..|  . ..|  |  .  |.| |
EIATYGMSPYPGIDLSHVYHKLEKGYRMERPEGCP

Kinase RTKA3.AA S_TKc 644-886 20 9.4e-28 99.44 SMART 1-231 (231) Show / Hide
Range on Protein: 644-886
Range on HMM: 1-231/231
Sequence Identity: 20% (55 aa)

IKVEHAVGHGNFSDVYQASLLRGEQAPWCVAIKKCHADKTTLLAWLREIMLLHSFRDQPNIIGLHGVLLSVAKLSNLSAVLEWAPH--GNLRDFVRRHP-
 ..   .|.| |. ||..   .       ||||. .         .||| .|..  . |||. |..|  .    ..|  |.| ...  |.|.|. .... 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGR

------LSEAQLHQALHQTVSALAYLAKLDIVHRDVAARNVLVMAASPTFVCKLGDFGLSRIMPSSEYYKSTADSEMPFRWMALECLVARRYSE-HSDVW
      ..| .    ..|...||.|. .. |.|||.   |.|.       . |..||||.|..                 .|| | |    |.   .|.|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWW

AFGVLVWELVTAGATPWQGMELPAIIQQLKAGAALPLPPGA--------------PSIAQRFA-------LPLR
..|....|... | .|..  .. .......       |..               |.. . ..        |  
SCGCILYEMLC-GYPPFP--QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase RTKA3.AA Pkinase 644-852 20 1e-24 88.47 Pfam 1-214 (293) Show / Hide
Range on Protein: 644-852
Range on HMM: 1-214/293
Sequence Identity: 20% (48 aa)

IKVEHAVGHGNFSDVYQASLLRGEQAPWCVAIKKCHADKTTLLAW---LR--EIMLLHSFRDQPNIIGLHGVLLSVAKLSNLSAVLEWAPHG----NLRD
....  .| |.|. ||..     ..    ||.|.   ...    .   .|  || ..... . |||. |...  .    ...  |.|....|     | |
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDLFD

FVR---RHPL--SEAQLHQALHQTVSALAYLAKLDIVHRDVAARNVLVMAASPTFVC----KLGDFGLSR---IMPSSEYYKSTADSEMPFRWMALECLV
...   . ..  || ..   . |....|.|. .  |.|||.   |.|.     . ..    |..||||..   . ..| ..  .  ..    .|| | . 
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID---NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW----YMAPEVIR

-ARRYSEHSDVWAFGVLVWELVTAGATPWQG
 .. |.  .|.|..|....|... | .|..|
GGQYYGPKVDMWSCGCILYEMLC-GRPPFPG