Gene CTKA1 (M.brevicollis)

CTKA1

Species: M.brevicollis
Alias: CTKA1
External Links:
Annotation:

Classification

Group: TK
Family: CTKA

Sequence

Name Sequence Type Origin Length Description Download
CTKA1.AA Protein None 954 None Fasta, JSON
CTKA1.kin_dom Protein Kinase Domain None 268 None Fasta, JSON
CTKA1.kin_dom2 Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of CTKA1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 CTKA1.AA SH2 10-86 37 3.6e-23 69.86 Pfam 1-81 (81) Show / Hide 
Range on Protein: 10-86
Range on HMM: 1-81/81
Sequence Identity: 37% (30 aa)

WLSRHISRQDAETALKG--HPDGTYLIRASVSAPGDYVLCVVCHGQIQHHQVCIKHNNGRM-LTRSGRE-LQNLSELLRHY
|  ..||||.||  |.    ||||.|.| | | ||||.|.|.. |.... . ......... . ..||.  ..|.||  ||
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 CTKA1.AA SH2 8-92 36 1.8e-22 81.93 SMART 1-87 (87) Show / Hide 
Range on Protein: 8-92
Range on HMM: 1-87/87
Sequence Identity: 36% (32 aa)

QIWLSRHISRQDAETALKG--HPDGTYLIRASVSAPGDYVLCVVCHGQIQHHQVCIKHNNGRMLTR-SGRELQNLSELLRHYKTTLDG
| |   .|||..||  ||.   |||..|.| | | ||||||.| ..|...| ... . ...  ..  ..|  ..| ||..||... .|
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
Kinase CTKA1.AA CTKA 208-475 61 1.1e-217 729.46 In-house 1-290 (290) Show / Hide 
Range on Protein: 208-475
Range on HMM: 1-290/290
Sequence Identity: 61% (177 aa)

LQIMSELGSGHYGQVFEAWLMPDPDDFKAQRKKGKLVAVKSLKAHGNDGAVRAFLGEARTLS--QFSHPNVLGLLGVVTRSKPWHMITEHIPYGDVRSVL
..||...|.|||||||.||||||||||||||||||.||||.||.|......||||.||..||  .|.|||||.||||.|..||||||.||..|||....|
HCIMFKIGEGHYGQVFRAWLMPDPDDFKAQRKKGKDVAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCYL

KACRSAS------------------TAVHAHEQVYMAAQAAAGMEYLASLGFVHRDLAARNILLGRYCHIKLADFGLSRALDTESQYYVVQSRSLLPFRW
.|||.|.                  ..||||||||||.|.||||.|||..||||||||.||.|||.|||||.||||..|.|.||||||.|.|....|.||
RACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYMAMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRW

MSIEALKEGKFTTQSDVWAFGVLLWEIMSMAKTPWRKNSTQEVKQLILAG--ERLPPPRNCPQTLYSLMTTCWQPAPAARPTFVTLRRSL
|..|||..|||...||||||||||||||||...|||..|.|||.|.....  .|||.||||||.||..|..||...|..||||.||.|.|
MAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase CTKA1.AA Pkinase_Tyr 208-475 35 2.9e-117 397.76 Pfam 1-270 (270) Show / Hide 
Range on Protein: 208-475
Range on HMM: 1-270/270
Sequence Identity: 35% (99 aa)

LQIMSELGSGHYGQVFEAWLMPDPDDFKAQRKKGKLVAVKSLKAHGNDGA--VRAFLGEARTLSQF-SHPNVLGLLGVVT-RSKP--WHMITEHIPYGDV
.... .||.|..|.|... . .       . ...  ||||.|| .  . .   ..|. ||....|. .|||.. |.||.| ...|  . ...|. |.|| 
ITFGKKLGEGAFGEVYKGTWKG------DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDL

RSVLKACRSASTAVHAHEQVYMAAQAAAGMEYLASLGFVHRDLAARNILLGRYCHIKLADFGLSRALDTESQYY-VVQSRSLLPFRWMSIEALKEGKFTT
.. |.. |.   ..  .. . |..| |.|||||.| ...||||||||.|...  ..| .||||.|.. ..  || .... . || .||. |....|||||
LDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

QSDVWAFGVLLWEIMSMAKTP-WRKNSTQEVKQLI-LAGERLPPPRNCPQTLYSLMTTCWQPAPAARPTFVTLRRSL
.||||.||||.|||..  ..| .   | .||...|   |.|.|.|.|||. .|.||. ||.. |. ||||  ... |
KSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase CTKA1.AA TyrKc 208-475 32 2.5e-116 393.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 208-475
Range on HMM: 1-280/280
Sequence Identity: 32% (98 aa)

LQIMSELGSGHYGQVFEAWLMPDPDDFKAQRKKGKLVAVKSLKAHGNDGAVRAFLGEARTLSQF--SHPNVLGLLGVVTRS-------KPWHMITEHIPY
..   .||.|..|.|... .                ||||.||..     ...|. ||| ....  .|||.. |.||.| .       .|  ...|. |.
ITLGKKLGEGAFGEVYKGTWK-------------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH

GDVRSVLKACRSASTAVHAHEQVYMAAQAAAGMEYLASLGFVHRDLAARNILLGRYCHIKLADFGLSRALDTE------SQYYVV----QSRSLLPFRWM
|| .. |...|     .   . .... |.|.|||||.| ...||||||||.|.|.  ..| .||||||... .      ..||..    .....|| |||
GDLKDYLRKHRPK---LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM

SIEALKEGKFTTQSDVWAFGVLLWEIMSMAKTPWRK-----NSTQEVKQLILAGERLPPPRN--------CPQTLYSLMTTCWQPAPAARPTFVTLRRSL
..|....|||||.||||.|||..|||..  ..|.        | ||| ... .|.|.|.| |        ||. .|..|..||.  |. |||| .... .
APECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase CTKA1.AA TK 208-475 22 1.5e-113 382.24 In-house 1-486 (486) Show / Hide 
Range on Protein: 208-475
Range on HMM: 1-486/486
Sequence Identity: 22% (109 aa)

