Gene N12 (M.brevicollis)
N12
Species: M.brevicollis
Alias: N12
External Links:
Annotation:
Sequence
Protein domains of N12.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| VWD | N12.AA | VWD | 95-106 | 91 | 0.198933 | 6.58 | Pfam | 5-16 (163) | Show / Hide |
Range on Protein: 95-106 Range on HMM: 5-16/163 Sequence Identity: 91% (11 aa) GDPHYTTFDGKY ||||||||||.| GDPHYTTFDGRY |
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| VWD | N12.AA | VWD | 223-241 | 57 | 0.005463 | 11.96 | Pfam | 138-156 (163) | Show / Hide |
Range on Protein: 223-241 Range on HMM: 138-156/163 Sequence Identity: 57% (11 aa) YQSGTVGVCGNFNGNSGDD || | | |||.||.. || YQNQTCGLCGNYNGEPRDD |
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| EGF_2 | N12.AA | EGF_2 | 429-455 | 43 | 3.3e-08 | 29.15 | Pfam | 1-29 (29) | Show / Hide |
Range on Protein: 429-455 Range on HMM: 1-29/29 Sequence Identity: 43% (14 aa) CPNSCSG-HGACN---NAKCVCDSG-FSGRDC | |.| || || ||.||.| ..| .| C---CNGHHGTCNNQGCGKCQCDDGWWQGDHC |
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| EGF | N12.AA | EGF | 429-454 | 25 | 0.001629 | 14.81 | Pfam | 1-36 (36) | Show / Hide |
Range on Protein: 429-454 Range on HMM: 1-36/36 Sequence Identity: 25% (9 aa) CPN---SCSGHGACNNA----KCVCDSG---FSGRD |. |..|| |.. .| | | ..|.. CNPNNNPCHHHGTCVDTPGGYTCQCPPGYLGYTGKR |
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| TIG | N12.AA | TIG | 463-576 | 18 | 0.000152 | 17.75 | Pfam | 1-82 (82) | Show / Hide |
Range on Protein: 463-576
Range on HMM: 1-82/82
Sequence Identity: 18% (21 aa)
PVITSLSTTTCNTKAAASCASEISVFGSNFWNAENLTCRYKVIASPAVASDNVLMVGQSASRSAFFLGSSEVICQLPPRSTLVPVGLQGDLVTIEISVRT
|.|||.| .| .. ..|.. |.|| . |. ..| .. . |....|..|| . .| ... . |
PTITSISP--NTTGPPSG-GTTITITGQNF---------------GNDS-DTKCYFGGTPCTVI-WWSSTQIVCTTPPHT-------PG-THNVSV-VNG
TDSIVSEASLPFTF
| ....||.
---QWSSNPTTFTY
|
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| EGF | N12.AA | EGF | 590-604 | 46 | 0.578763 | 6.29 | Pfam | 1-15 (36) | Show / Hide |
Range on Protein: 590-604 Range on HMM: 1-15/36 Sequence Identity: 46% (7 aa) CAPNPDSCNIDGVCV |.||.. |. .| || CNPNNNPCHHHGTCV |
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| EGF_2 | N12.AA | EGF_2 | 590-619 | 22 | 26.616959 | 1.3 | Pfam | 1-18 (29) | Show / Hide |
Range on Protein: 590-619 Range on HMM: 1-18/29 Sequence Identity: 22% (7 aa) CAPNPDSCNI-DGVCVLEGTHEASNVCRVCV | || .|.|. .|..|. C------CNGHHGTCNNQ-------GCGKCQ |
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| Cadherin | N12.AA | Cadherin | 750-833 | 34 | 3e-17 | 62.77 | Pfam | 1-94 (102) | Show / Hide |
Range on Protein: 750-833 Range on HMM: 1-94/102 Sequence Identity: 34% (32 aa) YTFNVTEDTPVGTVIGTIVAHDPD-EAGSLQYEWYSQVSGE---AGVLLIDESTGV---ITVGQSLDYERV-SSYLLLVSVRDG--GLQHMASV |.| | |..|||| ..|. |.||| . | .. || ..|. .. ||. ||. ||. ..||.| . | | |...|. | . . |. YHFSVCENAPVGTFVMTVTATDPDDPLGPNWRIFYSILGGNPDPGHWFRIDPDTGDNGIITTTKPLDREQQNGQYHLTVMATDHDDGGPPRSST |
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| CA | N12.AA | CA | 767-845 | 25 | 1e-14 | 56.16 | SMART | 1-121 (121) | Show / Hide |
Range on Protein: 767-845
Range on HMM: 1-121/121
Sequence Identity: 25% (32 aa)
IVAHDPDEA--GSLQY------EWYSQVSGEAGVLLIDESTG-----------VITVGQSLDYERV---------SSYLLLVSVRDGG------------
..|.|||| |. || |. ||..|| .||. ..||.| ..| | | ..|||
VTATDPDEGHNGPNGQPNDPEMVTYSIVG----WFSIDPNTGTNYPSLVYCEIWITTTKPLDREEQFNKNEQRHHPQYTLTVQATDGGGPPPPDSHPTRK
------LQHMASVHIFVGDVNEAPT
|. ..|.|.| |||. |
FQQNPPLSSTCTVTIHVLDVNDNPP
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| CA | N12.AA | CA | 867-946 | 21 | 1e-05 | 26.26 | SMART | 1-121 (121) | Show / Hide |
Range on Protein: 867-946
Range on HMM: 1-121/121
Sequence Identity: 21% (26 aa)
LTAEDQDAG---DSHT------FSVSGTDAAYFQVVGAT-------------LQTAQELDYEALLAAGK----NPLAITITATDAGG-------------
.|| | |.| .. .. | .. .|.. | . |...||.|. . .|..|||.||
VTATDPDEGHNGPNGQPNDPEMVTYSIVG--WFSIDPNTGTNYPSLVYCEIWITTTKPLDREEQFNKNEQRHHPQYTLTVQATDGGGPPPPDSHPTRKFQ
----LTLTKAFDITVQDVNEAPY
|. | . |.|.|||. |
QNPPLSSTCTVTIHVLDVNDNPP
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| Cadherin | N12.AA | Cadherin | 850-939 | 24 | 0.001724 | 14.85 | Pfam | 1-102 (102) | Show / Hide |
Range on Protein: 850-939 Range on HMM: 1-102/102 Sequence Identity: 24% (26 aa) SNNVVAENQPIGTVVANLTAEDQD----AGDSHTFSVSGTD---AAYFQVVG--AT---LQTAQELDYEALLAAGKNPLAITITATDA-G---GLTLTKA . | ||.|.|| |...|| | | . . ..| .|.. . | . . . |...||.|. . .|. |||. . ... | YHFSVCENAPVGTFVMTVTATDPDDPLGPNWRIFYSILGGNPDPGHWFRIDPDTGDNGIITTTKPLDREQQ----NGQYHLTVMATDHDDGGPPRSSTTT FDITVQ |||. VTITVC |
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| CA | N12.AA | CA | 967-1045 | 21 | 1e-07 | 32.85 | SMART | 1-121 (121) | Show / Hide |
Range on Protein: 967-1045
Range on HMM: 1-121/121
Sequence Identity: 21% (27 aa)
VTVQDQDAD-----QT------VTCTIVQESTPTFELLDMK-------------LYALPGQQLDHETN---------PSIELTIGCADDGTPM-------
||. | |.. ||..||. |.. . .... ..||.|. |. .||. | |.|
VTATDPDEGHNGPNGQPNDPEMVTYSIVG----WFSIDPNTGTNYPSLVYCEIWITTT--KPLDREEQFNKNEQRHHPQYTLTVQATDGGGPPPPDSHPT
--------KYATATFTITVLDAFDMPG
. .|.|.||.||| | |
RKFQQNPPLSSTCTVTIHVLDVNDNPP
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| Cadherin | N12.AA | Cadherin | 1003-1038 | 35 | 9.2e-05 | 19.28 | Pfam | 64-102 (102) | Show / Hide |
Range on Protein: 1003-1038 Range on HMM: 64-102/102 Sequence Identity: 35% (14 aa) QQLDHETN-PSIELTIGCADD--GTPMKYATATFTITVL ..|| |. . .||. . | |.| ...|.| ||||. KPLDREQQNGQYHLTVMATDHDDGGPPRSSTTTVTITVC |
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| Cadherin | N12.AA | Cadherin | 1051-1079 | 41 | 0.044279 | 9.94 | Pfam | 1-29 (102) | Show / Hide |
Range on Protein: 1051-1079 Range on HMM: 1-29/102 Sequence Identity: 41% (12 aa) QPETIFENATIGTVVGTVVAVDQDDDSTD .. .. ||| .|| |.|| |.| ||.... YHFSVCENAPVGTFVMTVTATDPDDPLGP |
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| Cadherin | N12.AA | Cadherin | 1168-1263 | 26 | 1.9e-09 | 35.58 | Pfam | 1-102 (102) | Show / Hide |
Range on Protein: 1168-1263 Range on HMM: 1-102/102 Sequence Identity: 26% (28 aa) TGGTVEENLALGGVIGTISAQDPD-----QGQTHTFSLASH---QDRFTLSNDASGMYATIRLSQTAASPLNYDSE-PSIELSVVVLDS--GNPPRSITT ..|.|| . | ..|. |.||| .. . . | . . |.. | . .... |. |.. . . .|.|.. |. | |||| || YHFSVCENAPVGTFVMTVTATDPDDPLGPNWRIFYSILGGNPDPGHWFRIDPDTGDN---GIITTTKP--LDREQQNGQYHLTVMATDHDDGGPPRSSTT SITITVE ..||||. TVTITVC |
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| CA | N12.AA | CA | 1185-1266 | 20 | 2.6e-05 | 23.71 | SMART | 1-121 (121) | Show / Hide |
Range on Protein: 1185-1266
Range on HMM: 1-121/121
Sequence Identity: 20% (26 aa)
ISAQDPDQG-----QT------HTFSLASHQDRFTLSNDASGMYA-----TIRLSQTAASPLNYDSE---------PSIELSVVVLDSGNPP--------
..| |||.| |.|. . |.. . |. | .. | ||.... |. .| |.. |.|.||
VTATDPDEGHNGPNGQPNDPEMVTYSIVG---WFSIDPNTGTNYPSLVYCEIWITTT--KPLDREEQFNKNEQRHHPQYTLTVQATDGGGPPPPDSHPTR
-------RSITTSITITVEN----QP
.| |...||.|. |
KFQQNPPLSSTCTVTIHVLDVNDNPP
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| CA | N12.AA | CA | 1293-1379 | 14 | 0.004613 | 0.72 | SMART | 1-121 (121) | Show / Hide |
Range on Protein: 1293-1379
Range on HMM: 1-121/121
Sequence Identity: 14% (19 aa)
VGKFVLEGN---DNQA------ATYTV-QFADDDRRRASEIFSIQGLN-------------LVLSSPLDAEEV---------QTQSLNVVAVETIGSEVN
| . .| ||.. . ||| . .... ||| || .. .|.|.|. | .
VTATDPDEGHNGPNGQPNDPEMVTYSIVG-----------WFSIDPNTGTNYPSLVYCEIWITTTKPLDREEQFNKNEQRHHPQYTLTVQATDGGGPPPP
-------------YYAAQQLIINVQNEDEAPV
. ...|.|. ... |
DSHPTRKFQQNPPLSSTCTVTIHVLDVNDNPP
|
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| CA | N12.AA | CA | 1406-1490 | 16 | 0.00049 | 10.69 | SMART | 1-121 (121) | Show / Hide |
Range on Protein: 1406-1490
Range on HMM: 1-121/121
Sequence Identity: 16% (21 aa)
LVASDPEG------AA------LTFSMASSSSQVMQTYFQVSTTTSG--------TFELSVTQNLVDADI-------AADTYNLDVQAEDATG-------
..|.|| . .|.|. . .|.. ..| ....|. | .. ....|.| ||| |. |
VTATDPDEGHNGPNGQPNDPEMVTYSIVG--------WFSIDPNTGTNYPSLVYCEIWITTTKPLDREEQFNKNEQRHHPQYTLTVQATDGGGPPPPDSH
----------HISTQRVVVTLTDGTTDPS
. || |.....| |
PTRKFQQNPPLSSTCTVTIHVLDVNDNPP
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| Cadherin | N12.AA | Cadherin | 1457-1483 | 31 | 21.957762 | 0.55 | Pfam | 72-100 (102) | Show / Hide |
Range on Protein: 1457-1483 Range on HMM: 72-100/102 Sequence Identity: 31% (9 aa) ADTYNLDVQAEDA--TGHISTQRVVVTLT ...|.| | | |. |. .....|| | NGQYHLTVMATDHDDGGPPRSSTTTVTIT |
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| SKG6 | N12.AA | SKG6 | 1493-1532 | 17 | 0.000253 | 18.5 | Pfam | 1-40 (40) | Show / Hide |
Range on Protein: 1493-1532 Range on HMM: 1-40/40 Sequence Identity: 17% (7 aa) QSTAASNKMGTGAVAGIVIGLLVLLVLIAFLVLVVLRKRQ .| ...| ... ..|.||.. |..... ...... |... KPTDKHWKTTVAIACGVVIPVGVIILVLICFLFCWWRRKK |
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| SH2 | N12.AA | SH2 | 1576-1666 | 32 | 3.6e-14 | 54.3 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 1576-1666 Range on HMM: 1-87/87 Sequence Identity: 32% (30 aa) YEWYQPEMTRQDCSSELAT--AAPGTFLVRDSKATPGWHILGVKTENDVLHEKIRATDDGMYQLLPSSGPAHEQPRFGDLPSLINHYGSRQTG ..|| ..|... . | . .|.|||||| .|| .| |.... | | .|| .|||.| . . ..| .| |.||| | QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDET-----WRRKFPSL-ELVNHYQHNPLG |
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| SH2 | N12.AA | SH2 | 1578-1660 | 32 | 7.2e-11 | 33.73 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 1578-1660 Range on HMM: 1-81/81 Sequence Identity: 32% (29 aa) WYQPEMTRQDCSSELAT--AAPGTFLVRDSKATPGWHILGVKTEN---DVLHEKIRATDDGMYQLLPSSGPAHEQPRFGDLPSLINHY || . ..||. | .||||||.| ||| | |.... | | .|. ||.| | . . ..|..|. |..|| WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYIT-------GRHKFCSLQELVEHY |
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