n8

Species: Tetrahymena
Alias: n8, 96.m00094, 8
External Links:
Annotation:

Classification

Group: Atypical
Family: PI3K
Subfamily: PI4K

Sequence

Name Sequence Type Origin Length Description Download
n8.AA Protein None 1559 None Fasta, JSON
n8.NA RNA None 4680 None Fasta, JSON

Protein domain

Protein domains of n8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3K_rbd n8.AA PI3K_rbd 251-359 14 0.000428 5.75 SMART 1-116 (116) Show / Hide
Range on Protein: 251-359
Range on HMM: 1-116/116
Sequence Identity: 14% (17 aa)

NKEKTTNNQP-LEDQYSVKIKAELV-----TAFLYKLYFNKNKNRADEVLKKTLREVYYKYKIKLQPQDNK--TFILKIEGYREYLSGHYPMLSYDRVRT
. .|.  . .   .. ...|  ..      .   . . .| | . .|.|.. ....   .... .|.   .   .|||. | .|||.. .|  ... .| 
MSRKCPEHIWMKTINNKIIIVVHWEKRVCNWQQTKTMDCNPNCT-PDSVMHQFFCKMMMNHSMHDQNDPTDECDYILKVCGRDEYLHPDHPLGQFEYIRN

NLRIKKSLKVILDQKQN
 .  ..  ...|...  
CIMWGRCPHFVLMECCK

PI3K_C2 n8.AA PI3K_C2 850-942 25 3.6e-13 49.64 Pfam 5-115 (168) Show / Hide
Range on Protein: 850-942
Range on HMM: 5-115/168
Sequence Identity: 25% (28 aa)

IQVQVKLM--YGNRALAVKK-ETQKIPFS----RSPRWDEWIKFPLIKISQLPLESRICFDIIVYSVTGLDS---------QIIGSTNFYIFDQ-FCKFT
. |.. .   .|.. |.     |.  ||.     ...|.|||.|| |....||...|.|. |  .. .  ..         . || .|...||.  | ..
FYVECQVYDGHGGKPLCKPVQSTSYKPFNNHFFPRWNWNEWITFPQIQYCDLPRDARLCITIWEIYCKKKSESNMNEQNKKCPIGWCNLPLFDHEKCMLR

QGISPLNI-WP
.|   |.  ||
CGMHKLHMTWP

PI3K_C2 n8.AA PI3K_C2 822-925 17 2.2e-05 24.71 SMART 1-133 (133) Show / Hide
Range on Protein: 822-925
Range on HMM: 1-133/133
Sequence Identity: 17% (23 aa)

FATDHGDKGCSYFQ--------QLCQKYDINFAP-Y-----LIQVQVKLMYG-NRALAVKKETQK----IPFSRS-----PRWDEWIKFPLIKISQLPLE
. . .  ..  .|.         . .  ..|. . |      . |.. | .| .. .. .  |..     .|. .     ..|.||..|  |....|| .
VKICSLWCCNRPFVFLPHEITIYCIHDIMLNWSQDYESSCVDLYVECQLYHGMGKQFCCPVRTSYHQYVKHFFNRTFHLFWKWNEWLTFFPIQYCDLPRM

SRICFDIIVYSVTGLDSQ-II----GSTNFYIF
.|.|. |  .. .. .|  ..    |..|| .|
ARLCITIWDVYDDSKKSEPFFSRCVGWSNFDWF

PI3Ka n8.AA PI3Ka 1075-1211 28 2.9e-24 85.03 Pfam 58-211 (211) Show / Hide
Range on Protein: 1075-1211
Range on HMM: 58-211/211
Sequence Identity: 28% (44 aa)

FLC-AVDWSNPEHIRETYNLLKQ--WKSPPCEECITFLDAHHAD--EVIRLYGVERISK-MADDEIKLYMIELVQALMFE----NNHYSPIQELLLERSL
||   | |....   ..| |..   |   . .. .  ||. ..|  . .| |.|... . | |||. .|.. ||||| .|    . | |.  ..||.|..
FLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNFPDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAW

LNPFVVGHELFWSLKSQL------HLKQS-YERYALVLEQLLMLSGEYRSELLK
 |. . || .|| .|| .      | |    .|....||...   | ....|.|
QNRQRIGHFFFWYMKSEMYKDDEGHDKDYICQRFGVLLESYCRECGTHMQHLNK

PI3Ka n8.AA PI3Ka 1029-1211 25 9e-20 72.93 SMART 6-232 (232) Show / Hide
Range on Protein: 1029-1211
Range on HMM: 6-232/232
Sequence Identity: 25% (58 aa)

P--QNQYLAELKELLKRDPINRNFDMRQKLILLICRNHFK-SIHQALD-----IFLCAVDWSNPEHIRETYNLLKQW--KSPPCEECITFLDAHHAD---
|   ...  .|....|..| .   .  ..||    |...  .  .||       || .|.||...   ..| |..||  .  . |. . .||....|   
PRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKF-RHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFPDYNC

EVIRLYGVERISKMADDEIKLYMIELVQALMFE--------------------------NNHYSPIQELLLERSLLNPFVVGHELFWSLKSQL------H
...| | |... .| |||. .|   ||||| .|                          ..| ||  . ||.|.| ||  .|| ..| ||| .      |
PHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNP-RIGHFFYWYLKSEMYDHCQLH

LKQSYERYALVLEQLLMLS-GEYRSELLK
 .. ..|....||...  . |..  .|.|
DPHYCQRFGMLLEMYCRGCCGHHMRHLFK

Kinase n8.AA PI3Kc 1302-1559 32 9.2e-96 325.37 SMART 1-336 (336) Show / Hide
Range on Protein: 1302-1559
Range on HMM: 1-336/336
Sequence Identity: 32% (108 aa)

SIMFKDGDDLRQDILTLQLIRIMDKIWLDN----NLDLRMKPYNVVATLDQVGMLEIVQNSQTTAAIHK-------------------------------
...|| ||||||| ...|..|.|.|||  .    ..||.|.||....| .. ||.| | |. | . |.|                               
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

-----------------------QNNQRFGC-LMKESIQKYLKKHNKNYE----QARANFRTSCAGYCVATYILGIGDRHSDNIMIT-KEGHFFHIDFGH
                       . .    |   ..........|.....    .|| ||  ||||||..||||||||||.||||.. |.|| |||||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

FLGNFKKKFGIN---RERSPFVFTRVMEYVML---EKQEDYEAFEKYCCQAYNLIRKHGNFFINIFRMMLSAGM-PELQRE-SDIEYLVETLQLN-LSDQ
..|...||.|..   ||| ||..|. | |||     . ...  | ..||.||...||| | ..|.|.||..... |... .  ||.|| ....|. |||.
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE

EAEQHFKK-----QIRIAREDKFKLFDNFIHEIVKK
|| |.|..      |.  .| ... . ...| . . 
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase n8.AA PI3_PI4_kinase 1300-1510 29 4e-76 263.99 Pfam 1-300 (300) Show / Hide
Range on Protein: 1300-1510
Range on HMM: 1-300/300
Sequence Identity: 29% (89 aa)

EFSIMFKDGDDLR--QDILTLQLI-----------------------RIMDKIWLDNNLDLR----MKPYNVVATLDQVGMLEIVQNSQTTAAIHKQN--
. ...|| |||||  || ...|.|                       |.|.|.|  ...|.|    | || ...| .. ||.| | |. | . |..    
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

---------NQRFGCLM------------------------KESIQKYLKKHNKNY--EQ--ARANFRTSCAGYCVATYILGIGDRHSDNIMI---TKEG
         . ..  .|                        |... ....|||..   |   || || .||||.||..||||.||||.||||.   .. |
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

HFFHIDFGHFLGNFKKKFGINRERSPFVFTR------VMEYVM-----LEKQEDYEAFEKYCCQAYNLIRKHGNFFINIF-------RMMLSAGMPELQR
| |||||||.....| |.....|| ||..|.       | ..|     |.  .||. |..||..||...|.|.|...| .        .|. .|.|.. .
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS





Kinase n8.AA ATR 1394-1500 30 1.8e-11 34.94 In-house 163-267 (267) Show / Hide
Range on Protein: 1394-1500
Range on HMM: 163-267/267
Sequence Identity: 30% (33 aa)

ARANFRTSCAGYCVATYILGIGDRHSDNIMITK-EGHFFHIDFGHFLGNFKKKFGINRERSPFVFTRVMEYVMLEKQEDYEAFEKYCCQAYNLIRKHGNF
.| |.  | | .|.  ||.|.||||.|||.| |  |   |.|.   . |  ..| .  |  ||  |. |.. |    . |  | . |     ..|.| . 
SRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDY-NCIFNSGEQFEVP-EIVPFRLTHNMVFGM-GPMKTYGLFRRACEVIMMCMRDHRDD

FINIFRMM
 . ..   
IMSVWDCF

Kinase n8.AA PIKK 1394-1437 51 5.7e-10 32.84 In-house 185-229 (290) Show / Hide
Range on Protein: 1394-1437
Range on HMM: 185-229/290
Sequence Identity: 51% (23 aa)

ARANFRTSCAGYCVATYILGIGDRHSDNIMITKE-GHFFHIDFGH
.| |.  | |  |.. ||||.|||| .|||| .. |   |||||.
RRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGC

Kinase n8.AA FRAP 1395-1436 51 3.6e-09 29.99 In-house 137-179 (251) Show / Hide
Range on Protein: 1395-1436
Range on HMM: 137-179/251
Sequence Identity: 51% (22 aa)

RANFRTSCAGYCVATYILGIGDRHSDNIMITKE-GHFFHIDFG
| |.  | |   .| ||||.||||  |||. .  |   |||||
RTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG

Kinase n8.AA DNAPK 1406-1440 52 1e-06 19.98 In-house 198-233 (301) Show / Hide
Range on Protein: 1406-1440
Range on HMM: 198-233/301
Sequence Identity: 52% (19 aa)

CVATYILGIGDRHSDNIMITKE-GHFFHIDFGHFLG
|.  .|||||||| .| |.  | |    |||||  |
CISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFG

Kinase n8.AA ATM 1401-1436 45 3.2e-05 12.18 In-house 143-179 (304) Show / Hide
Range on Protein: 1401-1436
Range on HMM: 143-179/304
Sequence Identity: 45% (17 aa)

SCAGYCVATYILGIGDRHSDNIMITKEG-HFFHIDFG
| |   .  ||||.||||  ||.|        ||| |
SVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG

Kinase n8.AA PIKK 1297-1386 25 0.002715 8.28 In-house 27-129 (290) Show / Hide
Range on Protein: 1297-1386
Range on HMM: 27-129/290
Sequence Identity: 25% (26 aa)

NQKEFSIMFKDGDDLRQDILTLQLIRIMDKIWLDN----NLDLRMKPYNVVATLDQVGMLEIVQNSQTTAAIHKQNNQRFGCLMKESIQK---------Y
. ||.  ..| ..|||||  ..||...| ..   .      .| .  |.|..  .. | .| |.|. |  .| ||. |... .    .|          .
DGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYKQWCQKKHIRHEQEAQMNYQTCMYRDW

LKK
||.
LKQ

Kinase n8.AA FRAP 1300-1320 38 0.136514 1.8 In-house 1-21 (251) Show / Hide
Range on Protein: 1300-1320
Range on HMM: 1-21/251
Sequence Identity: 38% (8 aa)

EFSIMFKDGDDLRQDILTLQL
|.  . |  .|.|||   .||
EYHFLLKGHEDIRQDERVMQL