Gene AqueK442 (A.queenslandica)

AqueK442

Species: A.queenslandica
Alias: AqueK442
External Links:
Annotation: Secondary Group: TK, Secondary Family: Tec

Classification

Group: TK
Family: Tec

Sequence

Name Sequence Type Origin Length Description Download
AqueK442.AA Protein None 252 None Fasta, JSON
AqueK442.kin_dom Protein Kinase Domain None 241 None Fasta, JSON
AqueK442.kin_dom2 Protein Kinase Domain None 285 None Fasta, JSON

Protein domain

Protein domains of AqueK442.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH2 AqueK442.AA SH2 6-35 36 8.5e-08 24.72 Pfam 52-81 (81) Show / Hide 
Range on Protein: 6-35
Range on HMM: 52-81/81
Sequence Identity: 36% (11 aa)

HYLIRIDEEKKYYIYNMHRFPTVTELIEYH
|| |. .....|||.  |.|... ||.|..
HYRIQRTDNGGYYITGRHKFCSLQELVEHY
Kinase AqueK442.AA Tec 77-252 50 9e-76 258.04 In-house 1-178 (254) Show / Hide 
Range on Protein: 77-252
Range on HMM: 1-178/254
Sequence Identity: 50% (90 aa)

LSLGKELGSGQFKRVVAGQWRNEVDVAIKIM-EGALNEDDLIKEAILMQKFQHDNLVKLCGVCIRQRSVYIITELMVNGSLLQYLCNNQRLVNKTD-ILL
| . ||||||||  |  |.||.. ||||| . ||.  |.| | ||  | | .| .||.| |||. || .||.|| | .|.|| ||  ..    |   |||
LTFMKELGSGQFGVVHLGKWRHQYDVAIKMIKEGSMSEEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHFQKNMAILL

DMAIQICATMKFLEQSGFIHRNLPARNCQVGYSNIVKVGGFSSARFVPDDEYEASVGVKYAVRWSPPEVITHARYSSK
.| ...|  | .||...|||| | |||| ||  ..|||  |  .|.| ||.|  ||| |. |.|.||||    |||||
EMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSK
Kinase AqueK442.AA SFK-Src 77-252 42 3e-60 176.99 In-house 1-179 (259) Show / Hide 
Range on Protein: 77-252
Range on HMM: 1-179/259
Sequence Identity: 42% (77 aa)

LSLGKELGSGQFKRVVAGQWRNEVDVAIKIM-EGALNEDDLIKEAILMQKFQHDNLVKLCGVCIRQRSVYIITELMVNGSLLQYLCN-NQRLVNKTDILL
  | | ||||||  |  | | |  .||.| .  ||  ..   .|| .| | .|.||..|  ||     .||||||| .|||| || . . |  .    | 
IRLEKKLGSGQFGDVWKGRWNNTTEVAVKTLKPGAMSAEEFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR-MPQLV

DMAIQICATMKFLEQSGFIHRNLPARNCQVGYSNIVKVGGFSSARFV-PDDE-YEASVGVKYAVRWSPPEVITHARYSSK
||| |. . | .||   |.|| | |||  || .|..||| |  .| .  ||| |.|  | |. ..|  ||  .  |.| |
DMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIK
Kinase AqueK442.AA Pkinase_Tyr 77-252 35 2.4e-54 184.7 Pfam 1-194 (270) Show / Hide 
Range on Protein: 77-252
Range on HMM: 1-194/270
Sequence Identity: 35% (70 aa)

LSLGKELGSGQFKRVVAGQWR-----NEVDVAIKIM-EGALNE----DDLIKEAILMQKF-QHDNLVKLCGVCI-RQRS--VYIITELMVNGSLLQYLCN
...||.||.|.| .|. | |.     ....||.|.. |||  |    .|...|| .| .. .|.|.|.| |||. ....  .||..|.| .|.|| || .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

N---QRLVNKTDILLDMAIQICATMKFLEQSGFIHRNLPARNCQVGYSNIVKVGGFSSARFV-PDDEY-EASVGVKYAVRWSPPEVITHARYSSK
.   .. ..  | ||.|..||.. | .||. ..||| | |||| |. .|.||.. |  || . .||.|  .. | |  ..| .||.| . ....|
HREDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTK
Kinase AqueK442.AA Src 77-252 38 3.2e-54 182.61 In-house 1-180 (255) Show / Hide 
Range on Protein: 77-252
Range on HMM: 1-180/255
Sequence Identity: 38% (70 aa)

LSLGKELGSGQFKRVVAGQWRNEVDVAIKIM-EGALNEDDLIKEAILMQKFQHDNLVKLCGVCIRQRSVYIITELMVNGSLLQYLC-NNQRLVNKTDILL
. | ..||.|||  |  | |.....||.| . .| .  ... .|| .| |..|..||.|  || .   .||.||.| .||||.||  . .    .  .|.
IKLCRKLGQGQFGEVWMGYWNGNTKVAVKTLKPGTMSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHLHLPQLI

DMAIQICATMKFLEQSGFIHRNLPARNCQVGYSNIVKVGGFSSARFVP--DDEYEASVGVKYAVRWSPPEVITHARYSSK
||| |. . |..||.  .||| | |||  || .|..||. |  || .   ||||.|. | |  ..|  || |.. |.. |
DMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIK
Kinase AqueK442.AA Abl 77-252 42 7.5e-52 171.0 In-house 1-178 (252) Show / Hide 
Range on Protein: 77-252
Range on HMM: 1-178/252
Sequence Identity: 42% (76 aa)

LSLGKELGSGQFKRVVAGQW-RNEVDVAIKIM-EGALNEDDLIKEAILMQKFQHDNLVKLCGVCIRQRSVYIITELMVNGSLLQYLCNNQRLVNKTDILL
... . || ||.  |  | | | .  ||.| . | ... .. .||| .|.. .| |||.| ||| |    ||||| | .| ||.|| ...|   .  .||
IMMKHKLGGGQYGEVYEGVWKRHDCTVAVKTLKEDTMEVHEFLKEAAIMKEMKHPNLVQLLGVCTREPPFYIITEFMCYGNLLDYLRECDREELPAVVLL

DMAIQICATMKFLEQSGFIHRNLPARNCQVGYSNIVKVGGFSSARFVPDDEYEASVGVKYAVRWSPPEVITHARYSSK
 || ||   |..||.  |||| | |||| ||  .||||  |  ||.. || | |  | |. ..|  || . . ..|||
YMATQIASGMSYLEKRHFIHRDLAARNCLVGEHHIVKVADFGLARMMKDDTYTAHAGAKFPIKWTAPESLAYNKFSSK
Kinase AqueK442.AA Frk 77-252 39 3.3e-49 168.56 In-house 1-182 (260) Show / Hide 
Range on Protein: 77-252
Range on HMM: 1-182/260
Sequence Identity: 39% (71 aa)

LSLGKELGSGQFKRVVAGQWRNEVDVAIKIME-GALNEDDLIKEAILMQKFQHDNLVKLCGVCIRQRSVYIITELMVNGSLLQYLC--NNQRLVNKTDIL
. | ..||||||  |  |.| |.. ||.| .  |... .|...|| .|.| .|  |..|  || ..  .||||||| .|||..||   |..    .  .|
IQLIRRLGSGQFGEVWEGLWNNTTPVAVKTLKPGTMDPNDFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQCQMQQL

LDMAIQICATMKFLEQSGFIHRNLPARNCQVGYSNIVKVGGFSSAR-FVPDDE--YEASVGVKYAVRWSPPEVITHARYSSK
.||| |. | | .||.  .||| | |||  || .||.|.  |  || .. |.|  ||. .|... ..|  || .   ... |
VDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIK
Kinase AqueK442.AA TK 77-252 17 2.6e-45 149.37 In-house 1-374 (486) Show / Hide 
Range on Protein: 77-252
Range on HMM: 1-374/486
Sequence Identity: 17% (65 aa)

LSLGKELGSGQFK---RVVAGQWRNE--------------------------VDVAIKIMEG--ALNEDDLIK--------------EAILMQKFQ----
. |||.||.|||    .|  |.||..                          ..||.|..    | .... .               ||  |....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HDNLVKLCGVCIRQRS------------VYIITELMVNGS----LLQYLCNNQRLVNK-----------------------------------------
 |.|.|.| ||| ....            ..|..|.| .|.    |..|| .. .  ..                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------TDILLD-------------------MAIQICATMKFLEQS------GFIHRNLPARNCQVGYSNI-----------VKVGGFS----
             |  ||.                   |. ||.. | .|..       .|.||.| |||| || .|.           .|.. |     
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----SARFVPDD-EYEASV------------------------GVKYAVRWSPPEVIT---------HARYSSK
     || ...| .| ..                         | |  .|| .||...         . ....|
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTK
Kinase AqueK442.AA SFK-Abl 79-252 42 8.1e-43 137.42 In-house 3-177 (251) Show / Hide 
Range on Protein: 79-252
Range on HMM: 3-177/251
Sequence Identity: 42% (75 aa)

LGKELGSGQFKRVVAGQWRNEVDVAIK-IMEGALNEDDLIKEAILMQKFQHDNLVKLCGVCIRQRSVYIITELMVNGSLLQYLCNNQRLVNKTDI-LLDM
||  || ||.  |  | | |   |||| | ....   |  |||  | . || |||.| ||| |    ||..| | .| || ||   |  .    . ..  
LGHRLGEGQYGEVYKGIWNNHR-VAIKTIKDESMETKDFMKEAHIMKRMQHPNLVRLIGVCTREGPMYIVQEFMNYGNLLDYLQSPQSRIQIDHVSMMHC

AIQICATMKFLEQSGFIHRNLPARNCQVGYSNIVKVGGFSSARFVPDDEYEASVGVKYAVRWSPPEVITHARYSSK
| ||   | |||   |||| | |||| ||    .||  |  ||||  | ||| .| |. ..|  ||    . .. |
AQQIADGMSFLEEQHFIHRDLAARNCLVGDNLQIKVADFGMARFVDSDFYEARIGTKMPIKWTAPESLCYDIFTIK
Kinase AqueK442.AA Src-Echino1 77-252 33 7.3e-42 142.88 In-house 1-177 (252) Show / Hide 
Range on Protein: 77-252
Range on HMM: 1-177/252
Sequence Identity: 33% (60 aa)

LSLGKELGSGQFKRVVAGQWRNEVDVAIKIM-EGALNEDDLIKEAILMQKFQHDNLVKLCGVCIRQRSVYIITELMVNGSLLQYLCNNQRLVNKTDILLD
| . |..|.|..  |  | |  . .||.| . |... . |.. || .|.| .|...|..  ||  .  .||.|||| ||.|..|| ...    |   |.|
LRMDKKIGKGHCGEVWKGVWNGNTPVAVKTLKEKTMSPADFLAEANVMKKCRHEGIVQIYAVCSDKEPIYIVTELMSNGNLQDYLKRGKCKHVKMTTLID

MAIQICATMKFLEQSGFIHRNLPARNCQVGYSNIVKVGGFSSARFVPDDEYEASVGVKYAVRWSPPEVITHARYSSK
|  .| . | .|..  ..||.| |||  ||  |..|.  |  ||.. .|.| .  | |. ..|  || . . |.  |
MGAHIASGMDYLGSKNVVHRDLAARNVLVGKGNVCKIADFGLARMMQKDVYCGKQGAKLPIKWTAPEAALYGRFTIK
Kinase AqueK442.AA SrcB 77-252 36 1.6e-41 138.17 In-house 1-176 (251) Show / Hide 
Range on Protein: 77-252
Range on HMM: 1-176/251
Sequence Identity: 36% (65 aa)

LSLGKELGSGQFKRVVAGQWRNEVDVAIKIM-EGALNEDDLIKEAILMQKFQHDNLVKLCGVCIRQRSVYIITELMVNGSLLQYLCNNQRLVNKTDILLD
| | | ||.|||  |  | ..|.. ||.| | .|..  .  ..|| .|.. ||| ||.|  |  .   .||||| | .|.|| .|  ..    . . |.|
LKLVKKLGAGQFGEVWMGYYNNHMKVAVKTMKQGTMSPEAFLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLSLPKLID

MAIQICATMKFLEQSGFIHRNLPARNCQVGYSNIVKVGGFSSARFVPDDEYEASVGVKYAVRWSPPEVITHARYSSK
|. ||   | ..|.  .||| | | |  |  . . |.  |  || . |.|| |  | |. ..|  || | .  .  |
MSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGCFTIK
Kinase AqueK442.AA Src-Unclassified 77-252 33 1.7e-40 136.5 In-house 1-207 (284) Show / Hide 
Range on Protein: 77-252
Range on HMM: 1-207/284
Sequence Identity: 33% (69 aa)

LSLGKELGSGQFKRVVAGQWRNEVDVAIKIM-EG---ALNEDDLI--------KEAILMQKFQHDNLVKLCGVCIRQRSVYIITELMVNGSLLQYLCNNQ
. | ..|| |||  |  | ||. ||||.| | .|    .              .|| .| |..| |||.| .|| .    |||||.|.||||||.|    
VHLLRKLGRGQFGEVWYGKWRGKVDVAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQWLREGG

RLVNKTDIL------------LDMAIQICATMKFLEQSGFIHRNLPARNCQVGYSN-----IVKVGGFSSA--RFVPDDEYEASVGVKYAVRWSPPEVIT
        .             |.| |.   |  ||  . .|| | |||  .|  |     .|||  |  |  . . ||.|..  | .  . |  || ..
GQYLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVPVVKVCDFGLARKKLMQDDNYCMRTGAMFPWKWMAPECFI

HARYSSK
    | |
YGNFSIK
Kinase AqueK442.AA TyrKc 77-252 23 2.3e-17 58.04 SMART 1-265 (280) Show / Hide 
Range on Protein: 77-252
Range on HMM: 1-265/280
Sequence Identity: 23% (63 aa)

LSLGKELGSGQFKRVVAGQWRNEVDVAIKIMEGALNEDDLIKEAILMQKF--QHDNLVKLCGVCIRQ-------RSVYIITELMVNGSLLQYLCNNQRLV
..|||.||.|.| .|. |.|.  ..||.| .     . |...|| .| |.  .|.|.|.| |||. |         ..|..|.| .|.|..|| ....  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-

NKTDILLDMAIQICATMKFLEQSGFIHRNLPARNCQVGYSNIVKVGGFSSARFVPDD--------EYEASV--GVK--YAVRWSPPEVITHARYSS----
 ... ||....||.. | .|.. ..||| | |||| ||  ..||.. |  .|.. ||         | ..   | |    .|| .||.| . ....    
LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDV

--------------------------------------------------------------------K
                                                                     
WSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHE
Kinase AqueK442.AA Pkinase 77-195 20 9.8e-15 53.19 Pfam 1-132 (293) Show / Hide 
Range on Protein: 77-195
Range on HMM: 1-132/293
Sequence Identity: 20% (27 aa)

LSLGKELGSGQFKRVVAGQWRNEVD-VAIKIMEGALNEDDLIK------EAILMQKFQHDNLVKLCGVCIRQRSVYIITELMVNG----SLLQYLC--NN
. .|. .||| | .|  ...... . ||.||..   ....  .      |. .|....|.| |.| ... . ...|...|.. .|    .|  |.   ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

QRLVNKTDILLDMAIQICATMKFLEQSGFIHR
 ..    . . ... ||.  .... . |.|||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHR
Kinase AqueK442.AA S_TKc 77-249 17 4.3e-10 -28.97 SMART 1-231 (231) Show / Hide 
Range on Protein: 77-249
Range on HMM: 1-231/231
Sequence Identity: 17% (42 aa)

LSLGKELGSGQFKRVVAGQWRN-EVDVAIKIMEGALNEDDLIKEAILMQKFQHDNLVKLCGVCIRQRSVYIITELMVN--GSLLQYLCNNQR----LVNK
  .....|.| | .|  .....    |||||.      .....|  ...| .|.|.||| .|.    ..|...|.. .  |.|..|.....|     .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

TDILLDMAIQICATMKFLEQSGFIHRNLPARNCQVGYSNIVKVGGFSSARFVPDD-------------EYEA------SVGV------------------
      .. |||  .... . |.||| |   |  .     .|.. | .||.. .               |        |.|.                  
E-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQMQMM

-------------------KYAVRWSPPEVIT-------HARY
                     . |..  |. .       |   
FKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF