Gene AqueK092 (A.queenslandica)

AqueK092

Species: A.queenslandica
Alias: AqueK092
External Links:
Annotation:

Classification

Group: CK1
Family: VRK

Sequence

Name Sequence Type Origin Length Description Download
AqueK092.AA Protein None 796 None Fasta, JSON
AqueK092.kin_dom Protein Kinase Domain None 163 None Fasta, JSON

Protein domain

Protein domains of AqueK092.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK092.AA VRK 49-313 40 1.4e-104 335.74 In-house 1-284 (284) Show / Hide 
Range on Protein: 49-313
Range on HMM: 1-284/284
Sequence Identity: 40% (117 aa)

WRLGKSIGKGAYGEVYEAFS--TAEE-FSGSYAIKVEP-ISNGPLFCEIQCYLDVAFSNKINDWVKSHD------------LKYLAMPQFIDWGKNETSP
|||||.||.| .|. |.|.   . ..  .. | .|.||  .||||| |. .|. .|  . |..| | |             |..|..| ..  |  .   
WRLGKPIGQGGFGCIYLASPNTCKPCEKDAQYVVKIEPPHENGPLFTEMHFYQRAAKPEQIQKWMKKHKSLPAPQTHVLSRLPWLGIPYCWGFGYHDFN-

SLQYCFLVMERFGDNIEKLFE-EAGRKFGVKTVCYLALRILEALEFLHNSGYAHADIKGSNILTGY-SQRDQVYLVDYGLSFVYQYSQGGHKPYTPDPGY
.  | |.||.|||  ..|. |   | .|  |||  ||.|.| .||.|| ..|.|.||| .||| |.    ||||||||||.. |. . | |..| .||  
GEKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCPN-GKHRQYKEDPRR

CY-GTLPFTSIDAHDGANPSRRGDLEILGYCLLEWSCGRLPWEDYIE--DRSKVASLKRRYKDAPTDLMKDCFKGNVYPKYLQKYM
|  ||. |||.||| | .||||.||||||||...|..| |||.|     |  ||   | .. | .  .|. ||. .  .....|||
CHNGTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAKQKFMDNIPEMMQKCFPWKQVCCEIGKYM
Kinase AqueK092.AA CK1 49-330 24 2.2e-63 216.87 In-house 1-339 (339) Show / Hide 
Range on Protein: 49-330
Range on HMM: 1-339/339
Sequence Identity: 24% (87 aa)

WRLGKSIGKGAYG-EVYEAF----STAEEFS----GSYAIKVEPI-SNGPLFCEIQCYLDVAFSNKINDWVK------SHDLK-YLA---MPQFIDWGKN
|...| ||.|..| ..|...    .  . ..      ||.||||. |.|... .. .|. ..  .....| |       |..|  ..    ..... |..
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKW-KASILKHKHFCKKHCGCPHPCMYWYHGEE

ETSPSLQYC-FLVMERFGDNIEKLFE---EAGRKFGVKTVCYLALRILEALEFLHNSGYAHADIKGSNILTGY--------------SQRDQVYLVDYGL
.     .|. ..||...| |.|.|..     .||| .||.  .|...|||||..|. |. | ||| .|.. |.              ....|||..|.|.
D-----DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGM

SF-VYQYSQGG------------HKPYTP---DPGYCYG-TLPFTSIDAHDGANPSRRGDLEILGYCLLEWSCGR--LPWED-YIEDR----SKVASLKR
.   |  ..|.            |.|. .     |.  | |. ..||..|.|  ..|| ||. ..|.|.||  |   ||| .   |..    . |   |.
ARRKYRDKDGHNRWNGPRDKTWQHRPPREHKKKKGF-RGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQ-VEKMKY

RYKDAPTDLMKDCFKGNV-----YPKYLQKYMECIYKLSYEETPKYNHL
 ..| .  .....  .       .|... |.|. | .|.|...|.|  .
EFIDEKKMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase AqueK092.AA CK1-D 135-330 33 2.4e-29 100.63 In-house 68-261 (261) Show / Hide 
Range on Protein: 135-330
Range on HMM: 68-261/261
Sequence Identity: 33% (66 aa)

QYCFLVMERFGDNIEKLFEEAGRKFGVKTVCYLALRILEALEFLHNSGYAHADIKGSNILTGYSQR-DQVYLVDYGLSFVYQYSQ-GGHKPYTPDPGYCY
.|  .||.  |  .| ||   .||| .|||  ||. ..  .|..|   . | |||  | | |  .| . ||..|.||.  |. ..   | ||  .     
DYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLT-

GTLPFTSIDAHDGANPSRRGDLEILGYCLLEWSCGRLPWEDYIEDRSKVASLKRRYKDAPTDLMKDCFKGNVYPKYLQKYMECIYKLSYEETPKYNHL
||  . ||  | |   ||| ||| ||| |. .  | |||        .    .   | . | . . |   . ||.  |.||.   .| ... | | .|
GTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLC---KGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase AqueK092.AA CK1-A 135-330 33 1.2e-28 98.23 In-house 68-261 (261) Show / Hide 
Range on Protein: 135-330
Range on HMM: 68-261/261
Sequence Identity: 33% (67 aa)

QYCFLVMERFGDNIEKLFEEAGRKFGVKTVCYLALRILEALEFLHNSGYAHADIKGSNILTGYSQR-DQVYLVDYGLSFVYQYSQG-GHKPYTPDPGYCY
.|  .||.  |  .| ||    |.| .|||  ||  ..  .|..|. .. | |||  | | |      ...|.|.||.  |. |.   | ||  |     
DYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYRED-KNLT

GTLPFTSIDAHDGANPSRRGDLEILGYCLLEWSCGRLPWEDYIEDRSKVASLKRRYKDAPTDLMKDCFKGNVYPKYLQKYMECIYKLSYEETPKYNHL
||  . ||.|| |   ||| |.| .||... .  |.|||        |    |   |   | . . | ||  .|  .  ||. . .| .||.| | .|
GTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLC-KG--FPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase AqueK092.AA CK1 138-271 37 5.1e-23 76.23 In-house 81-216 (271) Show / Hide 
Range on Protein: 138-271
Range on HMM: 81-216/271
Sequence Identity: 37% (52 aa)

FLVMERFGDNIEKLFEEAGRKFGVKTVCYLALRILEALEFLHNSGYAHADIKGSNILTGY--SQRDQVYLVDYGLSFVY-QYSQGGHKPYTPDPGYCYGT
..||.  | . |.||   .||| .|||. .|  ... .|..|| .. | |||  |.| |    . .|||..|.||.  | . . . | ||  . .   ||
IMVMDLLGPSLEDLFNFCNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLT-GT

LPFTSIDAHDGANPSRRGDLEILGYCLLEWSCGRLPW
  ..|| .| |   ||| |.| |||.|.    | |||
ARYASINTHLGIEQSRRDDMESLGYVLMYFLRGSLPW
Kinase AqueK092.AA Worm6 138-330 27 1e-22 78.54 In-house 79-279 (279) Show / Hide 
Range on Protein: 138-330
Range on HMM: 79-279/279
Sequence Identity: 27% (55 aa)

FLVMERFGDNIEKLFEEA-GRKFGVKTVCYLALRILEALEFLHNSGYAHADIKGSNILTGY------SQRDQVYLVDYGLSFVYQYSQGGHKPYTPD-PG
..||. .| | . | ... .||| . |   .|.  |||.| ||| |. | |.| .|   |        .. ..|..|.|..  ..|   | . .||  . 
YIVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTA

YCY-GTLPFTSIDAHDGANPSRRGDLEILGYCLLEWSCGRLPWEDYIEDRSKVASLKRRYKDAPTDLMKDCFKGNVYPKYLQKYMECIYKLSYEETPKYN
  . ||... .. .|.| . .|. |.|   | ..|. .|.|||   ..|.. |. .|..  .  .  |. .| |.. .. ... |. | ..||...| |.
CGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWR-HMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYK

HL
..
FI
Kinase AqueK092.AA TTBK 135-330 31 1.5e-20 69.41 In-house 69-257 (257) Show / Hide 
Range on Protein: 135-330
Range on HMM: 69-257/257
Sequence Identity: 31% (63 aa)

