n679

Species: Tetrahymena
Alias: 3677.m00078, n679, 679
External Links:
Annotation:

Classification

Group: Atypical
Family: PI3K
Subfamily: PI4K

Sequence

Name Sequence Type Origin Length Description Download
n679.AA Protein None 891 None Fasta, JSON
n679.NA RNA None 2676 None Fasta, JSON

Protein domain

Protein domains of n679.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3K_C2 n679.AA PI3K_C2 47-153 24 2.7e-11 42.86 Pfam 1-129 (168) Show / Hide
Range on Protein: 47-153
Range on HMM: 1-129/168
Sequence Identity: 24% (32 aa)

ENLEAMVTAQLV--VNEKKI-QPAQQT--LFID-----RMLFEQNIIFN-YKYKDLSYNSIIAITLWCSQKNKDE--------KK-PLGCTTISLFDD-Q
.. .  |..|.    . |.. .| |.|    .      |  . . |.|.  .|.||. .. . ||.|  . .| .        || |.|.....|||   
PYMDFYVECQVYDGHGGKPLCKPVQSTSYKPFNNHFFPRWNWNEWITFPQIQYCDLPRDARLCITIWEIYCKKKSESNMNEQNKKCPIGWCNLPLFDHEK

FRLRQGKYHLYI-WPDTLPDTSYTSITPG
  ||.|.. |.  ||.. |. . .  ||.
CMLRCGMHKLHMTWPSKPPCPMFPTHTPW

PI3Ka n679.AA PI3Ka 306-515 27 1e-39 139.18 SMART 1-232 (232) Show / Hide
Range on Protein: 306-515
Range on HMM: 1-232/232
Sequence Identity: 27% (67 aa)

PQQLKP--SKNELQIIENSIKKPILGELKQDEKLLFYRFR-YSLVQNPEALV-----KFLHSINWDNQKELNEAKKLLKIW--AKCSYGDALHLLSSSFC
 ..|||  ...| .  |. .|.| . || ..|| |...|| |.| ..|.||      |||...||... |...|  |...|  .. . .||| ||...| 
DYDLKPRWNEEERDQLEDIMKYPPTYELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPKFP

ANEFYNKKYKKPQDTAIYIRKYACEQLEKEQTSTICSILLQLTQALRYEPFD------------------------YQKSHLAQFLVKKACENTEIATLF
 .               ..|.|| . ||.     .   |||| |||.|| ||                        |..| |..||...|..|  |.  |
DY------------NCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNPRIGHFF

YWYLLVECDKEMDLKEKAKLSSTNQKVQEWFNQVF-ERMNEELEE
|||| .|. ..  |...   ..  . ..| . ... ... ..| .
YWYLKSEMYDHCQLHDPHY-CQRFGMLLEMYCRGCCGHHMRHLFK

PI3Ka n679.AA PI3Ka 307-482 31 2.6e-34 119.6 Pfam 1-180 (211) Show / Hide
Range on Protein: 307-482
Range on HMM: 1-180/211
Sequence Identity: 31% (62 aa)

QQLKP-SKNELQIIENSIKKPILGELKQDEKLLFYRFR-YSLVQNPEALV------KFLH-SINWDNQKELNEAKKLLKI--WAKCSYGDALHLLSSSFC
 .||| ...|. ..|  ||.. | .|...||.| ..|| |..  ||.||       |||  ...| .... ..|  |...  |.. .  ||| ||...| 
KDLKPVNNKERKQLEQIIKYDPLSQLTAEEKCLIWKFRHYCCMNNPKALPLMCVGPKFLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCNF-

ANEFYNKKYKKPQDTAIYIRKYACEQLEK-EQTSTICSILLQLTQALRYE----PFDYQKSHLAQFLVKKACENT-EIATLFYWYLLVEC--DKE
            .|  ...| || . ||.      .  .||||.|||.||    ||  ..| |..||...|  |  .|.  |.||. .|.  | |
------------PDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQALKYENFDEPF--HDSYLSRFLLWRAWQNRQRIGHFFFWYMKSEMYKDDE

