RTKH2

Species: M.brevicollis
Alias: RTKH2
External Links:
Annotation:

Classification

Group: TK
Family: RTKH

Sequence

Name Sequence Type Origin Length Description Download
RTKH2.AA Protein None 1907 None Fasta, JSON
RTKH2.kin_dom Protein Kinase Domain None 276 None Fasta, JSON

Protein domain

Protein domains of RTKH2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
EGF_CA RTKH2.AA EGF_CA 232-244 21 4.480358 2.81 Pfam 35-53 (53) Show / Hide
Range on Protein: 232-244
Range on HMM: 35-53/53
Sequence Identity: 21% (4 aa)

ECPEGFA------CIDSAC
.|..|.       | . .|
DCMDGYEMISENNCDGTNC

EGF RTKH2.AA EGF 250-282 44 2.7e-10 37.45 Pfam 1-36 (36) Show / Hide
Range on Protein: 250-282
Range on HMM: 1-36/36
Sequence Identity: 44% (16 aa)

CDGEASPCLNGGSCTNTIGGYTCDCPAT---YTGSN
|. . .||...| |..| |||||.||     ||| .
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR

EGF_CA RTKH2.AA EGF_CA 246-284 40 7.1e-10 40.06 SMART 1-34 (34) Show / Hide
Range on Protein: 246-284
Range on HMM: 1-34/34
Sequence Identity: 40% (17 aa)

RQNPCDGEASPCLNGG---SCTNTIGGYTCDCPATYTGSNCE
  . |     || |||    |.| .|.|.| ||. ||  .||
DIDEC-----PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE

EGF RTKH2.AA EGF 249-284 38 1.7e-08 35.47 SMART 1-32 (32) Show / Hide
Range on Protein: 249-284
Range on HMM: 1-32/32
Sequence Identity: 38% (16 aa)

PCDGEASPCLNG-----GSCTNTIGGYTCDCP-ATYTGSNCE
.|.    || .|     | |.    .||| || . ||| .||
ECA----PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE

EGF_CA RTKH2.AA EGF_CA 250-283 26 3.2e-05 18.99 Pfam 5-53 (53) Show / Hide
Range on Protein: 250-283
Range on HMM: 5-53/53
Sequence Identity: 26% (13 aa)

CDGEA-SPC---LNGGSCTNTIGGYTCD---CPATYT--------GSNC
|.. .   |    ....|.||||...|    |.. |.        | ||
CADGTHHMCGDPHRNTWCINTIGSFECVNQDCMDGYEMISENNCDGTNC

EGF_2 RTKH2.AA EGF_2 250-283 27 0.000758 15.52 Pfam 1-29 (29) Show / Hide
Range on Protein: 250-283
Range on HMM: 1-29/29
Sequence Identity: 27% (10 aa)

CDGEASPCLN-GGSCTNTIGG-YTCDCPAT-YTGSNC
|      | . .|.| |.  |   |.|.   ..|  |
C------CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC

EGF_CA RTKH2.AA EGF_CA 286-324 45 2.4e-15 58.23 SMART 1-34 (34) Show / Hide
Range on Protein: 286-324
Range on HMM: 1-34/34
Sequence Identity: 45% (19 aa)

DVNECNRGVSPCLNGG---SCTNTIGGYTCDCPATYTGSNCE
|..||     || |||    |.| .|.|.| ||. ||  .||
DIDEC-----PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE

EGF_CA RTKH2.AA EGF_CA 286-323 32 6.8e-11 36.83 Pfam 1-53 (53) Show / Hide
Range on Protein: 286-323
Range on HMM: 1-53/53
Sequence Identity: 32% (17 aa)

DVNECNRGV-SPC---LNGGSCTNTIGGYTCD---CPATYT--------GSNC
||.||. |    |    ....|.||||...|    |.. |.        | ||
DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDCMDGYEMISENNCDGTNC

EGF RTKH2.AA EGF 290-322 47 7e-11 39.42 Pfam 1-36 (36) Show / Hide
Range on Protein: 290-322
Range on HMM: 1-36/36
Sequence Identity: 47% (17 aa)

CNRGVSPCLNGGSCTNTIGGYTCDCPAT---YTGSN
||  ..||...| |..| |||||.||     ||| .
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR

EGF RTKH2.AA EGF 289-324 40 1.2e-08 36.0 SMART 1-32 (32) Show / Hide
Range on Protein: 289-324
Range on HMM: 1-32/32
Sequence Identity: 40% (17 aa)

ECNRGVSPCLNG-----GSCTNTIGGYTCDCP-ATYTGSNCE
||     || .|     | |.    .||| || . ||| .||
ECA----PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE

EGF_2 RTKH2.AA EGF_2 290-323 27 0.001514 14.58 Pfam 1-29 (29) Show / Hide
Range on Protein: 290-323
Range on HMM: 1-29/29
Sequence Identity: 27% (10 aa)

CNRGVSPCLN-GGSCTNTIGG-YTCDCPAT-YTGSNC
|      | . .|.| |.  |   |.|.   ..|  |
C------CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC

EGF_CA RTKH2.AA EGF_CA 326-364 38 1.6e-11 45.53 SMART 1-34 (34) Show / Hide
Range on Protein: 326-364
Range on HMM: 1-34/34
Sequence Identity: 38% (16 aa)

DVNECDGEANPCLNGG---SCTNTIGGYTCDCPQHHSGPTCD
|..||     || |||    |.| .|.|.| ||. .. ..|.
DIDEC-----PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE

EGF_CA RTKH2.AA EGF_CA 326-356 31 1.4e-10 35.85 Pfam 1-38 (53) Show / Hide
Range on Protein: 326-356
Range on HMM: 1-38/53
Sequence Identity: 31% (12 aa)

DVNECDGEA-NPC---LNGGSCTNTIGGYTCD---CPQ
||.||.. . . |    ....|.||||...|    |..
DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDCMD

EGF RTKH2.AA EGF 330-362 41 2.6e-09 34.2 Pfam 1-36 (36) Show / Hide
Range on Protein: 330-362
Range on HMM: 1-36/36
Sequence Identity: 41% (15 aa)

CDGEANPCLNGGSCTNTIGGYTCDCPQH---HSGPT
|. . |||...| |..| |||||.||..    .|..
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR

EGF RTKH2.AA EGF 329-364 33 3.7e-07 31.02 SMART 1-32 (32) Show / Hide
Range on Protein: 329-364
Range on HMM: 1-32/32
Sequence Identity: 33% (14 aa)

ECDGEANPCLNG-----GSCTNTIGGYTCDCP-QHHSGPTCD
||.    || .|     | |.    .||| || .  .| .| 
ECA----PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE

EGF_2 RTKH2.AA EGF_2 330-363 27 0.000166 17.58 Pfam 1-29 (29) Show / Hide
Range on Protein: 330-363
Range on HMM: 1-29/29
Sequence Identity: 27% (10 aa)

CDGEANPCLN-GGSCTNTIGG-YTCDCPQH-HSGPTC
|      | . .|.| |.  |   |.|..  ..|..|
C------CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC

EGF RTKH2.AA EGF 393-426 35 3e-06 28.1 SMART 1-32 (32) Show / Hide
Range on Protein: 393-426
Range on HMM: 1-32/32
Sequence Identity: 35% (14 aa)

PCALMTCYNG-----GTCIGDLYQGQCHCM-PGWVGSDCR
.||   | .|     ||||      .| |  ||. |  | 
ECA--PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE

EGF_2 RTKH2.AA EGF_2 394-425 34 1.2e-05 21.16 Pfam 1-29 (29) Show / Hide
Range on Protein: 394-425
Range on HMM: 1-29/29
Sequence Identity: 34% (12 aa)

CALMTCYN-GGTCIGDLYQ-GQCHCMPG-WVGSDC
|    | . .|||. .  . |.|.| .| | | .|
C----CNGHHGTCNNQ--GCGKCQCDDGWWQGDHC

EGF RTKH2.AA EGF 394-424 27 0.004677 13.28 Pfam 1-36 (36) Show / Hide
Range on Protein: 394-424
Range on HMM: 1-36/36
Sequence Identity: 27% (10 aa)

CALM--TCYNGGTCIGDLYQGQCHCMPG---WVGSD
|.     | ..|||.      .|.| ||   . | .
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR

EGF_CA RTKH2.AA EGF_CA 428-465 41 1.7e-09 38.76 SMART 1-34 (34) Show / Hide
Range on Protein: 428-465
Range on HMM: 1-34/34
Sequence Identity: 41% (17 aa)

DQDECATFNPCANGA---TCHNVPGSFSCSCTALQSGPYCN
| |||    || ||.   ||.| |||..| | .  . . | 
DIDEC----PCQNGGPTGTCIN-PGSYRC-CPPGYT-RHCE

EGF RTKH2.AA EGF 432-463 30 1.9e-07 27.92 Pfam 1-36 (36) Show / Hide
Range on Protein: 432-463
Range on HMM: 1-36/36
Sequence Identity: 30% (11 aa)

CATF-NPCANGATCHNVPGSFSCSCTAL---QSGPY
|.   ||| ...||...||...| |.      .|..
CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR

EGF_CA RTKH2.AA EGF_CA 428-455 36 3.1e-07 25.32 Pfam 1-36 (53) Show / Hide
Range on Protein: 428-455
Range on HMM: 1-36/53
Sequence Identity: 36% (13 aa)

DQDECATFN--PC---ANGATCHNVPGSFSCS---C
| ||||..    |   .....|.|  |||.|.   |
DVDECADGTHHMCGDPHRNTWCINTIGSFECVNQDC

EGF RTKH2.AA EGF 431-465 31 1.8e-05 25.41 SMART 1-32 (32) Show / Hide
Range on Protein: 431-465
Range on HMM: 1-32/32
Sequence Identity: 31% (13 aa)

ECATFNPCANG-----ATCHNVPGSFSCSCT-ALQSGPYCN
|||   || .|     .||.    |..| |  .  .| .| 
ECA---PCHHGGCEQHGTCI----SYTC-CPGPGYTG-RCE

EGF_2 RTKH2.AA EGF_2 432-464 23 15.444812 2.04 Pfam 1-29 (29) Show / Hide
Range on Protein: 432-464
Range on HMM: 1-29/29
Sequence Identity: 23% (9 aa)

CATFNPCAN-GATCHNVPGSFS---CSCTALQ-SGPYC
|     | . . || |         |.|.  . .|..|
C-----CNGHHGTCNNQ----GCGKCQCDDGWWQGDHC

EGF RTKH2.AA EGF 470-507 36 1e-05 26.23 SMART 1-32 (32) Show / Hide
Range on Protein: 470-507
Range on HMM: 1-32/32
Sequence Identity: 36% (16 aa)

PCASEPCLNT-----GSCTWNQEQPTPSYTCTCP-GWTSGARCE
.||  || .      | |.        |||| ||    .| |||
ECA--PCHHGGCEQHGTCI--------SYTC-CPGPGYTG-RCE

EGF RTKH2.AA EGF 471-505 30 0.000505 16.51 Pfam 1-36 (36) Show / Hide
Range on Protein: 471-505
Range on HMM: 1-36/36
Sequence Identity: 30% (12 aa)

CASE--PCLNTGSCTWNQEQPTPSYTCTCPGW---TSGAR
|...  ||.. | |.  .    ..||| ||      .| |
CNPNNNPCHHHGTCVDTP----GGYTCQCPPGYLGYTGKR

FN3 RTKH2.AA FN3 1261-1364 15 0.000141 22.45 SMART 1-69 (69) Show / Hide
Range on Protein: 1261-1364
Range on HMM: 1-69/69
Sequence Identity: 15% (18 aa)

PDSPPV---VARTMVHAR------GLTLELDDPVVANGPITRWPWSLSCADHTCPTVTGSTERSGSVQNGTANSTAELSEGGALLARELALGNLLPY---
|..||    .  | | ..       .||. . |      |...                                               . .| |.   
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR--------------------------------------------YTVTGLKPGQYP

-TQYTLEVSAATS--AGAG
 |.|.  |.| ..  || |
WTEYEFRVRAVNGNDAGEG

FN3 RTKH2.AA FN3 1378-1460 16 0.092037 6.28 SMART 1-69 (69) Show / Hide
Range on Protein: 1378-1460
Range on HMM: 1-69/69
Sequence Identity: 16% (16 aa)

PSAPRH---VQVQRKLV-AGKNQYNVSLVWDMPAEVNGILVGYEVGINLNQSGMRTNTSGNATELGLWTTSPD----DVYQVRARTA----AGWS
|..|..   ..|       .. .. |.| |. |       |||.                      .   .|.      |..| |      ||..
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR--------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG

Kinase RTKH2.AA RTKH 1531-1806 98 3.8e-260 870.52 In-house 1-276 (276) Show / Hide
Range on Protein: 1531-1806
Range on HMM: 1-276/276
Sequence Identity: 98% (273 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLHEHK
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLHEHK

PSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSYASD
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
PSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSYASD

VWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSSLLHEVS
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||...||||||
VWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEAIMRLLHEVS

Kinase RTKH2.AA TK 1531-1802 21 1.2e-105 355.23 In-house 1-486 (486) Show / Hide
Range on Protein: 1531-1802
Range on HMM: 1-486/486
Sequence Identity: 21% (105 aa)

IVLGKELGKGAYG---QVVQAVLKSH---------------------GSEAGVPVAVKMLTRGHGSRQQRQFA-------------FEMHIMKLLHR-AG
|.|||.||.|..|   .| .. ....                     .... .|||||||. |... |...|.              |...||.... .|
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

PHRNVLTICGQVTQE------------SPMMLATELMPLGN----LRDYLHEHKPSSNSNIEDGG-----------------------------------
 | |.. . | .||.             |.|. .|.||.|.    |||||....|  . . . ..                                   
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LSLPRLCDIAEGIASGMAFVSEL------RIVHRDLAARNVFVSRRLV-----------PKIGDFG---
                               |....|. ..  ||.||.. ...      ..|||||||||. |....|            ||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LGVLLDKSQETFVDS-----C------------------QEGLPMRWLAPEVISSGV---------FSYASDVWSFGVLLYELFTHG-GMPYPGQ
     |   ......  ..|     .                  .  || ||.|||.. ..|         |. .|||||||||..|.||.| ...|.| 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

TN---------EQVAASVVGG--------------LRLSQPEDCP--------------DAVYGIMLQAFALKARHRPTFEALSSLL
.|         ..|   .. |              .|. ||..||              ...| .|.| .......||||..| . |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase RTKH2.AA Pkinase_Tyr 1531-1802 38 3.5e-100 339.92 Pfam 1-270 (270) Show / Hide
Range on Protein: 1531-1802
Range on HMM: 1-270/270
Sequence Identity: 38% (107 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQ--QRQFAFEMHIMKLLHRAGPHRNVLTICGQVT-QESP--MMLATELMPLGNLRDY
|..||.||.||.|.|.....|  ... ..|||||||  |. ..|  .. |  |. ||| |   | | |..   | .| |. |  ... .|.||.|.|.||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQL---GHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LHEHKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLL-DKSQETFVDSCQEGLPMRWLAPEVISSGV
|..|.       ... |....|....  ||.||.. .. ...||||||||. |.. .| ||.||||  .. ....  .. .    || .|.|||.|. |.
LRKHR------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK

FSYASDVWSFGVLLYELFTHGGMP-YPGQTNEQVAASV-VGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSSLL
|. .|||||||||..|.|| |..| ||| .||.| . .   | |. .||.||| .| .|.|  . .. .||||... . |
FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL

Kinase RTKH2.AA TyrKc 1531-1802 34 2.9e-99 336.99 SMART 1-280 (280) Show / Hide
Range on Protein: 1531-1802
Range on HMM: 1-280/280
Sequence Identity: 34% (105 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAG-PHRNVLTICGQVTQE-------SPMMLATELMPLGNL
|.|||.|| ||.|.|.....|       ..||||||  ..    .. |  |. ||. |   |  | |.. . | .||.        |.|. .|.||.|.|
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA----REDFMREARIMCKL---GGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

RDYLHEHKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKS-------QETFVDS--CQEG-LPM
.|||..|.|          |... |....  ||.||.. .. ...||||||||. |..... ||.||||   ..         .   . .  .  . || 
KDYLRKHRPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

RWLAPEVISSGVFSYASDVWSFGVLLYELFTHGGMPYPG-----QTNEQVAASVVGGLRLSQPED--------CPDAVYGIMLQAFALKARHRPTFEALS
||.|||.|  |.|. .||||||||...|.|| |..||||      .|..| . |  | |. ||..        |||..| ||.|  . ..  ||||... 
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

SLL
...
ECF

Kinase RTKH2.AA Src 1531-1802 38 5.7e-85 288.6 In-house 1-255 (255) Show / Hide
Range on Protein: 1531-1802
Range on HMM: 1-255/255
Sequence Identity: 38% (105 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLHEHK
| | ..||.| .| | ... . .     ..|||| | .|.   .. .|  |  ||| |     | ... .   ..|| |    ||.|  |.| |||..  
IKLCRKLGQGQFGEVWMGYWNGN-----TKVAVKTLKPGT--MSPEAFLQEAQIMKKLR----HEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK--

PSSNSNIEDGG-LSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSYAS
       ..|. |.||.| |.|  .|.|||. .. ...||||||||| |.  .| |..||||  |...  .  . .    .|..| ||| |. |.|.  |
------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKS

DVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYG-IMLQAFALKARHRPTFEALSSLL
||||||.||.|..|.| .|||| ||..|   |  | |. .|. ||| .|  ||||    ... ||||| | . |
DVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL

Kinase RTKH2.AA UTK 1531-1802 33 1.3e-80 274.09 In-house 1-296 (296) Show / Hide
Range on Protein: 1531-1802
Range on HMM: 1-296/296
Sequence Identity: 33% (102 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGV-PVAVKMLT-RGHGSRQQR---QFAFEMH---IMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNL
. ||..||.||.|.|  | ..     ...  |||| .  .. . ....   .|  |     .|| .|    |.|||   | .|||.|.|..||.|. |.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFH---WHPNVLRLVGVCTQEEPWMIVTEYMENGDL

RDYLHEHKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRR-------LVPKIGDFG---LGVLLDK--------SQETFVD
|.||  |.|. .  ...  |.| .. . |  ||.||.. .. ..|||||||||..| .        .| ||.|||   .  ..          ... .  
RSYLRRHRPTPP--ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMA

SCQEGLPMRWLAPEVISSG-VFSYASDVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGG--LRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSSL
. |. .|.|| |||.. ..  |. .||||||||...|..|.| .|||| .|.||...|. |  .|. .|.|||..|| .|..  .   . ||.|| | . 
QHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQ

L
.
M

Kinase RTKH2.AA TK-Unique 1531-1802 31 4.5e-78 265.67 In-house 1-294 (294) Show / Hide
Range on Protein: 1531-1802
Range on HMM: 1-294/294
Sequence Identity: 31% (93 aa)

IVLGKELGKGAYGQVVQAVLKS--HGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQES-PMMLATELMPLGNLRDYLH
...|...|.||.|||  . ...   .... . |||||| ...   ....|  |  .|| |   |.| |.....|. |  . |.|.. | .| |||..||.
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKEL---GDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

EHKP---SS-------------NSNIEDGGLSLPRLCDIAEGIASGMAFVSE--LRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQ-E
. .|   ..             ..  ..  .|. .|  .| .||.||.. ..   .||||||.||||......| ||.|||.   ...  .  . .|. .
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQG

GLPMRWLAPEVIS--SGVF-SYASDVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDC-PDAVYGIMLQAFALKARHRPTFEALSSLL
 .| ||.|||...   |.. .. |||||||||..|.|| |..||||  ....   .  | |. ||| | ....| .| . . ... .||.|... . |
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL

Kinase RTKH2.AA RTKB 1531-1802 36 6.1e-68 228.13 In-house 1-264 (264) Show / Hide
Range on Protein: 1531-1802
Range on HMM: 1-264/264
Sequence Identity: 36% (100 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLHEHK
. ||..|| ||.|.| || ..  ..     .|.| |  |  .... .|  ||..|| |   |.| ||. | |   |. | .|  ||  ||||||||..  
VWLGEKLGNGAFGEVFQAWVRNRHMNTEQSCAAKVLKPGASYEERQDFCSEMTVMKEL---GWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMCR

PS-SNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSYAS
 | .|.      |.   | | .  ||.|||| .   ..||||.|||| |.  |  || |||.     .... ..      || .|.||| . .  ..  |
ASQHNPQS----LKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAR---EIDHECYETTCTRLPIKWMAPESWAHRIYTTKS

-DVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSSLL
 |||||||  .| |. || ||. . | ..      | || .|.  | |...|| .  .. | |||.|..| ...
GDVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF

Kinase RTKH2.AA Eph 1531-1802 36 2.4e-65 218.42 In-house 1-264 (264) Show / Hide
Range on Protein: 1531-1802
Range on HMM: 1-264/264
Sequence Identity: 36% (100 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGV---PVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLH
| . | .| | .| | .  ||    .. |   |||.|.|  |.  .|...|  |  ||        | |..   | ||. .|.|  || | .| | ..| 
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFD----HPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLR

EHKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQ--ETFVDSCQEGLPMRWLAPEVISSGVF
.|         || ..  .|  .  |||||| . |..  |||||||||. |. .|| |. ||||. .|.. .  |    .     | || |||.|. . |
QH---------DGQFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKF

SYASDVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSSLL
. ||||||.|... |  . |  ||   .|  |  ..  | ||  | ||| | . .||.  .    |||.|. . | |
TSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL

Kinase RTKH2.AA Frk 1531-1806 36 2.1e-63 216.96 In-house 1-260 (260) Show / Hide
Range on Protein: 1531-1806
Range on HMM: 1-260/260
Sequence Identity: 36% (103 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLH--E
| | ..|| | .|.|          .  .||||| |    |.   . |  |  ||| |     |  .. .    | | |... ||||  | | .||   .
IQLIRRLGSGQFGEVWEGLW-----NNTTPVAVKTLK--PGTMDPNDFLREAQIMKKLR----HPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAIN

HKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQE-TFVDSCQEGLPMRWLAPEVISSGVFSY
.| ..        . .. | |.|  .|.|||.. .   .||||||||| |   .. || ||||  .| | .|  .    .  .|..| ||| . .  |. 
DKGRQ--------CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTI

ASDVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSSLLHEVS
 |||||||.||.|. |.| ||||| || .|   |  | |. || .||  .| |||. .  ....||||| |   | .  
KSDVWSFGILLTEIITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF

Kinase RTKH2.AA SrcB 1531-1803 36 6e-62 208.3 In-house 1-251 (251) Show / Hide
Range on Protein: 1531-1803
Range on HMM: 1-251/251
Sequence Identity: 36% (101 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLGNLRDYLHEHK
. | | || | .| |  .  . |     . |||| . .|  | .   |  |  .|| |     |  .  .   ||.| |. . || |  | | |.|    
LKLVKKLGAGQFGEVWMGYYNNH-----MKVAVKTMKQGTMSPE--AFLAEANVMKTLQ----HDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTD-

PSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSYASD
       | . ||||.| |..  || |||.. .   .|||| | |. ||  |. || ||||  ...    |  .  .   |..| ||| |  |.|   ||
-------EGSKLSLPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAK--FPIKWTAPEAINFGCFTIKSD

VWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSSLLH
|||||.||.|. |.| .|||| || .|  ..  | |. .|. ||. .| || . .  ..  ||||. | | | 
VWSFGILLMEIVTYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD

Kinase RTKH2.AA Fer 1531-1803 27 3.6e-61 207.06 In-house 1-283 (283) Show / Hide
Range on Protein: 1531-1803
Range on HMM: 1-283/283
Sequence Identity: 27% (82 aa)

IVLGKELGKGAYGQVVQA--VLKS---HGSE-AGVPVAVKML-TRGHGSRQQRQFAFEMHIMKL-LHRAGPHRNVLTICGQVTQESPMMLATELMPLGNL
..||| ||.||.| | ..  .||     ...   |.|.||.. . . .  |.. |  |. ||.  .     | ||  . |  ..| | |.  |... |.|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYD----HPNVVKFYGVCVDEQPIMIVMEFCNGGSL

RDYLHEHKPSSNSNIEDGG-LSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSR-RLV--PKIGDFGLGVLLDKSQETFVDS-CQEGLPMRWLAP
..|| .         ...  .|.  . ... ..|.||..  .  ..|||.||||. ..   ..  .|| |||. . ... ...  .   .. .| |||||
DSYLKK---------NKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAP

EVISSGVFSYASDVWSFGVLLYELFTHGGMPYPG--------QT-NEQVAASVVGGLRLSQPEDCPDAVYGIML-QAFALKARHRPTFEALSSLLH
|....|..|...|||||||...| || |  ||||        .. ...... ...| ..  |. .|.... ||. | .. .   |||.  .   |.
ETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK

Kinase RTKH2.AA S_TKc 1531-1806 19 2.6e-34 121.24 SMART 1-231 (231) Show / Hide
Range on Protein: 1531-1806
Range on HMM: 1-231/231
Sequence Identity: 19% (55 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAFEMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPL--GNLRDYLHE
  .....||||.|.| ... |.     |  ||.|..         ...  |. |.|       | |. .. .     . . . .|...   |.|.||...
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKK

HKPSSNSNIEDGGLSLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVPKIGDFGLGVLLDKSQETFVDSCQEGLPMRWLAPEVISSGVFSY-
...  .    . ...  . . ..  |......  ...|.||||   |.....  . ||.||||  .|                  ..||||.    ... 
RGRHGL----RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKC

ASDVWSFGVLLYELFTHGGMPYPGQTNEQVAASVVGGLRLSQPEDCPDAVYGIMLQAFALKARHRPTFEALSS-----LLHEVS
..|.||.|..|||... |  |.|   ..|.   ..|          .. .  .. . .    ..|||   .        .|.  
KCDWWSCGCILYEMLC-GYPPFP---QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase RTKH2.AA Pkinase 1531-1802 21 2.7e-33 118.81 Pfam 1-293 (293) Show / Hide
Range on Protein: 1531-1802
Range on HMM: 1-293/293
Sequence Identity: 21% (68 aa)

IVLGKELGKGAYGQVVQAVLKSHGSEAGVPVAVKMLTRGHGSRQQRQFAF---EMHIMKLLHRAGPHRNVLTICGQVTQESPMMLATELMPLG----NLR
...|. .|.|..|.| ... |. |      |||| . . | . ...| ..   | .||| |.    | |.... . .. .. . . .|... |     | 
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN----HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

DYLHEHKPSSNSNIEDGGL--SLPRLCDIAEGIASGMAFVSELRIVHRDLAARNVFVSRRLVP----KIGDFGLGVLLDKSQETFVDSCQEGLP--MRWL
||..          ..|..  |   .....  |..|...  . .|.||||   |...... ..    ||.||||  ..|    .  .|   ..    ...
DYIST--------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYM

APEVIS-SGVFSYASDVWSFGVLLYELFTHGGMPYPGQ------TNEQVAASVVG-GLRLSQPEDCP-------------------DAVYGIMLQAFALK
|||||  .   ....|.||.|..|||... |  |.||.      .  |. . . |  |. . |..|.                   ..   ..   ....
APEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKD

ARHRPTFEALSSL--L
   |||.| .     .
PKKRPTAEQILQHPWF