Gene Dusty (Sea Urchin)

Dusty

Species: Sea Urchin
Alias: Dusty, Spk324
External Links: Sea Urchin Project Link
Annotation:

Classification

Group: Other
Family: Dusty

Sequence

Name Sequence Type Origin Length Description Download
Dusty.AA Protein None 965 None Fasta, JSON
Dusty.kin_dom Protein Kinase Domain None 195 None Fasta, JSON

Protein domain

Protein domains of Dusty.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Dusty.AA SgK496 665-917 79 6.2e-195 653.88 In-house 1-252 (265) Show / Hide 
Range on Protein: 665-917
Range on HMM: 1-252/265
Sequence Identity: 79% (201 aa)

PKLEREIGRGQYGVVYSCRSWGGVTHCAVKSVVPPDDKHWNDLAMEFHYTRSIAEHDRIVAVIGSVIDHGYGGMGCSPAVLLLMERMQRDLHTAIKANME
||||.|||||||||||||..|||..||||||||||||||||||||||||.|||..|||||.|.|||||..|||||||.||||.||||.|||.||||||||
PKLEQEIGRGQYGVVYSCDNWGGHFHCAVKSVVPPDDKHWNDLAMEFHYMRSIPKHDRIVDVHGSVIDYNYGGMGCSIAVLLIMERMHRDLYTAIKANME

LPERLHVALDVAEGVRYLHSLGLVHRDIKLKNVLLDKHDRGKITDLGFCKPEAMMSGSIVGTPIHMAPELFSGKYDNSVDTYAFGILLWYVCAGHVKLPQ
|.||||.||||.||.|||||.|||||||||||||||||.|.||||||||||||||||||||||||||||||.||||||||.||||||.||.|.||.|||.
LEERLHIALDVVEGIRYLHSQGLVHRDIKLKNVLLDKHNRAKITDLGFCKPEAMMSGSIVGTPIHMAPELFTGKYDNSVDVYAFGILFWYICSGHIKLPE

AFEQCANKDHLWTSVKKGVRPERLRPQFDDASWNLMKSSWAGEPSERPLLEKV
|||.|| |||||  |..| ||||| | ||.  | ||.. | |.|  ||||  |
AFERCASKDHLWNNVRRGTRPERL-PVFDEECWQLMEACWDGDPLKRPLLGIV
Kinase Dusty.AA TKL 671-912 18 6.9e-39 135.52 In-house 1-355 (364) Show / Hide 
Range on Protein: 671-912
Range on HMM: 1-355/364
Sequence Identity: 18% (69 aa)

IGRGQYGVVYSC--RSWGGV------THCAVKSVVPPDDKHWND-----------------------LAMEFHYTR-SIAE--HDRIVAVIGSVIDHGYG
||.| .|.||    | |||.      .  |||     .|. ...                       .  .. .   ..    |. ||  .|.... ..|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

GMGCSP--------AVLLLMERMQ-RDLHTAIKANMELPERLHVALDVAEGVRYLHSLG--------LVHRDIKLKNVLLDKHDR--------------G
.  ..|         |  ....   .....       .. |.. |||.| |. |||| .        ..|||.| ||.|.|.. .               
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KITDLGFCK-------PEAMM---------------SGSIVGTPIHMAPELFS-----------------GKYDNSVDTYAFGILLWYVCAGHVKLPQAF
||.|.|...        ...|               .....||| .||||..                  ..|. ..| |.|||.|| .... .     .
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR----PY

EQCANKDHLWT----SVKKGVRPERLRPQFD------------DASW----NLMKSSWAGEPSERP
..  . ....        ..|  ..|||  .            .  .    .||.  |. .|..||
YDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRP
Kinase Dusty.AA Pkinase 665-859 25 2.1e-37 133.34 Pfam 1-209 (293) Show / Hide 
Range on Protein: 665-859
Range on HMM: 1-209/293
Sequence Identity: 25% (56 aa)

PKLEREIGRGQYGVVYSCRSWGGVTHCAVKSVVPPDDKHWND-----LAMEFHYTRSIAEHDRIVAVIGSVIDHGYGGMGCSPAVLLLMERMQR-----D
 ...| ||.| .|.|| |.  |     ||| .  ...|.| |     | .| .. ...  |. ||  .... |        .. . . || ..      |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL-SEIQIMKRL-NHPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMD

LHTAIK-------ANMELPERLHVALDVAEGVRYLHSLGLVHRDIKLKNVLLDKHDRG----KITDLGFC----KPEAMMSGSIVGTPIHMAPEL--FSG
|.. |.         ..  |  .... ...|. |.|| | .|||.|. |.|.|...      ||.| |..            ...|||  ||||.  .. 
LFDYISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQ

KYDNSVDTYAFGILLWYVCAGH
.|. .|| ...|..|.... |.
YYGPKVDMWSCGCILYEMLCGR
Kinase Dusty.AA S_TKc 665-923 19 3e-31 111.05 SMART 1-231 (231) Show / Hide 
Range on Protein: 665-923
Range on HMM: 1-231/231
Sequence Identity: 19% (54 aa)

PKLEREIGRGQYGVVYSCRSWGGVTHCAVKSVVPPDDKHWNDLAMEFHYTRSIAEHDRIVAVIGSVIDHGYGGMGCSPAVLLLMERMQR---DLHTAIKA
 .. |.||.| .|.|| ||  .   ..|.| .        ...  |    ..   |. ||  ...  |           . . || .     ||.. || 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIKK

N--------MELPERLHVALDVAEGVRYLHSLGLVHRDIKLKNVLLDKHDRGKITDLGFCKPEAMMSGSIVGTPIHMAPELFSGKYDN-SVDTYAFGILL
.        .   .  ...  ..... |.||.| .|||.|  |.|||.  . ||.| |...       ...|||  ||||..  .|.  ..| ...|..|
RGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCIL

WYVCAGHVKLPQAFEQCANKDHLWTSVKKGVRPERLRPQFDDASWNLMKSSWAGEPSERPLLEKVHL-------SXQI
.  ..|    |       . . ..  ..            ..  .....  .  .|..||   ..            .
YEMLCGYPPFP-------QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Dusty.AA CAMK 670-852 15 1.3e-28 88.71 In-house 1-324 (425) Show / Hide 
Range on Protein: 670-852
Range on HMM: 1-324/425
Sequence Identity: 15% (51 aa)

EIGRGQYGVVYSCRSW-GGV-----------THCAVKSVVPP----------------------------DDKHWNDLAMEFHYTRSIAE------HDRI
..|||..|.|. |.    .            ...|.| .                               ..|    .  | .  ... .      |  |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VAVIGSVIDHGYGGMGCSPA---------------VLLLM---ERMQR-----DLHTAIKAN-----------------MELPERLHVALDVAEGVRYLH
.  .    |. |.. .   .               . . |   | ..      ||   |...                 ..  |  ..   ....|.|.|
IKLYEVYEDPHYFK-N---TNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCH

SLGLVHRDIKLKNVLLDKHDRG-----------------KITDLGFC--KPE------------------------AMMSGSIVGTPIHMA-PELFSGK-
|.. ||||.|. |.|||.....                 ||.| ||   ...                          .    .|||  || ||...|| 
SHNIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKG

--------------YDNSVDTYAFGILL
              |. ..|  . |..|
HCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase Dusty.AA TK 665-921 13 7.2e-28 89.88 In-house 1-486 (486) Show / Hide 
Range on Protein: 665-921
Range on HMM: 1-486/486
Sequence Identity: 13% (67 aa)

PKLEREIGRGQYG---VVYSC-------------------------RSWGGVTHCAVKSVV---PPDDKHWND--------------LAMEFHYTRS-IA
 .|....|.||.|   .|| .                         .. ||.| .||| .    . ...   |              .|.|    .. . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

EHDRIVAVIG-SVIDHGYGGMG---CSPAVLLLMERMQ-RD----LHTAIKAN-----------------------------------------------
.|. ||  .| .. . .  .      .. ....|| |.  |    |..  ...                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------MELPERLHVALDVAEGVRYLHSL------GLVHRDIKLKNVLLDKHDR-----------GKITDLGFCK
                               . ....|  ....|.| .||||.      ..||||.   |.|......            ||.| | ..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------PEAMMSGSIVGTPIH------------------------------MAPELFS----------GKYDNSVDTYAFGILLWYVCA-GHVKLP--Q
        .   ..  . .  .                              |||| .           ||.    | ..||.|.| ..  | .  .   
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

AFEQCANK---DHLWTSVKKGVRP---------ERLR-PQFDDAS-----------------WNLMKSSWAGEPSERPLLEKVHLSX
  .....    . .   ...| |.         .|.| || ....                   ||.. |. .|..||  . .|   
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Dusty.AA Dicty5 762-853 37 1.1e-26 88.92 In-house 100-194 (260) Show / Hide 
Range on Protein: 762-853
Range on HMM: 100-194/260
Sequence Identity: 37% (36 aa)

NMELPERLHVALDVAEGVRYLHSLGLVHRDIKLKNVLLDKHDRGKITDLGFCK-PEAMMSGSI-VGTPIHMAPELFSGK-YDNSVDTYAFGILLW
..  . .|| |.|.| . |.||| . .|||.|  |.|. .    || | |     ..     . |||.  ||.||| |. |.. .| |.||| ||
PIAYFQQLHMAIDIAQSMRHLHSMNIIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMTMHVGTQCWMACELFNGQPYHQKCDVYSFGIVLW
Kinase Dusty.AA MLK 772-853 35 6.5e-23 76.4 In-house 130-227 (291) Show / Hide 
Range on Protein: 772-853
Range on HMM: 130-227/291
Sequence Identity: 35% (35 aa)

ALDVAEGVRYLHSLG---LVHRDIKLKNVLLD------KHDRGKITDLG----FCKPEA-MMSGSIVGTPIHMAPELF----SGKYDNSVDTYAFGILLW
||..|.|. ||||.    ..|||.| .|.|.|      .|.  ||.| |    ... .. ||  |  ||.. |||| .    ..||. ..| . .|..||
ALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMM--SNAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLW
Kinase Dusty.AA LISK-DD1 754-852 32 6e-22 76.29 In-house 96-221 (290) Show / Hide 
Range on Protein: 754-852
Range on HMM: 96-221/290
Sequence Identity: 32% (42 aa)

DLHTAIKA---------------NMELPERLHVALDVAEGVRYLHSLGLVHRDIKLKNVLLDKH----DRGKITDLGFCKPEAMMSGS----------IV
||| ..|.               .   ..|.  |||.|.. .|||| ...||| | || |.|.      |.|. |.|| .   |....          |.
DLHWYLKNTPFDDTPEQYIHHKIPIPWKLRVKIALDIACAMAYLHSKNIIHRDLKSKNILVDENGDSQWRIKVCDFGFAR---MFEQKKNQQNNRHMTIC

GTPIHMAPELFSG-KYDNSVDTYAFGILL
||.. ||||.  | .|| |.| . ||..|
GTDNWMAPEVILGMSYDWSCDVFSFGMVL
Kinase Dusty.AA ULK 752-852 25 2.1e-21 72.72 In-house 101-242 (324) Show / Hide 
Range on Protein: 752-852
Range on HMM: 101-242/324
Sequence Identity: 25% (36 aa)

QRDLHTAIKANMELPERL------------HVALDVAEGVRYLHSLGLVHRDIKLKNVLLDKHDRGK------------ITDLGFCKP------EAMMSG
. || . || | .|||              ..  . ..| ..||. . .|||||. | |. ... ..            |.| ||.|       |..|  
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

SIV------GTPIHMAPELFSGK-----YDNS-VDTYAFGILL
..|      |||. |||....|.     |... .| . .|...
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIF
Kinase Dusty.AA Ciliate-E2 777-852 26 2.2e-21 70.12 In-house 171-286 (365) Show / Hide 
Range on Protein: 777-852
Range on HMM: 171-286/365
Sequence Identity: 26% (32 aa)

EGVRYLHSLG-LVHRDIKLKNVLLDKHDRGKITDLGFCK--------------PEAMMSGS---------------------IVGTPIHMAPELFSGK--
....|||| .  .|||||. |.|.      ||.|.|..|               . .|  .                     |.|||  |||| ..||  
LALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKY

--------YDNSVDTYAFGILL
        || ..| ...|..|
DNQQKQKGYDYKCDIWSLGVIL
Kinase Dusty.AA Ciliate-E2-Unclassified 775-852 30 5.6e-21 69.52 In-house 152-260 (352) Show / Hide 
Range on Protein: 775-852
Range on HMM: 152-260/352
Sequence Identity: 30% (33 aa)

VAEGVRYLHSLG-LVHRDIKLKNVLLDKHD---RGKITDLGFCK-------------------PEAMMSGSIVGTPIHM----APELFSG-KYDNS----
. .|  |||. .  .|||||. |.|.|.     . ||.|.|..|                   .. ||. ...|||. |    |||.. | .||.|    
ILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMW-TFCGTPNYMPQYTAPEVLQGQNYDHSKAYK

VDTYAFGILL
.| ...|..|
CDIWSLGVIL
Kinase Dusty.AA TyrKc 665-921 22 6.7e-16 34.38 SMART 1-280 (280) Show / Hide 
Range on Protein: 665-921
Range on HMM: 1-280/280
Sequence Identity: 22% (64 aa)

PKLEREIGRGQYGVVYSCRSWGGVTHCAVKSVVPPDDKHWNDLAMEFHYTRSI-AEHDRIVAVIGSVIDHGYGGMGCSPAVLLLMERMQR-DLHTAIKAN
 .|....|.|..|.|| ..     . .|||.. .       |.  |    ...  .|. ||. .| ....|      .. ....|| |   ||.  ....
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRKH

ME---LPERLHVALDVAEGVRYLHSLGLVHRDIKLKNVLLDKHDRGKITDLGFCKPEAMM------SGSIV------GT---PIH-MAPELF-SGKYDNS
 .   ... |. ....|.| .|||| ...|||.   |.|...  . ||.| | ..           .  ..      |    ||  |||| .  ||.   
RPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

VDTYAFGILLWYVCAGHVKLPQAFEQ--CANKDHLWTSVKKGVRPERLRP-------QFDDASWNLMKSSWAGEPSERPLLEKVHLSX
 | ..||...| ..    . .   .|  . |.. .   ||.| |...             |.  ..||. |. .|..||  . .|   
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE-VIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Dusty.AA Pkinase_Tyr 666-853 23 9.2e-16 54.01 Pfam 2-205 (270) Show / Hide 
Range on Protein: 666-853
Range on HMM: 2-205/270
Sequence Identity: 23% (50 aa)

KLEREIGRGQYGVVYSCRSW----GGVTHCAVKSVVPPDDKH---WNDLAMEFHYTRSIAEHDRIVAVIGSVIDHGYGGMGCSPAVLLLMERMQR-DLHT
.. ...|.|..|.|| ..      .. ...|||.. .  ...   . |.  |    ...  |. ||  .| ..|.|  .      ... || |.  ||..
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMPHGDLLD

AIKAN------MELPERLHVALDVAEGVRYLHSLGLVHRDIKLKNVLLDKHDRGKITDLGFCKPE-------AMMSGSIVGTPIH-MAPE-LFSGKYDNS
  ...        ... |. ....|.|  ||.| ...|||.  .|.|...    ||.| | ..          . .|.    ||  |||| .. ||.   
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK--LPIKWMAPECINYGKFTTK

VDTYAFGILLW
 | ..||.|.|
SDVWSFGVLMW
Kinase Dusty.AA LISK-DD1 670-680 63 0.007841 6.36 In-house 1-11 (290) Show / Hide 
Range on Protein: 670-680
Range on HMM: 1-11/290
Sequence Identity: 63% (7 aa)

EIGRGQYGVVY
|||.| .| ||
EIGKGSFGKVY
Kinase Dusty.AA Ciliate-E2 665-685 42 0.014917 4.56 In-house 1-21 (365) Show / Hide 
Range on Protein: 665-685
Range on HMM: 1-21/365
Sequence Identity: 42% (9 aa)

PKLEREIGRGQYGVVYSCRSW
 |. . ||.|..|.|| |. |
YKFIKKIGQGNFGSVYKCKVW
Kinase Dusty.AA Ciliate-E2-Unclassified 666-683 44 0.021094 4.17 In-house 2-19 (352) Show / Hide 
Range on Protein: 666-683
Range on HMM: 2-19/352
Sequence Identity: 44% (8 aa)

KLEREIGRGQYGVVYSCR
|. . ||.|..|.|| |.
KIIKQIGQGGFGKVYKCQ
Kinase Dusty.AA ULK 666-680 37 0.078778 2.35 In-house 2-17 (324) Show / Hide 
Range on Protein: 666-680
Range on HMM: 2-17/324
Sequence Identity: 37% (6 aa)

KLEREIGRGQYG-VVY
 | ...| |..| .||
CLNHCLGKGSFGVKVY
Kinase Dusty.AA MLK 665-681 29 0.115872 1.7 In-house 1-17 (291) Show / Hide 
Range on Protein: 665-681
Range on HMM: 1-17/291
Sequence Identity: 29% (5 aa)

PKLEREIGRGQYGVVYS
 .... || | .|.|..
IQFHEWIGSGSFGKVWK
Kinase Dusty.AA Pkinase_Tyr 898-912 46 0.924022 3.2 Pfam 247-261 (270) Show / Hide 
Range on Protein: 898-912
Range on HMM: 247-261/270
Sequence Identity: 46% (7 aa)

NLMKSSWAGEPSERP
.|||. |. .|..||
DLMKQCWHYDPEDRP