RTKD2

Species: M.brevicollis
Alias: RTKD2
External Links:
Annotation:

Classification

Group: TK
Family: RTKD

Sequence

Name Sequence Type Origin Length Description Download
RTKD2.AA Protein None 1683 None Fasta, JSON
RTKD2.kin_dom Protein Kinase Domain None 257 None Fasta, JSON

Protein domain

Protein domains of RTKD2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
EGF RTKD2.AA EGF 30-61 32 6e-06 22.96 Pfam 1-36 (36) Show / Hide
Range on Protein: 30-61
Range on HMM: 1-36/36
Sequence Identity: 32% (12 aa)

CRTD--PCLNEGICLLQGALFSECACQSG---YTGQR
|  .  ||.. |.|.  .    .| |. |   ||| |
CNPNNNPCHHHGTCVDTP-GGYTCQCPPGYLGYTGKR

EGF RTKD2.AA EGF 29-63 34 1.8e-05 25.46 SMART 1-32 (32) Show / Hide
Range on Protein: 29-63
Range on HMM: 1-32/32
Sequence Identity: 34% (14 aa)

DCRTDPCLNE-----GICLLQGALFSECACQ-SGYTGQRCE
.|   || .      |.|.       .| |.  |||| |||
ECA--PCHHGGCEQHGTCI-----SYTC-CPGPGYTG-RCE

EGF_2 RTKD2.AA EGF_2 30-62 26 4.7e-05 19.29 Pfam 1-29 (29) Show / Hide
Range on Protein: 30-62
Range on HMM: 1-29/29
Sequence Identity: 26% (10 aa)

CRTDPCLN-EGICLLQGALFSE---CACQSG-YTGQRC
|    | .  |.|  |     .   | | .| ..|  |
C----CNGHHGTCNNQ-----GCGKCQCDDGWWQGDHC

EGF_2 RTKD2.AA EGF_2 69-98 41 4.5e-07 25.62 Pfam 1-29 (29) Show / Hide
Range on Protein: 69-98
Range on HMM: 1-29/29
Sequence Identity: 41% (14 aa)

CASDSECG--HGECEDD-EGECECDDG-WSGTFC
|     |.  || |...  | |.|||| |.|  |
C-----CNGHHGTCNNQGCGKCQCDDGWWQGDHC

EGF RTKD2.AA EGF 68-99 28 0.000589 20.39 SMART 1-32 (32) Show / Hide
Range on Protein: 68-99
Range on HMM: 1-32/32
Sequence Identity: 28% (11 aa)

ACASDSECGHG------ECEDDEGECECD-DGWSGTFCD
 ||    |.||      .|     .| |  .|..|  | 
ECA---PCHHGGCEQHGTCI--SYTC-CPGPGYTG-RCE

EGF RTKD2.AA EGF 69-97 27 0.002988 13.93 Pfam 1-36 (36) Show / Hide
Range on Protein: 69-97
Range on HMM: 1-36/36
Sequence Identity: 27% (10 aa)

CASD-SECGH-GECEDD--EGECECDDG---WSGTF
|... . | | |.| |   . .|.|  |   ..| .
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR

NCD3G RTKD2.AA NCD3G 117-142 38 0.00355 11.4 Pfam 29-54 (54) Show / Hide
Range on Protein: 117-142
Range on HMM: 29-54/54
Sequence Identity: 38% (10 aa)

LPCPTGYYSYEYYNTICFPVPFGYYP
.|||.| || .   . | | | ...|
IPCPEGEYSNTTDSYTCTPCPEDQWP

GCC2_GCC3 RTKD2.AA GCC2_GCC3 106-135 32 5.697311 2.87 Pfam 1-30 (49) Show / Hide
Range on Protein: 106-135
Range on HMM: 1-30/49
Sequence Identity: 32% (11 aa)

GYYYDPDQPAVL----PCPTGYYSYEYYNTICFP
|.||.    . .    ||| |.|  |. .. | |
GTYYN----KGQNPCEPCPRGTYQNEEGQDSCIP

GCC2_GCC3 RTKD2.AA GCC2_GCC3 201-226 38 0.007931 12.16 Pfam 7-29 (49) Show / Hide
Range on Protein: 201-226
Range on HMM: 7-29/49
Sequence Identity: 38% (10 aa)

GDKECEPCDAGTYNPNYGETRSRACL
| ..||||  ||| ...| .   .|.
GQNPCEPCPRGTYQNEEGQD---SCI

EGF RTKD2.AA EGF 165-206 24 0.233004 4.52 SMART 1-32 (32) Show / Hide
Range on Protein: 165-206
Range on HMM: 1-32/32
Sequence Identity: 24% (12 aa)

ECLPDTFSPTSCS-------GRYKSKDYAGICTDKHYCP-PGFFGDKECE
||.        |.       |.         |     || ||. |   ||
ECA-------PCHHGGCEQHGTCI----SYTC-----CPGPGYTG--RCE

NCD3G RTKD2.AA NCD3G 204-220 29 1.091919 4.01 Pfam 27-43 (54) Show / Hide
Range on Protein: 204-220
Range on HMM: 27-43/54
Sequence Identity: 29% (5 aa)

ECEPCDAGTYNPNYGET
.|.||..|.|  . ...
DCIPCPEGEYSNTTDSY

EGF RTKD2.AA EGF 195-203 41 8.334431 2.42 Pfam 25-36 (36) Show / Hide
Range on Protein: 195-203
Range on HMM: 25-36/36
Sequence Identity: 41% (5 aa)

CPPG---FFGDK
||||   . |..
CPPGYLGYTGKR

NCD3G RTKD2.AA NCD3G 284-292 55 8.255667 1.4 Pfam 46-54 (54) Show / Hide
Range on Protein: 284-292
Range on HMM: 46-54/54
Sequence Identity: 55% (5 aa)

QPCPPGQVP
.|||..| |
TPCPEDQWP

NCD3G RTKD2.AA NCD3G 299-322 33 3.2e-05 17.48 Pfam 28-54 (54) Show / Hide
Range on Protein: 299-322
Range on HMM: 28-54/54
Sequence Identity: 33% (9 aa)

CEYCDAGEIIVNG---QCQACPENYWS
|. |..||.  .    .|. ||| .|.
CIPCPEGEYSNTTDSYTCTPCPEDQWP

GCC2_GCC3 RTKD2.AA GCC2_GCC3 305-320 33 5.233366 2.99 Pfam 1-18 (49) Show / Hide
Range on Protein: 305-320
Range on HMM: 1-18/49
Sequence Identity: 33% (6 aa)

GEIIVNGQ--CQACPENY
|.   .||  |..|| ..
GTYYNKGQNPCEPCPRGT

HYR RTKD2.AA HYR 630-691 32 7.7e-08 27.83 Pfam 23-86 (86) Show / Hide
Range on Protein: 630-691
Range on HMM: 23-86/86
Sequence Identity: 32% (21 aa)

DSQATVTWVPPVAMDNSG--SVEQLTSNFEPGTRVDWVELPLPITYNARDAAGNEG-RCSFYVNL
.| . |.| .| | ||||  .... . . .||    . |    .|| ..|.|||.. .|.| |. 
TSTVNVFWTEPTATDNSGDIQANLISRTAQPGDFFPVGE-QTTVTYTFQDNAGNQADTCTFTVTV

HYR RTKD2.AA HYR 886-966 26 2.6e-09 32.68 Pfam 1-86 (86) Show / Hide
Range on Protein: 886-966
Range on HMM: 1-86/86
Sequence Identity: 26% (24 aa)

LDAKPPVI-YCPADVVEIVDSANDTANLSAAVLEPVRFSDDSG-----LVELLPLVNMTFGVG-RHTVTRVAVDPSNNTA-NCSFRIVV
 |  ||..  ||  ..  |.. . |.| .    ... ..| ||     |..  .    .|.||  .||| .. |.. |.|  |.|.. |
VDTTPPTVENCPNNIFRTVELGTSTVNVF---WTEPTATDNSGDIQANLISRTAQPGDFFPVGEQTTVTYTFQDNAGNQADTCTFTVTV

Kinase RTKD2.AA RTKD 1081-1339 64 1.4e-211 709.17 In-house 1-262 (262) Show / Hide
Range on Protein: 1081-1339
Range on HMM: 1-262/262
Sequence Identity: 64% (168 aa)

LKVLEILGTGNWGVVSKGMLEEHKSAGIPGFIVAVKILKQGNTEAVIELSREAAFMAQFNHDNVVRLHGVVTVNEPVAMVMEYCEHGSLQAYLRKR--DM
.|.||..|.||||.|.|.|||||...|||||.|||||.|....|.|.|..|||||||||||||.||||||||.|.|..||||||||||||||||..  ||
IKCLEPIGKGNWGMVFKAMLEEHIMKGIPGFLVAVKIMKNQSQEQVMEMTREAAFMAQFNHDNIVRLHGVVTTNQPHIMVMEYCEHGSLQAYLRENGEDM

RLISRLSVARDAAAGLAYLSGRGVVHRDVAARNILLSSDYRGKVADLGLTR-EAGSNSEYYTSRGGAIPVRWSAPEALEEHKFSQASDVWSWAVTLYEIQ
....|...|||.|.|||||..||..|||.|||||||.|.||.|..|.|||| .|...||||.|.|.||||||.|||.|||||||||||||||||..|||.
DNQHRFRMARDVAMGLAYLHFRGCCHRDIAARNILLDSNYRAKIGDFGLTRQQANGDSEYYISHGQAIPVRWCAPEVLEEHKFSQASDVWSWAVFVYEIW

TQARLPYEGMSNQKVWISVAGGYRLPRPEETSNELYDLMCSCWSDVPKERPSFKQLEVQMQN
|||.|||..|.|||||..|..||||.||.........||..||...|||||...|...||..
TQAQLPYRDMHNQKVWHYVIQGYRLTRPMQCPRDIWALMMDCWAEDPKERPRMCQVVDQMTK

Kinase RTKD2.AA RTKC 1081-1337 47 6.30000000001e-118 390.84 In-house 1-261 (261) Show / Hide
Range on Protein: 1081-1337
Range on HMM: 1-261/261
Sequence Identity: 47% (125 aa)

LKVLEILGTGNWGVVSKGMLEEHKSAGIPGFIVAVKILKQGNTE-AVIELSREAAFMAQFNHDNVVRLHGVVTVNEPVAMVMEYCEHGSLQAYLRKR-DM
|..|. || |  |.| |. ||| .  |.||..||.| |.. . . .  ||  ||| ||||.| |||.| ||||| .|.  |.|.|| |||  || .  | 
LTLLDELGRGAFGIVYKALLEEPG--GMPGYLVACKSLHHTAMDNDRQELLEEAAVMAQFEHPNVVHLIGVVTVGKPILVVLEFCERGSLKSYLMNNPDC

RLISRLSVARDAAAGLAYLSGRGVVHRDVAARNILLSSDYRGKVADLGLTREA----GSNSEYYTSRGGAIPVRWSAPEALEEHKFSQASDVWSWAVTLY
    ..  ....|.|..   . | .||||||||.||||| . |||| || ||.    .|   || ||.| .||||.|||||.. |||..||||.  ...|
TEHQKVRFCYQCASGMEHIHSFGFIHRDVAARNVLLSSDLTCKVADFGLARESPCNDDSHEAYYRSRSGNLPVRWTAPEALDDRKFSEKSDVWAFGILMY

EIQTQARLPYEGMSNQKVWISVAGGYRLPRPEETSNELYDLMCSCWSDVPKERPSFKQLEVQM
|| |.| .||.| ||| ||. |. |||||.||... |.||.| .||.  |..||.| ... ..
EIYTKAEMPYDGWSNQRVWVEVCAGYRLPCPEDCHKEVYDMMMDCWMHTPHDRPTFSEVVHWL

Kinase RTKD2.AA TK 1081-1337 22 5.3e-107 359.86 In-house 1-486 (486) Show / Hide
Range on Protein: 1081-1337
Range on HMM: 1-486/486
Sequence Identity: 22% (109 aa)

LKVLEILGTGN---WGVVSKGMLEEHKSAGIPGF-------------------IVAVKILKQGNTEAVIELSR--------------EAAFMAQFN----
..... || |.   .|.| ||......  . ..|                    ||||.|| |....  |                 ||. |....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDNVVRLHGVVTVN------------EPVAMVMEYCEHGS----LQAYLRKRD----------------------------------------------
 |.|.|||.||.| .            ||. .||||..||.    |. ||||..                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------MRLISRLSVARDAAAGLAYLSGR------GVVHRDVAARNILLSSDYR-----------GKVADLG---
                               . .  .|  ....|.|..||. .      ..||||.||||.|......            |.|| |   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LTREAGSNSEYYTSR------------------------GGAIPVRWSAPEALEEHK---------FSQASDVWSWAVTLYEIQTQARLPYEG-M
     |.|. .|...||...                        || .|.|| |||.|....         |. .|||||. |...|| | .. || | |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SNQKVWI-----------------------SVAGGYRLPRPEETS--------------NELYDLMCSCWSDVPKERPSFKQLEVQM
|||.||.                       .| ...|.|.|.  .               |.||||..||.  |..||.|.||  |.
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase RTKD2.AA TyrKc 1081-1337 34 5.3e-106 359.39 SMART 1-280 (280) Show / Hide
Range on Protein: 1081-1337
Range on HMM: 1-280/280
Sequence Identity: 34% (101 aa)

LKVLEILGTGNWGVVSKGMLEEHKSAGIPGFIVAVKILKQGNTEAVIELSREAAFMAQF--NHDNVVRLHGVVTVN-------EPVAMVMEYCEHGSLQA
.. ...|| |. |.| ||..            |||| || .    . .. |||  | ..  .|.|.|||.||.|         ||. .||||..||.|. 
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRKRD--MRLISRLSVARDAAAGLAYLSGRGVVHRDVAARNILLSSDYRGKVADLGLTREAGSN------SEYYTSR---GGA--IPVRWSAPEALEEH
||||.     .   || . ..|.| .||. ....||| ||||.|...... |..| ||.|. ..       ..||...   ||   .|.|| |||.. ..
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

KFSQASDVWSWAVTLYEIQTQARLPYEG-----MSNQKVWISVAGGYRLPRPEE--------TSNELYDLMCSCWSDVPKERPSFKQLEVQM
||. .|||||. |...|| |    ||.|     |||| |   |  |||.|.|..         . |.|..| .||   |..||.|...  ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase RTKD2.AA Pkinase_Tyr 1081-1337 37 6.4e-102 345.8 Pfam 1-270 (270) Show / Hide
Range on Protein: 1081-1337
Range on HMM: 1-270/270
Sequence Identity: 37% (102 aa)

LKVLEILGTGNWGVVSKGMLEEHKSAGIPGFIVAVKILKQGNTEA---VIELSREAAFMAQF-NHDNVVRLHGVVT-VNEP--VAMVMEYCEHGSLQAYL
.. .. || |. |.| || .    . . ..  ||||.||.| ..      .. |||. | |. .|.|.|||.||.|   ||  . .||||..||.|  ||
ITFGKKLGEGAFGEVYKGTWKG--DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RKR-----DMRLISRLSVARDAAAGLAYLSGRGVVHRDVAARNILLSSDYRGKVADLGLTREAGSNSEY-YTSRGGAIPVRWSAPEALEEHKFSQASDVW
||.        .   |. ... |.|..||. .. .|||.||||.|....   |..| ||.|   . ..| ... || .|..| |||.. . ||. .||||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SWAVTLYEIQTQARLP-YEGMSNQKVWISV-AGGYRLPRPEETSNELYDLMCSCWSDVPKERPSFKQLEVQM
|  |...|| |  . | |.||||. |   .   |||.|.|| .. |.||||..||   |..||.|...  |.
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase RTKD2.AA UTK 1081-1337 37 4.7e-98 332.06 In-house 1-296 (296) Show / Hide
Range on Protein: 1081-1337
Range on HMM: 1-296/296
Sequence Identity: 37% (110 aa)