Kinase n679.AA PI3Kc 617-888 25 2.5e-85 290.7 SMART 1-336 (336) Show / Hide
Range on Protein: 617-888
Range on HMM: 1-336/336
Sequence Identity: 25% (91 aa)

EMIYKNGDDLRQDQLVMQIFNLMDGLLKGV----GQDFRLMPYKVLACSKNDGFMEFVPNSTTIQDLL--------------------------------
 .|.|.|||||||...||.|.||. ...      ..|... |||... ....|..|.|||..|.  ..                                
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

--------------------------------KGGKQFSQYLQNLAANPENPIYEEYKRLRMQNDEQGKLSNIEYVSQKIMENYMLSCAGYSVMTYFLGV
                                . .  . .....   .|.                         . .. ..|. .|||||...|| ||.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPN------------------------EDWWEARDNFTRSCAGYCMVTYILGI

GDRHLENLMVD-ITGKFFHIDFGFILGQDPKPYPP--------PLKLCRQMIEGMG--GKDSKVYAEFRKKCVHAYIYLRKYAKLIVNLFHLMIDSGI-K
||||..|.|.|  ||. ||||||.|.|..||. ..        | .|...|...||  ||.|... .||. |..||  .||.. ||.||| .|....|  
GDRHNDNIMLDMKTGHCFHIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMP

DMSIE--ALEKLAEKFYLD-FNDTQAELHFLN----ILDESE-TALFARVTDMIHKWATY
. . .  ....| ..| ||  .| .|  .| .     |.|..  ... |. .|.|.|| |
CWRMMEKDIKYLRQRFRLDHLSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

Kinase n679.AA PI3_PI4_kinase 615-840 23 8e-69 239.75 Pfam 1-300 (300) Show / Hide
Range on Protein: 615-840
Range on HMM: 1-300/300
Sequence Identity: 23% (76 aa)

KVEMIYKNGDDLR--QDQLVMQIF-----------------------NLMDGLLKGVGQDFR----LMPYKVLACSKNDGFMEFVPNSTTIQDLLKGG--
 . .| |.|||||  ||...||..                       .||....|. | |.|    . ||........ |..|.|||.||.. ...    
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

------------------------------------------KQFSQYLQNLAANPENPIYEEYKRLRMQNDEQGKLSNIEYVSQKIMENYMLSCAGYSV
                                            . |..     ..    |||. .                     ..|. .||||..|
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDA----YEEWWE--------------------ARDNFVRSCAGMCV

MTYFLGVGDRHLENLMV---DITGKFFHIDFGFILG-----QDPKPYPPPLKLCR------QMIEGMGG----KDSKVYAEFRKKCVHAYIYLRKYAKLI
..| ||.||||..|.||   . ||. ||||||....      ..|| ..| ....      .|...|||    ..|. | .||. |.|||  ||... |.
VDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLC

VNLF-------HLMIDSGIKDMSI
.||.       ..|...|. . . 
MNLLKKAVMRGECMVHDGLPMWRS

Kinase n679.AA ATR 730-830 30 1.1e-13 42.58 In-house 165-267 (267) Show / Hide
Range on Protein: 730-830
Range on HMM: 165-267/267
Sequence Identity: 30% (32 aa)

ENYMLSCAGYSVMTYFLGVGDRHLENLMVD-ITGKFFHIDFGFILGQ---DPKPYPPPLKLCRQMIEGMGGKDSKVYAEFRKKCVHAYIYLRKYAKLIVN
|||. | | .... | .| |||| .|...| |.|   |.|.  | ..      |   | .| . |. |||    | |  ||. |.     .|.    |. 
ENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMG--PMKTYGLFRRACEVIMMCMRDHRDDIMS

LFHLM
...  
VWDCF

Kinase n679.AA FRAP 731-770 53 1.1e-10 35.63 In-house 139-179 (251) Show / Hide
Range on Protein: 731-770
Range on HMM: 139-179/251
Sequence Identity: 53% (22 aa)