LQIMSELGSGHYG---QVFEAWLMPDPDDFKAQ---------------RKKGKLVAVKSLK--AHGNDGAVRA-----------FLGEARTLSQFS----
...  .||.|..|   .|..... .....   .               ...   |||| ||  .. .. . ..           || ||. .....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVLGLLGVVTRS------------KPWHMITEHIPYGD----VRSVLKACRSASTA-----------------------------------------
 |||.. |.||.|..            .|| ...|. |.||     |. |..||   .                                          
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VHAHEQVYMAAQAAAGMEYLASL------GFVHRDLAARNILLGRYCH-----------IKLADFG---
                               .. |... |..|.|.|||||.|.      .||||||||||.|.|.  .           .|.||||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSRALDTESQYYVVQ-----------------------SRSLLPFRWMSIEALK---------EGKFTTQSDVWAFGVLLWEIMSMAKTPWRKNS
     |.|... .. ||...                       |.  ||.|||. |.|.         .|||||.||||.||||.|||.. ...|.  . 
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

T----------QEVKQLILAG--------------ERLPPPRNCP--------------QTLYSLMTTCWQPAPAARPTFVTLRRSL
.          ||| ... .|               |.|.| .||              . .| ||. ||.. |. |||| .|.. |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase CTKA1.AA UTK 208-475 36 1.2e-105 357.31 In-house 1-296 (296) Show / Hide 
Range on Protein: 208-475
Range on HMM: 1-296/296
Sequence Identity: 36% (110 aa)

LQIMSELGSGHYGQVFEAWLMPDPDDFKAQRKKGKLVAVKSLKAHGNDGAVRA----FLGEAR---TLSQFS-HPNVLGLLGVVTRSKPWHMITEHIPYG
.|.. .||.|..|.|..| . ....  . .     .|||| ...|...   ..    |. |||    ..||. |||||.|.||.|...|| ..||. . |
VQLGRQLGQGAFGEVHKARFTQCSEHMYEM-----DVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENG

DVRSVLKACRS----ASTAVHAHEQVYMAAQAAAGMEYLASLGFVHRDLAARNILLGRY-------CHIKLADFG---LSRALDT--------ESQYYVV
| ||.|  .|     . ...  |....||.. |.||.||.| |||||||||||.|...          .|.||||   .||.. |        ||.||  
DLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMA

QSRSLLPFRWMSIEALKEG-KFTTQSDVWAFGVLLWEIMSMAKTPWRKNSTQEVKQLILAG--ERLPPPRNCPQTLYSLMTTCWQPAPAARPTFVTLRRS
|..  .|.|||. ||| .. .|||.||||.|||..|||......|.   |...| . ...|   |.|.|. || ..| ||. ||.. |. ||.|..|.  
QHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQ

L
.
M
Kinase CTKA1.AA HMTK 261-474 42 1.4e-88 300.56 In-house 71-291 (291) Show / Hide 
Range on Protein: 261-474
Range on HMM: 71-291/291
Sequence Identity: 42% (93 aa)

FLGEARTLSQFSHPNVLGLLGVVTRSKPWHMITEHIPYGDVRSVLKACRSASTAVHAHEQVYMAAQAAAGMEYLASLGFVHRDLAARNILLGRYCHIKLA
|| || ...|..|||.. | ||.  ..|| .  |  .|||.|.|||.||...  .. ||| |...| |.||.|.|| ..||.||||||.|.|  ...|.|
FLREAEVMCQLRHPNLVQLVGVCMQQRPWLCVLEYMQYGDLRNVLKTCREKNIQLTYHEQLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIA

DFGLSRALDTESQYYVVQSRS-LLPFRWMSIEALK--EGKFTTQSDVWAFGVLLWEIMSMAKTPWR--KNSTQEVKQLILAGERLP-PPRN-CPQTLYSL
||||.| || . .|.. . ..  || .||..||..  .. |  .||||||||..|||.. . .|.      ..||   . .| ||  || . ||  .. |
DFGLTRRLDPGQDYWHLRKHMVKLPIKWMAPEAMDGKRKIFSEKSDVWAFGVTMWEIWMYGEQPYESQQIKNKEVQRHVREGRRLTQPPPDDCPDDFWDL

MTTCWQPAPAARPTFVTLRRS
|.|||.  |. ||||  |...
MCTCWHKDPHQRPTFAQLQKM
Kinase CTKA1.AA TK-Unique 208-475 34 2.9e-80 272.98 In-house 1-294 (294) Show / Hide 
Range on Protein: 208-475
Range on HMM: 1-294/294
Sequence Identity: 34% (104 aa)

LQIMSELGSGHYGQVFEAWLMPDPDDFKAQRKKGKLVAVKSLKAHGNDGAVRAFLGEARTLSQFS-HPNVLGLLGVVTRSK-PWHMITEHIPYGDVRSVL
| . ...|.| .|||. . . ...    . . | | |||| ||.. .|  ...|| |.. ...   |||.. .||. |.|  ||..| |..|.|. .. |
LEVGDVIGEGAFGQVWRGEVWGIW----KHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYL

KACRSA---------------------STAVHAHEQVY-MAAQAAAGMEYLAS--LGFVHRDLAARNILLGRYCHIKLADFGLSRALDTESQYYVVQSRS
. || |                     .|.    ...|  | | | |||||||   ..|||||.|||.||.... .|..|||..| ..|. .|   .|..
RTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG

LLPFRWMSIEALK--EGKF-TTQSDVWAFGVLLWEIMSMAKTPWRKNSTQEVKQLILAGERLPPPRNC-PQTLYSLMTTCWQPAPAARPTFVTLRRSL
 .| |||. |.||  .| . ||.||||.||||.|||... ..| .. .  .. ..| .| |.| | .| ....|.|| .|||  |  ||.| ...  |
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase CTKA1.AA Src 208-475 35 6.1e-78 264.37 In-house 1-255 (255) Show / Hide 
Range on Protein: 208-475
Range on HMM: 1-255/255
Sequence Identity: 35% (95 aa)

