Gene 10537 (M.brevicollis)

10537

Species: M.brevicollis
Alias: 10537
External Links:
Annotation:

Classification

Group: TK-assoc
Family: SH2
Subfamily: Unique

Sequence

Name Sequence Type Origin Length Description Download
10537.AA Protein None 1698 None Fasta, JSON

Protein domain

Protein domains of 10537.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

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Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 10537.AA SH2 144-154 36 14.01014 0.59 Pfam 71-81 (81) Show / Hide 
Range on Protein: 144-154
Range on HMM: 71-81/81
Sequence Identity: 36% (4 aa)

FPTLSALIAAY
|..|. |.  |
FCSLQELVEHY
Sam7 10537.AA sam7 196-221 25 0.394216 2.01 In-house 24-53 (70) Show / Hide 
Range on Protein: 196-221
Range on HMM: 24-53/70
Sequence Identity: 25% (8 aa)

AFARQKV-----DGLVLAELTPQMLQERFGM
.| ....     || .|...| . |.| .|.
NFRDHGIDDWVTDGDHLCHMTEEDLME-MGI
Sam7 10537.AA sam7 369-411 13 0.001551 10.54 In-house 1-51 (70) Show / Hide 
Range on Protein: 369-411
Range on HMM: 1-51/70
Sequence Identity: 13% (7 aa)

WDNADLRAWFEHVSL---PELSAVLATETM-----TGATFANASTADLQAL
|.  |.  | |.. .   ..    .  . .     .|..... .  ||...
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEM
SH2 10537.AA SH2 461-545 22 0.001182 4.59 SMART 1-87 (87) Show / Hide 
Range on Protein: 461-545
Range on HMM: 1-87/87
Sequence Identity: 22% (20 aa)

ATWYFGT-DHVAALTDLDDSEAPDGAFVVCENPQRHGELMLEVLQDGANVDLAIKPVD-SGIQLEG-TTYIAKTLSELVAYHSAYHED
  ||.|  .   |   |   . |||.|.| .  .  |.. | |  .| .    |.. | ..  ... . .   .| |||....     
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 10537.AA SH2 531-539 44 3.416276 2.39 Pfam 73-81 (81) Show / Hide 
Range on Protein: 531-539
Range on HMM: 73-81/81
Sequence Identity: 44% (4 aa)

TLSELVAYH
.|.||| ..
SLQELVEHY
SH2 10537.AA SH2 564-646 21 0.000154 14.08 SMART 1-87 (87) Show / Hide 
Range on Protein: 564-646
Range on HMM: 1-87/87
Sequence Identity: 21% (19 aa)

MPWYLNFTPSIEDVQTLQT--RPVGSFLLHPKNG-SKDFCLQILRGSDIGKYFIQNEE-QGVRIMS-SKYVFATFMDLIDFYSFVPSN
.|||  . .  | .| |..   | |.||. .     .|..| .  .. .  | |. ..  ...|   ... | .  .|...|.  |  
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 10537.AA SH2 614-640 25 0.042291 7.99 Pfam 55-81 (81) Show / Hide 
Range on Protein: 614-640
Range on HMM: 55-81/81
Sequence Identity: 25% (7 aa)

IQNEEQG-VRIMSSKYVFATFMDLIDFY
||....| . |.  .. |.. ..|...|
IQRTDNGGYYITGRHK-FCSLQELVEHY
SH2 10537.AA SH2 709-783 30 1.1e-11 36.08 Pfam 1-81 (81) Show / Hide 
Range on Protein: 709-783
Range on HMM: 1-81/81
Sequence Identity: 30% (25 aa)

WLYPDLDRERAEQLLVN--KPDGTFAIRDGS-EEAAWVLSYACGG---QVEHAHMDAVETG--IGLRDHEARFQTLQAFVDYY
| .... |. ||.|| |  .||||| .|. . ..   .||  ..|   .|.| .    ..|      .|   |..||  |..|
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHK--FCSLQELVEHY
SH2 10537.AA SH2 707-789 28 8.9e-11 43.04 SMART 1-87 (87) Show / Hide 
Range on Protein: 707-789
Range on HMM: 1-87/87
Sequence Identity: 28% (25 aa)

