Gene RTKJ2 (M.brevicollis)

RTKJ2

Species: M.brevicollis
Alias: RTKJ2
External Links:
Annotation:

Classification

Group: TK
Family: RTKJ

Sequence

Name Sequence Type Origin Length Description Download
RTKJ2.AA Protein None 1262 None Fasta, JSON
RTKJ2.kin_dom Protein Kinase Domain None 278 None Fasta, JSON

Protein domain

Protein domains of RTKJ2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Recep_L_domain RTKJ2.AA Recep_L_domain 53-114 30 0.000172 16.81 Pfam 3-62 (121) Show / Hide 
Range on Protein: 53-114
Range on HMM: 3-62/121
Sequence Identity: 30% (19 aa)

SVLQGSLTIDTTGTDANWLAAATAVLAPLTDIRGYVSVIDAGDLLTNLELLANVRVIRGRQL
.|. |.|.|  ...  . |     ... .. |.||. .    ..|.|| .. | |.||||||
TVIYGNLEITWRDEHNE-LEEDLSFFPNIREITGYLLIYRT-YNLKNLSFFPNLRIIRGRQL
FU RTKJ2.AA FU 260-303 31 6.2e-08 33.61 SMART 1-48 (48) Show / Hide 
Range on Protein: 260-303
Range on HMM: 1-48/48
Sequence Identity: 31% (15 aa)

ATTC--CDSSCLGGCLA--NGQCLACAEGLVMSSQGVCVSSCPGTLSR
...|  |...|..||    ..||..|..|... . |.|||.||    .
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Furin-like RTKJ2.AA Furin-like 218-298 26 0.289898 4.76 Pfam 1-99 (182) Show / Hide 
Range on Protein: 218-298
Range on HMM: 1-99/182
Sequence Identity: 26% (28 aa)

NTSCT-------GACAVSC------NGT--CWLASDDSACQT---NVFP-ACGR---VGVAVNDATTCCDSSCLGGCLANG---QCLACAEGLVMSSQGV
| .|          |  .|      .    || ....  |||    |.|  |..    |   .. . ||...||||| ...    |.||        .|.
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCW-GPNPQHCQTLTKKVCPEQCKHRRCTG---PKPGECCHEQCLGGCTGPNNDTDCVACRHFYH---NGT

CVSSCP
||..||
CVDQCP
Recep_L_domain RTKJ2.AA Recep_L_domain 425-508 25 2e-06 23.11 Pfam 26-121 (121) Show / Hide 
Range on Protein: 425-508
Range on HMM: 26-121/121
Sequence Identity: 25% (24 aa)

ALQRIQRIKGAITATET-LFVNLDFFKGLIDLRAATPT---SVALNVTQNPV--LASLGLNNLRSVQG---HVLLRDNY--YLCFTSE-LKWTDLL
... |. | | ..   | ...||.||. |   |  .     ..||..  ||   | .|.. ||. ..     |   .|    ||.| . . | ...
FFPNIREITGYLLIYRTYNLKNLSFFPNLRIIRGRQLFHDDNYALYIYDNPNMGLQELWMWNLKNITRKNGGVYIHNNPHPKLCYTHTEIMWWMIY
FU RTKJ2.AA FU 575-620 42 1.9e-12 48.62 SMART 1-48 (48) Show / Hide 
Range on Protein: 575-620
Range on HMM: 1-48/48
Sequence Identity: 42% (21 aa)

RLTT--CDAQCATRPCWSSDPDACQRCPSGQRLQE-GRCVAACDEGYYP
. .   |...|||  ||...||.|. ||.|  |.. |.||. | .||||
DGVCKPCHPECAT-GCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
Furin-like RTKJ2.AA Furin-like 580-598 14 1.293649 2.63 Pfam 1-41 (182) Show / Hide 
Range on Protein: 580-598
Range on HMM: 1-41/182
Sequence Identity: 14% (6 aa)