LKVLEILGTGNWGVVSKGMLEEHKSAGIPGFIVAVKILK-QGNTEAVIE----LSREAA---FMAQFN-HDNVVRLHGVVTVNEPVAMVMEYCEHGSLQA
.. .. || |. |.|.|..... .  . .  .|||| ..  ....   |    . .||.   .|.||. | ||.|| ||.|  || ..|.||.| |.|..
VQLGRQLGQGAFGEVHKARFTQCSEHM-YEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRS

YLR----KRD-----MRLISRLSVARDAAAGLAYLSGRGVVHRDVAARNILLSSD-------YRGKVADLG---LTREAGS--------NSEYYTSRG-G
|||    . .      .| .||. |.| |.|..||...|.||||.||||.|. ..       .  |.||.|   ..|....        .|.||.... .
YLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQD

AIPVRWSAPEALEEH-KFSQASDVWSWAVTLYEIQTQARLPYEGMSNQKVWISVAGG--YRLPRPEETSNELYDLMCSCWSDVPKERPSFKQLEVQM
..|.|| ||||| .| .|...|||||. |...|| | .||||.||||..|| .|  |  ||.|.|.. . ..|.|| .||   | |||.|..|. ||
RWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM

Kinase RTKD2.AA Eph 1081-1337 40 1.4e-80 270.35 In-house 1-264 (264) Show / Hide
Range on Protein: 1081-1337
Range on HMM: 1-264/264
Sequence Identity: 40% (107 aa)

LKVLEILGTGNWGVVSKGMLEEH-KSAGIPGFIVAVKILKQGNTE-AVIELSREAAFMAQFNHDNVVRLHGVVTVNEPVAMVMEYCEHGSLQAYLRKRDM
.|. ...|.|  | | .|.|    . . .   .||.| ||.| || . ..  .||. | ||.| |..|| ||||  .||  | || |.||| ..||..| 
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

RLISR--LSVARDAAAGLAYLSGRGVVHRDVAARNILLSSDYRGKVADLGLTREAGSNS---EYYTSRGGAIPVRWSAPEALEEHKFSQASDVWSWAVTL
.. .   .   |  |.|  |||  . |||| ||||||..|. . ||.|.||.|.  ...     ||.||| ||.|| ||||.   ||. ||||||. . .
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

YEIQTQARLPYEGMSNQKVWISVAGGYRLPRPEETSNELYDLMCSCWSDVPKERPSFKQLEVQM
 |. .    ||  ||||.|  ..  ||||| | .  . |. ||  ||   ...|| |.|.   .
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL

Kinase RTKD2.AA SFK-Src 1113-1341 39 3.6e-78 231.14 In-house 26-259 (259) Show / Hide
Range on Protein: 1113-1341
Range on HMM: 26-259/259
Sequence Identity: 39% (93 aa)

VAVKILKQGNTEAVIELSREAAFMAQFNHDNVVRLHGVVTVNEPVAMVMEYCEHGSLQAYLRK---RDMRLISRLSVARDAAAGLAYLSGRGVVHRDVAA
|||| || | . |  |  .||. | .  |.| ..|. | |  ||.  . | .  |||  ||.    | .|.      | . |.|.||| .   |||| ||
VAVKTLKPGAMSAE-EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLRMPQLVDMAAQVAHGMAYLEAQNFVHRDLAA

RNILLSSDYRGKVADLGLTREAGSNSEYYTSRGGA-IPVRWSAPEALEEHKFSQASDVWSWAVTLYEIQTQARLPYEGMSNQKVWISVAG--GYRLPRPE
||.|       ||.| |. |  . ..| || . ||  |..| ||||    .||  |||||  . ..|| |  | ||.||.|. |   |    |||.| | 
RNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPYPGMTNMEVLQQVDRPEGYRMPCPP

ETSNELYDLMCSCWSDVPKERPSFKQLEVQMQNMI
 . .|.| .|  ||   | .|| |  | .|| .  
NCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF

Kinase RTKD2.AA Src 1081-1337 38 2.6e-76 258.76 In-house 1-255 (255) Show / Hide
Range on Protein: 1081-1337
Range on HMM: 1-255/255
Sequence Identity: 38% (100 aa)

LKVLEILGTGNWGVVSKGMLEEHKSAGIPGFIVAVKILKQGNTEAVIELSREAAFMAQFNHDNVVRLHGVVTVNEPVAMVMEYCEHGSLQAYLRK----R
.| .. ||.|. | | .|.   .         |||| ||.|.  ..  . .||  | .. |...|.|. |..  ||.  | || .||||..||.|    |
IKLCRKLGQGQFGEVWMGYWNGN-------TKVAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGR

DMRLISRLSVARDAAAGLAYLSGRGVVHRDVAARNILLSSDYRGKVADLGLTREAGSNSEYYTSRGGA-IPVRWSAPEALEEHKFSQASDVWSWAVTLYE
 ..|   .. |   |.| |||. . ..||| ||||.| . .   |||| || |    . . |..| || .|..| ||||. ...|.. |||||  . |.|
HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

IQTQARLPYEGMSNQKVWISVAGGYRLPRPEETSNELYD-LMCSCWSDVPKERPSFKQLEVQM
| |  | ||.||.|. |   |  |||.|.|..   |||. .|. ||   |..|| |. |   .
IVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL

Kinase RTKD2.AA TK-Unique 1081-1337 33 1.8e-69 237.08 In-house 1-294 (294) Show / Hide
Range on Protein: 1081-1337
Range on HMM: 1-294/294
Sequence Identity: 33% (100 aa)

LKVLEILGTGNWGVVSKGMLEEHKSAGIPGF-IVAVKILKQGNTEA-VIELSREAAFMAQFN-HDNVVRLHGVVTVN-EPVAMVMEYCEHGSLQAYLR--
|.|....|.|. | | .|.... . ..   . .|||| || ..|.  . .. .|...| .   | |.|.. |. | . ||. ..||||. |.|| |||  
LEVGDVIGEGAFGQVWRGEVWGIW-KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

--------------------KRDMRL--IS---RLSVARDAAAGLAYLSG--RGVVHRDVAARNILLSSDYRGKVADLGLTREAGSNSEYYTSRG-GAIP
                    ....|.  ||    .. | . | |..||..  ...||||..|||.||..|.. |..|.|..|.   | .| .... | ||
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIP

VRWSAPEALE--EHKF-SQASDVWSWAVTLYEIQTQARLPYEGMSNQKVWISVAGGYRLPRPEET-SNELYDLMCSCWSDVPKERPSFKQLEVQM
.|| |||.|   .. . .  ||||| .|...|| |    || ||.. ..   .  |||.|.||.  |.|.| || |||...|.||||| |.  . 
IRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL

Kinase RTKD2.AA Fer 1081-1338 29 1.5e-68 232.52 In-house 1-283 (283) Show / Hide
Range on Protein: 1081-1338
Range on HMM: 1-283/283
Sequence Identity: 29% (83 aa)

LKVLEILGTGNWGVVSKG----MLEEHKSAGIPGFIVAVKIL-KQGNTEA-VIELSREAAFMAQ-FNHDNVVRLHGVVTVNEPVAMVMEYCEHGSLQAYL
 .  ..|| |. | | ||    ..  .|..  .   |.|| .   . |..  .|. .|| .| . ..|.|||...|| .  .|.  |||.| .|||. ||
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RKRD---MRLISRLSVARDAAAGLAYLSGRGVVHRDVAARNILLSS-DYRGK--VADLGLTREAGSNSEYYTSR--GGAIPVRWSAPEALEEHKFSQASD
.| .   . .  ..  . .||.|..|| .....|||.||||.|..  .   |  ..| |. |.   . . |. .     .|.|| |||...   .| ..|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSWAVTLYEIQTQARLPYEG----MSNQKV-----WISVAGGYRLPRPEETSNELYDLMC-SCWSDVPKERPSFKQLEVQMQ
|||. |...|| | .  ||.|    | .  |        . .||..| |...  |.. .|. .||   |..||..|..  .. 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK

Kinase RTKD2.AA CTKA 1185-1337 41 4.4e-54 180.04 In-house 135-290 (290) Show / Hide
Range on Protein: 1185-1337
Range on HMM: 135-290/290
Sequence Identity: 41% (64 aa)

SVARDAAAGLAYLSGRGVVHRDVAARNILLSSDYRGKVADLGLTREAGSN-SEYYTSRGGAIPVRWSAPEALEEHKFSQASDVWSWAVTLYEIQTQARLP
. |...|||  ||. .| |||| |.||.|| .    |.||.|. |   .    || |  . .|||| ||||| . ||| |||||.  | |.|| . . .|
YMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKP

YEGMSNQKVWISVAGG--YRLPRPEETSNELYDLMCSCWSDVPKERPSFKQLEVQM
. .|| | |   ....   ||| |      || .|  ||   |..||.| .|    
WRHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML

Kinase RTKD2.AA S_TKc 1081-1341 23 5.5e-42 146.73 SMART 1-231 (231) Show / Hide
Range on Protein: 1081-1341
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

LKVLEILGTGNWGVVSKGMLEEHKSAGIPGFIVAVKILKQGNTEAVIELSREAAFMAQFNHDNVVRLHGVVTVNEPVAMVMEYCEH--GSLQAYLRKRD-
 ..|...| |  |.| |.   .       | |||.||.|       . . || . . . .|.|.|.|..|    . . ||||||..  |.|  |..||  
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------MRLISRLSVARDAAAGLAYLSGRGVVHRDVAARNILLSSDYRGKVADLGLTREAGSNSEYYTSRGGAIPVRWSAPEALEEHKFSQ-ASDVWSWA
      .      ....  . .|.|.  .|..|||.   ||||..  . |..| || |.          .       . ||| |   ...  ..|.||  
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

VTLYEIQTQARLPYEGMSNQKVWISVAGGYRLPRPEETSNELYDLMCSCWSDVPKERPSFKQLEV-----QMQNMI
..|||  .  . |..   .... . . |          | |. |... |.   |..||.  ..        .   .
CILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase RTKD2.AA Pkinase 1081-1333 24 2.8e-39 139.97 Pfam 1-287 (293) Show / Hide
Range on Protein: 1081-1333
Range on HMM: 1-287/293
Sequence Identity: 24% (72 aa)

LKVLEILGTGNWGVVSKGMLEEHKSAGIPGFIVAVKILKQGNTEAVIE-----LSREAAFMAQFNHDNVVRLHGVVTVNEPVAMVMEYCEHG----SLQA
.......| |. |.| |..            ||||||.|  ...   .     | .|.. |. .||.|.|||..... .  . |||||||.|    .| .
YHIGRKIGSGSFGCVYKCHHKGTGK------IVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

YLR---KRDM--RLISRLSVARDAAAGLAYLSGRGVVHRDVAARNILLSSDYRG----KVADLGLTREA-GSNSEYYTSRGGAIPVRWSAPEALE-EHKF
|..   .. .        ....  . ||.|.  .|..|||.   |||.....      |..| || . .   |.. .|.. | .  .. ||| .    . 
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTP--WYMAPEVIRGGQYY

SQASDVWSWAVTLYEIQTQARLPYEGM-----SNQKVWISVAGGYRLPRPEETS---------------------NELYDLMCSCWSDVPKERPSFKQL
....|.||  ..|||  .  |.|. |       .|.. |   .| .|.......                      |. |....|.   ||.||...|.
GPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

Kinase RTKD2.AA CTKA 1081-1174 34 3.6e-16 50.69 In-house 1-101 (290) Show / Hide
Range on Protein: 1081-1174
Range on HMM: 1-101/290
Sequence Identity: 34% (35 aa)

LKVLEILGTGNWGVVSKGML----EEHKSAGIPGFIVAVKILKQGNTEAVI-ELSREAAFMA--QFNHDNVVRLHGVVTVNEPVAMVMEYCEHGSLQAYL
. .   .| | .| | . .|    .. |     |  |||| ||.  ||.   .   ||   .  .| | ||.|| ||.|  .|  |.||.   | |. ||
HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCYL

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