EAWLYPDLDRERAEQLLVN--KPDGTFAIRDGSE-EAAWVLSYACGGQVEHAHMDAVE-TGIGLRD-HEARFQTLQAFVDYYSSSSQR
. | . ...|| ||||| |  .|||.| .|| .    . |||. ..|.| | .    .  .  . . .. .|..|   |..|.  ...
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 10537.AA SH2 832-914 32 7.9e-20 73.11 SMART 1-87 (87) Show / Hide 
Range on Protein: 832-914
Range on HMM: 1-87/87
Sequence Identity: 32% (29 aa)

DDWFHPNMSREEAETRLDG--QPDGVFLVRRSTT-TNAHVISYAAENETHHALVDTIEDGFVVRDS--NTVFASLDVLINYHRDPSQE
  |.| |.||||||  | .  .||| |||| | .  .. |.|.  ... .| .. . .|| .. |   .. | ||  |.|... ... 
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 10537.AA SH2 834-908 29 2.5e-17 52.71 Pfam 1-81 (81) Show / Hide 
Range on Protein: 834-908
Range on HMM: 1-81/81
Sequence Identity: 29% (24 aa)

WFHPNMSREEAETRLDG--QPDGVFLVRRST-TTNAHVISYAAEN---ETHHALVDTIEDGFVVRDSNTVFASLDVLINYH
|.|...||.||| .|    .||| |||| |  | .  ..|   ..   . .|  . . ..| . .  .. |.||  |....
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHKFCSLQELVEHY
SH2 10537.AA SH2 972-1063 27 3e-10 41.29 SMART 1-87 (87) Show / Hide 
Range on Protein: 972-1063
Range on HMM: 1-87/87
Sequence Identity: 27% (26 aa)

YPWLMLHPHSREAALDTIAN--REDGAFVIRSSQRVPECMVLSFVNGDRILHELIVVDIDERDNEIGLHLMIDD--QRIFPDVRSLVDFHSQHKRV
.|| . .  ||| | .   |   .||.|..| |.. | . |||.  .... | .|  . |           ||.   | ||..  ||....... .
QPWYHGNI-SREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDD-------GKYYIDETWRRKFPSL-ELVNHYQHNPLG
SH2 10537.AA SH2 993-1057 22 0.000288 14.35 Pfam 21-81 (81) Show / Hide 
Range on Protein: 993-1057
Range on HMM: 21-81/81
Sequence Identity: 22% (15 aa)

EDGAFVIRSSQRVPECMVLSFVNGD---RILHELIVVDIDERDNEIGLHLMIDDQRIFPDVRSLVDFH
.||.|..| |.. | . .||.. ..   |. |  |  . ..       .. | . . |...  ||...
PDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNG-------GYYITGRHKFCSLQELVEHY
SH2 10537.AA SH2 1121-1197 27 5.5e-09 28.2 Pfam 1-81 (81) Show / Hide 
Range on Protein: 1121-1197
Range on HMM: 1-81/81
Sequence Identity: 27% (23 aa)

WIVTGLREQDALSLIYD--KPDGTFIVRPSDHAQASLVLCYIFQG---MVEQELIVMHEEG--FSLRRHTSQTFSTLHDMVAYY
|.   .  |.|  | .   .|||||.||.|.  . . .|.  ..|    |.   |  ...|  .   ||.   |..|...| .|
WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHK---FCSLQELVEHY
SH2 10537.AA SH2 1119-1203 22 1.7e-08 35.43 SMART 1-87 (87) Show / Hide 
Range on Protein: 1119-1203
Range on HMM: 1-87/87
Sequence Identity: 22% (20 aa)

APWIVTGLREQDALSLIYD--KPDGTFIVRPSDHAQASLVLCYIFQGMVEQELIVMHE-EGFSLRRHTSQTFSTLHDMVAYYSQYQAV
 ||    .  ..| .|     .|||.|.||.|..   ..||.. ..| |   .|   .  ....  ... .|..| ..|..|..   .
QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG