Gene N4 (M.brevicollis)
N4
Species: M.brevicollis
Alias: N4
External Links:
Annotation:
Sequence
Protein domains of N4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| SH3_1 | N4.AA | SH3_1 | 8-32 | 48 | 1.2e-08 | 32.27 | Pfam | 1-25 (49) | Show / Hide |
Range on Protein: 8-32 Range on HMM: 1-25/49 Sequence Identity: 48% (12 aa) KALYDFKAHEEDELELTEGDVIDVS .||||..|...||| ...||.| |. VALYDYQAQQPDELSFKKGDIIHVI |
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| Sam7 | N4.AA | sam7 | 37-98 | 24 | 1.3e-14 | 49.79 | In-house | 1-70 (70) | Show / Hide |
Range on Protein: 37-98 Range on HMM: 1-70/70 Sequence Identity: 24% (17 aa) WGIPDVQLFLLAAKL---ELYEQLFVNGKI-----DGSKLLTLNHRKLQALGVEDTLHRRMILSCIEELR | ||. .| .... . |.. | . .| ||. |. ... |...|. . ||. |...|. .| WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR |
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| SAM | N4.AA | SAM | 34-100 | 29 | 4.1e-13 | 50.81 | SMART | 1-67 (67) | Show / Hide |
Range on Protein: 34-100 Range on HMM: 1-67/67 Sequence Identity: 29% (20 aa) LPKWGIPDVQLFLLAAKLELYEQLFVNGKIDGSKLLTLN-HRKLQALGVEDTLHRRMILSCIEELRTG . | .||. .| . ... |. | .|||. || |. | |. .|.... ||. ||..|..... VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ |
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| SAM_2 | N4.AA | SAM_2 | 34-98 | 22 | 5.9e-12 | 43.87 | Pfam | 1-71 (71) | Show / Hide |
Range on Protein: 34-98 Range on HMM: 1-71/71 Sequence Identity: 22% (16 aa) LPKWGIPDVQLFLLAAKL-ELYEQLFVNGKIDG-SKL-LTLNHRKL--Q-ALGVEDTLHRRMILSCIEELR . | .||. .| . .. . |.. | .|.| . | . ..| .| . ..|.... ||..|...|.... VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK |
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| SAM_1 | N4.AA | SAM_1 | 35-98 | 28 | 5.1e-11 | 42.01 | Pfam | 1-66 (66) | Show / Hide |
Range on Protein: 35-98 Range on HMM: 1-66/66 Sequence Identity: 28% (19 aa) PKWGIPDVQLFLLAAKLELYEQLF-VNGKIDGSKLLTLNHRKLQA-LGVEDTLHRRMILSCIEELR . | ||. .| . ... |. | .|.||...|| . |.. .|| || |.. |. |. DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK |
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| C1_1 | N4.AA | C1_1 | 119-156 | 25 | 4.9e-11 | 44.18 | Pfam | 1-40 (55) | Show / Hide |
Range on Protein: 119-156 Range on HMM: 1-40/55 Sequence Identity: 25% (10 aa) HQFKLK-SFANMTWCDYSRKLLFG-IERQGLQCSTCGYTV |... . .| ..|.|.. .....| ...||..|..|.|.. HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNC |
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| C1 | N4.AA | C1 | 119-167 | 27 | 5.6e-07 | 30.43 | SMART | 1-61 (61) | Show / Hide |
Range on Protein: 119-167 Range on HMM: 1-61/61 Sequence Identity: 27% (17 aa) HQFKLKSFANMTWCDYSRKLLFGIERQ-----GLQCSTCGYTVSAAYLDEVP--------SC |... ..| ..|.|.. ||...|. .| |..|| |.|.. .| || .| HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC |
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| RhoGAP | N4.AA | RhoGAP | 200-346 | 25 | 4.6e-25 | 90.5 | SMART | 1-193 (193) | Show / Hide |
Range on Protein: 200-346 Range on HMM: 1-193/193 Sequence Identity: 25% (51 aa) HQAPPVVEKCIAAIENGKGMKTT-----------------------------------------GRDPHLLTTLLKRYFAELPDSLIPGEWYDRTIAAAS .. |..|.|||..||. ||.| .|.| ....||.|| |||..||. | |.. | |.. SHIPIIVRKCIEYIEK-HGMDTEGIYRKCGNQSRIQELRNAFDRGPDDLCSTDNYITHEFNDWEEWDVHDVAGVLKQYFRELPEPLITFELYEEFIEAMK L--------------PTEEEQVAELDRVMSNIKGATATTLSYLLGHLGRVIANHKSTKMDAVSVAEAWGPILLRPKPSESAKAVADRQIQVNAVRLLIGV . ..|||.. .| .. | . || ||. || ||.......||.| | .|| |..|. ..| | . | || CYQIEQTSRKQWNHSEDEEERIHALHQLISQLPPCHRNTLRYLM-HLNRVAEHSDVNKMNAHNLAICFGPTLFWPP-------MMDMRHQNKCVEFLIEH CK . YD |
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| RhoGAP | N4.AA | RhoGAP | 225-326 | 33 | 6.6e-24 | 82.75 | Pfam | 53-156 (156) | Show / Hide |
Range on Protein: 225-326 Range on HMM: 53-156/156 Sequence Identity: 33% (35 aa) DPHLLTTLLKRYFAELPDSLIPGEWYDRTIA--AASLPTEEEQVAELDRVMSNIKGATATTLSYLLGHLGRVIANHKSTKMDAVSVAEAWGPILLRPKPS |.| ....||.|| |||..|.. | |.. |. ||... |||.. .. .. . . || ||..|| ||..... .||.| . | .|| |..|... DVHDVASVLKQYFRELPEPLFTFELYEEFIEAMAAKIEDEEERIEAMRELIRKLPPPNYDTLRYLMRHLHRVAQHSDVNKMNAHNLAICFGPNLFWPPDD ESAK .|. DSMD |
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| RhoGAP | N4.AA | RhoGAP | 203-223 | 47 | 0.00016 | 16.81 | Pfam | 1-20 (156) | Show / Hide |
Range on Protein: 203-223 Range on HMM: 1-20/156 Sequence Identity: 47% (10 aa) PPVVEKCIAAIENGKGMKTTG |..|.|||..|| .|..| | PMIVRKCIEYIEQ-HGLDTEG |
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| SH2 | N4.AA | SH2 | 426-507 | 31 | 7.8e-25 | 89.74 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 426-507 Range on HMM: 1-87/87 Sequence Identity: 31% (28 aa) EPWFAGNVNRVQAEKMLAG--LVDGSFLVRSSQS-RKGFSLTVKF-REIRHIVLLEAN-GKYGFSR-ESCDFKTIAELVRHFEKETLA .||. ||..| .||..| . ||.|||| |.| .....|.|.. ....|... . . ||| . . | .. |||.|. . | QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| SH2 | N4.AA | SH2 | 428-501 | 31 | 1.5e-22 | 68.04 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 428-501 Range on HMM: 1-81/81 Sequence Identity: 31% (26 aa) WFAGNVNRVQAEKMLAG--LVDGSFLVRSSQSRK-GFSLTVKFRE----IRH-IVLLEANG-KYGFSRESCDFKTIAELVRHF |. |...| .||..| ||.|||| |.| . ...|.|.. ..| .. ..|| | . |. | ...||| |. WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHK--FCSLQELVEHY |
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| SH2 | N4.AA | SH2 | 698-738 | 40 | 5.5e-09 | 28.21 | Pfam | 1-43 (81) | Show / Hide |
Range on Protein: 698-738 Range on HMM: 1-43/81 Sequence Identity: 40% (18 aa) YFVGSMSRQEAGAALAM--EPPGTFLIRRSDR-PDKPYSLSLKC .. |..||||| | |.||||.| |.. | |.||... WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGD-YTLSVRD |
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