Gene RTKA1 (M.brevicollis)
RTKA1
Species: M.brevicollis
Alias: RTKA1
External Links:
Annotation:
Sequence
Protein domains of RTKA1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| LDLa | RTKA1.AA | LDLa | 534-574 | 27 | 6e-06 | 26.91 | SMART | 1-47 (47) | Show / Hide |
Range on Protein: 534-574 Range on HMM: 1-47/47 Sequence Identity: 27% (13 aa) FCPKP-AQNVACPASGSVLSIVQVCNGVDDCSNGEDE------ASCYG || .|. .| .. .||.|..||..|.|| . | TCPPDHPNQFQCG-NGRCIPKSWVCDGDNDCGDGSDEWPFFDPENCPQ |
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| Ldl_recept_a | RTKA1.AA | Ldl_recept_a | 555-572 | 45 | 2.8e-05 | 18.88 | Pfam | 22-41 (41) | Show / Hide |
Range on Protein: 555-572 Range on HMM: 22-41/41 Sequence Identity: 45% (9 aa) QVCNGVDDCSNGEDE--ASC .||.| .|| .|.|| ..| WVCDGDPDCHDGSDEWPENC |
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| Kinase | RTKA1.AA | RTKA | 809-1050 | 52 | 1.5e-181 | 609.4 | In-house | 1-314 (314) | Show / Hide |
Range on Protein: 809-1050 Range on HMM: 1-314/314 Sequence Identity: 52% (164 aa) IDVEQVIGHGHFSNVYQGSLLDGE----QKPRRVAIKECD----GDKTMLSAWLREILLLHSLCNQPNIIGLHGVLLRTAE---QSTLSAVLEWAPHGNL ..|..|.||||||.||| ||.|.| |.|..||||||| |||.||||.|||.||||....|.|||||||.|.... ||....|.||.||||| MQVRHVVGHGHFSQVYQASLQDMEDEMRQGPQCVAIKECDDLMLNDKTTLSAWMREIMLLHSMRDCPHIIGLHGVCLPREDKHHQSHCGMVCEWCPHGNL RDFVQRHP------------------------LSEAQLHQALYQTA-------TALACLAKLEIVHRDVAARNVLVMAAGPAFACKLGDFGLSRVMPSSK ||||..|| |||||.||||.|.. .|.|.|||..||||||||||||||.. |||.|||.|||||||||||. RDFVRQHPHFSAPVVATIAMQHSGEPNASPKLLSEAQCHQALLQMCPCWAQVAQAMAYLAKCGIVHRDVAARNVLVMSLQPAFHCKLADFGLSRVMPSSD YYRSVADSEMPFRWMALECLMAQRYSEHSDVWAFGVLAWELVTAGATPWQ------------------------------GLSLPAIIQELKAGATLPLP ||.|.||.||||||||.||.|..|||||||||.||||.|||.|.|.|||| |..|..|||.||.|.|||.| YYKSRADDEMPFRWMAPECIMERRYSEHSDVWSFGVLVWELLTHGQTPWQNCESHQIVALLMRGERLTFAPTINAALRDSGCDLHHIIQMLKQGQTLPMP PGAPLIAQRCVPSC |..| ..||.. | PCCPPCLQRFCFWC |
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| Kinase | RTKA1.AA | TK | 809-1046 | 18 | 6.9e-75 | 250.3 | In-house | 1-468 (486) | Show / Hide |
Range on Protein: 809-1046
Range on HMM: 1-468/486
Sequence Identity: 18% (88 aa)
IDVEQVIGHGHFS---NVYQGSLLD----------------------GEQKPRRVAIKECDGDKTMLSAW------------------LREILLLHS-LC
| .....|.|.| ||.| . . .|... .||.| . . .| .. ..|. .... |.
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG
NQPNIIGLHGVLLRTAE---------QSTLSAVLEWAPHGN----LRDFVQRH-----------------------------------------------
. |||. |.|| .. .. | . |.|..|||. |||. ...
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY
----------PLSEAQLHQ-------------------ALYQTATALACLAKL------EIVHRDVAARNVLVMAAGPA--------FACKLGDFG----
||....|.| .| | ... |... .||||.||||.|| .. . ||..|||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ
----LSRVMPS------------------------SKYYRSVADSEMPFRWMALECLM---------AQRYSEHSDVWAFGVLAWELVTAGATPWQG-LS
|.| ..| ..|||. . .|.|||| |||. .... ||||.|||| ||..| |..|. | .|
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS
L---------PAIIQELKAG--------------ATLPLPPGAP------------------LIAQRC
... |..| .| ||..| .. |.|
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQC
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| Kinase | RTKA1.AA | RTKF | 809-1040 | 38 | 1.9e-64 | 206.46 | In-house | 1-238 (272) | Show / Hide |
Range on Protein: 809-1040 Range on HMM: 1-238/272 Sequence Identity: 38% (91 aa) IDVEQVIGHGHFSNVYQGSLLDGEQKPRRVAIKECDGDKTML--SAWLREILLLHSLCNQPNIIGLHGVLLRTAEQSTLSAVLEWAPHGNLRDFVQRHP- | .. ..||||| | .| |||| | .. ||| .. | || ..|.| || ... |.| |||| .| . |.| IMLGEQLGHGHFGRVHHGYWRQQKGQRQPVAIKHIHTQDMMNWRRQMLRECCAMNRVGQHPHIIQFFGILMTPFEQNEMAFVMEFAPHGDMRRYLQQHDV -LSEAQLHQALYQ-TATALACLAKLEIVHRDVAARNVLVMAAGPAFACKLGDFGLSRVMPSS-KYYRSVADSEMPFRWMALECLMAQRYSEHSDVWAFGV | |.. .| | | |.. . |||||||||||| . | || |||| || . |||| . | |||||| | |. |... |||| ||. DLGRAHMLDAAHQVVAEAMVFISRQGLVHRDVAARNVLVFEDQPRMYVKLTDFGLARVLSQHQDYYRSMQNEELPFRWMAPEAIMHRRFTQKSDVWSFGM LAWELVTAGATPWQGLSLPAIIQELKAGATLPLPPGAP . .||.| | |. . . |...| | || .|. .| MLFELFTRGDVPYGNMPHPVVLQFIRRGKTLQMPDSCP |
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| Kinase | RTKA1.AA | Pkinase_Tyr | 809-1040 | 32 | 2.6e-62 | 211.64 | Pfam | 1-242 (270) | Show / Hide |
Range on Protein: 809-1040 Range on HMM: 1-242/270 Sequence Identity: 32% (79 aa) IDVEQVIGHGHFSNVYQGSLL-DGEQKPRRVAIKEC--DGDKTM--LSAWLREILLLHSLCNQPNIIGLHGVLLRTAEQSTLSAVLEWAPHGNLRDFVQR | ...|.|.| .||.| . |.... ||.| . . .. . . .||. ....|.. |||. |.|| .. |.. . |.| .|||.|.|. .. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK H-----PLSEAQLHQALYQTATALACLAKLEIVHRDVAARNVLVMAAGPAFACKLGDFGLSRVMPSSKYY-RSVADSEMPFRWMALECLMAQRYSEHSDV | ||. .| | .| | ... |. ..|||.||||.|| . .| .||||.| . . || |. .. .| .|||.||.. .... ||| HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV WAFGVLAWELVTAGATP-WQGLSLPAIIQEL-KAGATLPLPPGAP |.|||| ||..| |..| ..|.| ... . . | .| |...| WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCP |
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| Kinase | RTKA1.AA | RTKL | 811-1051 | 38 | 4.5e-58 | 151.92 | In-house | 3-242 (259) | Show / Hide |
Range on Protein: 811-1051
Range on HMM: 3-242/259
Sequence Identity: 38% (96 aa)
VEQVIGHGHFSNVYQGSLLDGEQKPRRVAIKECDGDKTML--SAWLREILLLHSLCNQPNIIGLHGVLLRTAEQSTLSAVLEWAPHGNLRDFVQRHP---
| | | || |||... . | |||| . | |.| .||| | |.|| .||. || . .|| || |||| . ||.
LENELGRGQFSRVYQARSC-SRMVPTQVAIKIAHEQQSKNQMDAVLYEAVLLHQL-HHPHIIQMHGC---TAVPQRMAMILELAPNGNLREYL-RHDDAP
---LSEAQLHQALYQTATALACLAKLEIVHRDVAARNVLVMAAGPAFACKLGDFGLSRVMPSSK-YYRSVADSEMPFRWMALECLMAQRYSEHSDVWAFG
.| | | | | ||| . ..||| |.|||| | ||| |||||| . . ||| . ..||||| .| | |||||||
SSSWPQRQRLQWLCQVAQALAYIHQRRMIHRDLASRNVLLV---PMMVCKLSDFGLSRRLQNEQDYYRPQQNDHVPFRWMSPETLNGKPHTMASDVWAFG
VLAWELVTAGATPWQGLSLPAIIQELKAGATLPLPPGAPLIAQRCVPSCY
|...| .| | |. .. | .. || | || | | | | |.
VVCYEVIT-GQVPYADTDMPQVVALLKNEGRLALPAGTPPGLERLVAACW
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| Kinase | RTKA1.AA | UTK | 809-1041 | 26 | 3.4e-54 | 183.81 | In-house | 1-269 (296) | Show / Hide |
Range on Protein: 809-1041 Range on HMM: 1-269/296 Sequence Identity: 26% (72 aa) IDVEQVIGHGHFSNVYQGSLLD-GEQKPR-RVAIKECD--GDKTMLSA----WLREIL---LLHSLCNQPNIIGLHGVLLRTAEQSTLSAVLEWAPHGNL . . .|.|.| .|. ... . |. . .||.|.|. .|.. .. ...| .. . ||...| || .. . |.| .. |.| VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP---WMIVTEYMENGDL RDFVQRHPL---------SEAQLHQALYQTATALACLAKLEIVHRDVAARNVLVMAAG----PAFACKLGDFG---LSRVMP---------SSKYYRSVA |....||. .. |. . .. | ... |. .||||.||||.|| . . ||..||| .|| .. .| ||.. RSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQH DSEMPFRWMALECLMAQ-RYSEHSDVWAFGVLAWELVTAGATPWQGLSLPAIIQELKAG--ATLPLPPGAPL . ..|.|||| |.| . |....||||.|||. ||..| |..|. |.| ....... .| . .| |.. |. QDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPH |
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| Kinase | RTKA1.AA | TyrKc | 809-1055 | 28 | 9e-53 | 182.56 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 809-1055 Range on HMM: 1-280/280 Sequence Identity: 28% (83 aa) IDVEQVIGHGHFSNVYQGSLLDGEQKPRRVAIKECDGDKTMLSAWLREILLLHSL-CNQPNIIGLHGVLLRTAEQ----STLSAVLEWAPHGNLRDFVQR | ....|.|.| ||.| . . ||.| . |. . . .||. ....| . |||. |.|| . .. | |.| .|||.|.|. .. ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK HP--LSEAQLHQALYQTATALACLAKLEIVHRDVAARNVLVMAAGPAFACKLGDFGLSRVMPSS-------KYYRSVA--DSE--MPFRWMALECLMAQR | |. ..|.. .| | . |.. ..||| ||||.|| . . .| .|||||| . .|||. .. .| ||||.||.. . HRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK YSEHSDVWAFGVLAWELVTAGATPWQG-----LSLPAIIQELKAGATLPLPPG--------APLIAQRCVPSCYSR-------------CV ... ||||.|||. ||. | |..|. | .| .|. .|.| .| || .| . .| . | FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | RTKA1.AA | TK-Unique | 809-1038 | 29 | 5.3e-50 | 170.61 | In-house | 1-263 (294) | Show / Hide |
Range on Protein: 809-1038
Range on HMM: 1-263/294
Sequence Identity: 29% (80 aa)
IDVEQVIGHGHFSNVYQGSLLDGE---QKPRRVAIKECDGDKTMLS--AWLREILLLHSLCNQPNIIGLHGVLLRTAEQSTLSAVLEWAPHGNLRDFVQ-
. |..||| | |. |. | . . |...||.| . . | .. . |.|| .. .| .|||. . |. .. |. . ..|..| |||... .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMI--IMEYCPCGNLQHYLRT
------RH--------------------PLSEAQLHQALYQTATALACLAK--LEIVHRDVAARNVLVMAAGPAFACKLGDFGLSR-VMPSSKYYRSVAD
.| |.|. .| . ..| | ... ||. .|||||..|||||. . ||..|||..| |. .| ..
CRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE---DKVCKICDFGMARDVYTNGVYSMMCSQ
SEMPFRWMALECLM--AQRY-SEHSDVWAFGVLAWELVTAGATPWQGLSLPAIIQELKAGATLPLPPG
...| ||||.| | . | .. ||||.|||| ||..| ||.| |.. . |......| ..|.|..
GRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEH
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| Kinase | RTKA1.AA | Met | 810-1014 | 31 | 3.7e-38 | 122.52 | In-house | 1-219 (271) | Show / Hide |
Range on Protein: 810-1014 Range on HMM: 1-219/271 Sequence Identity: 31% (71 aa) DVEQVIGHGHFSNVYQGSLLDGEQKPRRVAIKECD----GDKTMLSAWLREILLLHSLCNQPNIIGLHGVLLRTAEQSTLSAVLEWAPHGNLRDFVQ--R ....||| ||| .|| | ..|. .. ..|.| .| |. ||| .. . . ||. | |. |. . . . ||.. || |. |. HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHF-DHPNVLSLIGICLDPEGHMPW-VVLPYMKHGDLKTFIRNPQ HPLSEAQLHQALYQTATALACLAKLEIVHRDVAARNVLVMAAGPAFACKLGDFGLSRVM-PSSKYYRSVADSE---MPFRWMALECLM--------AQR- . . .| | | .| . |||| |.|| . . | | .||||.| | || | .|||.||| ..| NNPCVRDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDE---HFTVKVADFGLCRDMDYDKEYYSQMHHTHPARLPVKWMAPECLQQGVCLGCPTYRQ YSEHSDVWAFGVLAWELVTAGATP .. |||| |||. ||| | ||.| FTTKSDVWSFGVVMWELMTRGAPP |
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| Kinase | RTKA1.AA | FAK | 809-1040 | 31 | 1.3e-37 | 123.49 | In-house | 1-252 (285) | Show / Hide |
Range on Protein: 809-1040
Range on HMM: 1-252/285
Sequence Identity: 31% (82 aa)
IDVEQVIGHGHFSNVYQGSLLDGEQ------------------------KPRRVAIKEC--DGDKTMLSAWLREILLLHSLCNQPNIIGLHGVLLRTAEQ
| ..|| | | .|||| . .. |||| | . |. . | . .. . | |. | |. |
ITLNRCIGEGQFGDVYQGVYTNHKNGKGKNLAGNGKNSNSDQRNADSRPDKIQVAIKTCKKCCDDDNKEKFMQEAYIMKQF-DHPHIVKLIGIC----EE
STLSAVLEWAPHGNLRDFVQRH--PLSEAQLHQALYQTATALACLAKLEIVHRDVAARNVLVMAAGPAFACKLGDFGLSRVMPSSKYYRSVADSEMPFRW
..| .. | || . ||. |. | | || ..|.| | ||||.||||||| . ||||||||| | . ||.. .| .|
MPIWIIMELCKYGELRHYLQRNKNSLKHATLILYCYQLCMAMAYLESKKFVHRDIAARNVLVSSPD---CVKLGDFGLSRWMHDHSYYKASPKGKLPIKW
MALECLMAQRYSEHSDVWAFGVLAWELVTAGATPWQGLSLPAIIQELKAGATLPLPPGAP
|. | |. |||| ||| || | | |.. .| . | ||.|| |
MSPESINFRRFTTASDVWMFGVCMWEILMYGVKPFQWVKNNDVIGRIENGERLPMPPNCP
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| Kinase | RTKA1.AA | CTKA | 925-1040 | 39 | 1.6e-37 | 123.51 | In-house | 147-262 (290) | Show / Hide |
Range on Protein: 925-1040 Range on HMM: 147-262/290 Sequence Identity: 39% (47 aa) LAKLEIVHRDVAARNVLVMAAGPAFACKLGDFGLSRVMPSS-KYYRSVADSEMPFRWMALECLMAQRYSEHSDVWAFGVLAWELVTAGATPWQGLSLPAI || . .|||| |.||.|. | |. |||..| . .|| . . ||.|||| | | ..| ||||||||| ||. . | .|| ..| . LAEMGFVHRDLACRNCLL---GQYCHIKIADFGHGRTLRTESQYYYVSSQRVMPVRWMAPEALCFGKFSCASDVWAFGVLLWEIMSMGEKPWRHMSDQEV IQELKAG--ATLPLPPGAP | .. ||.|. .| CQAYTSHGMRRLPVPRNCP |
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| Kinase | RTKA1.AA | EGFR | 809-1037 | 32 | 3.1e-37 | 121.08 | In-house | 1-226 (258) | Show / Hide |
Range on Protein: 809-1037 Range on HMM: 1-226/258 Sequence Identity: 32% (77 aa) IDVEQVIGHGHFSNVYQGSLL-DGEQKPRRVAIKEC--DGDKTMLSAWLREILLLHSLCNQPNIIGLHGVLLRTAEQSTLSAVLEWAPHGNLRDFVQRH- . .| | | | || | .||. ||||. .. . |.| . . |. . |... | || . .|.. | |.|.| |.|. | LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLREQTGPKANEEMLDEAYVMASV-DHPHLVRLLGVCM----HSQMQLVTQYMPYGCLLDYVRQHK -PLSEAQLHQALYQTATALACLAKLEIVHRDVAARNVLVMAAGPAFACKLGDFGLSRVMPSSKYYRSVADSEMPFRWMALECLMAQRYSEHSDVWAFGVL . .| .| | . | . ..|||| ||||||| | ||||...... . ... || .||||||. ..| ||||..|| DNIGSQHLLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPN---HVKITDFGLAKLLEHDEKEYHAQGGKMPIKWMALECIHHRCYTHQSDVWSYGVT AWELVTAGATPWQGLSLPAIIQELKAGATLPLPP |||.| |. |..|... | . |. | || || CWELMTFGQKPYDGIPAREIPDLLEKGERLPQPP |
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| Kinase | RTKA1.AA | S_TKc | 809-1055 | 20 | 4.4e-28 | 100.55 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 809-1055
Range on HMM: 1-231/231
Sequence Identity: 20% (56 aa)
IDVEQVIGHGHFSNVYQGSLLDGEQKPRRVAIKECDGDKTMLSAWLREILLLHSLCNQPNIIGLHGVLLRTAEQSTLSAVLEWAPH--GNLRDFVQRHP-
.. ..||.| |. ||.. . |.||||. . .||| .|.. . |||. |..| . | |.| ... |.|.|. ....
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK------EHIRREIQILKK--HHPNIVKLYDVFQD----DHLYMVMEYCDGDLGDLFDYIKKRGR
------LSEAQLHQALYQTATALACLAKLEIVHRDVAARNVLVMAAGPAFACKLGDFGLSRVMPSSKYYRSVADSEMPFRWMALECLMAQRYSE-HSDVW
..| . .||.. ||. . .. |.|||. |.|. |..||||.|.. .|| | | |. .|.|
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWW
AFGVLAWELVTAGATPWQGLSLPAIIQELKAGATLPLPPGAPLIAQRCVPSCY----------------SRCV
..|.. .|... | .|.. . .... .. |.. .| . .. .
SCGCILYEMLC-GYPPFP--QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
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| Kinase | RTKA1.AA | Pkinase | 809-1017 | 22 | 9e-24 | 85.13 | Pfam | 1-214 (293) | Show / Hide |
Range on Protein: 809-1017 Range on HMM: 1-214/293 Sequence Identity: 22% (53 aa) IDVEQVIGHGHFSNVYQGSLLDGEQKPRRVAIKECDGDKTMLSAW---LR--EILLLHSLCNQPNIIGLHGVLLRTAEQSTLSAVLEWAPHG----NLRD . ....|| | |. ||.. . .. .||.|. . ... . . .| || ....| | |||. |... . . . |.|....| | | YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---KDHIYMVMEYCEGGLYVMDLFD FVQ---RHPL--SEAQLHQALYQTATALACLAKLEIVHRDVAARNVLVMAAGPAFAC----KLGDFGLSR---VMPSSKYYRSVADSEMPFRWMALECLM ... . .. || .. .||.. .|. . . |.|||. |.|. | . |..||||.. ..| .. . .. .|| | .. YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNG---HIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW----YMAPEVIR -AQRYSEHSDVWAFGVLAWELVTAGATPWQG .| |. .|.|..|.. .|... | .|..| GGQYYGPKVDMWSCGCILYEMLC-GRPPFPG |
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