DAQCA--------TRP--------------CWSSDPDACQR
. .|.         ..              ||...|. ||.
NRECPDVCPGTCEPCHPCCKTTINGHYGYRCWGPNPQHCQT
TNFR_c6 RTKJ2.AA TNFR_c6 595-605 41 43.098659 0.33 Pfam 18-29 (41) Show / Hide 
Range on Protein: 595-605
Range on HMM: 18-29/41
Sequence Identity: 41% (5 aa)

ACQRCPS-GQRL
.|.||.. ||..
SCTRCHPMGQYM
FU RTKJ2.AA FU 623-668 43 2.7e-12 48.09 SMART 1-48 (48) Show / Hide 
Range on Protein: 623-668
Range on HMM: 1-48/48
Sequence Identity: 43% (21 aa)

DWLCAACYATCAT-CSGPGEDQCTSCTGSLSLSE-DECIVNCPSRQYS
|  |..| ..||| |.|||.||||||   ..| . ..|.  ||.  | 
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHNGTCVSQCPPGYYP
FU RTKJ2.AA FU 670-718 34 4e-06 27.74 SMART 1-48 (48) Show / Hide 
Range on Protein: 670-718
Range on HMM: 1-48/48
Sequence Identity: 34% (17 aa)

LNVCHDCSPLCTT-CRDGTNSSCPTCAPGAVKMPGVADTCVTECPDGYFL
 .||. |.| | | |   .. .| .|..| .. .   .|||..||.||. 
DGVCKPCHPECATGCWGPGPDQCTSCPHGYYLHHN--GTCVSQCPPGYYP
Furin-like RTKJ2.AA Furin-like 708-737 36 0.000653 13.44 Pfam 151-182 (182) Show / Hide 
Range on Protein: 708-737
Range on HMM: 151-182/182
Sequence Identity: 36% (12 aa)

CVTECPDGYFLN--SVAGSCDRCRDLRC-KICA
|..||| ||  |  .  ..|  |. . | |.| 
CMRECPSGYTENEENNTMMCEPCEGP-CPKVCY
TNFR_c6 RTKJ2.AA TNFR_c6 745-782 30 0.009994 12.75 Pfam 1-41 (41) Show / Hide 
Range on Protein: 745-782
Range on HMM: 1-41/41
Sequence Identity: 30% (13 aa)

CFAG-NFYDLDQ--LACQPYTSCTN-TTYMSQAPTPTSNREC
|  |  ..| .     |.. |.| .  .||.|  |.|.|..|
CPPGKTYTD-WNHVPHCLSCTRCHPMGQYMVQPCTWTQNTVC
FU RTKJ2.AA FU 722-770 21 0.050415 6.43 SMART 1-48 (48) Show / Hide 
Range on Protein: 722-770
Range on HMM: 1-48/48
Sequence Identity: 21% (11 aa)

AGSCDRCRDLRCKI-CAI--DGTCEACFAGNFYDLDQLACQPYTSCTNTTYM
.| | .|    |.  |    ...| .|  |.. . .  .| .  .|.  .| 
DGVCKPCH-PECATGCWGPGPDQCTSCPHGYYLHHN-GTCVS--QCPPGYYP
TNFR_c6 RTKJ2.AA TNFR_c6 712-729 23 0.756737 6.33 Pfam 1-20 (41) Show / Hide 
Range on Protein: 712-729
Range on HMM: 1-20/41
Sequence Identity: 23% (5 aa)

CPDG-YFLNSVA--GSCDRCR
||.| ...   .    | .|.
CPPGKTYTD-WNHVPHCLSCT
Kinase RTKJ2.AA RTKJ 853-1130 73 8.4e-254 849.44 In-house 1-278 (278) Show / Hide 
Range on Protein: 853-1130
Range on HMM: 1-278/278
Sequence Identity: 73% (205 aa)

VVVGTKLGGGFFGIVSRGLLRPSITSNAGARDVAVKQLKRDVEVGSREVTEFFDEMELMMDLGRHRNVLSLLGACRREQPVLMILEFADKGDLMHFLRDC
||.|..||.|.||||||||||.|||.|.|..|||||||||||.|.|.||.|||.||.||||||.|..|.||.|.||||||.|||..||.||||||.||||
VVIGQQLGAGHFGIVSRGLLRKSITDNTGNMDVAVKQLKRDVDVDSDEVDEFFHEMKLMMDLGHHQHVVSLVGVCRREQPILMIIDFANKGDLMHHLRDC

RATDARAALLTRSDFFDFAAQIAAGMEFLAGHKIIHRDLAARNVLVQSKGRTEIDGYTLKIADFGLARTAGDDDNYTKTSDGAVPFKWLAIESLRDRVFS
|..|.|.|.|.|.||||..|||||||||||.|.|||||||||||||...|||||.||.||||||||.|.|..||||.|..|.||||||||||..||||||
RPNDRREATLRRDDFFDYCAQIAAGMEFLAFHRIIHRDLAARNVLVHDDGRTEINGYVLKIADFGLTRQARNDDNYRKCEDDAVPFKWLAIECFRDRVFS

EASDVWAFGITCWEIFTFGQGPYPGIANASIYDELVKGHRLAKPFLCSKLMYGIMVHCWKENPRERPTFAALLKSIAP
.||||||||||||||.||||.|||||.|..|||.||||||...||.|||.||.||.||||.||||||||..||..|.|
QASDVWAFGITCWEIYTFGQSPYPGIQNNEIYDRLVKGHRMPRPFDCSKQMYDIMMHCWKFNPRERPTFSTLLNEISP
Kinase RTKJ2.AA TyrKc 853-1128 35 2.5e-120 406.98 SMART 1-280 (280) Show / Hide 
Range on Protein: 853-1128
Range on HMM: 1-280/280
Sequence Identity: 35% (108 aa)

VVVGTKLGGGFFGIVSRGLLRPSITSNAGARDVAVKQLKRDVEVGSREVTEFFDEMELMMDLG-RHRNVLSLLGACRRE-------QPVLMILEFADKGD
.. | ||| |.||.| .| ..         ..|||| || |       . .| .|...|. || .| |.. |.|.|. .       .|.....|....||
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGD

LMHFLRDCRATDARAALLTRSDFFDFAAQIAAGMEFLAGHKIIHRDLAARNVLVQSKGRTEIDGYTLKIADFGLARTAGDD-------DNYTKTS--DGA
| ..||..| .      |. .|. .|. |||.|||.|. ...|||||||||.|| ...       | ||.||||.|  .||       | |.|..  .| 
LKDYLRKHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

--VPFKWLAIESLRDRVFSEASDVWAFGITCWEIFTFGQGPYPG-----IANASIYDELVKGHRLAKPFL--------CSKLMYGIMVHCWKENPRERPT
  .| .|.|.|......|...||||.||...|||||.|| ||||     . |. ..  . .|.|. .|          |.. || ||  ||.|.| .|||
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPT

FAALLKSI
|... . .
FSEIHECF
Kinase RTKJ2.AA Pkinase_Tyr 853-1128 36 1.6e-119 405.43 Pfam 1-270 (270) Show / Hide 
Range on Protein: 853-1128
Range on HMM: 1-270/270
Sequence Identity: 36% (104 aa)

VVVGTKLGGGFFGIVSRGLLRPSITSNAGARDVAVKQLKRDVEVGSRE--VTEFFDEMELMMDLGRHRNVLSLLGACR-REQP--VLMILEFADKGDLMH
.. | ||| | || | .| ...      .  .|||| ||      ...    .|. |...|. ||.| |...|.|.|  ...|  .....|.. .||| .
ITFGKKLGEGAFGEVYKGTWKG--DPDNTKIPVAVKMLKE--GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

FLRDCRATDARAALLTRSDFFDFAAQIAAGMEFLAGHKIIHRDLAARNVLVQSKGRTEIDGYTLKIADFGLARTAGDDDNY-TKTSDGAVPFKWLAIESL
.||. |        || .|  ....|||.|||.|. ...|||||||||.|| .       . . ||.||||||.  .||.| .|...| .| ||.| |..
YLRKHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE-------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECI

RDRVFSEASDVWAFGITCWEIFTFGQGP-YPGIANASIYDEL-VKGHRLAKPFLCSKLMYGIMVHCWKENPRERPTFAALLKSI
....|...||||.||...|||||.|. | |||. |. .|. .  .|.|...| .|.. .| .| .||...| .||||....  .
NYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase RTKJ2.AA TK 853-1128 23 7.89999999999e-114 383.15 In-house 1-486 (486) Show / Hide 
Range on Protein: 853-1128
Range on HMM: 1-486/486
Sequence Identity: 23% (113 aa)

VVVGTKLGGGFFG---IVSRGLLRPSIT-------------------SNAGARDVAVKQLKRDVEVGSREVTE--------------FFDEMELMMD-LG
...| ||| | ||    | .|..|. .                    .. |  .||||.|| . .  ..|  .              .  ||..|.  ||
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHRNVLSLLGACRRE------------QPVLMILEFADKGD----LMHFLRDCRATDARAAL--------------------------------------
.| |...|.|.| ..            .|.....|....||    | ..||.|| .    .                                       
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-----------LTRSDFFD-------------------FAAQIAAGMEFLAGH------KIIHRDLAARNVLVQSKGRT----EIDGYTLKIADFG----
           || .|. .                   ...|||.|||.|. .      ...||||||||.|| .....    . .|.. ||||||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LARTAGDDDNYTKTS------------------------DGAVPFKWLAIESLRDRV---------FSEASDVWAFGITCWEIFTFGQGPYPG-IA
    |||  ..||.|...|                        .| .|..|.| |.|.|||         |...||||.||...|||||.||.||.| . 
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

N---------ASIYDELVKG--------------HRLAKPFLCS--------------KLMYGIMVHCWKENPRERPTFAALLKSI
|         . ... |..|              .|...| .|.              ...| .|  ||...|..||||..|.. .
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase RTKJ2.AA UTK 853-1128 32 2.6e-94 319.63 In-house 1-296 (296) Show / Hide 
Range on Protein: 853-1128
Range on HMM: 1-296/296
Sequence Identity: 32% (97 aa)

VVVGTKLGGGFFGIVSRGLLRPSITSNAGARDVAVKQLKRDVEVGSREVT---EFFDEME---LMMDLGRHRNVLSLLGACRREQPVLMILEFADKGDLM
|  | .|| | ||.|... ... ..  ..  |||||...   ... .| .   .|  |     .|. .  |.||| |.| | .|.| ....|.. .||| 
VQLGRQLGQGAFGEVHKARFTQ-CSEHMYEMDVAVKVCQ-HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLR

HFLRDCRA-TDARAALLTRSDFFDFAAQIAAGMEFLAGHKIIHRDLAARNVLVQSKG-RTEIDGYTLKIADFG---LARTAG---------DDDNYTKTS
..||..|  ..|. ..||  .  ..|..||.||..|......||||||||.|| . .      ... ||||||   ..| ..         ... |....
SYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWH-CMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQH

DGAVPFKWLAIESLRDR-VFSEASDVWAFGITCWEIFTFGQGPYPGIANASIYDELVKG--HRLAKPFLCSKLMYGIMVHCWKENPRERPTFAALLKSI
....|..| | |.| ..  |...||||.||..||||.|.|. ||||..|. .  ....|  .|...|  |.  .| .|. ||. .|.|||.|  |.. .
QDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase RTKJ2.AA TK-Unique 853-1128 34 5.8e-94 318.48 In-house 1-294 (294) Show / Hide 
Range on Protein: 853-1128
Range on HMM: 1-294/294
Sequence Identity: 34% (106 aa)

VVVGTKLGGGFFGIVSRGLLRPSITSNAGAR-DVAVKQLKRDVEVGSREVTEFFDEMELMMDLGRHRNVLSLLGACRREQ-PVLMILEFADKGDLMHFLR
..|| ..| | || | || ... .  . ...  ||||.||...     .. .|..| ..|. ||.| |....||.| . . |...|.|.. .|.| |.||
LEVGDVIGEGAFGQVWRGEVWGIW-KHWDKQKCVAVKMLKDNATD--TDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

DCRAT-------------------DARAALLTRSDFFDFAAQIAAGMEFLAG--HKIIHRDLAARNVLVQSKGRTEIDGYTLKIADFGLARTAGDDDNYT
 || .                   . | . ..  |.. || ||| |||.||.  .||.||||.|||||...       ....||.|||.||   ..  | 
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE-------DKVCKICDFGMARDVYTNGVYS

KT-SDGAVPFKWLAIESLR--DRVF-SEASDVWAFGITCWEIFTFGQGPYPGIANASIYDELVKGHRLAKPFLC-SKLMYGIMVHCWKENPRERPTFAAL
.. | | .| .|.| |||.  .... .. ||||.||.. |||||.|. ||||. ...| ... .|.|. .|  | |. || .|  ||...| |||.|...
MMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQI

LKSI
.. .
KHRL
Kinase RTKJ2.AA RTKB 853-1128 37 1.1e-85 288.88 In-house 1-264 (264) Show / Hide 
Range on Protein: 853-1128
Range on HMM: 1-264/264
Sequence Identity: 37% (105 aa)

VVVGTKLGGGFFGIVSRGLLRPSITSNAGARDVAVKQLKRDVEVGSREVTEFFDEMELMMDLGRHRNVLSLLGACRREQPVLMILEFADKGDLMHFLRDC
|  | ||| | || | ....| . .   ... .|.|.||  . . ..|  .| .|| .| .|| | ||. ..| | .. | .   |... | |  .|| |
VWLGEKLGNGAFGEVFQAWVRNRHM--NTEQSCAAKVLK--PGASYEERQDFCSEMTVMKELGWHPNVIGIIGHCLQDEPYILLVELCELGNLRDYLRMC

RATDARAALLTRSDFFDFAAQIAAGMEFLAGHKIIHRDLAARNVLVQSKGRTEIDGYTLKIADFGLARTAGDDDNYTKTSDGAVPFKWLAIESLRDRVFS
||.. ..  |  .   ||. ||| || ||  |..|||||.|||||| ..        . ||.|||.||.  |.. |..| . . | ||.|.||. .| ..
RASQHNPQSLKQAQLVDFCHQIACGMAFLHQHNVIHRDLCARNVLVDQQ-------LHCKICDFGMAREI-DHECYETTCT-RLPIKWMAPESWAHRIYT

EAS-DVWAFGITCWEIFTFGQGPYPGIANASIYDELVKGHRLAKPFLCSKLMYGIMVHCWKENPRERPTFAALLKSI
  | |||.||.|.||||..|  ||.  .|. | . | .|||| || . .  ...||  || . . .||.|..|... 
TKSGDVWSFGVTMWEIFSLGGTPYQQYRNGDIFYWLESGHRLPKPRQMPQAADHIMQMCWQMEAQHRPDFDELVDAF
Kinase RTKJ2.AA Src 853-1128 35 1e-75 256.73 In-house 1-255 (255) Show / Hide 
Range on Protein: 853-1128
Range on HMM: 1-255/255
Sequence Identity: 35% (99 aa)

VVVGTKLGGGFFGIVSRGLLRPSITSNAGARDVAVKQLKRDVEVGSREVTEFFDEMELMMDLGRHRNVLSLLGACRREQPVLMILEFADKGDLMHFLRDC
.    ||| | || |  |. . ..       .|||| ||..      ... |  | ..|  | || ....|.  | .| |.. . |.  .| |  .|.. 
IKLCRKLGQGQFGEVWMGYWNGNT-------KVAVKTLKPGT----MSPEAFLQEAQIMKKL-RHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK-

RATDARAALLTRSDFFDFAAQIAAGMEFLAGHKIIHRDLAARNVLVQSKGRTEIDGYTLKIADFGLARTAG-DDDNYTKTSDGAVPFKWLAIESLRDRVF
   | .   |   .  |.|||.|.||..|   ..||||||||||||  .          |.|||||||    |||.|.  ..  .| || | | .. ..|
---DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENN-------VCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRF

SEASDVWAFGITCWEIFTFGQGPYPGIANASIYDELVKGHRLAKPFLCSKLMYG-IMVHCWKENPRERPTFAALLKSI
.  |||| |||  .||.|.|. ||||  |.   ... .| |. .|  | . .|  || .||.. |..||||. | .  
TIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase RTKJ2.AA FGFR 962-1128 48 3.8e-72 245.21 In-house 133-293 (293) Show / Hide 
Range on Protein: 962-1128
Range on HMM: 133-293/293
Sequence Identity: 48% (81 aa)

LTRSDFFDFAAQIAAGMEFLAGHKIIHRDLAARNVLVQSKGRTEIDGYTLKIADFGLARTAGDDDNYTKTSDGAVPFKWLAIESLRDRVFSEASDVWAFG
||  |   .| |.| |||.||  |.||||||||||||        |.| .||.||||||   . | | ||..|  | || | |.| |||.   |||| .|
LTQKDLVSCAYQVARGMEYLASRKCIHRDLAARNVLVT-------DDYVMKICDFGLARDIHCIDYYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYG

ITCWEIFTFGQGPYPGIA-NASIYDELVKGHRLAKPFLCSKLMYGIMVHCWKENPRERPTFAALLKSI
.  |||.|.|. |||.|.    .|. |  |||. || .||. .| .|  ||...| .||||. |  ..
VLLWEIMTYGGQPYPHIPSVEELYKYLKEGHRMEKPHNCSQEIYHMMCQCWHFKPCQRPTFKQLVEYL
Kinase RTKJ2.AA Ack 853-1128 36 8.2e-70 234.67 In-house 1-266 (266) Show / Hide 
Range on Protein: 853-1128
Range on HMM: 1-266/266
Sequence Identity: 36% (102 aa)

VVVGTKLGGGFFGIVSRGLLRPSITSNAGARDVAVKQLKRDVEVGSR-EVTEFFDEMELMMDLGRHRNVLSLLGACRREQPV-LMILEFADKGDLMHFLR
. .. ||| | ||.| ||.     ...     |||| |..| .. .  .  .|. |   |. | .|.... | |  .  ||   |. |.|  | |   | 
ITLCEKLGDGCFGVVWRGEWT---NPGGKHIQVAVKCLRSD-KMQQPNCMDDFLREVAIMHSL-DHPHLVRLYGVVL-DQPMLMMVTELAPCGSLLDCL-

DCRATDARAALLTRSDFFDFAAQIAAGMEFLAGHKIIHRDLAARNVLVQSKGRTEIDGYTLKIADFGLARTAGDDDN-YTKTSDG--AVPFKWLAIESLR
  |. ..| | .. .   ||. ||| || .|    .|||||||||.|. |.        . ||.|||| |  |  .. |.        ||| | | |.||
--RK-HCRTAFFLIHTLCDFCMQIAMGMRYLEMKRCIHRDLAARNILLFSDD------RKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLR

DRVFSEASDVWAFGITCWEIFTFGQGPYPGIANASIYDELV-KGHRLAKPFLCSKLMYGIMVHCWKENPRERPTFAALLKSI
 | || |||||.|| | || |..|. |. |   . |   .  .| || .| .|..  | .|. ||...| .||||.|.    
HRQFSHASDVWMFGVTLWEMFSYGEEPWAGCNGYQILQKIDKEGERLPRPDCCPEDIYQMMMQCWQHHPADRPTFSAIRDQL
Kinase RTKJ2.AA Axl 853-1126 39 2.4e-69 236.72 In-house 1-267 (267) Show / Hide 
Range on Protein: 853-1126
Range on HMM: 1-267/267
Sequence Identity: 39% (110 aa)

VVVGTKLGGGFFGIVSRGLLRPSITSNAGARDVAVKQLKRDVEVGSREVTEFFDEMELMMDLGRHRNVLSLLGACRREQP------VLMILEFADKGDLM
.|.|  || | || |  | |.           |||| .| |. . ..|. ||  |   | .   | ||. |.| | . .        ..|| |   ||| 
FVLGKMLGEGEFGSVMEGQLK---QEDGSFVKVAVKMMKIDI-CTQSEIEEFLSEAACMKEF-DHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLH

HFLRDCRATDARAALLTRSDFFDFAAQIAAGMEFLAGHKIIHRDLAARNVLVQSKGRTEIDGYTLKIADFGLARTAGDDDNYTKTSDGAVPFKWLAIESL
 ||   |  |    | .      | . ||.|||.|. .. ||||||||| ...       .  |  .|||||..   . | | .     .| ||.|||||
TFLLYSRLGDQPFYLPLQM-LVKFMVDIACGMEYLSNRNFIHRDLAARNCMLR-------EDMTVCVADFGLSKKIYSGDYYRQGCIAKMPVKWIAIESL

RDRVFSEASDVWAFGITCWEIFTFGQGPYPGIANASIYDELVKGHRLAKPFLCSKLMYGIMVHCWKENPRERPTFAALLK
 |||.   |||||||.| ||| | || ||||. |. .|| |..|||| .|  |   .| .| .||. .|..||.|. | .
ADRVYTSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase RTKJ2.AA VEGFR 962-1128 42 4.7e-66 225.76 In-house 170-332 (332) Show / Hide 
Range on Protein: 962-1128
Range on HMM: 170-332/332
Sequence Identity: 42% (72 aa)

LTRSDFFDFAAQIAAGMEFLAGHKIIHRDLAARNVLVQSKGRTEIDGYTLKIADFGLART-AGDDDNYTKTSD-GAVPFKWLAIESLRDRVFSEASDVWA
||  |   .. |.| ||||||  |.|||||||||.|. ..       ...|| ||||||    .|..| .  | |  | ||.|.||..|.|..  ||||.
LTMEDLICYSFQVARGMEFLASRKCIHRDLAARNILLCEN-------NVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWS

FGITCWEIFTFGQGPYPGIA-NASIYDELVKGHRLAKPFLCSKLMYGIMVHCWKENPRERPTFAALLKSI
.|.  ||||. |  ||||.  .   .  |  | |. .| .|   .| ||  || ..| |||.|..| .  
YGVFLWEIFSLGGSPYPGVQIDEEFCNRLKDGYRMRAPDYCTPEIYHIMLDCWHKEPEERPHFSELVEHL
Kinase RTKJ2.AA S_TKc 853-1132 20 4e-36 127.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 853-1132
Range on HMM: 1-231/231
Sequence Identity: 20% (60 aa)

VVVGTKLGGGFFGIVSRGLLRPSITSNAGARDVAVKQLKRDVEVGSREVTEFFDEMELMMDLGRHRNVLSLLGACRREQPVLMILEFADK--GDLMHFLR
  .. |.| | || | ..  .         | ||.|..|            .  |.....   .| |.  |.....  . . |..|..|   |||.....
YEILRKIGKGAFGKVYKCRHKK------TGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIK

DCRATDARAALLTRSDFFDFAAQIAAGMEFLAGHKIIHRDLAARNVLVQSKGRTEIDGYTLKIADFGLARTAGDDDNYTKTSDGAVPFKWLAIESLRDRV
...    |   ..  .   ...||. ..|..  |.||||||   |.|. .         ..||.||||||           .   .   ..| | |    
KRGRHGLR-FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL---------TTFCGTPWYMAPEVL---G

FSE-ASDVWAFGITCWEIFTFGQGPYPGIANASIYDELVKGHRLAKPFLCSKLMYGIMVHCWKENPRERPTFAALLKSI-----APLA
..  ..|.|..|.. .| .. |. |.|    . ... ..           |. .  .. .|.. .|..|||   .|..       |  
YGKCKCDWWSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RTKJ2.AA Pkinase 853-1128 22 2.1e-34 122.73 Pfam 1-293 (293) Show / Hide 
Range on Protein: 853-1128
Range on HMM: 1-293/293
Sequence Identity: 22% (69 aa)

VVVGTKLGGGFFGIVSRGLLRPSITSNAGARD-VAVKQLKRDVEVGSREVTEFF-DEMELMMDLGRHRNVLSLLGACRREQPVLMILEFADKG----DLM
 ..| |.| | || |        .  . | .. ||||..|.. |  . ..| .   | ..|  | .| |.. |........ . |..|....|    ||.
YHIGRKIGSGSFGCV-------YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF

HFLRDCRATDARAALL--TRSDFFDFAAQIAAGMEFLAGHKIIHRDLAARNVLVQSKGRTEIDGYTLKIADFGLARTAGDDDNYTKTSDGAVPFKWLAIE
....       |   .  .  .  ... ||. |.|..  ..||||||   |.|. ..| ..    ..||.|||||. .    |.. ... ..   ..| |
DYIST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA---CVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPE

SLR-DRVFSEASDVWAFGITCWEIFTFGQGPYPGI-------ANASIYDELVKGHRLAKPFLCS-------------------KLMYGIMVHCWKENPRE
 .| ..  . ..|.|..|....| .. |. |.||         .. |.  . .  .   | .||                   . .  ..  |.. .| .
VIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKK

RPTFAALLKS--I
|||.. .|..  .
RPTAEQILQHPWF
Kinase RTKJ2.AA FGFR 853-953 33 3.1e-15 48.33 In-house 1-100 (293) Show / Hide 
Range on Protein: 853-953
Range on HMM: 1-100/293
Sequence Identity: 33% (34 aa)

VVVGTKLGGGFFGIVSRGLLRPSITS-NAGARDVAVKQLKRDVEVGSREVTEFFDEMELMMDLGRHRNVLSLLGACRREQPVLMILEFADKGDLMHFLRD
 ..|  || | || | ..       .  . .  |||| || .     ..      ||| |   |.| |.. |||.|  | |   | |.. .| |  ||| 
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKMNHT--DKDLSDLVSEMEMMKMIGKHKNIINLLGCCTQEGPLYVIVEYCHHGNLRDFLRA

CR
 |
RR
Kinase RTKJ2.AA VEGFR 853-955 29 2.6e-13 46.75 In-house 1-103 (332) Show / Hide 
Range on Protein: 853-955
Range on HMM: 1-103/332
Sequence Identity: 29% (31 aa)

VVVGTKLGGGFFGIVSRGLLRPSITSNAGARDVAVKQLKRDVEVGSREVTEFFDEMELMMDLGRHRNVLSLLGACRR---EQPVLMILEFADKGDLMHFL
   |  || | || |  .     |   .. . ||||.||      . |. .   |....  .| | || ..||.|       |...| |.  .| |  .|
LKLGKMLGRGAFGQVHEASAF-GIRKMETCTTVAVKMLKEGAT--ASEHRALMSELKMLIHIGHHLNVVNFLGCCTKNIQKGPLMVIVEYCCFGNLSNYL

RDCRAT
|. | .
RTKRMY