Gene UTK14 (M.brevicollis)
UTK14
Species: M.brevicollis
Alias: UTK14
External Links:
Annotation:
Sequence
Protein domains of UTK14.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | UTK14.AA | UTK | 560-827 | 31 | 5.70000000001e-103 | 348.39 | In-house | 1-296 (296) | Show / Hide |
Range on Protein: 560-827 Range on HMM: 1-296/296 Sequence Identity: 31% (96 aa) VPLSLGSGQGVFGTVAKAMLEQAN--AVDMIRALKKLDHPSVRALAPHASRP-PLWLSLQK-IAFLLKVANLICPSQVVKFLGIHLVPPRAMLALEHMVD | |. ||| ||.| ||...|.. . .|..|.|... ..| |.....| | .. ... .... ... . .|....|... |...|.|.. VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ---HHADAQQEPEPYPDFMEEARELQMMKQFH---WHPNVLRLVGVCTQEEPWMIVTEYMEN GHLASYLARQGKNVP-------LHRRMEFAMDVATGMDYLASVGVVHRDLRAENVWVCRD--------FAKLYDFG---YSRQAS--------------- |.|.||| |.....| ||.|...|.|.| || ||.| |.||||| | |..|... ..|..||| .||... GDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYM -NDVDQLTWAWMAPELNARDEPSDREHTILSDVFSFGVFLMELVATNGGLSYPTEWSQDLIKRQVETG-YRLSRPADCPESVFTIATRCWHSTPAERPDF ...|.....||||| . . .|..|||.||||...|... | | || . ......... | ||. .|.|||..|... .||||..|.||||| AQHQDRWPIRWMAPEALTHHT----RFTTKSDVWSFGVVCWEIWTW-GRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDF EWLVKRI |.||... EDLVQQM |
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| Kinase | UTK14.AA | TK | 633-827 | 16 | 9.7e-53 | 174.73 | In-house | 105-486 (486) | Show / Hide |
Range on Protein: 633-827
Range on HMM: 105-486/486
Sequence Identity: 16% (65 aa)
VVKFLG-------------IHLVPPRAMLALEHMVDGH----LASYLARQGKN-----------------------------------------------
.|...| . .. . |. .|.| | | .|| . ..
IVRLYGVCTQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDD
----------------------------VPLHRRMEFAMDVATGMDYLASV------GVVHRDLRAENVWVCRDF------------AKLYDFGYS----
...|... .....| || ||.| ..||||| | |. |... .|. ||| |
LIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGS
----RQASND-------------------------------VDQLTWAWMAPELNARDEPS----DREHTILSDVFSFGVFLMELVATNGGLSYPTEWSQ
| .| ..| ||||| . ..| .. .|. |||.||||.. |.. |.| |. ..|
GVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF-TYGQEPYYGGMSN
---------DLIKRQVETG--------------YRLSRPADCP--------------ESVFTIATRCWHSTPAERPDFEWLVKRI
. . .....| .|. .|..|| | .. . ..||| |..||.|. |....
QDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | UTK14.AA | Pkinase_Tyr | 633-827 | 29 | 4.2e-40 | 136.45 | Pfam | 66-270 (270) | Show / Hide |
Range on Protein: 633-827 Range on HMM: 66-270/270 Sequence Identity: 29% (62 aa) VVKFLGIHL-V-PP-RAMLALEHMVDGHLASYLARQ---GKNVPLHRRMEFAMDVATGMDYLASVGVVHRDLRAENVWVC-RDFAKLYDFGYSRQA-SND .|...|. . | . .. .|.| | | .|| .. ........ ......| ||.||.| . .||||.| |. | ..| ||| .| . | IVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDD VD-QLTW------AWMAPE-LNARDEPSDREHTILSDVFSFGVFLMELVATNGGLS-YPTEWSQDLIKRQV-ETGYRLSRPADCPESVFTIATRCWHSTP . . ||||| .| . |. ||| |||| . |.. | |. || | ..... | |||. .| .||. . .. ..||| | YYYRKRGGGKLPIKWMAPECINYGK------FTTKSDVWSFGVLMWEIF-TYGEQPTYPGM-SNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDP AERPDFEWLVKRI ..|| |. .. .. EDRPTFSEIHEQL |
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| Kinase | UTK14.AA | Src | 651-827 | 35 | 4.1e-36 | 120.16 | In-house | 74-255 (255) | Show / Hide |
Range on Protein: 651-827 Range on HMM: 74-255/255 Sequence Identity: 35% (68 aa) EHMVDGHLASYLA--RQGKNVPLHRRMEFAMDVATGMDYLASVGVVHRDLRAENVWVCRD-FAKLYDFGYSRQAS--NDVD------QLTWAWMAPELNA | | | | || ..|....| . ..| || ||.|| | ..||||.| || | . .| ||| | |. . . |.||| EYMSHGSLLDYLKKDGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAIN RDEPSDREHTILSDVFSFGVFLMELVATNGGLSYPTEWSQDLIKRQVETGYRLSRPADCPESVFT-IATRCWHSTPAERPDFEWLVKRI . . || ||| |||. |.|.| | | || .. .. ||| |||. .|. ||.... | ..|||..| .|| || | . Y-----GRFTIKSDVWSFGILLTEIV-TYGRVPYPGMTNHEVLQ-QVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL |
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| Kinase | UTK14.AA | Src-Echino1 | 651-827 | 37 | 9.4e-33 | 110.7 | In-house | 74-252 (252) | Show / Hide |
Range on Protein: 651-827
Range on HMM: 74-252/252
Sequence Identity: 37% (69 aa)
EHMVDGHLASYLAR-QGKNVPLHRRMEFAMDVATGMDYLASVGVVHRDLRAENVWVCR-DFAKLYDFGYSRQASNDV------DQLTWAWMAPELNARDE
| | .|.| .|| | ..|.| . . .. ..| ||||| | |||||| | || | . . |. ||| | .|| .| | |||
ELMSNGNLQDYLKRGKCKHVKMTTLIDMGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYG-
PSDREHTILSDVFSFGVFLMELVATNGGLSYPTEWSQDLIKRQVETGYRLSRPADCPESVFTI-ATRCWHSTPAERPDFEWLVKRI
|| |||.|||. . |.| | |.. || ..... ||. |||. .. .||.|.. . .||| | || ||.| . .
----RFTIKSDVWSFGILMTEMV-TFGRYPYPGMMNREVLD-QVDRGYRMPKMHHCPDSLYMMCMMKCWHKDPQQRPTFEFLHDFF
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| Kinase | UTK14.AA | TK-Unique | 633-827 | 27 | 1.5e-32 | 109.64 | In-house | 66-294 (294) | Show / Hide |
Range on Protein: 633-827 Range on HMM: 66-294/294 Sequence Identity: 27% (65 aa) VVKFLGIHLVPP-RAMLALEHMVDGHLASYLARQGKN-------------------------VPLHRRMEFAMDVATGMDYLAS--VGVVHRDLRAENVW .|..||. . . |...|.. | | .|| . ... . ... || ..| || |||| ..||||| | || IVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVL VCRDF-AKLYDFGYSR-------QASNDV-DQLTWAWMAPELNARDEPSDREH-TILSDVFSFGVFLMELVATNGGLSYPTEWSQDLIKRQVETGYRLSR . .|. .|. ||| .| ..... . .||||| .. .. . |. ||| ||||.. |.. |.|. || . | | .... |||. . LTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCY---HGMYHTTKSDVWSFGVLMWEIF-TLGACPYPGMPWKD-IMECIRDGYRMPQ PADC-PESVFTIATRCWHSTPAERPDFEWLVKRI |. | .. .. . .||.. | |||.|. ...|. PEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL |
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| Kinase | UTK14.AA | TyrKc | 562-827 | 25 | 5.9e-32 | 113.41 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 562-827 Range on HMM: 1-280/280 Sequence Identity: 25% (78 aa) LSLGS--GQGVFGTVAKAMLEQANAVDMIRALKKLDHPSVRALAPHASRPPLWLSLQKIAFLLKVANLICPS-----QVVKFLGIHLVP-------PRAM ..|| | | ||.| |... . | |.| . . .. ... |.. | .|...|. . . . | ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-------------------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLM LALEHMVDGHLASYLARQGKNVPLHRRMEFAMDVATGMDYLASVGVVHRDLRAENVWVCRDF-AKLYDFGYSRQASND----------------VDQ--L . .|.| | | .|| . ...... .|. ..| ||.||.| ...|||| | |. | ... .| ||| || .| | IVMEYMPHGDLKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML TWAWMAPELNARDEPSDREHTILSDVFSFGVFLMELVATNGGLSYPTE----WSQDLIKRQVETGYRLSRPAD--------CPESVFTIATRCWHSTPAE ||||| ... |. |||.|||| . |. |.|. || . | . . ..|..|||. .|.. ||. ...| ..||| |.. PIRWMAPECI-----NYGKFTTKSDVWSFGVCMWEIF-TYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED RPDFEWLVKRI || |. ..... RPTFSEIHECF |
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| Kinase | UTK14.AA | Frk | 651-831 | 32 | 1.6e-30 | 102.76 | In-house | 74-260 (260) | Show / Hide |
Range on Protein: 651-831 Range on HMM: 74-260/260 Sequence Identity: 32% (64 aa) EHMVDGHLASYLA---RQGKNVPLHRRMEFAMDVATGMDYLASVGVVHRDLRAENVWVC-RDFAKLYDFGYSR-QASNDV--------DQLTWAWMAPEL | | .| | || ..|... .. .. | ||.|| || | .|||| | || | |. ||| | .. .. | ||| ELMRHGSLQEYLQAINDKGRQCQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEA NARDEPSDREHTILSDVFSFGVFLMELVATNGGLSYPTEWSQDLIKRQVETGYRLSRPADCPESVFTIATRCWHSTPAERPDFEWLVKRIKVTQ . . || |||.|||. |.|.. | | . || .. .. .|. |||. .|..||. .. | |||| | .|| || | ... ANYN-----KFTIKSDVWSFGILLTEII-TYGRMPYPGMTNAEVLQ-MVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF |
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| Kinase | UTK14.AA | TKL | 658-827 | 23 | 2.3e-30 | 106.56 | In-house | 125-364 (364) | Show / Hide |
Range on Protein: 658-827
Range on HMM: 125-364/364
Sequence Identity: 23% (57 aa)
LASYLARQGKNVPLHRRMEFAMDVATGMDYLAS--------VGVVHRDLRAENVWVCRDF---------------AKLYDFGYSRQASNDVD--------
| .|| .|.|. .|.|.| ||.|| | ...|||| .|. | ... .|. ||| || |.. .
LLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTM
---------------QL-TWAWMAPELNARDEPSD-----------REHTILSDVFSFGVFLMELVA----TNGGLSYPTEWS---QDLIKRQVETGYRL
| | .|||||. ... . .| . .||.|||. | |... . ..| ... .. .. .. |.|.
MESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRP
SRP------------ADCPESVFTIATRCWHSTPAERPDFEWLVKRI
.| |||.|. ....||.. | .|| |. ..||.
PIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
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| Kinase | UTK14.AA | SrcB | 651-828 | 34 | 1.3e-29 | 97.3 | In-house | 73-251 (251) | Show / Hide |
Range on Protein: 651-828
Range on HMM: 73-251/251
Sequence Identity: 34% (64 aa)
EHMVDGHLASYL-ARQGKNVPLHRRMEFAMDVATGMDYLASVGVVHRDLRAENVWVCRDFA-KLYDFGYSRQASN------DVDQLTWAWMAPELNARDE
|.| | | .| . .| ..| . .... .| || |. .|||||| |. | |. ||| | . . . | |||
EYMAKGCLLDFLKTDEGSKLSLPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFG-
PSDREHTILSDVFSFGVFLMELVATNGGLSYPTEWSQDLIKRQVETGYRLSRPADCPESVFTIATRCWHSTPAERPDFEWLVKRIK
|| |||.|||. |||.| | | . || . | |..| |||. || ||| .. | ..||.. | ||| |..| .
----CFTIKSDVWSFGILLMEIV-TYGRIPYPGMTNPEVI-RNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
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| Kinase | UTK14.AA | Csk | 634-827 | 34 | 4.5e-28 | 92.93 | In-house | 57-251 (251) | Show / Hide |
Range on Protein: 634-827 Range on HMM: 57-251/251 Sequence Identity: 34% (69 aa) VKFLGIHLVPP-RAMLALEHMVDGHLASYL-ARQGKNVPLHRRMEFAMDVATGMDYLASVGVVHRDLRAENVWVCRDF-AKLYDFGYSRQASNDVD---- |...|. | . . .|.| | | || | . . . |||||. || || . .||||| | |. | | || ||| ..... | VQLIGVILHQKNHLYIVMEYMSKGNLVDYLRSRGRHVITRRQLLKFAMDVCEGMCYLEQKKFVHRDLAARNILVSEDCVAKVSDFGLAKEECSQQDDSTS -QLTWAWMAPELNARDEPSDREHTILSDVFSFGVFLMELVATNGGLSYPTEWSQDLIKRQVETGYRLSRPADCPESVFTIATRCWHSTPAERPDFEWLVK . | ||| | . . . ||| |||..| |. | || .| |. || ||| | ||..|... ||| ||.|| |. ... GKFPIKWTAPE--ALRH---KKFSTKSDVWSFGILLWEIYS-FGRVPYPRIPLKDVVKH-VEKGYRMEAPEGCPPHVYKVMKQCWHLNPAKRPTFRQVRE RI . QL |
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| Kinase | UTK14.AA | RTKC | 789-827 | 41 | 6e-18 | 55.7 | In-house | 223-261 (261) | Show / Hide |
Range on Protein: 789-827 Range on HMM: 223-261/261 Sequence Identity: 41% (16 aa) GYRLSRPADCPESVFTIATRCWHSTPAERPDFEWLVKRI |||| .|.||...|. . .|| .||..||.|. .|... GYRLPCPEDCHKEVYDMMMDCWMHTPHDRPTFSEVVHWL |
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| Kinase | UTK14.AA | Pkinase | 633-827 | 17 | 1.4e-16 | 59.67 | Pfam | 62-293 (293) | Show / Hide |
Range on Protein: 633-827
Range on HMM: 62-293/293
Sequence Identity: 17% (43 aa)
VVKFLGIHLVPPRAMLALEHMVDG----HLASYLA-RQGKNV--PLHRRMEFAMDVATGMDYLASVGVVHRDLRAENVWVC-RDFA----KLYDFGYSRQ
.|..... ... . .|.. | |..|. ...... . . .. .. |..|. | |..|||| ||. . .. |. ||| ..|
IVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQ
--ASNDVDQLTW-----AWMAPELNARDEPSDREHTILSDVFSFGVFLMELVATNGGLSYPTE------WSQDLIKRQVETGYRLSRPADCP--------
|.. .|. .||||. ...... .|..|.|. | |.. | . .| . . .|.| .. .. ..| .|.
FDY-NNS--MTTFCGTPWYMAPEVIR----GGQYYGPKVDMWSCGCILYEMLC--GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRH
-----------ESVFTIATRCWHSTPAERPDFEWLVKR--I
|. . ..|.. |..|| .| ... .
WHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
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| Kinase | UTK14.AA | S_TKc | 562-833 | 18 | 3.5e-14 | 31.0 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 562-833 Range on HMM: 1-231/231 Sequence Identity: 18% (52 aa) LSLGS--GQGVFGTVAKAMLEQANAVDMIRALKKLDHPSVRALAPHASRPPLWLSLQKIAFLLKVANLICPSQVVKFLGIHLVPPRAMLALEHMVD--GH .. |.| ||.| |. . | |.|... .... .|| .||.... . . .|.. | YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK-----------------EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGD LASYLARQGKN-----VPLHRRMEFAMDVATGMDYLASVGVVHRDLRAENVWVCRDFAKLYDFGYSRQASNDVDQLTWAWMAPELNARDEPSDREHTI-L | .|. ..|.. | . .. .. ...|. | |..|||| ||. ... |. ||| .|| . | .||||. .. LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-HIKICDFGLARQL--TTFCGTPWYMAPEVL--------GYGKCK SDVFSFGVFLMELVATNGGLSYPTEWSQDLIKRQVETGYRLSRPADCPESVFTIATRCWHSTPAERPDFEWLVK---RIKVTQGV .|. |.|. | |... | .| .... ... .... . .|.. |..|| . . || . . CDWWSCGCILYEMLC--GYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | UTK14.AA | RTKC | 650-724 | 36 | 4e-12 | 36.19 | In-house | 80-155 (261) | Show / Hide |
Range on Protein: 650-724 Range on HMM: 80-155/261 Sequence Identity: 36% (28 aa) LEHMVDGHLASYLARQGKNVPLHRRMEFAMDVATGMDYLASVGVVHRDLRAENVWVCRDF-AKLYDFGYSRQA-SND ||.. | | ||| . .. | . |. ..| || .| | .|||. | || . | .|. ||| | . .|| LEFCERGSLKSYLMNNP-DCTEHQKVRFCYQCASGMEHIHSFGFIHRDVAARNVLLSSDLTCKVADFGLARESPCND |
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| SH2 | UTK14.AA | SH2 | 1163-1240 | 19 | 9.5e-05 | 16.3 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 1163-1240 Range on HMM: 1-87/87 Sequence Identity: 19% (18 aa) PEWLHGCMDRTEAAELVQLKALGGGLPGAYFVRR-KTEANSFAITVMSDWAQVDHYLLNYDDALGWYMNG------------STQQKCGGA .| || ..| || .| . |. .|.. || .........|... .| ||... .| ..| . |.. . QPWYHGNISREEAEQLLKNP---GMPDGDFLVRDSESNPGDYVLSVRWK-GKVKHYRIRRNDDGKYYIDETWRRKFPSLELVNHYQHNPLG |
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