Gene AqueK043 (A.queenslandica)

AqueK043

Species: A.queenslandica
Alias: AqueK043
External Links:
Annotation:

Classification

Group: Atypical
Family: PIKK
Subfamily: ATM

Sequence

Name Sequence Type Origin Length Description Download
AqueK043.AA Protein None 1792 None Fasta, JSON

Protein domain

Protein domains of AqueK043.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FAT AqueK043.AA FAT 943-1039 22 0.000237 14.8 Pfam 56-169 (408) Show / Hide 
Range on Protein: 943-1039
Range on HMM: 56-169/408
Sequence Identity: 22% (26 aa)

LLTL--KHNKKA--QFDEFITKGRASIINEMVS-TSLESVCNINPHLTRLQTLNELESTFQLV-LEPDL-------SPSVLLSN---WKGKLSNM-STDF
.| |  .||.    .. ..| |.|   . |. . .. ||     | . |.| | |||   |     ..        ||. . .    |.  | ..   ..
ILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNV

ELVELVLSVRFHAL
|  .  |..| |..
EVWQRILTWRQHVF
Kinase AqueK043.AA ATM 1458-1717 63 1.2e-146 471.93 In-house 1-259 (304) Show / Hide 
Range on Protein: 1458-1717
Range on HMM: 1-259/304
Sequence Identity: 63% (166 aa)

RQLIKGRDDLRQDAVMQQVFGLVNQLLCKKPSTANRKLLIRTYKVVPLSQCSGIVQWCEGTVPIGMYLVGPPESPLEGAHVRYRPKDWKNNECRAKFAQS
|||.|||||||||||||||| . | || .   |  ||| | ||||||||| ||.. || ||.||. .|.   .    ||| |||| |.    |  |    
RQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTGTIPIDKFLINNED----GAHKRYRPNDFSAFQCQKKMMEV

SK---GDKLTVYNQICKHFKPVFHHFFMESFPDPALWYERRLTYTRSIATSSIVGYIMGLGDRHVQNILIDKQSAELIHIDLGVAFEQGRALPTPEVIPF
 |    .|  |.  .|. |.|||  | || | |||.|.|.|| ||||.|||||||||.||||||||||||  |||||.|||||||||||. ||||| .||
QKKSFEEKYEVFMDVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPF

RLTRDLVSGMGITGVVGVFQRCCEETMEVMRSSHEELRTIVEVLLHDPLYIWTISNKKARHIQ
|||||.| ||||||| ||| |||| |||||| | | | ||||||| |||. ||.   ||  .|
RLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYDPLFDWTMNPLKALYLQ
Kinase AqueK043.AA PIKK 1427-1698 36 2e-98 333.31 In-house 1-290 (290) Show / Hide 
Range on Protein: 1427-1698
Range on HMM: 1-290/290
Sequence Identity: 36% (106 aa)

TITSFDAHFSLCGGVNLPKVLSALCSDGKRRRQLIKGRDDLRQDAVMQQVFGLVNQLLCKKPSTANRKLLIRTYKVVPLSQCSGIVQWCEGTVPIGMYLV
 | ..|           || .. . .|||  ..| ||..|||||....|.|.|.| .| | | .  |.| ||||.|.|.|| .|...|....|...  ..
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

GPPESPLEGAHVRYRPK--------------------DWKNNECRAKFAQSSKGDKLTVYNQICKH-FKPVFHHFFMESFPDPALWYERRLTYTRSIATS
       ...| |....                    . .  .   .   ..  .|..| . ..   . ..|. .|...||||. |.|||  |||| |..
----QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVM

SIVGYIMGLGDRHVQNILIDKQSAELIHIDLGVAFE-QGRALPTPEVIPFRLTRDLVSGMGITGVVGVFQRCCEETMEVMRSSHEELRTIVEVL
..|||| ||||||..||.||.|..|..|||.|..|| ... ||.|| .||||||..| .||..|| ||| |||| .|..||.. | | |..||.
CMVGYILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase AqueK043.AA PI3Kc 1458-1775 23 5.1e-76 259.79 SMART 1-336 (336) Show / Hide 
Range on Protein: 1458-1775
Range on HMM: 1-336/336
Sequence Identity: 23% (85 aa)

RQLIKGRDDLRQDAVMQQVFGLVNQLLCKKPSTANRKLLIRTYKVVPLSQCSGIVQWCEGTVPIGMYLVGP--------------------PESPLEGAH
. . |..||||||. |.|.|.|.| .. |   ...|.| .|.||..|.....|...|.  .... . ..                      ||.  .   
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEI--Q-K-

VRYRPKDWKNNEC----RAKFAQSSKGDKLTVYNQICKHFKPVFHHFFMESFPDP-ALWYERRLTYTRSIATSSIVGYIMGLGDRHVQNILIDKQSAELI
 .| . .|. ..|    ... . ...  |..   ..|....||....|.| ||||   |.|.| ..||| |  ..|.||.|.|||| .||..|... ...
NMY-MMIWHQQACHWMMMYQHMTHMEWLKYFEG-ATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCF

HIDLGVAFEQGRALPTP-----EVIPFRLTRDLVSGMG----ITGVVGVFQRCCEETMEVMRSSHEELRTIVEVLLHDPLYIWTISN-KKARHIQSSTAV
|||.| .|..|. .|..     |. |||||.|.| .||    ..|. | |..||......||...... ...|....||. ..  .. |. ......  .
HIDFGHIFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMMEKDIKYLRQRFRL

EWAGGDTSGANDVSSNNKMAERVLIRLQEK-----LEGVENGVQLSVGGQVTHLIQEA
.                 . ..  ..  ..     | . .|. ...   .. |.....
DH----------------LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase AqueK043.AA ATR 1426-1698 31 7.5e-60 202.48 In-house 1-267 (267) Show / Hide 
Range on Protein: 1426-1698
Range on HMM: 1-267/267
Sequence Identity: 31% (87 aa)

VTITSFDAHFSLCGGVNLPKVLSALCSDGKRRRQLIKGRDDLRQDAVMQQVFGLVNQLLCKKPSTANRKLLIRTYKVVPLSQCSGIVQWCEGTVPIGMYL
  |. ||    .   .  || .|   ||||    . | .||||.|   ...  |.|... |      | . .||| |.|| . ..|. | . |. .   |
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

VGPPESPLEGAHVRYRPKDWKNNECRAKFAQSSKGDKLTVY-NQICKHFKPVFHHFFMESFPDPALWYERRLTYTRSIATSSIVGYIMGLGDRHVQNILI
    .   .   .. . .. .    .   ...   .|. |. . .     |.|| .|   ||||  ||  |  | || |  ..||||.|||||| .||||
----DKLWKEKKQYMQFYQLRQCMDKKSREEW---EKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILI

DKQSAELIHIDLGVAFEQGRALPTPEVIPFRLTRDLVSGMGITGVVGVFQRCCEETMEVMRSSHEELRTIVEVL
||   |..|.|  . | .|. .  ||..|||||. .| |||  .  |.| | ||..| .||   ...  ...  
DKINGECVHVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase AqueK043.AA PI3_PI4_kinase 1458-1708 20 1.9e-57 201.94 Pfam 3-300 (300) Show / Hide 
Range on Protein: 1458-1708
Range on HMM: 3-300/300
Sequence Identity: 20% (69 aa)

RQLIKGRDDLR--QDAVMQQVF-----------------------GLVNQLLCKKPSTANRKLLIRTYKVVPLSQCSGIVQWCEGTVPIGMYLVGPPESP
... || ||||  ||. | | .                       .|.| .. |.  . .|.. ...|...|.. ..|...                   
PFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIE-------------------

LEGAHVRYRPKDWKNNECRAKFAQSSKGDKLTVYN-----------------------------QICKHFKPVFHHFFMESFPDP-ALWYERRLTYTRSI
            | .| .  .  .. .. |.   .                             .|.| .||.....|....||.   | |.| ...||.
------------WVPNCTTFHEIPRTYMVKCKHKHFNKEHKMWMKMWPDWWHLMRMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSC

ATSSIVGYIMGLGDRHVQNILI--DKQSAELIHIDLGVAFE--QGRALPTPEVIPFRLTR------DLVSGM------GITGVVGVFQRCCEETMEVMRS
|  ..|.||.|.||||  ||..  || . .|.||| | .|.  ..  .. || .|||.|.      ..|..|      . .|  | |...|.......|.
AGMCVVDYILGNGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRR

SHEELRTIV-------EVLLHDPLYIWTI
 .. . .         | ..||.|  |. 
HMNLCMNLLKKAVMRGECMVHDGLPMWRS
Kinase AqueK043.AA FRAP 1586-1708 44 1.8e-37 130.8 In-house 128-251 (251) Show / Hide 
Range on Protein: 1586-1708
Range on HMM: 128-251/251
Sequence Identity: 44% (55 aa)

PDPALWYERRLTYTRSIATSSIVGYIMGLGDRHVQNILIDKQSAELIHIDLGVAFEQG-RALPTPEVIPFRLTRDLVSGMGITGVVGVFQRCCEETMEVM
|   .|.|||  ||||.|| |..|||.||||||  ||......  ..||| |  ||   |    || ||||||| ||  | ..|. | .   ||  |.|.
PNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVI

RSSHEELRTIVEVLLHDPLYIWTI
|   | .  . |    |||. | .
REHKESVMAVLEAFVYDPLFYWRL
Kinase AqueK043.AA SMG1 1588-1650 49 6.8e-21 65.83 In-house 180-242 (242) Show / Hide 
Range on Protein: 1588-1650
Range on HMM: 180-242/242
Sequence Identity: 49% (31 aa)

PALWYERRLTYTRSIATSSIVGYIMGLGDRHVQNILIDKQSAELIHIDLGVAFEQGRALPTPE
|  |.     | || |  |.||||.||||||. |.|||    | .|||  . ||.|..|  ||
PDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase AqueK043.AA DNAPK 1607-1708 31 1.5e-16 56.59 In-house 199-301 (301) Show / Hide 
Range on Protein: 1607-1708
Range on HMM: 199-301/301
Sequence Identity: 31% (32 aa)

IVGYIMGLGDRHVQNILIDKQSAELIHIDLGVAFE-QGRALPTPEVIPFRLTRDLVSGMGITGVVGVFQRCCEETMEVMRSSHEELRTIVEVLLHDPLYI
| ..| | ||||  | ..     . | || | .|   .  || ||  ||||||  .  |   .. |..       |  .|.    |   ..|   ||.  
ISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTNFCDVFINDPSFD

WTI
|  
WKN
Kinase AqueK043.AA FRAP 1460-1514 43 2.3e-14 49.27 In-house 5-59 (251) Show / Hide 
Range on Protein: 1460-1514
Range on HMM: 5-59/251
Sequence Identity: 43% (24 aa)

LIKGRDDLRQDAVMQQVFGLVNQLLCKKPSTANRKLLIRTYKVVPLSQCSGIVQW
|.||..|.|||    | |||.|.||   | |  . | |. | ..|||  .|.. |
LLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGW
Kinase AqueK043.AA FATC 1760-1792 51 6.4e-14 47.63 Pfam 1-33 (33) Show / Hide 
Range on Protein: 1760-1792
Range on HMM: 1-33/33
Sequence Identity: 51% (17 aa)

VQLSVGGQVTHLIQEARDSVNLSSLFHGWQPWI
. ||| .|| .||||| |  ||. ...||.|| 
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase AqueK043.AA DNAPK 1426-1519 29 1.4e-09 30.83 In-house 2-95 (301) Show / Hide 
Range on Protein: 1426-1519
Range on HMM: 2-95/301
Sequence Identity: 29% (28 aa)

VTITSFDAHFSLCGGVNLPKVLSALCSDGKRRRQLIKGRDDLRQDAVMQQVFGLVNQLLCKKPSTANRKLLIRTYKVVPLSQCSGIVQWCEGTV
| |  ||        .  || .     | .    ..||  |||||    | |   |  .   |    | |  ||| ..|.    | . | . ||
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDNTV
Kinase AqueK043.AA SMG1 1444-1524 36 2.4e-08 23.6 In-house 10-91 (242) Show / Hide 
Range on Protein: 1444-1524
Range on HMM: 10-91/242
Sequence Identity: 36% (30 aa)

PKVLSALCSDGKRRRQLIKGRDDLRQDAVMQQVFGLVNQLLCKKPSTANRKLLIRTYKVVPLSQCSGIVQWCEGTVPI-GMY
|| |  | ||||    | || .||  |  . |   .|| .          .   | | | ||   ||..|| .|  |. |.|
PKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLY
Kinase AqueK043.AA ATM 1737-1752 81 4.3e-07 18.27 In-house 289-304 (304) Show / Hide 
Range on Protein: 1737-1752
Range on HMM: 289-304/304
Sequence Identity: 81% (13 aa)

SNNKMAERVLIRLQEK
| ||.|||||.|||||
SFNKVAERVLMRLQEK