Gene RTKD4 (M.brevicollis)

RTKD4

Species: M.brevicollis
Alias: RTKD4
External Links:
Annotation:

Classification

Group: TK
Family: RTKD

Sequence

Name Sequence Type Origin Length Description Download
RTKD4.AA Protein None 1621 None Fasta, JSON
RTKD4.kin_dom Protein Kinase Domain None 259 None Fasta, JSON

Protein domain

Protein domains of RTKD4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
EGF RTKD4.AA EGF 63-99 30 0.001861 18.73 SMART 1-32 (32) Show / Hide 
Range on Protein: 63-99
Range on HMM: 1-32/32
Sequence Identity: 30% (13 aa)

PCNDHNDLHCEAG-----AFCSHNHGFPVCLCP-PGRRGTRCE
.|       |. |     . |      . | || || .| |||
ECA-----PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE
EGF RTKD4.AA EGF 64-97 35 0.011618 11.96 Pfam 1-36 (36) Show / Hide 
Range on Protein: 64-97
Range on HMM: 1-36/36
Sequence Identity: 35% (13 aa)

CNDHNDLHCEAGAFCSHNHGFPVCLCPPG---RRGTR
||..|   |  ...|    | . | ||||     | |
CNPNN-NPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR
EGF_2 RTKD4.AA EGF_2 64-98 20 4.900487 3.6 Pfam 1-29 (29) Show / Hide 
Range on Protein: 64-98
Range on HMM: 1-29/29
Sequence Identity: 20% (8 aa)

CNDHNDLHCEA-GAFCSHNHGFPV---CLCPPG-RRGTRC
|       |   . .|  .    .   | |..|   |  |
C-------CNGHHGTCNNQ----GCGKCQCDDGWWQGDHC
EGF RTKD4.AA EGF 103-142 21 0.000644 20.26 SMART 1-32 (32) Show / Hide 
Range on Protein: 103-142
Range on HMM: 1-32/32
Sequence Identity: 21% (10 aa)

ECANADVETPACASN-----AVCVTTANANDVCRCA-TGWAGPACD
|||        |  .     ..|.        | |.  |. |  | 
ECA-------PCHHGGCEQHGTCI-----SYTC-CPGPGYTG-RCE
EGF_2 RTKD4.AA EGF_2 104-141 20 0.000689 15.65 Pfam 1-29 (29) Show / Hide 
Range on Protein: 104-141
Range on HMM: 1-29/29
Sequence Identity: 20% (9 aa)

CANADVETPACAS-NAVCVTTANANDV---CRCATG-WAGPAC
|         |   . .|...     .   | |  | | |. |
C---------CNGHHGTCNNQ-----GCGKCQCDDGWWQGDHC
EGF RTKD4.AA EGF 114-140 26 1.907069 4.56 Pfam 8-36 (36) Show / Hide 
Range on Protein: 114-140
Range on HMM: 8-36/36
Sequence Identity: 26% (8 aa)

CASNAVCVTTANANDVCRCATG---WAGPA
|  .. || |      |.|. |   ..|. 
CHHHGTCVDTP-GGYTCQCPPGYLGYTGKR
Kinase RTKD4.AA RTKD 1166-1426 61 2.6e-211 708.28 In-house 1-262 (262) Show / Hide 
Range on Protein: 1166-1426
Range on HMM: 1-262/262
Sequence Identity: 61% (161 aa)

VTCIESIGKGNWGTVFKGLLEEDLPLGLSRFLVAVKAMTNASPSQLDEFTREAAFMAQLQHEHIVRLYGVVTTSTPHYLVMEYCEHGSLQNYLRARGELI
..|.|.|||||||.|||..|||....|...||||||.|.|.|..|..|.|||||||||..|..||||.|||||..||..|||||||||||.|||..||..
IKCLEPIGKGNWGMVFKAMLEEHIMKGIPGFLVAVKIMKNQSQEQVMEMTREAAFMAQFNHDNIVRLHGVVTTNQPHIMVMEYCEHGSLQAYLRENGEDM

DLSHRIRFAVDVAKALEYLAFRGICHNDIASRNVLLNSLYQAKLGDFGLSR-QVGGVNADYIGKDQVFPVRWSAPELLRDHILSHASDMWSWAVFVYEIF
|..||.|.|.|||..|.||.|||.||.|||.||.||.|.|.||.|||||.| |..|....||...|..||||.|||.|..|..|.|||.||||||||||.
DNQHRFRMARDVAMGLAYLHFRGCCHRDIAARNILLDSNYRAKIGDFGLTRQQANGDSEYYISHGQAIPVRWCAPEVLEEHKFSQASDVWSWAVFVYEIW

TNAEVPYADMPNQLVWHSVLNGHRLTRPEICPEPAFAVMAQCWSEDPSERPRATVVVDQLTE
|.|..||.||.||.|||.|..|.|||||..||....|.|..||.|||.||||...||||.|.
TQAQLPYRDMHNQKVWHYVIQGYRLTRPMQCPRDIWALMMDCWAEDPKERPRMCQVVDQMTK
Kinase RTKD4.AA TyrKc 1166-1424 32 1.6e-98 334.53 SMART 1-280 (280) Show / Hide 
Range on Protein: 1166-1424
Range on HMM: 1-280/280
Sequence Identity: 32% (94 aa)

VTCIESIGKGNWGTVFKGLLEEDLPLGLSRFLVAVKAMTNASPSQLDEFTREAAFMAQL--QHEHIVRLYGVVTTS-------TPHYLVMEYCEHGSLQN
.| .. .| |. |.|.|| .            |||| . . .   . .| |||  | .|  .|..|||||||.|..        |...||||..||.|..
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLRARGELIDLSHRIRFAVDVAKALEYLAFRGICHNDIASRNVLLNSLYQAKLGDFGLSRQVGGV-----NADYI------GKDQVFPVRWSAPELLRDH
|||.... . ... . |....|.  |||. ... | |.| ||.|... ...| .|||||| ..       . ||.      |.. ..|.|| ||| ....
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

ILSHASDMWSWAVFVYEIFTNAEVPYAD-----MPNQLVWHSVLNGHRLTRPEI--------CPEPAFAVMAQCWSEDPSERPRATVVVDQL
. ...|| ||. |  .||||. . || .     |.|| | . | .|.|. .|.         ||.  . .| ||| |||..||. . .....
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase RTKD4.AA TK 1166-1424 19 1.9e-97 327.25 In-house 1-486 (486) Show / Hide 
Range on Protein: 1166-1424
Range on HMM: 1-486/486
Sequence Identity: 19% (96 aa)

VTCIESIGKGN---WGTVFKGLLEEDLPLGLSRF-------------------LVAVKAMTNASPSQLDEFTR--------------EAAFMAQLQ----
.| .. .|.|.   .|.|.||..... |.. .||                    |||| ..  .... .||                ||. |....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HEHIVRLYGVVTTS------------TPHYLVMEYCEHGS----LQNYLRARGEL--------------------------------------------
 |..|||||||.| .             | ..||||..||.    |..|||.. .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------IDLSHRIRFAVDVAKALEYLAFR------GICHNDIASRNVLLNSLYQ-----------AKLGDFG---
                               ... ... .....|...|||. .      .. | |.| ||.|... ..           .|..|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRQVGGVNADYIGK------------------------DQVFPVRWSAPELLRDHI---------LSHASDMWSWAVFVYEIFTNA-EVPYADM
     |.| ..     |  .                        .  .|.|| ||| |.|..          ...||.||. |...||||.. | .| .|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

PNQLVWH-----------------------SVLNGHRLTRPEICP--------------EPAFAVMAQCWSEDPSERPRATVVVDQL
.|| ||.                       .| ...|. .|. ||              |  . .| |||..||..||. . ...||
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RTKD4.AA Pkinase_Tyr 1166-1424 34 1.6e-94 320.78 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1166-1424
Range on HMM: 1-270/270
Sequence Identity: 34% (93 aa)

VTCIESIGKGNWGTVFKGLLEEDLPLGLSRFLVAVKAMTNASPSQ---LDEFTREAAFMAQL-QHEHIVRLYGVVT-TSTP--HYLVMEYCEHGSLQNYL
.| .. .|.|. |.|.|| .      .  .  |||| . . . ..   ...| |||. | || .|..|||||||.|  . |  .|.||||..||.| .||
ITFGKKLGEGAFGEVYKGTWKG--DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RAR---GELIDLSHRIRFAVDVAKALEYLAFRGICHNDIASRNVLLNSLYQAKLGDFGLSRQVGGVNADY--IGKDQVFPVRWSAPELLRDHILSHASDM
|..   .. ..... . .....||..|||. ... | |.| ||.|...  ..| .||||.| .      |   ...  .|..| ||| ... . ...|| 
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

WSWAVFVYEIFTNAEVP-YADMPNQLVWHSV-LNGHRLTRPEICPEPAFAVMAQCWSEDPSERPRATVVVDQL
||  |  .||||  | | |..|.|. | . .  .|.|. .|| ||..   .| ||| .||..||. . .. ||
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RTKD4.AA UTK 1166-1424 31 7.2e-87 294.9 In-house 1-296 (296) Show / Hide 
Range on Protein: 1166-1424
Range on HMM: 1-296/296
Sequence Identity: 31% (92 aa)

VTCIESIGKGNWGTVFKGLLEEDL-PLGLSRFLVAVKAMTNASPSQLD---EFTREAA---FMAQLQ-HEHIVRLYGVVTTSTPHYLVMEYCEHGSLQNY
|   . .|.|. |.|.|. ....  . ....  | |   . ... . .   .| .||.   .|.|.. |....||.||.| . | ..|.||.| |.|..|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LR-------ARGELIDLSHRIRFAVDVAKALEYLAFRGICHNDIASRNVLLNSL-------YQAKLGDFG---LSRQVG---------GVNADYIGKDQV
||       |.... .| .|. .|.|.| ...||. .|. |.|.| ||.|...        ...|..|||   .||.|.         . .  .   .. 
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

FPVRWSAPELLRDH-ILSHASDMWSWAVFVYEIFTNAEVPYADMPNQLVWHSVLNG--HRLTRPEICPEPAFAVMAQCWSEDPSERPRATVVVDQL
 |.|| ||| | .|   ...||.||. |...||.|.. .||..| |. |||.|.||  .|. .|. ||.| . .| .||  ||.|||..  .|.|.
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase RTKD4.AA RTKC 1166-1424 39 2e-74 245.05 In-house 1-261 (261) Show / Hide 
Range on Protein: 1166-1424
Range on HMM: 1-261/261
Sequence Identity: 39% (104 aa)

VTCIESIGKGNWGTVFKGLLEEDLPLGLSRFLVAVKAM-TNASPSQLDEFTREAAFMAQLQHEHIVRLYGVVTTSTPHYLVMEYCEHGSLQNYLRARGEL
.|  .  |.|  | | |.||||  | |   .|||.|     |. .   |   ||| |||..|. .|.| ||||   | . |.|.|| |||  || . .  
LTLLDELGRGAFGIVYKALLEE--PGGMPGYLVACKSLHHTAMDNDRQELLEEAAVMAQFEHPNVVHLIGVVTVGKPILVVLEFCERGSLKSYLMNNP-D

IDLSHRIRFAVDVAKALEYLAFRGICHNDIASRNVLLNSLYQAKLGDFGLSRQV----GGVNADYIGKDQVFPVRWSAPELLRDHILSHASDMWSWAVFV
.  . ..||. ..|  .|  .  |  | |.| ||||| |.  .|. |||| |      ..  | |       ||||.||| | | . |..|| |.  .  
CTEHQKVRFCYQCASGMEHIHSFGFIHRDVAARNVLLSSDLTCKVADFGLARESPCNDDSHEAYYRSRSGNLPVRWTAPEALDDRKFSEKSDVWAFGILM

YEIFTNAEVPYADMPNQLVWHSVLNGHRLTRPEICPEPAFAVMAQCWSEDPSERPRATVVVDQL
|||.|.|| || .  || ||  | .|.|| .|| |... ...| .||...|..||    || .|
YEIYTKAEMPYDGWSNQRVWVEVCAGYRLPCPEDCHKEVYDMMMDCWMHTPHDRPTFSEVVHWL
Kinase RTKD4.AA TK-Unique 1166-1424 30 2.6e-71 243.23 In-house 1-294 (294) Show / Hide 
Range on Protein: 1166-1424
Range on HMM: 1-294/294
Sequence Identity: 30% (91 aa)

VTCIESIGKGNWGTVFKGLLEEDLPLGLSRF-LVAVKAMT-NASPSQLDEFTREAAFMAQLQ-HEHIVRLYGVVTTST-PHYLVMEYCEHGSLQNYLRAR
..  ..||.|. |.|..| ....   . ...  ||||.   ||.. . ..|..|...| .|  |..||...|. |.|. |....||||. |.||.||| .
LEVGDVIGEGAFGQVWRGEVWGIW-KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

G-------------------------ELIDLSHRIRFAVDVAKALEYLAF--RGICHNDIASRNVLLNSLYQAKLGDFGLSRQVGGVNADYIGKD--QVF
.                         | |..   ..||...|...||||   ..| |.|...|||||.. ...|..|||..| |   | .|. ..  .  
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRI

PVRWSAPELLR--DHIL-SHASDMWSWAVFVYEIFTNAEVPYADMPNQLVWHSVLNGHRLTRPEIC-PEPAFAVMAQCWSEDPSERPRATVVVDQL
|.|| ||| |.  ...  .  || || .|. .||||. . || .||.  .   . .|.|. .|| | ..  . .| .||...|.|||  . ....|
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase RTKD4.AA Fer 1166-1425 31 2.6e-68 231.72 In-house 1-283 (283) Show / Hide 
Range on Protein: 1166-1425
Range on HMM: 1-283/283
Sequence Identity: 31% (89 aa)

VTCIESIGKGNWGTVFKGLLEEDLPLGLSRFLV----AVKAMTN----ASPSQLDEFTREAAFMAQ-LQHEHIVRLYGVVTTSTPHYLVMEYCEHGSLQN
|| .. .|.|. |.|.||    .| ..... .|    ||| ...    |.  |. || .|| .| . ..| ..|..||| .   | ..|||.| .|||..
VTLGKKLGEGAFGEVYKGR-R-TLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDS

YLRARGE-LIDLSHRIRFAVDVAKALEYLAFRGICHNDIASRNVLLNS-LYQAK--LGDFGLSRQ-VGGVNADYIG-KDQVFPVRWSAPELLRDHILSHA
||.  .. .. .  .||.. ..|. .|||  ... | |||.||.|.     . |  . |||.|||  ..... . . | .  |.|| ||| ... | |..
YLKKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPK

SDMWSWAVFVYEIFTNAEVPYAD----MPNQLV-----WHSVLNGHRLTRPEICPEPAFAVMA-QCWSEDPSERPRATVVVDQLT
.|.||. |  .|||||.. ||..    | .  |        . .|.... |. .|..   .|. ||| .||..|| .. .. .| 
TDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase RTKD4.AA TKL 1172-1424 21 2.9e-60 206.54 In-house 1-364 (364) Show / Hide 
Range on Protein: 1172-1424
Range on HMM: 1-364/364
Sequence Identity: 21% (81 aa)

IGKGNWGTVFKGLLEE-----DLPLGLSRFLVAVKAMTNAS--------------------------PSQLDEFTREAAFM-AQLQHEHIVRLYGVVTTS
||.|  |.|.|| .           ...   |||| .   .                          .|.. .| .| . |  .|.|..||...|... .
IGSGGFGEVYKGKWRGWGGKCP---SDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCP

TP-------------HYLVMEYCEHGSLQNYLRARGELIDLSHRIRFAVDVAKALEYLAF--------RGICHNDIASRNVLLNSLYQ------------
..             ...|||||..||| .||        ...|.|.| |.|....||          ..| | |. |.|.|... ..            
PCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--AKLGDFGLSRQVGGVNADYIGKD-----------------QVFPVRWSAPELLRDH----------------ILSHASDMWSWAVFVYEIFTNAEVPY
  .|..|||||| . . . .  ..                  |.   || |||.||..                  | ..|..|...  .||.|  . ||
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PY

ADMPN----------QLVWHSVLNGHRLTRP------------EICPEPAFAVMAQCWSEDPSERPRATVVVDQL
.|.|.          .  .  ...|.|...|            . ||..    | .||..||..|| .. ....|
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase RTKD4.AA Ack 1166-1424 35 1.3e-58 196.31 In-house 1-266 (266) Show / Hide 
Range on Protein: 1166-1424
Range on HMM: 1-266/266
Sequence Identity: 35% (95 aa)

VTCIESIGKGNWGTVFKGLLEEDLPLGLSRFLVAVKAMTNA---SPSQLDEFTREAAFMAQLQHEHIVRLYGVVTTSTPH-YLVMEYCEHGSLQNYLRAR
.|  | .| |  | | .|.     | |  .  ||||        .|  .|.| ||.| | .|.|.|.|||||||  ..|   .|.| .. |||   ||. 
ITLCEKLGDGCFGVVWRGEWTN--PGG-KHIQVAVKCLRSDKMQQPNCMDDFLREVAIMHSLDHPHLVRLYGVVL-DQPMLMMVTELAPCGSLLDCLRKH

GE--LIDLSHRIRFAVDVAKALEYLAFRGICHNDIASRNVLLNSL-YQAKLGDFGLSRQVGGVNADYIGKDQV---FPVRWSAPELLRDHILSHASDMWS
       ..   .|.. .|... ||  ... | | | ||.|| |    .| .||||.|  |.    |  . ..    |  | ||| ||    |||||.|.
CRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWM

WAVFVYEIFTNAEVPYADMPNQLVWHSVL-NGHRLTRPEICPEPAFAVMAQCWSEDPSERPRATVVVDQL
  |   | |.  | |.| ..  .. . .  .| ||.||. |||   ..| ||| ..| .||.   ..|||
FGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase RTKD4.AA Eph 1166-1424 35 7.5e-58 192.86 In-house 1-264 (264) Show / Hide 
Range on Protein: 1166-1424
Range on HMM: 1-264/264
Sequence Identity: 35% (94 aa)

VTCIESIGKGNWGTVFKGLLEEDLPLGLSRF---LVAVKAMTNASP-SQLDEFTREAAFMAQLQHEHIVRLYGVVTTSTPHYLVMEYCEHGSLQNYLRAR
..  ..|| |  | | .| |   || |       .||.|.    .. .|  .| .||. | | .| .|.|| |||| | |   | || |.|||  .|| .
IKIEKVIGAGEFGEVCCGRLK--LPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQH

GELIDLSHRIRFAVDVAKALEYLAFRGICHNDIASRNVLLNSLYQAKLGDFGLSRQ---VGGVNADYIGKDQVFPVRWSAPELLRDHILSHASDMWSWAV
 . .     .     .| .  ||.  .  | | | ||.|.||    |  ||||||.    ..|.| |  .    |.|| ||| .   . . ||| ||. .
DGQFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGI

FVYEIFTNAEVPYADMPNQLVWHSVLNGHRLTRPEICPEPAFAVMAQCWSEDPSERPRATVVVDQL
 . |. .  | || ||.|| |  ..  | ||  |  |||. .  | .||  |...||. . .|  |
VMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase RTKD4.AA Src 1166-1415 33 1.9e-57 193.69 In-house 1-246 (255) Show / Hide 
Range on Protein: 1166-1415
Range on HMM: 1-246/255
Sequence Identity: 33% (86 aa)

VTCIESIGKGNWGTVFKGLLEEDLPLGLSRFLVAVKAMTNASPSQLDEFTREAAFMAQLQHEHIVRLYGVVTTSTPHYLVMEYCEHGSLQNYLR--ARGE
.. .. .|.|. | |..|.     .       |||| .  ..  . . | .||  | .|.||..|.|| |...  | | | || .||||. ||.   .| 
IKLCRKLGQGQFGEVWMGYWNGNTK-------VAVKTLKPGT-MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGR

LIDLSHRIRFAVDVAKALEYLAFRGICHNDIASRNVLLNSLYQAKLGDFGLSRQVGGVNADY-IGKDQVFPVRWSAPELLRDHILSHASDMWSWAVFVYE
 . | . | .|  ||.  .||  . . | | | |||| .    .| .|||| | .      |   ..  ||..| ||| .. .  .  || ||  .  .|
HLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTE

IFTNAEVPYADMPNQLVWHSVLNGHRLTRPEICPEPAFA-VMAQCWSEDPSERP
|.|   |||  | |. |   | .| |. .|. ||.  .  .| ||| .|| .||
IVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRP
Kinase RTKD4.AA S_TKc 1166-1431 23 4.2e-45 157.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 1166-1431
Range on HMM: 1-231/231
Sequence Identity: 23% (66 aa)

VTCIESIGKGNWGTVFKGLLEEDLPLGLSRFLVAVKAMTNASPSQLDEFTREAAFMAQLQHEHIVRLYGVVTTSTPHYLVMEYCEH--GSLQNYLRARGE
 . .. ||||  |.|.|.   .      .  .||.| .        . . || . . . .|..||.||.|  . .  |.|||||..  |.|  |.. || 
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

L-----IDLSHRIRFAVDVAKALEYLAFRGICHNDIASRNVLLNSLYQAKLGDFGLSRQVGGVNADYIGKDQVFPVRWSAPELLRDHILSH-ASDMWSWA
      ..  |  ...  ...||||.  .||.| |.   |.||..  . |..||||.||.         . ..    . |||.|     .. ..|.||  
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

VFVYEIFTNAEVPYADMPNQLVWHSVLNGHRLTRPEICPEPAFAVMAQCWSEDPSERPRATVVVD--QLTEMLQLL
. .|| ..  . |.     |.... ..           ...|   . .|.  ||..|| |  .    ..  . . .
CILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RTKD4.AA Pkinase 1166-1424 21 2.2e-32 115.58 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1166-1424
Range on HMM: 1-293/293
Sequence Identity: 21% (66 aa)

VTCIESIGKGNWGTVFKGLLEED-LPLGLSRFLVAVKAM--TNASPSQLDEFTR--EAAFMAQLQHEHIVRLYGVVTTSTPHYLVMEYCEHG----SLQN
 .... ||.|. |.|.|.    .         .|||| .   ....... . .|  |.. |. |.|..|||||.......  |.||||||.|    .|  
YHIGRKIGSGSFGCVYKCHHKGTGK-------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

YLR-ARGELI--DLSHRIRFAVDVAKALEYLAFRGICHNDIASRNVLLNSLYQA----KLGDFGLSRQVGGVNADYIGKDQVFPVRWSAPELLR-DHILS
|..  |.  .  .  . ....  ....|||.  .||.| |. . |.|... ..     |..||||..|.     .   .. .   .. |||..| .   .
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

HASDMWSWAVFVYEIFTNAEVPYAD------MPNQLVWHSVLNGHRLTRPEICP-------------------EPAFAVMAQCWSEDPSERPRATVVVDQ
...||||  . .|| ..     . .       ..|..        .  .|. |.                   |..  ..  |.  ||..|| |. ..  
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF