Gene N22 (M.brevicollis)
N22
Species: M.brevicollis
Alias: N22
External Links:
Annotation:
Sequence
Protein domains of N22.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| PI-PLC-X | N22.AA | PI-PLC-X | 105-252 | 57 | 2.2e-90 | 311.4 | Pfam | 1-152 (152) | Show / Hide |
Range on Protein: 105-252 Range on HMM: 1-152/152 Sequence Identity: 57% (88 aa) MSYPLACYFIASSHNTYLMGDQLR--SESSTEAYVRCLRDGCRCLEIDCW-DGPNNE--TIVYHGHTLTSKIKFHDVLEAIKANAFVTSDYPLILSIENH ||.|| |||.|||||||.|.||. .|||.|.|...|..||||.||||| |||..| |||||||.||||.| ||.|||| |||||.||.|||.||| MSQPLSHYFINSSHNTYLTGNQLSVWGESSVEMYIQALQRGCRCVEIDCWPDGPDGEDEPIVYHGHTMTSKIPFRDVCEAIKDYAFVTSPYPVILSLENH CSVSQQ-LFMANEFKRVFAEKLVIEPVDGCDDPMRDCYPSPDQLRHRIIIKHKK ||. || ||. .| .| ..|...|.| . . |||.||...|.||.|| CSPEQQDKKMAQIMKEIFGDMLYTPPLDDW--EDSTELPSPEQLKGKILIKVKK |
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| PLCXc | N22.AA | PLCXc | 103-251 | 46 | 1.3e-79 | 271.72 | SMART | 1-182 (182) | Show / Hide |
Range on Protein: 103-251 Range on HMM: 1-182/182 Sequence Identity: 46% (86 aa) QDMSYPLACYFIASSHN-------------------------------TYLMGDQLRSESSTEAYVRCLRDGCRCLEIDCWDGPNNETIVYHGHTLTSKI |||..||. ||| |||| |||.|.||..|.. |.| .||. ||||.||||||||..| ..|||||.||.| QDMDQPLSHYFINSSHNSMTFNIQMFPFGLDAPEKLRLPPYVTFLLRFTYLTGHQLWGECQMEMYIQCLKHGCRCVEIDCWDGPDGEPVIYHGHTFTSHI KFHDVLEAIKANAFVTSDYP--LILSIENHCSVSQQLFMANEFKRVFAEKLVIEPVDGCDDP--MRDCYPSPDQLRHRIIIKHK ||.||||||| |||||.|| .|.|.|||||. || ||. .| .|...|...| |. ... |. |||.|||..|..|.| KFQDVLEAIKKYAFVTSPYPEFVIMSLENHCSYDQQHKMAQMMKEIFGDMLYTPPPDSHKEYPNMN--LPSPWQLRRKILLKNK |
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| Efhand_like | N22.AA | efhand_like | 34-102 | 19 | 3.8e-07 | 26.4 | Pfam | 12-94 (94) | Show / Hide |
Range on Protein: 34-102 Range on HMM: 12-94/94 Sequence Identity: 19% (16 aa) GDRTALTAADVKTFFIKEQGESTV--------S-QAKVDDVMKQ------WGAEDGTTITLQRFVEYLFSADNSLWNPDEDLVY ... .||.. |...||... | . .. . ... .... .||. | |..| .|...||. . || KNKDYMTAEQLMRFLNEEQRDPRVNEILYPPYTTEEQCQQIIEKYEPNEPENKHR-GQMTLDGFFRYMMSPENNIFNPEHLDVY |
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| PH | N22.AA | PH | 273-332 | 18 | 0.032015 | 10.66 | Pfam | 1-49 (92) | Show / Hide |
Range on Protein: 273-332 Range on HMM: 1-49/92 Sequence Identity: 18% (11 aa) TRKIGSLHLEDHINSTWYKHYFALSDSRLFYAEIEDDEDDEDEEDEDEQQDAVPTNEADL .| | ||. ...| |..| | ...|.| . .. . . .| ..... VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK----------YRPKGSIPLSDCQV |
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| SH2 | N22.AA | SH2 | 338-414 | 41 | 1.8e-35 | 105.96 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 338-414 Range on HMM: 1-81/81 Sequence Identity: 41% (34 aa) WYHGNIDRDRSEDALRLYRDQEGTFLVRDSGTFRGEYTLSFVREG---QPQHVRIRLRDE-QYYLTDEVAFDSLYELIEYH ||||.| | |. |. . ..||||||.| . |.||||....| . .| ||. |. .||.|... |.||.||.|.. WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY |
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| SH2 | N22.AA | SH2 | 336-420 | 40 | 3.8e-32 | 114.03 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 336-420 Range on HMM: 1-87/87 Sequence Identity: 40% (36 aa) EPWYHGNIDRDRSEDALRLYRDQEGTFLVRDSGTFRGEYTLSFVREGQPQHVRIRLRD-EQYYLTD--EVAFDSLYELIEYHRMVPLR .|||||||.|. |. |. . ..|.|||||| ...|.|.||. .|. .| ||| | .||... .. |.|| ||..... ||. QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| SH2 | N22.AA | SH2 | 443-517 | 34 | 2e-29 | 88.24 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 443-517 Range on HMM: 1-81/81 Sequence Identity: 34% (28 aa) WFHKYITRAGAEDMLKR-LNFDGAFLIRSSELQPTNFAISFRAEG---KIKHCRIQKEGRM--FCIGDAEYETLEALVDYF |.|. |.|. ||..|. | ||.||.| || .| ...|.| .| ..||.|||..... ...|. ...| ||... WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY |
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| SH2 | N22.AA | SH2 | 441-523 | 35 | 1.7e-26 | 95.27 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 441-523 Range on HMM: 1-87/87 Sequence Identity: 35% (31 aa) KNWFHKYITRAGAEDMLKRL-NFDGAFLIRSSELQPTNFAISFRAEGKIKHCRIQKEG-RMFCIGD---AEYETLEALVDYFQRKPLY .|.| |.|. ||..||. . ||.||.| || .| ...|.| .||.||.||.... ....|.. ...| ||...|. ||. QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| SH3 | N22.AA | SH3 | 570-626 | 55 | 1.5e-19 | 72.22 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 570-626 Range on HMM: 1-58/58 Sequence Identity: 55% (32 aa) VNCRALYPYAAAQPDELSFPAGATITNVVKKDGGWWQGDYG-GRIGGWLPSNYVEEID . .||||.| | .|||||| .| .|| . | |.|||.| . || ||||||||| PYVRALYDYQAQNPDELSFKKGDIITVLEKDDDGWWKGRCNRTGQEGWFPSNYVEEID |
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| SH3_1 | N22.AA | SH3_1 | 573-619 | 46 | 3e-15 | 54.4 | Pfam | 1-49 (49) | Show / Hide |
Range on Protein: 573-619 Range on HMM: 1-49/49 Sequence Identity: 46% (23 aa) RALYPYAAAQPDELSFPAGATITNVVKKDG-GWWQGDYGGR-IGGWLPS .|||.|.| ||||||| |..|... |.|. .|| | . .. || || VALYDYQAQQPDELSFKKGDIIHVIEKSDDWDWWKGRCNNTGQEGWFPS |
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| SH3_2 | N22.AA | SH3_2 | 571-625 | 30 | 6e-06 | 23.68 | Pfam | 1-68 (68) | Show / Hide |
Range on Protein: 571-625 Range on HMM: 1-68/68 Sequence Identity: 30% (21 aa) NCRALYPYAA-AQPDE-----LSFPAGATITNVV----KKDGGWWQG-DY--GGRI-GGWLPSNYVEEI .|.. | . . ..| |.| .| .|. | |....||.. . ||| || ||..|||. YYRVHCDYVPATYCNENHEPQLHFKKGDVIK-VIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC |
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| PH | N22.AA | PH | 635-704 | 25 | 0.000138 | 19.19 | Pfam | 32-92 (92) | Show / Hide |
Range on Protein: 635-704 Range on HMM: 32-92/92 Sequence Identity: 25% (18 aa) EDDHENLLGSLEKAFVELKHIQIVPREPRGGQQYIFGIMDLLRPDKGFDAAADSEDDMNDWIKAIELAVH .||. . | . |...|... .. .....| | | . . .|.||..||||..||. |.. KDDK-----YRPKGSIPLSDCQVTKVPDN-KRPHCFQIRT-DR--RTYYFQAESEEEMNDWMQAIQSACR |
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| PI-PLC-Y | N22.AA | PI-PLC-Y | 725-844 | 51 | 4.7e-64 | 211.42 | Pfam | 1-121 (121) | Show / Hide |
Range on Protein: 725-844 Range on HMM: 1-121/121 Sequence Identity: 51% (63 aa) DLSDLIYYSRSVRFQSFADSEKEE--YYNMSSFNEKKALSFVKQNGGQPMEMSNYCIRQFARVYPQGKRVDSSNYDPQMMWNCGVQLVALNYQTGDRPMW .||||. | .|| |..| . |... ||.|.||.|.||. .| . .|.|. .. ||. |.|| | |.|||||.|| .||||.|.||||.|| |..|. ELSDLVVYCQSVHFRNFEHPEAKTQKYYHMFSFSETKAEKLHK-DSENPEEFVKHNRRQLMRIYPKGMRIDSSNYNPQPFWNCGCQMVALNWQTYDLMMQ LNHGFFQRNGRCGYVLKPERLL ||.| |. ||||||||||| .. LNQGMFAQNGRCGYVLKPECMR |
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| PLCYc | N22.AA | PLCYc | 726-844 | 52 | 3.7e-60 | 207.08 | SMART | 1-119 (119) | Show / Hide |
Range on Protein: 726-844 Range on HMM: 1-119/119 Sequence Identity: 52% (64 aa) LSDLIYYSRSVRFQSFADSEKE--EYYNMSSFNEKK-ALSFVKQNGGQPMEMSNYCIRQFARVYPQGKRVDSSNYDPQMMWNCGVQLVALNYQTGDRPMW ||||. | ..| |.|| ..|. .|.||||.| | | .|... ||.. .| ||. |.||.|.|||||||.||..||||.|.||||.||.|.||| LSDLVNYCQPVHFRSFEHCEEKDWPCYHMSSFSETKAAKKMVEKH---PMDFVRYNQRQLSRIYPKGTRVDSSNYNPQPFWNCGCQMVALNFQTHDKPMW LNHGFFQRNGRCGYVLKPERLL .|.| |. ||.|||||||. .. MNQGMFRYNGGCGYVLKPDCMR |
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| C2 | N22.AA | C2 | 865-951 | 32 | 9.5e-21 | 73.24 | Pfam | 1-90 (90) | Show / Hide |
Range on Protein: 865-951 Range on HMM: 1-90/90 Sequence Identity: 32% (30 aa) VTIKVIAGRHLPKTS---RGTTSPLVELEMCGVENDHNKFKTPTVPDNGFNPTWDSDCAFDVSMQDLAT-MRIVVLDEDIFGEANAIAQAC ....|| .|.||.. |...| |.... |.. | .|.|| ..... .||.|. .. |||. ||. |. | |.| ||. | |.| LRVHVIEARNLPPMDWDKNGKSDPYVKVYLGGDPKDTQKYKTKVIKNT-LNPVWNETFTFDVPPPDLQHTLRFTVWDWDRFGRDDFIGQCC |
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| C2 | N22.AA | C2 | 864-966 | 19 | 6.8e-13 | 50.08 | SMART | 1-92 (92) | Show / Hide |
Range on Protein: 864-966
Range on HMM: 1-92/92
Sequence Identity: 19% (24 aa)
AVTIKVIAGRHLPKTSRGTTSPLVELEMCGVENDHNKFKTPTVPDNG--FNPTWDS---DCAFDVSMQDLATMRIVVLDEDIFGEANAIAQACFP-----
.|...| .|.|| | |... || .|.... |||.|. . |||. . .|. | |. | ..|.|
TLTVHIIEARNLP-------DPYVKVY-----------KTKVVKNTLSGFNPVWNEWMETFYFDVHP---Q-LRFEVWDH------DFIGHCCIPPNNPH
---------LGSEKRQTLRTGY
| . . . . ..
WHQWDGCIHLSDIL-GYRH-WW
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