Gene N7 (M.brevicollis)
N7
Species: M.brevicollis
Alias: N7
External Links:
Annotation:
Sequence
Protein domains of N7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| CH | N7.AA | CH | 4-112 | 17 | 3.6e-14 | 54.31 | SMART | 1-100 (100) | Show / Hide |
Range on Protein: 4-112
Range on HMM: 1-100/100
Sequence Identity: 17% (21 aa)
LWQQCAHWLRDLGVLSADDVSLQAHARVFDLAMALQDGTILCHAANRIRP-GCISHINNSPEMQFMKMQNINQFIECLHTTF----NLPENVFSADELYY
.... |..... .| ... ...||..||. .|.||| ..|. .. .|..|.|||.|.. .. . . . | .....
QEETFLRWCNSHL-------------PVNNFSTDWKDGVVLCQLINKIRPQDSIDWWH-----RFHCMENINYFLNFCEKYGMFLGVCCVVNFDPEDIVD
----ASNFAKVRLCLSLW
....| ||...
GNNNRKDILGVIWCLMQL
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| CH | N7.AA | CH | 5-110 | 17 | 6.6e-11 | 43.04 | Pfam | 1-112 (119) | Show / Hide |
Range on Protein: 5-110 Range on HMM: 1-112/119 Sequence Identity: 17% (21 aa) WQQCAHWLRDLGVLSAD--DVSLQAHARVFDL-AMALQDGTILCHAANRIRPG--C-ISHI----NNSPEMQFMKMQNINQFIECLHTTFNLPENV-FSA .. . |... . .| . | .. ..|| .||. .....|| . ... ... |.| .|.|||.... . ...|. | . EKAFLRWCNRHLEKY-GHWGVPITP---V-NFFFTDWRDGVALCALIHKYCPGLLIDWKKVFPPRMRK--MPFHCMENINYALDFCEKKLGCPCVNLFDP DELYY--ASNFAKVRLCLS ....| |. .| .|. EDIVYMPDGNPKSVMTYLW |
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| RhoGEF | N7.AA | RhoGEF | 238-403 | 28 | 2.7e-38 | 133.26 | Pfam | 1-196 (196) | Show / Hide |
Range on Protein: 238-403 Range on HMM: 1-196/196 Sequence Identity: 28% (56 aa) VLDELTQTEKNYVGVLEVIHNTFKPAL-----ESILDARDIRVIFNNVHQLLDVHHQFLQDLQG--VMQRT---TGRV--ISVIFNQHMK----AFRCYG |. |. |||..|| |..|.. .. | ..||.. .|. || |.......| .||.||. |. . |. .| ..| |..|. VIQEIIQTERSYVRDLNIIIEHYMKPLRNCANPPILSPDEIHTIFSNIEEIYEFHQRFLEDLEERDRMECWNPPDYQCQTIGDCFM-FLKHMFPFFKMYS QFVCNIPEAQRRLSELQTKNT-IVKKLEEVKR---QSKQRFE-LKDLLNVPMQRI--------ELIKRTPD-AHP-EKANLPSALKAVEELAKYINQ ... | |.|. |.... || . |..... . .| . |...| |.||| ||.|.||. || .. .| ||.|..|.|..||. EYCNNYPKAMKLLKKCRKKNPKFQQFLKWCEKENDPCCRRLDLLQSFLIKPVQRIPRYPLLLKELLKHTPPCDHPKDYEDLQKALEAMKEVASHINE |
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| RhoGEF | N7.AA | RhoGEF | 238-403 | 23 | 1.4e-29 | 105.49 | SMART | 1-211 (211) | Show / Hide |
Range on Protein: 238-403 Range on HMM: 1-211/211 Sequence Identity: 23% (49 aa) VLDELTQTEKNYVGVLEVIHNTFKPALES--------ILDARDIRVIFN-NVHQLLDVHHQFLQDLQGVMQRT----------------TGRVISVIFNQ |. || |||.||| |..| ... .... .|. .... || |.. ....| .||..| .. . . .|. .| . VIQELMQTERNYVRDLHIIVQHYMKPMQKEEKCHKLPFLSPDEVNHIFGPNIEEIYEFHRRFLDELEERIEEWDCSMDWKSFRNFQIRDICDRIGDCFMK H---MKAFRCYGQFVCNIPEAQRRLSEL---QTKNTIVKKLEEVKRQSKQR------FELKDLLNVPMQRI--------ELIKRTPDAHPEKANLPSALK . .. |..|.... | |.|.. |... .... | ..|. ... | ..|.|.| .||||| |..| ||..||.. .| ||. WFHAEEMFKMYSEYCNNHPYALKHLKKWMCCKKNPRFQKFCKECESHPNCRSNSEHRLTLEDFLIKPMQRITKYPLLLKEILKHTPPDHPDYEDLQKALD AVEELAKYINQ .....|...|. CMKDVAQHCNE |
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| PH | N7.AA | PH | 432-540 | 19 | 3.4e-09 | 37.8 | SMART | 1-82 (82) | Show / Hide |
Range on Protein: 432-540 Range on HMM: 1-82/82 Sequence Identity: 19% (21 aa) LVKDGDLGFRNMRTREKLKVRYIFLLSEAVIVAKSKGSRFNFKACLELLDNMELVEADYPADEPQDGTHTHAFGLKPADARAPIYLFAAKNPNTKKKWMA ..| | | . . . | |. .| . .. |.| | .. | | ...| . .| .. | |.|..... ....||. VIKEGWLYKKS---K-RWKKRWFVLFNDCLYYYKDK----KPKGSIPLSDC-TVRE-P-------------CFEIHH-DR---TYYFQCESEEEMQEWMQ AFQDCIDAI |.|..|. AIQKAIHNN |
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| PH | N7.AA | PH | 432-538 | 19 | 3e-08 | 32.37 | Pfam | 1-92 (92) | Show / Hide |
Range on Protein: 432-538 Range on HMM: 1-92/92 Sequence Identity: 19% (21 aa) LVKDGDLGFRNMRTREKLKVRYIFLLSEAVIVAKSKGSRFNFKACLELLDNMELVEADYPADEPQDGTHTHAFGLKPADARAPIYLFAAKNPNTKKKWMA ..| | | . |.. | |...| . .. |... .. | .. | | ...... . . | | .. | |.|.|... .. ||. VIKEGWLHKKG--KRKSWKKRWFVLFNNCLYYYKDDK--YRPKGSIPLSDC-QVTKVPDN-------KRPHCFQIRT-DR--RTYYFQAESEEEMNDWMQ AFQDCID |.|... AIQSACR |
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| SH2 | N7.AA | SH2 | 615-690 | 34 | 1.6e-27 | 82.66 | Pfam | 1-81 (81) | Show / Hide |
Range on Protein: 615-690 Range on HMM: 1-81/81 Sequence Identity: 34% (28 aa) WFAGVMDRGQAVSVLAG--MTDGAFLVRESVQRLGEYSLSIMYRG---DAKHIKINRSGNK-FDVAPDSKAFSTVQDLVSYF |. | . | .| | ..||.|||||| |.|.|| .. | ||..|.| .|. . .. . | |...|.||... WYHGKISRQEAERLLMNPGNPDGTFLVRESESTPGDYTLSVRDDGPGDRVKHYRIQRTDNGGYYITGRHK-FCSLQELVEHY |
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| SH2 | N7.AA | SH2 | 613-696 | 31 | 3.8e-27 | 97.44 | SMART | 1-87 (87) | Show / Hide |
Range on Protein: 613-696 Range on HMM: 1-87/87 Sequence Identity: 31% (28 aa) DQWFAGVMDRGQAVSVLAG--MTDGAFLVRESVQRLGEYSLSIMYRGDAKHIKINRSG-NKFDVAP-DSKAFSTVQDLVSYFQQHSLS .|. | ..| .|.. | . | ||.||||.| . |.|.||....| ||..|.|.. .|. .. ... |... .|| ..|...|. QPWYHGNISREEAEQLLKNPGMPDGDFLVRDSESNPGDYVLSVRWKGKVKHYRIRRNDDGKYYIDETWRRKFPSL-ELVNHYQHNPLG |
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| SH3 | N7.AA | SH3 | 724-783 | 41 | 7.7e-20 | 73.16 | SMART | 1-58 (58) | Show / Hide |
Range on Protein: 724-783 Range on HMM: 1-58/58 Sequence Identity: 41% (25 aa) GKARSRFPYVARNPDELSFERGADIIITSLEEADPGWWRGTVVGTSEEGIFPANFVERLT ...| ..| |.|||||||..| |.... . |.|||.|.. .| .||.||.|.||... PYVRALYDYQAQNPDELSFKKGDIITVLEKD--DDGWWKGRCNRTGQEGWFPSNYVEEID |
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| SH3_1 | N7.AA | SH3_1 | 727-776 | 36 | 1.2e-13 | 49.09 | Pfam | 1-49 (49) | Show / Hide |
Range on Protein: 727-776 Range on HMM: 1-49/49 Sequence Identity: 36% (18 aa) RSRFPYVARNPDELSFERGADIIITSLEEADPGWWRGTVVGTSEEGIFPA . ..|.|..||||||..|. |.. . ... ..||.| . .| .||.||. VALYDYQAQQPDELSFKKGDIIHVIEKSDD-WDWWKGRCNNTGQEGWFPS |
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| SH3_2 | N7.AA | SH3_2 | 725-782 | 21 | 2e-05 | 21.86 | Pfam | 1-68 (68) | Show / Hide |
Range on Protein: 725-782 Range on HMM: 1-68/68 Sequence Identity: 21% (15 aa) KARSRFPYVA-RNPDE-----LSFERGADIIITSL---EEADPGWWRG-TVVGTSEE--GIFPANFVERL ..| . ||. ....| |.|..| .|. . .. ...||.. .. .. .. | || ..|| . YYRVHCDYVPATYCNENHEPQLHFKKGD--VIKVIDNGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC |
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