Gene Tec (M.brevicollis)
Tec
Species: M.brevicollis
Alias: Tec
External Links:
Annotation:
Sequence
Protein domains of Tec.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PH | Tec.AA | PH | 4-112 | 22 | 1.7e-13 | 52.05 | SMART | 1-82 (82) | Show / Hide |
Range on Protein: 4-112 Range on HMM: 1-82/82 Sequence Identity: 22% (25 aa) PIHQGMLTKRARGLRAMGRRNWKDRLFILSTEKLCYYESYGGKVDESRLKGSLKVSDIVAVEDLGNDVFGRPYMMVVQSQDNNFLYCQAHGLNERNLWLE .|..| |.|. . .||.| |.| . |.||.. ..|||. .||. .| . . . |. .| |. |.. |.. VIKEGWLYKKS-------K-RWKKRWFVLFNDCLYYYKDK-------KPKGSIPLSDCTVRE-P---------CFEIHH-DR-TYYFQCESEEEMQEWMQ KLRHTVKNN .. ..|| AIQKAIHNN |
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| PH | Tec.AA | PH | 4-110 | 27 | 2.3e-11 | 43.62 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 4-110 Range on HMM: 1-92/92 Sequence Identity: 27% (29 aa) PIHQGMLTKRARGLRAMGRRNWKDRLFILSTEKLCYYESYGGKVDESRLKGSLKVSDIVAVEDLGNDVFGRPYMMVVQSQDNNFLYCQAHGLNERNLWLE .|..| |.|. .|..||.| |.| . .|.||.. . .|.|||. .||. |... . .||.. .. . |.. .| || |.| |.. VIKEGWLHKKG------KRKSWKKRWFVLFNNCLYYYKDDK-----YRPKGSIPLSDC-QVTKVPDN--KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQ KLRHTVK .. .. AIQSACR |
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| BTK | Tec.AA | BTK | 112-147 | 29 | 0.000139 | 13.03 | SMART | 1-37 (37) | Show / Hide |
Range on Protein: 112-147 Range on HMM: 1-37/37 Sequence Identity: 29% (11 aa) NSNLLGAVHKGRY-DGRWLCCGNASVTCKGCQPAFDY |.... | . . ||.||||. . . ||.| .. NNHRMQKYHPCFWMDGHWLCCQQTCKNAPGCCPCHPH |
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| SH3 | Tec.AA | SH3 | 233-289 | 41 | 3.3e-22 | 81.0 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 233-289 Range on HMM: 1-58/58 Sequence Identity: 41% (24 aa) FEVQSLYDYDALEPTDLSLSKGERLVIVDQMEEHWWKARNN-AGQEGYIPANYVRKLG ..|. ||||.| .| .||..||. . .... ...|||.|.| ||||..|.|||... PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID |
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| SH3_1 | Tec.AA | SH3_1 | 236-282 | 40 | 6.8e-18 | 63.28 | Pfam | 1-49 (49) | Show / Hide |
Range on Protein: 236-282 Range on HMM: 1-49/49 Sequence Identity: 40% (20 aa) QSLYDYDALEPTDLSLSKGERLVIVDQMEE-HWWKARNNA-GQEGYIPA . ||||.| .| .||. ||. . .... .. .|||.|.| ||||..|. VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS |
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| SH3_2 | Tec.AA | SH3_2 | 234-288 | 17 | 2.7e-10 | 38.94 | Pfam | 1-68 (68) | Show / Hide |
Range on Protein: 234-288 Range on HMM: 1-68/68 Sequence Identity: 17% (12 aa) EVQSLYDYDA-LEPTD-----LSLSKGERLVIV---DQMEEHWWKA-RN-NAGQE--GYIPANYVRKL .. . ||.. ... |.. ||. ... |. ..||.. .. . |.. |..| ..|... YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC |
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| SH2 | Tec.AA | SH2 | 295-370 | 43 | 3.3e-37 | 111.07 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 295-370 Range on HMM: 1-81/81 Sequence Identity: 43% (35 aa) WFMADTSKAMASALLNM-CGQDGAFLVRESESTPGSYSLSVFYQG---KLKHYKIKHDQDM-YRVSERHTFASISELIEYH |.. . |.. | ||. ..||.|||||||||||.|.|||...| . |||.|. .... | ...||.|.|..||.|.. WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY |
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| SH2 | Tec.AA | SH2 | 293-376 | 42 | 2.1e-31 | 111.55 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 293-376 Range on HMM: 1-87/87 Sequence Identity: 42% (37 aa) EPWFMADTSKAMASALLNMC-GQDGAFLVRESESTPGSYSLSVFYQGKLKHYKIKHDQ-DMYRVSE--RHTFASISELIEYHKHNGGG .||.. . |.. | .||. ..||.||||.|||.||.|.|||...|| |||.|.... ..|.. | |..| |. ||.....|| .| QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| Kinase | Tec.AA | Tec | 408-661 | 54 | 3e-153 | 515.4 | In-house | 1-254 (254) | Show / Hide |
Range on Protein: 408-661 Range on HMM: 1-254/254 Sequence Identity: 54% (139 aa) IELGRELGSGNFGVVRAGVYKSNRPVAIKMMKEGSMSEDDFIAEAQVMMKFRHKNLVELLGVVTSVKPIYIVTELMSNGNLLDYLKKNQSMLQGKPQILH . . .||||| ||||. | ..... |||||.|||||||.||| ||.|||| | .|| | || . .||||||| |..| ||.||.... ..|.. || LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL YMSVQVASGMAFLEDHGFIHRDLAARNCLVGDNNVVKVADFGLARFVIDDEYTASEGTKFPIKWASPEVYLYARFSTKSDVWSYGVLLWEIWSLGTTPYP .| .| |||.|| |.|||||||||||||||..||||.|||..|.|.||.|| | |||||.||..||| | |.| |||||..||| ||..|.| ||. EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYE QWTNAETVDRVGRGERMGRPSLASELIYDIMSMCWHQDPESRISFIEIVEKLEE . .| |.|..| .| |. || |.|. ||.|| ||| || | .| . ....| NMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE |
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| Kinase | Tec.AA | Pkinase_Tyr | 408-659 | 47 | 9.40000000001e-137 | 463.78 | Pfam | 1-270 (270) | Show / Hide |
Range on Protein: 408-659 Range on HMM: 1-270/270 Sequence Identity: 47% (129 aa) IELGRELGSGNFGVVRAGVYK-----SNRPVAIKMMKEGSMSE----DDFIAEAQVMMKF-RHKNLVELLGVVT-SVKP--IYIVTELMSNGNLLDYLKK |..|..||.|.||.|. |..| . |||.||.|||.|.| .||..||..|... .|.|.| |.||.| .| ||||.|.| .|.|||||.| ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK N--QSMLQGKPQILHYMSVQVASGMAFLEDHGFIHRDLAARNCLVGDNNVVKVADFGLARFV-IDDEY-TASEGTKFPIKWASPEVYLYARFSTKSDVWS . . .. | |..|.|.||..||....||||||||||||..|||||..|||||| . ||.| ....|.|.|||| .||. | .|.||||||| HREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS YGVLLWEIWSLGTTP-YPQWTNAETVDRV-GRGERMGRPSLASELIYDIMSMCWHQDPESRISFIEIVEKL .|||.||| ..| .| || ..|.| .... .|.|| .| .... |||.| .|||.||| | .| ||.|.| FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL |
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| Kinase | Tec.AA | TyrKc | 408-659 | 41 | 5.70000000001e-133 | 448.97 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 408-659 Range on HMM: 1-280/280 Sequence Identity: 41% (118 aa) IELGRELGSGNFGVVRAGVYKSNRPVAIKMMKEGSMSEDDFIAEAQVMMKF--RHKNLVELLGVVTSV-------KPIYIVTELMSNGNLLDYLKKNQSM |.||..||.|.||.|. |..| ..||.||.||.. . ||. ||..|.|. .|.|.| |.||.|. .|..||.|.|..|.|.|||.|.. ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK LQGKPQILHYMSVQVASGMAFLEDHGFIHRDLAARNCLVGDNNVVKVADFGLARFVIDD--------EYTASE--GTK--FPIKWASPEVYLYARFSTKS ... |.....|.|.||..|.....|||||||||||||.|..||..||||.|.. || |...| |.| .||.| .||. | .|.||| --LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS DVWSYGVLLWEIWSLGTTPYPQ-----WTNAETVDRVGRGERMGRPSL--------ASELIYDIMSMCWHQDPESRISFIEIVEKL ||||.||..||| ..| .||| .|.| . .| .|.|| .| ... .|.||..||| |||.| .| ||.|.. DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | Tec.AA | Src | 408-659 | 52 | 2.6e-129 | 435.92 | In-house | 1-255 (255) | Show / Hide |
Range on Protein: 408-659 Range on HMM: 1-255/255 Sequence Identity: 52% (134 aa) IELGRELGSGNFGVVRAGVYKSNRPVAIKMMKEGSMSEDDFIAEAQVMMKFRHKNLVELLGVVTSVKPIYIVTELMSNGNLLDYLKKNQSMLQGKPQILH | | |.||.|.|| | |... | .||.| .|.|.|| ..| .|||.| |.||..||.|. |.. .|||||||.||.|.|||||||.. . . ..| IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI YMSVQVASGMAFLEDHGFIHRDLAARNCLVGDNNVVKVADFGLARFVI--DDEYTASEGTKFPIKWASPEVYLYARFSTKSDVWSYGVLLWEIWSLGTTP .|. |||.|||.|| .||||||||| |||.|||.||||||||| . ||||.|..| |||||| || .| ||..||||||.|.||.|| . | .| DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVP YPQWTNAETVDRVGRGERMGRPSLASELIYD-IMSMCWHQDPESRISFIEIVEKL || .||.|....| || || .|. . .|. || .|||.||| | | . ..| YPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | Tec.AA | SFK-Src | 408-663 | 49 | 5.3e-122 | 363.51 | In-house | 1-259 (259) | Show / Hide |
Range on Protein: 408-663 Range on HMM: 1-259/259 Sequence Identity: 49% (129 aa) IELGRELGSGNFGVVRAGVYKSNRPVAIKMMKEGSMSEDDFIAEAQVMMKFRHKNLVELLGVVTSVKPIYIVTELMSNGNLLDYLKK-NQSMLQGKPQIL |.| . |||| || | |. ||.| .| |.||.. | .||||| | || ||. | | | ||||.|||| .| |||||. . | . . | IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSL--RMPQL HYMSVQVASGMAFLEDHGFIHRDLAARNCLVGDNNVVKVADFGLARFVI-DDE-YTASEGTKFPIKWASPEVYLYARFSTKSDVWSYGVLLWEIWSLGTT | |||.|||.||. |.|||||||| |||||||.||.|||..| . ||| ||| || |||||| || .. |||.||||||.|.|. || .| VDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRI PYPQWTNAETVDRVGR--GERMGRPSLASELIYDIMSMCWHQDPESRISFIEIVEKLEENA ||| ||.| . .| | |.|| | . | || || . |. | | ..|. PYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF |
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| Kinase | Tec.AA | TK | 408-659 | 24 | 8.49999999999e-121 | 406.91 | In-house | 1-486 (486) | Show / Hide |
Range on Protein: 408-659
Range on HMM: 1-486/486
Sequence Identity: 24% (121 aa)
IELGRELGSGNFG---VVRAGVYKSNR--------------------------PVAIKMMKEG-SMSEDDFIA--------------EAQVMMKFR----
|.||..||.|.|| .|. | ... . |||.||.||| .||...|.. ||..|....
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
-HKNLVELLGVVTSV------------KPIYIVTELMSNGN----LLDYLKKN-----------------------------------------------
|.|.| |.||.| . .|..||.|.|..|. |.|||.|.
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
------QSMLQGKPQILHY-------------------MSVQVASGMAFLEDH------GFIHRDLAARNCLVGDNNV-----------VKVADFG----
.. .. . |.. |..|.|.||..|... .|.||||||||||||.||| .|.||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ
----LARFV-IDDEYTASE------------------------GTKFPIKWASPEVYL---------YARFSTKSDVWSYGVLLWEIWSLG-TTPYPQWT
||| . ||.|.... |.|.||.| .||. . | .|.|||||||.|||.|||...| ...|....
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS
N---------AETVDRVGRG--------------ERMGRPSLAS--------------ELIYDIMSMCWHQDPESRISFIEIVEKL
| .| .... || || .| ... |..||.| .||| ||| | .| ...|.|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | Tec.AA | Src-Unclassified | 408-649 | 43 | 2.8e-107 | 362.73 | In-house | 1-274 (284) | Show / Hide |
Range on Protein: 408-649 Range on HMM: 1-274/284 Sequence Identity: 43% (118 aa) IELGRELGSGNFGVVRAGVYKSNRPVAIKMMKEG---SMSEDDFI--------AEAQVMMKFRHKNLVELLGVVTSVKPIYIVTELMSNGNLLDYLKKNQ . | |.|| |.|| | | .. ||.| |..| || | .|||.| |.|| ||| |..| . .|.||.||.|.|| ||..|.. VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG SMLQGKPQI-----------LHYMSVQVASGMAFLEDHGFIHRDLAARNCLVGDNN-----VVKVADFGLA--RFVIDDEYTASEGTKFPIKWASPEVYL . . . ... |||||| || . .|||||||| |.|.|| ||||.||||| . . ||.| . | .||.|| || . GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI YARFSTKSDVWSYGVLLWEIWSLGTTPYPQWTNAETVDRVGRGERMGRP--SLASELIYD-IMSMCWHQDPESR | ||.||||||||.||||| .| |||| . | |.. | || || .| . . ||. || |||.||. | YGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRR |
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| Kinase | Tec.AA | SFK-Abl | 408-659 | 49 | 2.9e-104 | 341.25 | In-house | 1-251 (251) | Show / Hide |
Range on Protein: 408-659
Range on HMM: 1-251/251
Sequence Identity: 49% (124 aa)
IELGRELGSGNFGVVRAGVYKSNRPVAIKMMKEGSMSEDDFIAEAQVMMKFRHKNLVELLGVVTSVKPIYIVTELMSNGNLLDYLKKNQSMLQGKPQILH
| || || |..| | |.. |. |||| |..|| || || .| . .| ||| |.|| | |.|||.| | .|||||||. || | . .
IILGHRLGEGQYGEVYKGIW-NNHRVAIKTIKDESMETKDFMKEAHIMKRMQHPNLVRLIGVCTREGPMYIVQEFMNYGNLLDYLQSPQSRIQIDHVSMM
YMSVQVASGMAFLEDHGFIHRDLAARNCLVGDNNVVKVADFGLARFVIDDEYTASEGTKFPIKWASPEVYLYARFSTKSDVWSYGVLLWEIWSLGTTPYP
. |.| || |||. |||||||||||||||| .||||||.|||| | |.| |||.|||| || |. |. ||||||.|. |||| | |||
HCAQQIADGMSFLEEQHFIHRDLAARNCLVGDNLQIKVADFGMARFVDSDFYEARIGTKMPIKWTAPESLCYDIFTIKSDVWSFGITLWEIATYGDVPYP
QWTNAETVDRVGRGERMGRPSLASELIYDIMSMCWHQDPESRISFIEIVEKL
. ... | || || ||.|| || .|. | || . |
GIHHRDVINQLMMGYRMQRPQDCPMEIYNIMTQCWDVNPDERPSFHDLQHQL
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| Kinase | Tec.AA | Abl | 408-659 | 48 | 1.1e-101 | 340.09 | In-house | 1-252 (252) | Show / Hide |
Range on Protein: 408-659 Range on HMM: 1-252/252 Sequence Identity: 48% (122 aa) IELGRELGSGNFGVVRAGVYKS-NRPVAIKMMKEGSMSEDDFIAEAQVMMKFRHKNLVELLGVVTSVKPIYIVTELMSNGNLLDYLKKNQSMLQGKPQIL | . || | .| | ||.| . ||.| .|| .| ..|..|| .| . .|.|||.|||| | | ||.|| |..|||||||.... . .. .| IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREEL-PAVVL HYMSVQVASGMAFLEDHGFIHRDLAARNCLVGDNNVVKVADFGLARFVIDDEYTASEGTKFPIKWASPEVYLYARFSTKSDVWSYGVLLWEIWSLGTTPY || |.|||| .|| . ||||||||||||||....||||||||||.. || ||| | |||||| || | .||.||||| .||||||| | .|| LYMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSKSDVWAFGVLLWEIATYGMSPY PQWTNAETVDRVGRGERMGRPSLASELIYDIMSMCWHQDPESRISFIEIVEKL | . ... .| || || . .|..| ||. .. | || || ... PGIDLSHVYHKLEKGYRMERPEGCPPKVYELMRQCWQWSHTDRPSFKEIHHAM |
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| Kinase | Tec.AA | UTK | 408-659 | 35 | 1.1e-100 | 340.86 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 408-659 Range on HMM: 1-296/296 Sequence Identity: 35% (104 aa) IELGRELGSGNFGVVRAGVYKSNR---PVAIKMMKEGSMSED---------DFIAEAQ---VMMKFR-HKNLVELLGVVTSVKPIYIVTELMSNGNLLDY ..|||.||.|.||.|. . .. . ..... |. . ..| ||. ||. .|..|. | |.. |.||.|. .|..||||.|.||.|..| VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY LKKNQSMLQGKPQILH-----YMSVQVASGMAFLEDHGFIHRDLAARNCLVGDN-------NVVKVADFG---LARFVI----------DDEYTASEGTK | .. . . | .| .|....|.||..|. .||.|||||||||||... .|.|.|||| ..| | ...|.|.. .. LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR FPIKWASPEVYLYA-RFSTKSDVWSYGVLLWEIWSLGTTPYPQWTNAETVDRVGRG--ERMGRPSLASELIYDIMSMCWHQDPESRISFIEIVEKL ||.| .||.. .. ||.|||||||.||..||||. | .||| ..|.... .|..| || .| .. .|..| |||.||. | .| ..|... WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM |
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| Kinase | Tec.AA | Frk | 408-663 | 48 | 1.3e-100 | 340.56 | In-house | 1-260 (260) | Show / Hide |
Range on Protein: 408-663 Range on HMM: 1-260/260 Sequence Identity: 48% (127 aa) IELGRELGSGNFGVVRAGVYKSNRPVAIKMMKEGSMSEDDFIAEAQVMMKFRHKNLVELLGVVTSVKPIYIVTELMSNGNLLDYLK-KNQSMLQGKPQIL |.| |.|||| || | | . . |||.| .| |.| .||..|||.| | || |..| | | .||||.|||| .| |..||. |. | . |.| IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL HYMSVQVASGMAFLEDHGFIHRDLAARNCLVGDNNVVKVADFGLAR-FVIDDE--YTASEGTKFPIKWASPEVYLYARFSTKSDVWSYGVLLWEIWSLGT |. |||.|||.||.. .||||||||| |||..|..|.||||||| .. |.| | . | .||||| || | .|..||||||.|.|| || | VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTEIITYGR TPYPQWTNAETVDRVGRGERMGRPSLASELIYDIMSMCWHQDPESRISFIEIVEKLEENA ||| |||| .. | .| || .|. . .|.|| |||.||. | | . |||. MPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF |
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| Kinase | Tec.AA | SrcB | 408-660 | 47 | 1.5e-94 | 320.29 | In-house | 1-251 (251) | Show / Hide |
Range on Protein: 408-660 Range on HMM: 1-251/251 Sequence Identity: 47% (121 aa) IELGRELGSGNFGVVRAGVYKSNRPVAIKMMKEGSMSEDDFIAEAQVMMKFRHKNLVELLGVVTSVKPIYIVTELMSNGNLLDYLKKNQSMLQGKPQILH . | . ||.| || | | |. . ||.| ||.|.|| . |.||| || . |. || | ||| ||||.|| | .| |||.|| .. . |... LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID YMSVQVASGMAFLEDHGFIHRDLAARNCLVGDNNVVKVADFGLARFVIDDEYTASEGTKFPIKWASPEVYLYARFSTKSDVWSYGVLLWEIWSLGTTPYP || |.| |||..| . .||||| | | || . . |.||||||| . |.|||| || |||||| || . | ||||||.|.|| || | ||| -MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIVTYGRIPYP QWTNAETVDRVGRGERMGRPSLASELIYDIMSMCWHQDPESRISFIEIVEKLE ||.| . . || || || | .|.|| |||.. || | | . |. GMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD |
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| Kinase | Tec.AA | S_TKc | 408-657 | 27 | 1.5e-56 | 195.14 | SMART | 1-220 (231) | Show / Hide |
Range on Protein: 408-657 Range on HMM: 1-220/231 Sequence Identity: 27% (70 aa) IELGRELGSGNFGVVRAGVYKS-NRPVAIKMMKEGSMSEDDFIAEAQVMMKFRHKNLVELLGVVTSVKPIYIVTELMSN--GNLLDYLKKNQSM---LQG |..|..|.| ||.|. .. |. .| ||||..| .... | |...| .|.|.| |..| . . .|.|.|.... |.|.||.||... . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF KPQILHYMSVQVASGMAFLEDHGFIHRDLAARNCLVGDNNVVKVADFGLARFVIDDEYTASEGTKFPIKWASPEVYLYARFST-KSDVWSYGVLLWEIWS . .. |........ .||.||||| | |. . ..|..||||||.. . .||| ... |.|.|| |..|.| . PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC LGTTPYPQWTNAETVDRVGRGERMGRPSLASELIYDIMSMCWHQDPESRISFIEIVE | .|.| . ... ...| |. |... |.. ||| |.. |. . -GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQ |
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| Kinase | Tec.AA | Pkinase | 408-659 | 23 | 5.1e-48 | 170.65 | Pfam | 1-293 (293) | Show / Hide |
Range on Protein: 408-659 Range on HMM: 1-293/293 Sequence Identity: 23% (70 aa) IELGRELGSGNFGVVRAGVYKSNR-PVAIKMMKEGSMSEDDFIA-----EAQVMMKFRHKNLVELLGVVTSVKPIYIVTELMSNG----NLLDYLK--KN ...|| .|||.||.|. .. |... ||.| .| . ... .. |.|.| ...|.| |.|...... . ||.|.|.. .| | ||.. .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH QSMLQGKPQILHYMSVQVASGMAFLEDHGFIHRDLAARNCLVGDNNVV----KVADFGLAR---FVIDDEYTASEGTKFPIKWASPEVYL-YARFSTKSD ... . .. . . |...|.... ..|.||||| |.|. .|... |..|||||. . .| || . ...||| . . ..|.| GCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW---YMAPEVIRGGQYYGPKVD VWSYGVLLWEIWSLGTTPYPQW------TNAETVDRVGRGERMGRPS--------------------LASELIYDIMSMCWHQDPESRISFIEIVEK--L .||.|..|.| . | .|.|. . . ..|..... . . ..|| |... |...||..|... .|.. . MWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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