NYMLSCAGYSVMTYFLGVGDRHLENLMVD-ITGKFFHIDFG
||  | |  |.  | || ||||. |.| .  |||  |||||
NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG

Kinase n679.AA PIKK 730-774 50 2.9e-09 30.26 In-house 187-232 (290) Show / Hide
Range on Protein: 730-774
Range on HMM: 187-232/290
Sequence Identity: 50% (23 aa)

ENYMLSCAGYSVMTYFLGVGDRHLENLMVD-ITGKFFHIDFGFILG
|||  | |  ..  | || ||||.||.|.| .||.  |||||.. .
ENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFE

Kinase n679.AA ATM 732-795 36 7.4e-08 20.76 In-house 140-207 (304) Show / Hide
Range on Protein: 732-795
Range on HMM: 140-207/304
Sequence Identity: 36% (25 aa)

YMLSCAGYSVMTYFLGVGDRHLENLMV-DITGKFFHIDFGFILGQD---PKPYPPPLKLCRQMIEGMG
|  | |  |.. | ||.||||  |... .      ||| |    |    | |   | .| | ...|||
YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLTRDIVDGMG

Kinase n679.AA PIKK 580-681 28 8.9e-08 24.78 In-house 1-100 (290) Show / Hide
Range on Protein: 580-681
Range on HMM: 1-100/290
Sequence Identity: 28% (30 aa)

IVESIHQQSTVFKSAMAPIKMTFTSYPIGQKEKEGKVEMIYKNGDDLRQDQLVMQIFNLMDGLLKGV----GQDFRLMPYKVLACSKNDGFMEFVPNSTT
.. .. .  || ..  .| |...     |  .||    . .| ..|||||| ||| | || ..|         .. .  |.| . | . |  | |.|..|
RIRFMDRMVTVMAHKQKPKKIYI----RGHDGKE--YPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVT

IQDLLK
.....|
LKEIYK

Kinase n679.AA SMG1 732-769 46 3e-06 16.61 In-house 190-228 (242) Show / Hide
Range on Protein: 732-769
Range on HMM: 190-228/242
Sequence Identity: 46% (18 aa)

YMLSCAGYSVMTYFLGVGDRHLENLMVDI-TGKFFHIDF
|  | |  |.. | .|.|||||.| ..|. ||   |||.
YARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY

Kinase n679.AA DNAPK 744-774 50 2.7e-05 14.99 In-house 202-233 (301) Show / Hide
Range on Protein: 744-774
Range on HMM: 202-233/301
Sequence Identity: 50% (16 aa)

YFLGVGDRHLENLMVDI-TGKFFHIDFGFILG
. ||.|||||.| ||   .|    ||||.  |
WILGIGDRHLNNFMVNMENGDIISIDFGHSFG

Kinase n679.AA FRAP 615-681 26 0.000605 10.55 In-house 1-71 (251) Show / Hide
Range on Protein: 615-681
Range on HMM: 1-71/251
Sequence Identity: 26% (19 aa)

KVEMIYKNGDDLRQDQLVMQIFNLMDGLLK----GVGQDFRLMPYKVLACSKNDGFMEFVPNSTTIQDLLK
    . |  .|.|||  |||.| |.  ||.        .  .  | ..  | | | .  |..  |.. |..
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIR

Kinase n679.AA DNAPK 619-643 44 0.005709 6.43 In-house 36-60 (301) Show / Hide
Range on Protein: 619-643
Range on HMM: 36-60/301
Sequence Identity: 44% (11 aa)

IYKNGDDLRQDQLVMQIFNLMDGLL
.|| . |||||| . | |  | . .
CYKGIEDLRQDQRIEQLFQVMNNIF

Kinase n679.AA ATM 618-644 40 0.011371 3.9 In-house 2-28 (304) Show / Hide
Range on Protein: 618-644
Range on HMM: 2-28/304
Sequence Identity: 40% (11 aa)

MIYKNGDDLRQDQLVMQIFNLMDGLLK
 . |  ||||||  . |.| .   ||.
QLVKGRDDLRQDAVMQQVFQMCNTLLQ