LQIMSELGSGHYGQVFEAWLMPDPDDFKAQRKKGKLVAVKSLKAHGNDGAVRAFLGEARTLSQFSHPNVLGLLGVVTRSKPWHMITEHIPYGDVRSVLKA
..   .||.|..| |...        .. . |    ||||.||.     .. ||| || .. ...|.... |. |... .|   .||    |     ||.
IKLCRKLGQGQFGEVWMGY-------WNGNTK----VAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK

CRSASTAVHAHEQVYMAAQAAAGMEYLASLGFVHRDLAARNILLGRYCHIKLADFGLSRALDTESQYYVVQSRSLLPFRWMSIEALKEGKFTTQSDVWAF
 ..   ..|  ....|||| |.||.|| |  ..||||||||.| |     | ||||| | .. .   |. .. . .| .|.  ||. .|.||. |||| |
-DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSF

GVLLWEIMSMAKTPWRKNSTQEVKQLILAGERLPPPRNCPQTLYS-LMTTCWQPAPAARPTFVTLRRSL
|.||.||..  ..| .  . .|| | . .| |.| |.|||. ||  .|. ||.  |  |||| .|.  |
GILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase CTKA1.AA Trk 208-475 35 2.4e-67 227.37 In-house 1-275 (275) Show / Hide 
Range on Protein: 208-475
Range on HMM: 1-275/275
Sequence Identity: 35% (100 aa)

LQIMSELGSGHYGQVFEA---WLMPDPDDFKAQRKKGKLVAVKSLKAHGNDGAVRAFLGEARTLSQFSHPNVLGLLGVVTRSKPWHMITEHIPYGDVRSV
. .  ||| | .|.|| |    |.|. |          .|||| ||   .  | . |  ||. | .  |...  . || |  .|  |. |.   || .  
IVLKWELGEGAFGKVFLAECYNLCPEQDKM--------MVAVKTLKDASE-NARKDFQREAELLTNLQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKY

LKACRSASTAVHAHEQV-------------YMAAQAAAGMEYLASLGFVHRDLAARNILLGRYCHIKLADFGLSRALDTESQYYVVQSRSLLPFRWMSIE
|.. .     . |. |              . | | |.|| |.||. |||||.|.|| | |    .| .|||.|| .   . || |  .  || |||  |
LRQ-HGPDAMCYAQYQPRQAPGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPE

ALKEGKFTTQSDVWAFGVLLWEIMSMAKTPWRKNSTQEVKQLILAGER-LPPPRNCPQTLYSLMTTCWQPAPAARPTFVTLRRSL
.    |||. |||| ||| .||...  | ||   | .|| . |..|   |  || ||| .| .|  |||  |  | .   .   .
SIMYRKFTYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIECIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase CTKA1.AA Musk 208-475 36 5.6e-67 220.29 In-house 1-282 (282) Show / Hide 
Range on Protein: 208-475
Range on HMM: 1-282/282
Sequence Identity: 36% (105 aa)

LQIMSELGSGHYGQVFEAW---LMPDPDDFKAQRKKGKLVAVKSLKAHGNDGAVRAFLGEARTLSQFSHPNVLGLLGVVTRSKPWHMITEHIPYGDVRSV
     ..| | .| || |    |.|. ..         .|||| ||.   .     |  ||  . .|.|||.  ||||    .|  .  |   |||    
IIYVRDIGEGAFGRVFQARAPGLVPYEEET--------MVAVKMLKDDASKQMQMDFQREACMMAEFDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEF

LKAC---RSASTAVHAH-----------------EQVYMAAQAAAGMEYLASLGFVHRDLAARNILLGRYCHIKLADFGLSRALDTESQYYVVQSRSLLP
|..|   |. |                       .|  ||.| |.|| ||    ||||||| || | .    .| |||||||    .  ||. .     |
LHSCSPHRTCSRTHQDRGMRAQVSSPGPPQLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQ-DYYKGHENDHIP

FRWMSIEALKEGKFTTQSDVWAFGVLLWEIMSMAKTPWRKNSTQEVKQLILAGERLPPPRNCPQTLYSLMTTCWQPAPAARPTFVTLRRSL
 |||  |..   .||. |||||.||.|||| | |  |.   .  ||   |  | .|  | |||| .| ||  |||  || || |  . ...
IRWMPPESIWYNQFTYESDVWAYGVCLWEIFSYALQPYYGMTHEEVIYYIRQGNILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase CTKA1.AA DDR 208-419 36 7.8e-63 215.06 In-house 1-241 (306) Show / Hide 
Range on Protein: 208-419
Range on HMM: 1-241/306
Sequence Identity: 36% (88 aa)

LQIMSELGSGHYGQVFEAWLMPDPD----DFKAQRKKGK--LVAVKSLKAHGNDGAVRAFLGEARTLSQFS-HPNVLGLLGVVTRSKPWHMITEHIPY-G
| . . .|.|  | | .  .    |    ||  . .||.  |||||.|..  .. | ..|. |.. .|| . |||.  |.|| |. .|  ||.|.  . |
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQCKRHPNIVRLVGVCTQDEPYCMIMEYMENLG

DVRSVLKACR---SASTAVH------------AHEQVYMAAQAAAGMEYLASLGFVHRDLAARNILLGRYCHIKLADFG--LSRALDTESQYYVVQS---
| .. . .     |.. ...                ||...| |.|| ||.|. |||||||.||.| |   ||| .|||  .|| |   . || |.    
DLNQFWMEHEAENSGLMNCKADTQNCQKPTISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYS-QDYYRVEGFTG

--RSLLPFRWMSIEALKEGKFTTQSDVWAFGVLLWEIMSMAK
  |  .| |||. |..  ||||| |||||||| .||......
RQRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCR
Kinase CTKA1.AA Ror 321-468 52 6.8e-57 195.32 In-house 122-268 (308) Show / Hide 
Range on Protein: 321-468
Range on HMM: 122-268/308
Sequence Identity: 52% (77 aa)

VYMAAQAAAGMEYLASLGFVHRDLAARNILLGRYCHIKLADFGLSRALDTESQYYVVQSRSLLPFRWMSIEALKEGKFTTQSDVWAFGVLLWEIMSMAKT
.. |.| |||||||.|  ||||||||||.| |   |.| .||||.|     | || .|..|..| |||| ||   |||.. ||.| ||| |||| |    
LHIAIQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYS-SDYYRMQHKSWMPIRWMSPEAIMYGKFSEDSDIWSFGVVLWEIWSYGMQ

PWRKNSTQEVKQLILAGERLPPPRNCPQTLYSLMTTCWQPAPAARPTF
|.   | |||  .|     || | |||.  ||||. ||   |. ||.|
PYYGYSNQEVIEMIRNRHLLPCPHNCPTWIYSLMIECWHEIPSRRPRF
Kinase CTKA1.AA S_TKc 208-482 21 8.3e-44 152.78 SMART 1-231 (231) Show / Hide 
Range on Protein: 208-482
Range on HMM: 1-231/231
Sequence Identity: 21% (61 aa)

LQIMSELGSGHYGQVFEAWLMPDPDDFKAQRKKGKLVAVKSLKAHGNDGAVRAFLGEARTLSQFSHPNVLGLLGVVTRSKPWHMITEHIPY--GDVRSVL
 .|. ..|.| .|.|. ..              |..||.| .|        . .. | . |..  |||.  |..|    .  .|..|...   ||.....
YEILRKIGKGAFGKVYKCRHKK----------TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYI

KACRSASTA--VHAHEQVYMAAQAAAGMEYLASLGFVHRDLAARNILLGRYCHIKLADFGLSRALDTESQYYVVQSRSLLPFRWMSIEALKEGKFTT-QS
| ...  .    .  .  ....| . ..||. |.|..||||   |||| .  |||..||||.| |          .       .|. | |   ....  .
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKC

DVWAFGVLLWEIMSMAKTPWRKNSTQEVKQLILAGERLPPPRNCPQTLYSLMTTCWQPAPAARPTFVTLRR--SLEQQGELL
|.|..|..|.| ..  ..|..    |.. ..|.           .. . ...  |.|  |. |||   . .  ..  . . .
DWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CTKA1.AA Pkinase 208-475 19 2.2e-34 122.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 208-475
Range on HMM: 1-293/293
Sequence Identity: 19% (62 aa)

LQIMSELGSGHYGQVFEAWLMPDPDDFKAQRKKGKLVAVKSLKAHGNDGAVR--AFL-GEARTLSQFSHPNVLGLLGVVTRSKPWHMITEHIPYG----D
..| . .||| .|.|...    ...          .|||| .| ....  ..  ...  |.. .  ..|||.. |........  .|..|. . |    |
YHIGRKIGSGSFGCVYKCHHKGTGK----------IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMD

VRSVLKACRSASTAV--HAHEQVYMAAQAAAGMEYLASLGFVHRDLAARNILLGRYCHI----KLADFGLSRALDTESQYYVVQSRSLLPF----RWMSI
  .....  ......    .|   .. | . |.||. | |..||||   |||. . .||    |..||||.. .|     |  .|  .  |    ..|. 
LFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS--MTTFCGTPWYMAP

EALK-EGKFTTQSDVWAFGVLLWEIMSMAKTPWRKN----STQEVKQLILAGERLPPPRNCP-----------------------QTLYSLMTTCWQPAP
| ..   . .. .|.|..|..|.| ..  ..|..      .  . .|.|    . |.....|                       ... .... |... |
EVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP

AARPTFVTLRRS--L
. |||.  .  .  .
KKRPTAEQILQHPWF
Kinase CTKA1.AA Ror 208-300 29 9.2e-11 39.23 In-house 1-88 (308) Show / Hide 
Range on Protein: 208-300
Range on HMM: 1-88/308
Sequence Identity: 29% (27 aa)

LQIMSELGSGHYGQVFEAWLMPDPDDFKAQRKKGKLVAVKSLKAHGNDGAVRAFLGEARTLSQFSHPNVLGLLGVVTRSKPWHMITEHIPYGD
.. | ||| .  | |.   ||       .  ..  .||.| .|   .      |  |..  ... |||.  ||||.|  .|  |. | .. ||
VRFMEELGECQFGKVYKGHLM-----GPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCTMDQPYCMLFEYMNHGD
Kinase CTKA1.AA DDR 440-475 37 1.7e-10 32.9 In-house 270-306 (306) Show / Hide 
Range on Protein: 440-475
Range on HMM: 270-306/306
Sequence Identity: 37% (14 aa)

LPPPRNCPQTLY-SLMTTCWQPAPAARPTFVTLRRSL
|| |..||...|  ||. ||.  .  ||.|  . . |
LPMPPMCPYEIYNQLMCRCWRRDQSQRPSFEEIHKFL
Kinase CTKA1.AA CTKA 563-814 60 7.2e-201 673.61 In-house 37-290 (290) Show / Hide 
Range on Protein: 563-814
Range on HMM: 37-290/290
Sequence Identity: 60% (154 aa)

VAAKMLKDNATEADREAFDAEVNLRASELLDHPNVVALIGLCTKDEPPFMVMEYLSLGDLQSYLTASAPAPGQVCPARARRSIPRSFHPLSLSTYEQTSM
||.|||||.|||.||.||..|.....||...||||..|.|.||...|..|.||....|||..||.|..||.||||||||||||||||||......||..|
VAVKMLKDHATEEDRRAFLHEAFVLSSEHFHHPNVLRLLGVCTQHKPWHMIMEHMQYGDLHCYLRACRPADGQVCPARARRSIPRSFHPIEVHAHEQVYM

ARDIAAGMSYLAERDIVHRDLAARNCVVGQGPVVKISNFGLGKTLRGG--DYYSSSSGVMPVRWMAPEAVCFGKHSCASDVWSFGIVLAEIFTFGEKPFA
|..|||||.||||...||||||.|||..||....||..||.|.|||..  .||.||..|||||||||||.||||.|||||||.||..|.||...||||..
AMQIAAGMNYLAEMGFVHRDLACRNCLLGQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWR

HMTDLEICNAYASGGMSALPVPPSAPDVIVHCMQECLKGEPKERVSFEQLQEML
||.|.|.|.||.|.||..||||...|.|..||||||.|.||..|..||.||.||
HMSDQEVCQAYTSHGMRRLPVPRNCPQVLYHCMQECWKFEPNQRPTFETLQRML
Kinase CTKA1.AA TK 532-814 23 3.4e-97 326.41 In-house 1-486 (486) Show / Hide 
Range on Protein: 532-814
Range on HMM: 1-486/486
Sequence Identity: 23% (112 aa)

LIVINELGAGD---FYQLVLMEMTSGL--------------------TGGAKCHVAAKMLKDNATEADREAFD----------------AEVNLRASELL
......||.|    |..  . |. ..                     ..|.|. || ||||. ......| ||                .|  .  ..|.
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHPNVVALIGLCTKD------------EPPFMVMEYLSLGD----LQSYLTASAPAPGQVCPARARRSIPR-----------------------------
.|||.| |.| ||..            ||. .|||| ..||    |..|| .. |   . ..  .... ..                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----SFHPLSLSTYEQTS-------------------MARDIAAGMSYLAERDI------VHRDLAARNCVVGQGPV-----------VKISNFG----
     . ||..|.| .. .                   |...||.||.||... .      |||||||||| ||.. |           .||. ||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LGKTL-RGGDYYSSS------------------------SGVMPVRWMAPEAVC---------FGKHSCASDVWSFGIVLAEIFTFGEKPFAH-MT
    | . . ...|||..|                        .| .|.||||||..          .||.. .|||||||... ||||.|..|..  |.
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

D---------LEICNAYASGGM------------SALPVPPSAP--------------DVIVHCMQECLKGEPKERVSFEQLQEML
.          |...   .||.              .| || .|              ...   ||.| . .|..| .|.||.|.|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase CTKA1.AA Pkinase_Tyr 532-814 34 6.1e-85 288.29 Pfam 1-270 (270) Show / Hide 
Range on Protein: 532-814
Range on HMM: 1-270/270
Sequence Identity: 34% (102 aa)

LIVINELGAGDFYQLVLMEMTSGLTGGAKCHVAAKMLKDNATEAD--REAFDAEVNLRASELL-DHPNVVALIGLCT-KDEP--PFMVMEYLSLGDLQSY
.. . .||.| | . .. ...  . .. |..|| ||||..|.. .  ||.| .|...  .  | .|||.| |.| || ..||  ...||||  .||| .|
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQ--LGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LTASAPAPGQVCPARARRSIPRSFHPLSLSTYEQTSMARDIAAGMSYLAERDIVHRDLAARNCVVGQGPVVKISNFGLGKTLRGGDYY--SSSSGVMPVR
| .                      . .|.. .  .|...||.||.||... ..||||||||| |. . ||||. ||| ...   |||  ....| .|..
LRKHR------------------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIK

WMAPEAVCFGKHSCASDVWSFGIVLAEIFTFGEKP-FAHMTDLEICNAY-ASGGMSALPVPPSAPDVIVHCMQECLKGEPKERVSFEQLQEML
|||||.  .|| . .|||||||... ||||.||.| .. |.. |....   .|.   .| |. .|| | . |..| . .|..| .|....|.|
WMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYR--MPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase CTKA1.AA TyrKc 532-814 31 4.8e-81 276.48 SMART 1-280 (280) Show / Hide 
Range on Protein: 532-814
Range on HMM: 1-280/280
Sequence Identity: 31% (100 aa)

LIVINELGAGDFYQLVLMEMTSGLTGGAKCHVAAKMLKDNATEADREAFDAEVNLRASELL--DHPNVVALIGLCTKD-------EPPFMVMEYLSLGDL
.  . .|| | | . .. ...          || ||||..|    ||.|  | ..  .  |  .|||.|.|.| ||..       ||...|||| ..|||
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCK--LGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

QSYLTASAPAPGQVCPARARRSIPRSFHPLSLSTYEQTSMARDIAAGMSYLAERDIVHRDLAARNCVVGQGPVVKISNFGLGKTLRGG-------DYYSS
..|| .. |                      |.. .  |.. .||.||.||... ..||||||||| || . .|||| ||| . .  .       |||..
KDYLRKHRPK---------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRK

S---SGV--MPVRWMAPEAVCFGKHSCASDVWSFGIVLAEIFTFGEKPFAH-----MTDLEICNAYASGGMSALPVP------PSAPDVIVHCMQECLKG
.   .|   .|.||||||.  .|| . .|||||||... ||||.|..|        |.. |. .   .|..   |        . .|| .   |..| . 
KEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE

EPKERVSFEQLQEML
.|..| .|... | .
DPEDRPTFSEIHECF
Kinase CTKA1.AA UTK 592-814 34 1.4e-73 250.71 In-house 66-296 (296) Show / Hide 
Range on Protein: 592-814
Range on HMM: 66-296/296
Sequence Identity: 34% (85 aa)

LD-HPNVVALIGLCTKDEPPFMVMEYLSLGDLQSYLTASAPAPGQVCPARARRSIPRSFHPLSLSTYEQTSMARDIAAGMSYLAERDIVHRDLAARNCVV
.. ||||. |.|.||..||. .|.|| . |||.|||  ..|.|.               .|..|.  ....||.|||.||.||... .|||||||||| |
FHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPP--------------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLV

GQG-------PVVKISNFG---LGKTLR---------GGDYYSSS-SGVMPVRWMAPEAVCFG-KHSCASDVWSFGIVLAEIFTFGEKPFAHMTDLEICN
..         |.||..||   . . .          . .|| ..  . .|.|||||||.. . ... .|||||||.|. ||.|.| .|...|.. ... 
HMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWH

AYASGGMSALPVPPSAPDVIVHCMQECLKGEPKERVSFEQLQEML
.   ||   .| |.. |. .   |..| . .| || .||.| . .
QVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase CTKA1.AA TK-Unique 532-814 35 1.5e-71 243.97 In-house 1-294 (294) Show / Hide 
Range on Protein: 532-814
Range on HMM: 1-294/294
Sequence Identity: 35% (108 aa)

LIVINELGAGDFYQLVLMEMTSGL-TGGAKCHVAAKMLKDNATEADREAFDAEVNLRASELLDHPNVVALIGLCTKD-EPPFMVMEYLSLGDLQSYLTAS
| | ...| | | |    |....  . ... .|| ||||||||. |. .|  | ..  .|| ||||.| ..| |||. ||....|||.. |.||.||  .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMM-KELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTC

APA--PGQ------VCPARARRSIPRS-FHPLSLSTYEQTSMARDIAAGMSYLAE--RDIVHRDLAARNCVVGQGPVVKISNFGLGKTLR-GGDYYSS-S
.||  ..|        ....... ...   | .| .      | .|| ||.|||.  . ||||||.|||. .. . |.||..||. . .. .|.| .. |
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYH-----FAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCS

SGVMPVRWMAPEAVC--FGKH-SCASDVWSFGIVLAEIFTFGEKPFAHMTDLEICNAYASGGMSALPVPPSA-PDVIVHCMQECLKGEPKERVSFEQLQE
.| .|.||||||. .   | . .. |||||||... ||||.|. |.  | . .| ..   |  . .|.|..  .. .   |..|.. ||.||.||.|.  
QGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDG--YRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKH

ML
.|
RL
Kinase CTKA1.AA Musk 555-814 34 1.3e-66 219.07 In-house 24-282 (282) Show / Hide 
Range on Protein: 555-814
Range on HMM: 24-282/282
Sequence Identity: 34% (91 aa)

LTGGAKCHVAAKMLKDNATEADREAFDAEVNLRASELLDHPNVVALIGLCTKDEPPFMVMEYLSLGDLQSYLTASAPAPGQVCPARAR--RSIPRSFHPL
. . .   || |||||.| .   . |. |  . |    ||||.| | | |    |  . .||.. |||. .| .  |      .   |  |.   |  |.
VPYEEETMVAVKMLKDDASKQMQMDFQREACMMAE--FDHPNIVKLLGVCFVGRPMCLLFEYMAYGDLNEFLHSCSPHRTCSRTHQDRGMRAQVSSPGPP

SLSTYEQTSMARDIAAGMSYLAERDIVHRDLAARNCVVGQGPVVKISNFGLGKTLRGGDYY-SSSSGVMPVRWMAPEAVCFGKHSCASDVWSFGIVLAEI
 |..|.|  ||..||.|| || |.  |||||| ||| ..   .|||. ||| .     |||        |.|||.||..   . . .||||..|..| ||
QLKCYHQLCMAKQIACGMAYLSEMMFVHRDLATRNCLINEHMDVKIADFGLSRYIYHQDYYKGHENDHIPIRWMPPESIWYNQFTYESDVWAYGVCLWEI

FTFGEKPFAHMTDLEICNAYASGGMSALPVPPSAPDVIVHCMQECLKGEPKERVSFEQLQEML
| ... |.  ||  |.   |   |   |  |   |  .   | .| . .| .| .| |.....
FSYALQPYYGMTHEEVI-YYIRQGN-ILSCPENCPQKVYQLMRRCWQKNPADRPFFCQIHHCI
Kinase CTKA1.AA Trk 532-814 33 2.5e-64 216.97 In-house 1-275 (275) Show / Hide 
Range on Protein: 532-814
Range on HMM: 1-275/275
Sequence Identity: 33% (96 aa)

LIVINELGAGDFYQLVLMEMTSGLTGGAKCHVAAKMLKDNATEADREAFDAEVNLRASELLDHPNVVALIGLCTKDEPPFMVMEYLSLGDLQSYLTASAP
.. . ||| | | . .| |    .    |  || | ||| |.|. |. |  |  |     |.|...|.. |.|| ..| .|| ||.  |||. || . .|
IVLKWELGEGAFGKVFLAECYNLCPEQDKMMVAVKTLKD-ASENARKDFQREAELLTN--LQHQHIVKFYGVCTDHDPLLMVFEYMKHGDLNKYLRQHGP

APGQVCPARARRSIPRSFHPLSLSTYEQTSMARDIAAGMSYLAERDIVHRDLAARNCVVGQGPVVKISNFGLGKTLRG-GDYYS-SSSGVMPVRWMAPEA
         .| .      |. |   .    |..||.|| |.|.  .||||.|.||| |||. .|||. ||.   .    |||     . .|.||| ||.
DAMCYAQYQPRQA------PGPLTIDQMLWIAKQIASGMVYMASQHFVHRDMATRNCLVGQNLIVKIGDFGMSRDVYSHTDYYRVGHHTMLPIRWMPPES

VCFGKHSCASDVWSFGIVLAEIFTFGEKPFAHMTDLEICNAYASGGMSALPVPPSAPDVIVHCMQECLKGEPKERVSFEQLQEML
. . | .  |||||||.|. |.||.|  |.  .  .|. . .   |   |  |   |  .   |  | . ||..|..  .. ...
IMYRKFTYESDVWSFGVVMWECFTYGKQPWYQLSNHEVIE-CIHQGRHRLERPRRCPQEVYDIMLGCWQREPQQRMNIKDIHDII
Kinase CTKA1.AA DDR 532-814 32 7.2e-60 205.22 In-house 1-306 (306) Show / Hide 
Range on Protein: 532-814
Range on HMM: 1-306/306
Sequence Identity: 32% (101 aa)

LIVINELGAGDFYQLVLMEMTSGL---TGGAKCH--------VAAKMLKDNATEADREAFDAEVNLRASELLD-HPNVVALIGLCTKDEPPFMVMEYLSL
||.   .| | |  . | |  ...     .  |         || |||.  |....| .|  |.   ..  .  |||.| |.| || |||  |.|||   
LIFVEKIGEGQFGEVHLCEVEGMQDYIEFDFHCDVHKGHPTLVAVKMLRPDACKHARNDFHKEIKCMSQ--CKRHPNIVRLVGVCTQDEPYCMIMEYMEN

-GDLQSYLTASAPAPGQVCPARARRSIPRSFHPLSLSTYEQTSMARDIAAGMSYLAERDIVHRDLAARNCVVGQGPVVKISNFG--LGKTLRGGDYYSSS
 ||| ... .. .   ...   ..        | ..|.    ... .||.|| ||.   .||||||.||| ||    .||  ||  .   |  .|||   
LGDLNQFWMEHEAE--NSGLMNCKADTQNCQKP-TISYECCVYICTQIASGMKYLESMNFVHRDLATRNCLVGKEYHIKICDFGTVMSRNLYSQDYY-RV

SG-------VMPVRWMAPEAVCFGKHSCASDVWSFGIVLAEIFTFG-EKPFAHMTDLEI----CNAYASGGMSA-LPVPPSAPDVIV-HCMQECLKGEPK
 |       .||.||||.|..  || . .||||.||. . |.|.|  |.|. ..||  .    |  .  .||   || ||  |. |    | .| . ...
EGFTGRQRHHMPIRWMAWESILLGKFTTKSDVWAFGVTMWEMFMFCREQPYEQLTDEQVIENACEFFRHQGMQVYLPMPPMCPYEIYNQLMCRCWRRDQS

ERVSFEQLQEML
.| |||..   |
QRPSFEEIHKFL
Kinase CTKA1.AA Src 562-814 34 6.6e-57 191.86 In-house 25-255 (255) Show / Hide 
Range on Protein: 562-814
Range on HMM: 25-255/255
Sequence Identity: 34% (88 aa)

HVAAKMLKDNATEADREAFDAEVNLRASELLDHPNVVALIGLCTKDEPPFMVMEYLSLGDLQSYLTASAPAPGQVCPARARRSIPRSFHPLSLSTYEQTS
.|| | ||      . ||| .| ..  .  |.|...|.|   |...|| . | || | | |. || .                   .    .|.  .. .
KVAVKTLKPGT--MSPEAFLQEAQIMKK--LRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-------------------DGEGRHLHLPQLID

MARDIAAGMSYLAERDIVHRDLAARNCVVGQGPVVKISNFGLGKTLRGG-DYYSSSSGV-MPVRWMAPEAVCFGKHSCASDVWSFGIVLAEIFTFGEKPF
||  .|.||.|| .. ..||||||||  ||.. |.|.  ||| . .  . | |....|  .|..|.||||. .|. .  |||||||| | ||.|.|  | 
MAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPY

AHMTDLEICNAYASGGMSALPVPPSAPDVIVH-CMQECLKGEPKERVSFEQLQEML
  ||  |   .   |    .| |.  || . . .|..| . .|..|  || ||. |
PGMTNHEVLQQVERG--YRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase CTKA1.AA Ror 666-759 54 1e-41 144.88 In-house 128-222 (308) Show / Hide 
Range on Protein: 666-759
Range on HMM: 128-222/308
Sequence Identity: 54% (52 aa)

IAAGMSYLAERDIVHRDLAARNCVVGQGPVVKISNFGLGKTLRGGDYYS-SSSGVMPVRWMAPEAVCFGKHSCASDVWSFGIVLAEIFTFGEKPF
||||| ||. .  |||||||||| || . .|||| |||  .  ..|||   .  .||.|||.|||. .|| | .||.||||.|| ||. .|  |.
IAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQHKSWMPIRWMSPEAIMYGKFSEDSDIWSFGVVLWEIWSYGMQPY
Kinase CTKA1.AA HMTK 652-761 41 1.1e-30 104.25 In-house 123-239 (291) Show / Hide 
Range on Protein: 652-761
Range on HMM: 123-239/291
Sequence Identity: 41% (48 aa)

LSLSTYEQTSMARDIAAGMSYLAERDIVHRDLAARNCVVGQGPVVKISNFGLGKTLR-GGDYYSSSSGV--MPVRWMAPEAVC--FGKHSCASDVWSFGI
. |.. || .... .|.||.|.|.   ||.||||||| || . .|||  |||.  |  | ||. .      .|..||||||     .  | .||||.||.
IQLTYHEQLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHLRKHMVKLPIKWMAPEAMDGKRKIFSEKSDVWAFGV

VLAEIFTFGEKPFA--H
.. ||.. || |..  .
TMWEIWMYGEQPYESQQ
Kinase CTKA1.AA S_TKc 532-814 18 1.2e-26 95.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 532-814
Range on HMM: 1-231/231
Sequence Identity: 18% (56 aa)

LIVINELGAGDFYQLVLMEMTSGLTGGAKCHVAAKMLKDNATEADREAFDAEVNLRASELLDHPNVVALIGLCTKDEPPFMVMEYLSL--GDLQSYLTAS
  .....| | | .  .   ..      . .|| |..|        | .  |...  .   .|||.| |.. .   .  .|||||..   ||| .|.   
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK---HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKR

APAPGQ--VCPARARRSIPRSFHPLSLSTYEQTSMARDIAAGMSYLAERDIVHRDLAARNCVVGQGPVVKISNFGLGKTLRGGDYYSSSSGVMPVRWMAP
 . ...    . .||.                  ... |. .. |. .. |.||||   |  . .  ..||. ||| . |        .. .    .|||
GRHGLRFPFPE-HARF------------------YMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAP

EAVCFGKHSC-ASDVWSFGIVLAEIFTFGEKPFAHMTDLEICNAYASGGMSALPVPPSAPDVIVHCMQECLKGEPKERVSFEQLQE---------ML
| .   .... ..|.||.|..|.| .. |. ||   .. .. .                ..   . .. ||. .|..| .  .. .          .
EVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CTKA1.AA Pkinase 586-814 20 1.2e-18 66.97 Pfam 51-293 (293) Show / Hide 
Range on Protein: 586-814
Range on HMM: 51-293/293
Sequence Identity: 20% (55 aa)

LRASELLDHPNVVALIGLCTKDEPPFMVMEYLSLG----DLQSYLTASAPAPGQVCPARARRSIPRSFHPLSLSTYEQTSMARDIAAGMSYLAERDIVHR
..    |.|||.| |.. .. .  . |||||.  |    || .|...                  ..  ....|  |  .... |. |. |. .. |.||
IQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST------------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHR

DLAARNCVVGQGPVV----KISNFGLGKTLRGGDYYSSSSGVMPV----RWMAPEAVC-FGKHSCASDVWSFGIVLAEIFTFGEKPFAHM----TDLEIC
||   |. . . ...    ||. ||| | ..    | ..|  . .    ..|||| .    ... ..|.||.|..|.| .. |. || .     . ..  
DLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQM

NAYASGGMSALPVPPSAP---------------------DVIVHCMQECLKGEPKERVSFEQLQEM--L
  ..  ..  |. . . .                     .   . .  ||.  ||.| ..||. .   .
QMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CTKA1.AA Ror 532-622 34 3.2e-16 60.2 In-house 1-89 (308) Show / Hide 
Range on Protein: 532-622
Range on HMM: 1-89/308
Sequence Identity: 34% (31 aa)

LIVINELGAGDFYQLVLMEMTSGLTGGAKCHVAAKMLKDNATEADREAFDAEVNLRASELLDHPNVVALIGLCTKDEPPFMVMEYLSLGDL
. .  ||| . |      . .... .     || | .|..|. | .. |  |. |.|.  |.|||.| |.| ||.|.|  |. ||.. |||
VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMAT--LHHPNIVCLLGVCTMDQPYCMLFEYMNHGDL
Kinase CTKA1.AA HMTK 562-622 42 2.6e-09 28.71 In-house 53-111 (291) Show / Hide 
Range on Protein: 562-622
Range on HMM: 53-111/291
Sequence Identity: 42% (26 aa)

HVAAKMLKDNATEADREAFDAEVNLRASELLDHPNVVALIGLCTKDEPPFMVMEYLSLGDL
|.| |||...|...||| | .|  . ...| .|||.| |.| |    |  .| ||.  |||
HRAVKMLRGDASHEDREEFLREAEV-MCQL-RHPNLVQLVGVCMQQRPWLCVLEYMQYGDL
Kinase CTKA1.AA HMTK 800-813 50 0.152076 1.27 In-house 278-291 (291) Show / Hide 
Range on Protein: 800-813
Range on HMM: 278-291/291
Sequence Identity: 50% (7 aa)

EPKERVSFEQLQEM
.| .| .| ||| |
DPHQRPTFAQLQKM
PH CTKA1.AA PH 845-952 28 1.5e-20 75.53 SMART 1-82 (82) Show / Hide 
Range on Protein: 845-952
Range on HMM: 1-82/82
Sequence Identity: 28% (31 aa)

FVHTGWMIKQGSGQGAFSRSSWKRRWFALRDNGTLSYHKAERPDAKPLGTIALGDTIKVHPRPPFELTFAQKSCFSMVTPGRVYNFVCDSDGERDVWIRL
... ||. |..       . .||.||| |.. ..|.|.| .    || |.| | |  .| . |          ||  .. .|.| | |.|. |.. |.. 
VIKEGWLYKKS-------K-RWKKRWFVLFN-DCLYYYKDK----KPKGSIPLSDC-TVRE-P----------CFEIHH-DRTYYFQCESEEEMQEWMQA

LKAAIDAL
...||. .
IQKAIHNN
PH CTKA1.AA PH 845-950 29 2.9e-17 64.91 Pfam 1-92 (92) Show / Hide 
Range on Protein: 845-950
Range on HMM: 1-92/92
Sequence Identity: 29% (32 aa)

FVHTGWMIKQGSGQGAFSRSSWKRRWFALRDNGTLSYHKAERPDAKPLGTIALGDTIKVHPRPPFELTFAQKSCFSMVTPGR-VYNFVCDSDGERDVWIR
 .. ||. |.|      .|.|||.||| |.. ..|.|.| .   ..| |.| | |  .| . |.      .. || ..| .| .| | ..|. |.. |..
VIKEGWLHKKG------KRKSWKKRWFVLFN-NCLYYYKDDK--YRPKGSIPLSDC-QVTKVPDN----KRPHCFQIRT-DRRTYYFQAESEEEMNDWMQ

LLKAAID
 ...|. 
AIQSACR
PDK1_PH CTKA1.AA PDK1_PH 919-951 27 0.000342 12.36 In-house 81-112 (112) Show / Hide 
Range on Protein: 919-951
Range on HMM: 81-112/112
Sequence Identity: 27% (9 aa)

FSMVTPGRVYNFVCDSDGERDVWIRLLKAAIDA
|  .||.|.|.| .|..|. ..|..   ...  
FFIHTPNRTYYF-EDPKGCANKWCEAIEKVCKR