n737

Species: Tetrahymena
Alias: 32.m00265, 737, n737
External Links:
Annotation:

Classification

Group: Atypical
Family: PI3K
Subfamily: PI4K

Sequence

Name Sequence Type Origin Length Description Download
n737.AA Protein None 1200 None Fasta, JSON
n737.NA RNA None 3603 None Fasta, JSON

Protein domain

Protein domains of n737.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PI3K_rbd n737.AA PI3K_rbd 147-202 24 1.6e-07 30.29 Pfam 44-100 (115) Show / Hide
Range on Protein: 147-202
Range on HMM: 44-100/115
Sequence Identity: 24% (14 aa)

ADEVIKNILRKIYKEYKIALKPKDQN-HQFILQVKGFREYLAGNHPMLNYDRVRTSL
.. |.. ...|  . ... .... ||  ...|.| |..|||.|.||  ... .| ..
PFQVMHQAFCKMAMKHSVHDQNDVQNPGDYVLKVCGRDEYLHGDHPLCQFEYIRNCI

PI3K_rbd n737.AA PI3K_rbd 111-217 18 2.3e-05 18.9 SMART 1-116 (116) Show / Hide
Range on Protein: 111-217
Range on HMM: 1-116/116
Sequence Identity: 18% (21 aa)

LNVNLDEYIN--QLREKKPAEVDWD------CKSLTIEAGLVTGADEVIKNILRKIYKEYKIALKPKDQNH-QFILQVKGFREYLAGNHPMLNYDRVRTS
  . . |.|     ..|  . | |.       .. |..  .   .|.|.. ...|. . ... .... ..  ..||.| |..|||...||  ... .| .
MSRKCPEHIWMKTINNKIIIVVHWEKRVCNWQQTKTMDCNPNCTPDSVMHQFFCKMMMNHSMHDQNDPTDECDYILKVCGRDEYLHPDHPLGQFEYIRNC

LRGLDHLDVKLTEMPI
.   .  ...| | . 
IMWGRCPHFVLMECCK

PI3K_C2 n737.AA PI3K_C2 463-540 23 8.8e-12 44.63 Pfam 22-115 (168) Show / Hide
Range on Protein: 463-540
Range on HMM: 22-115/168
Sequence Identity: 23% (22 aa)

KSV-ETKRVPYG----NTCKFNQWISFNNIKVSQLPLESRLCFNLKAYAQNSNDY---------QIIGSSTLPIFNS-QELFQQGLNAINV-WP
| |  |...|..    .. ..|.|| |..|....||...|||. . ... .. .          . || ..||.|..   .. .|  .... ||
KPVQSTSYKPFNNHFFPRWNWNEWITFPQIQYCDLPRDARLCITIWEIYCKKKSESNMNEQNKKCPIGWCNLPLFDHEKCMLRCGMHKLHMTWP

PI3K_C2 n737.AA PI3K_C2 395-523 15 0.000171 15.43 SMART 1-133 (133) Show / Hide
Range on Protein: 395-523
Range on HMM: 1-133/133
Sequence Identity: 15% (23 aa)

KQNKDIQ-LQQEQQKQRKDQVTPKLNTRIVNHGIKGV-----EFMKQIQGYYGMNLVPFSISIEAIIMNGSTCIKSVETKR----VPYGNT-----CKFN
.  . .. . .....     .| .....|  .  . .     ..  ..| |.|               .|    ..| |..    .. .|.      |.|
VKICSLWCCNRPFVFL-PHEITIYCIHDIMLNWSQDYESSCVDLYVECQLYHG---------------MGKQFCCPVRTSYHQYVKHFFNRTFHLFWKWN

QWISFNNIKVSQLPLESRLCFNLKAYAQNSNDYQ-II----GSSTLPIF
.|. | .|....|| ..|||. . ..  .| ..  ..    |.|.. .|
EWLTFFPIQYCDLPRMARLCITIWDVYDDSKKSEPFFSRCVGWSNFDWF

PI3Ka n737.AA PI3Ka 622-812 28 6.9e-38 133.1 SMART 1-232 (232) Show / Hide
Range on Protein: 622-812
Range on HMM: 1-232/232
Sequence Identity: 28% (67 aa)

HRNFNQTPKTEDLARLQFLLNADPLKRPEFTPEDKHILMISRNHYK-TLTQALQ-----VFLLAVDWLDPEQVKEAILMLKKW--TPLQPEDALPLLDAH
..... .   |.  .|. ... .|..  | | |.|  .   |..|  .  .||       ||..|.| ....||.|. ....|  .|..||||| |||..
DYDLKPRWNEEERDQLEDIMKYPPTY--ELTEEEKDLIWKFRHYYLTNHPKALPSMCFPKFLRCVNWSWADEVKQAYQLMHQWWWPPIDPEDALELLDPK

ISN---EIVRLYAVERISTFSDDEIALYMLELTQLLLYE--------------------------RNHFSPLAEMLLERSLLNPYVVGHEFFWQLKSQL-
  .   . || |||...  .||||. .| | | | | ||                          ..| |||...||.|.| ||  .|| |.|.||| . 
FPDYNCPHVRQYAVQCLEQMSDDELLHYLLQLVQALKYENFDHIKHHFCEFDQDQSMSMTKEEDGPYHDSPLCRFLLQRALCNP-RIGHFFYWYLKSEMY

-----NVKAFHERFSLLIEQFIMVC-GSFRKEIAN
     . . ...|| .| |... .| |   ... .
DHCQLHDPHYCQRFGMLLEMYCRGCCGHHMRHLFK

PI3Ka n737.AA PI3Ka 626-812 30 1.6e-33 116.87 Pfam 1-211 (211) Show / Hide
Range on Protein: 626-812
Range on HMM: 1-211/211
Sequence Identity: 30% (64 aa)

NQTPK--TEDLARLQFLLNADPLKRPEFTPEDKHILMISRNHYK-TLTQALQ------VFLL-AVDWLDPEQVKEAILMLKK--WTPLQPEDALPLLDAH
.....   ... .|. ... |||   . | |.|  .  .| ..  .  .||        ||.  | | |..||..|.  ...  |.|. |.||| |||. 
KDLKPVNNKERKQLEQIIKYDPLS--QLTAEEKCLIWKFRHYCCMNNPKALPLMCVGPKFLQLCVKWHDYDQVAQAYQLMDCRVWPPIDPCDALELLDCN

ISN--EIVRLYAVERIST-FSDDEIALYMLELTQLLLYE----RNHFSPLAEMLLERSLLNPYVVGHEFFWQLKSQL------NVKAF-HERFSLLIEQF
 ..  . || |||... . .||||. .|.| |.| | ||    . | |.|.. ||.|.. |. . || ||| .|| .        |..  .||..| |..
FPDNCPMVRQYAVKCLESYMSDDELLCYLLQLVQALKYENFDEPFHDSYLSRFLLWRAWQNRQRIGHFFFWYMKSEMYKDDEGHDKDYICQRFGVLLESY

IMVCGSFRKEIAN
   ||  ... . 
CRECGTHMQHLNK

Kinase n737.AA PI3Kc 939-1200 35 1.5e-114 387.78 SMART 1-336 (336) Show / Hide
Range on Protein: 939-1200
Range on HMM: 1-336/336
Sequence Identity: 35% (119 aa)

KILFKRGDDIRQDQLTLQLLKIMDKIWLDA----GQDFRMKPYKVITTGDQVGMIEVVVNAETTARIH--------------------------------
 ..|| ||| |||....|....|.|||       ..|..|.|||.| ||.. ||||.| |.|| . |.                                
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

-----------------------KQEGGGLGALKEDTLKNYLQKHNPDK-ENLKSATENFIRSCAGYCVATYILGIGDRHPDNIMLS-QTGHLFHIDFGH
                       | ..| ... |...|......|.||  |.  .| .||.|||||||..||||||||||.|||||  .|||.|||||||
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

FLGNFKKKLGID---RERAPFVFTEEMAFVMG--GKESADFKNFTDYCTQAYNLIRKQGNFIINIFLLMLDAGI-PELQSA-KNIEYLKNKLALQ-LSEQ
..|...||.|.    |||.||..| .|  |||  ||.| .|..| ..| .||...||. | |.|.| .|....| |....  | |.||.... |. ||..
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRLDHLSDE

EATNKFKK-----EIHFSLNSRFRKLDNLIHNLVKQ
||...|..      |. |..| . .. ...||. . 
EAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY

PI3_PI4_kinase n737.AA PI3_PI4_kinase 937-1151 31 2.5e-88 304.52 Pfam 1-300 (300) Show / Hide
Range on Protein: 937-1151
Range on HMM: 1-300/300
Sequence Identity: 31% (95 aa)

EMKILFKRGDDIR--QDQLTLQLL-----------------------KIMDKIWLDAGQDFR----MKPYKVITTGDQVGMIEVVVNAETTARIHKQEGG
.....||.||| |  ||....|..                       ..|.|.|   | |.|    | ||..| ||.. ||||.| |..| ..|..  . 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

GLGALK-----------------------------------EDTLKNYLQKHNPDK-ENLKSATENFIRSCAGYCVATYILGIGDRHPDNIML---SQTG
 ...                                      . | ... |||||  |.. .| .||.|||||.||..||||.||||.||||.     ||
KCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMVKDDKTTG

HLFHIDFGHFLGNFKKKLGIDRERAPFVFTE------EMAFVMGG----KESADFKNFTDYCTQAYNLIRKQGNFIINIF-------LLMLDAGIPELQS
|||||||||.....| | .. .|| ||..|       .|  .|||    ..| |.  | ||| .||...|...|...| .       ..|...|.|.. |
HLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHDGLPMWRS





Kinase n737.AA ATR 1018-1141 28 2.2e-15 48.48 In-house 147-267 (267) Show / Hide
Range on Protein: 1018-1141
Range on HMM: 147-267/267
Sequence Identity: 28% (35 aa)

KNYLQKHNPDKENLKSATENFIRSCAGYCVATYILGIGDRHPDNIMLSQ-TGHLFHIDFGHFLGNFKKKLGIDRERAPFVFTEEMAFVMGGKESADFKNF
...  .  || ..  |. ||..|| | .|.  ||.|.|||| |||.. . .| . |.|.   . |  ... .  |  ||  |. | | ||  ..     |
HDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECVHVDY-NCIFNSGEQFEVP-EIVPFRLTHNMVFGMGPMKTYGL--F

TDYCTQAYNLIRKQGNFIINIFLLM
   |     ..|.. . |. ..   
RRACEVIMMCMRDHRDDIMSVWDCF

Kinase n737.AA PIKK 1033-1077 56 3.4e-15 52.05 In-house 184-229 (290) Show / Hide
Range on Protein: 1033-1077
Range on HMM: 184-229/290
Sequence Identity: 56% (26 aa)

SATENFIRSCAGYCVATYILGIGDRHPDNIML-SQTGHLFHIDFGH
...||..|| |  |.. ||||.|||||.|||. .||| . |||||.
ERRENYTRSYAVMCMVGYILGLGDRHPENIMIDMQTGEIVHIDFGC

Kinase n737.AA FRAP 1037-1076 60 1e-12 43.18 In-house 139-179 (251) Show / Hide
Range on Protein: 1037-1076
Range on HMM: 139-179/251
Sequence Identity: 60% (25 aa)

NFIRSCAGYCVATYILGIGDRHPDNIMLS-QTGHLFHIDFG
|. || |   .| ||||.||||| ||||  .|| . |||||
NYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFG

Kinase n737.AA DNAPK 1036-1080 50 1.1e-08 27.59 In-house 188-233 (301) Show / Hide
Range on Protein: 1036-1080
Range on HMM: 188-233/301
Sequence Identity: 50% (23 aa)

ENFIRSCAGYCVATYILGIGDRHPDNIMLS-QTGHLFHIDFGHFLG
| |||. |  |.  .|||||||| .| |    .|    |||||  |
EHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFG

Kinase n737.AA ATM 1038-1076 47 2.7e-07 18.93 In-house 140-179 (304) Show / Hide
Range on Protein: 1038-1076
Range on HMM: 140-179/304
Sequence Identity: 47% (19 aa)

FIRSCAGYCVATYILGIGDRHPDNIMLS-QTGHLFHIDFG
. || |   .  ||||.||||  ||..  |   | ||| |
YTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLG

Kinase n737.AA SMG1 1035-1075 42 1.1e-05 14.69 In-house 187-228 (242) Show / Hide
Range on Protein: 1035-1075
Range on HMM: 187-228/242
Sequence Identity: 42% (18 aa)

TENFIRSCAGYCVATYILGIGDRHPDNIMLS-QTGHLFHIDF
|  . || |   .  ||.|.|||| ||...   ||   |||.
TQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY

Kinase n737.AA PIKK 941-961 47 0.109668 2.37 In-house 34-54 (290) Show / Hide
Range on Protein: 941-961
Range on HMM: 34-54/290
Sequence Identity: 47% (10 aa)

LFKRGDDIRQDQLTLQLLKIM
|.| ..|.|||| ..||. .|
LCKGHEDLRQDQRVMQLFQLM

Kinase n737.AA FRAP 937-957 47 0.152608 1.62 In-house 1-21 (251) Show / Hide
Range on Protein: 937-957
Range on HMM: 1-21/251
Sequence Identity: 47% (10 aa)

EMKILFKRGDDIRQDQLTLQL
|   | |  .|||||   .||
EYHFLLKGHEDIRQDERVMQL