QYCFLVMERFGDNIEKLFEEAGR-KFGVKTVCYLALRILEALEFLHNSGYAHADIKGSNILTGY--SQRDQVYLVDYGLSFVYQYSQGGHKPYTPDPGYC
.. ..||.  | |   |  .. | .| . |   | . ||...|  |. |. | ||| ||   |   |.. ..|..|.||   |  ..|   |  .  |. 
KFNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFR

YGTLPFTSIDAHDGANPSRRGDLEILGYCLLEWSCGRLPWEDYIEDRSKVASLKRRYKDAPTDLMKDCFKGNVYPKYLQKYMECIYKLSYEETPKYNHL
 ||  . || ||   .  |. ||  | | | |   | |||   | |. .| ..| .|     .|.|.|      |. .. .|. |  | ||..| |  .
-GTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWRK-IKDKDQVGEMKEKYDHR--MLLKHC------PHEFHQFMDHIKSLNYEDRPDYQLI
Kinase AqueK092.AA CK1-Unclassified 138-211 40 5.1e-20 55.8 In-house 80-155 (244) Show / Hide 
Range on Protein: 138-211
Range on HMM: 80-155/244
Sequence Identity: 40% (31 aa)

FLVMERFGDNIEKLFEEAGRKFGVKTVCYLALRILEALEFLHNSGYAHADIKGSNILTG--YSQRDQVYLVDYGLS
..||.  | ..|.||   .||| .|||  .|  ... .|.||| .. | |||  |.| |    ...|||..|.|||
IMVMDLLGPSLEDLFNMCNRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLS
Kinase AqueK092.AA CK1-G 136-330 31 4.4e-19 61.24 In-house 70-266 (266) Show / Hide 
Range on Protein: 136-330
Range on HMM: 70-266/266
Sequence Identity: 31% (63 aa)

YCFLVMERFGDNIEKLFEEAGRKFGVKTVCYLALRILEALEFLHNSGYAHADIKGSNILTG-YSQRDQ--VYLVDYGLSFVYQYSQGG-HKPYTPDPGYC
|  .||.  |   | ||.  .||| ||||| .|  ... .| .|       |.|  | | | .|..||  ....|.|.   |   . . | ||       
YNIMVMDLLGPSLEDLFDWCDRKFSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLT

YGTLPFTSIDAHDGANPSRRGDLEILGYCLLEWSCGRLPWEDYIEDRSKVASLKRRYK---DAPTDL-MKDCFKGNVYPKYLQKYMECIYKLSYEETPKY
 ||  . ||  | |   ||| |.| ||   .    | |||        |   .| ||.   |    . ..|  ..| .|. . .|.. . .|...|.| |
-GTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGL-----KADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDY

NHL
..|
DYL
Kinase AqueK092.AA TTBKL 135-211 30 7.1e-15 46.73 In-house 73-156 (288) Show / Hide 
Range on Protein: 135-211
Range on HMM: 73-156/288
Sequence Identity: 30% (26 aa)

QYCFLVMERFGDNIEKLFEEAGRK--FGVKTVCYLALRILEALEFLHNSGYAHADIKGSNILTGYSQ-----RDQVYLVDYGLS
.|.|.||.  |.|. .|     .|  | . |.  .. ..|.||  .|  |. | |.| .|. .||..     .  |||.|.|..
DYNFMVMTLCGPNLQDLRKMMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMA
Kinase AqueK092.AA S_TKc 49-316 15 5.8e-11 -16.2 SMART 1-231 (231) Show / Hide 
Range on Protein: 49-316
Range on HMM: 1-231/231
Sequence Identity: 15% (45 aa)

WRLGKSIGKGAYGEVYEAFSTAEEFSGSYAIKVEPISNGPLFCEIQCYLDVAFSNKINDWVKSHDLKYLAMPQFIDWGKNETSPSLQYCFLVMERFGD--
..... |||||.|.|| .  .       .|||. .         .. .  ..   |          .     ...|.  .      .. ..|||  .   
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK---------EHIRREIQILKK----------HHPNIVKLYDVFQD------DHLYMVMEYCDGDL

-NIEKLFEEAGRK-----FGVKTVCYLALRILEALEFLHNSGYAHADIKGSNILTGYSQRDQVYLVDYGLSFVYQYSQGGHKPYTPDPGYCYGTLPFTSI
 .  .. .. ||.     |   ......  |..|||..|. |  | |.| .|||       .. . | ||. ..                . ||. . . 
GDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAP

DAHDGANPSR-RGDLEILGYCLLEWSCGRLPWEDYIEDRSKVASLKRRYKDAPTDLMKDCFKGNVY----PKYLQK-Y-----MECI
        .. . |   .| .| |  ||. |..    .  ..  . .   .   |... |.. .         . .       .. .
EVL---GYGKCKCDWWSCGCILYEMLCGYPPFP----QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK092.AA TTBKL 233-334 31 2.5e-08 24.31 In-house 191-288 (288) Show / Hide 
Range on Protein: 233-334
Range on HMM: 191-288/288
Sequence Identity: 31% (32 aa)

GTLPFTSIDAHDGANPSRRGDLEILGYCLLEWSCGRLPWEDYIEDRSKVASLKRRYKDAPTDLMKDCFKGNVYPKYLQKYMECIYKLSYEETPKYNHLRQ
||. ..|...||..  .|  ||  . | . |  || |||. ..||. .....|.  ||  .||.||...    |... | |. .  |.| ..| |  ...
GTTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWT-NMEDKMEIEHMKKNMKD--EDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYE

LF
.|
CF
Kinase AqueK092.AA CK1-Unclassified 237-271 54 3.9e-08 20.14 In-house 182-216 (244) Show / Hide 
Range on Protein: 237-271
Range on HMM: 182-216/244
Sequence Identity: 54% (19 aa)

FTSIDAHDGANPSRRGDLEILGYCLLEWSCGRLPW
..|| || |   ||| ||| |||.|.    |.|||
YASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPW
Kinase AqueK092.AA TTBKL 49-83 28 2e-06 17.46 In-house 1-33 (288) Show / Hide 
Range on Protein: 49-83
Range on HMM: 1-33/288
Sequence Identity: 28% (10 aa)

WRLGKSIGKGAYGEVYEAFSTAEEFSGSYAIKVEP
|.  |.||.|..|.||.. ..  . ....|...|.
WMIVKMIGEGGFGQVYHVWDM--KDKKDCAAMKEE
Kinase AqueK092.AA CK1 49-84 31 6e-06 16.62 In-house 1-36 (271) Show / Hide 
Range on Protein: 49-84
Range on HMM: 1-36/271
Sequence Identity: 31% (12 aa)

WRLGKSIGKGAYGEVYEAFSTAE--EFSGSYAIKVEPI
 |.|. || |. |..|..  .    |.   .|||.|..
YRVGRKIGQGSFGDIYLGINM-TNGEEN-HVAIKLEKN
Kinase AqueK092.AA TTBK 49-82 44 2.3e-05 14.92 In-house 1-33 (257) Show / Hide 
Range on Protein: 49-82
Range on HMM: 1-33/257
Sequence Identity: 44% (15 aa)

WRLGKSIGKGAYGEVYEAFSTAEEFSGSYAIKVE
|.  | || |..||.|||     .     |||||
WKVVKKIGGGGFGEIYEAKDMINHH-EQVAIKVE
Kinase AqueK092.AA Worm6 49-82 33 4.7e-05 14.46 In-house 1-34 (279) Show / Hide 
Range on Protein: 49-82
Range on HMM: 1-34/279
Sequence Identity: 33% (12 aa)

WRLGKSIGKGAYGEVYEAF--STAEEFSGSYAIKVE
| ..| ||.|..| ||..   |. .     .|.|.|
WKVTKKIGEGGFGAVYKVEDKSDKKK--KQFAMKCE
Kinase AqueK092.AA Pkinase 135-226 19 5.8e-05 18.62 Pfam 73-171 (293) Show / Hide 
Range on Protein: 135-226
Range on HMM: 73-171/293
Sequence Identity: 19% (20 aa)

QYCFLVMERFGDNIEKLFEEA-------GRKF--GVKTVCYLALRILEALEFLHNSGYAHADIKGSNILTGYSQRDQV----YLVDYGLSFVYQYSQGGH
... .|||  .   . ... .       ...|    ....  .. ||..||..|. |  | |.| .|||  .......     . | ||. ...    ..
DHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENIL--IDNNGHIDACVKICDFGLAKQFD-Y-NNS

KPYTP
 ..|.
-MTTF
Kinase AqueK092.AA CK1 300-328 34 0.000213 11.28 In-house 244-271 (271) Show / Hide 
Range on Protein: 300-328
Range on HMM: 244-271/271
Sequence Identity: 34% (10 aa)

FKGNVYPKYLQKYMECIYKLSYEETPKYN
.||| .|.... |.. . .|..||.|.| 
CKGN-FPNEFAMYLNYCRQLHFEEKPDYM
Kinase AqueK092.AA CK1-D 49-84 39 0.00032 10.61 In-house 1-34 (261) Show / Hide 
Range on Protein: 49-84
Range on HMM: 1-34/261
Sequence Identity: 39% (15 aa)

WRLGKSIGKGAYGEVY--EAFSTAEEFSGSYAIKVEPI
.|.|. || |..|..|  .  .| ||     |||.|.|
YRIGRKIGSGSFGDIYHGTNIQTNEEV----AIKLECI
Kinase AqueK092.AA CK1-Unclassified 49-82 32 0.000412 8.05 In-house 1-32 (244) Show / Hide 
Range on Protein: 49-82
Range on HMM: 1-32/244
Sequence Identity: 32% (11 aa)

WRLGKSIGKGAYGEVYEAFSTAEEFSGSYAIKVE
 |... || |. ||.|..  . ..    .|||.|
YRVIEKIGQGSFGEIYKCINMQTN--EEVAIKLE
Kinase AqueK092.AA Pkinase 49-66 38 0.001347 13.8 Pfam 1-18 (293) Show / Hide 
Range on Protein: 49-66
Range on HMM: 1-18/293
Sequence Identity: 38% (7 aa)

WRLGKSIGKGAYGEVYEA
...|. ||.|..|.||..
YHIGRKIGSGSFGCVYKC
Kinase AqueK092.AA CK1-G 49-65 52 0.005389 5.89 In-house 1-17 (266) Show / Hide 
Range on Protein: 49-65
Range on HMM: 1-17/266
Sequence Identity: 52% (9 aa)

WRLGKSIGKGAYGEVYE
.| || || | .||..|
YRVGKKIGCGNFGELFE
Kinase AqueK092.AA CK1-A 49-82 32 0.031261 3.48 In-house 1-32 (261) Show / Hide 
Range on Protein: 49-82
Range on HMM: 1-32/261
Sequence Identity: 32% (11 aa)

WRLGKSIGKGAYGEVYEAFSTAEEFSGSYAIKVE
.|| . || |..|..| . .. .      |||.|
YRLVRKIGSGSFGDIYLGINITN--GEEVAIKME
Kinase AqueK092.AA VRK 457-719 44 2.6e-125 402.98 In-house 1-284 (284) Show / Hide 
Range on Protein: 457-719
Range on HMM: 1-284/284
Sequence Identity: 44% (127 aa)

WRLEKSIRNGGFGLINEV----SPTTKSSGSYAIKVKP-QDNGPLFCEVAFYRRAATSDLINDWVKSHD------------LKYLAIPQFIDCGKHESSS
||| |.|  ||||.| .     ........ | .|. | ..||||| |. || |||  ..|..| | |             |..|.|| ..  | |.. .
WRLGKPIGQGGFGCIYLASPNTCKPCEKDAQYVVKIEPPHENGPLFTEMHFYQRAAKPEQIQKWMKKHKSLPAPQTHVLSRLPWLGIPYCWGFGYHDFNG

LQYRFLIMKRFGDNIEKLFE-EAGSKFGVKTVCYLALRILEALEYLHDSHYVHANIKGAHILTGY-SHRDQVYLVDYGLAFRYSPNGEHKPYKPDPRRSH
  |||..| |||  ..|. |   | .|  |||  ||.|.| .|||||.. |||..|| | || |.    |||||||||||.|| ||| |..||.|||| |
EKYRFMVMPRFGRDLQKIYEDQNGHRFSMKTVLQLACRMLDVLEYLHENEYVHGDIKAANILLGFEKNPDQVYLVDYGLAYRYCPNGKHRQYKEDPRRCH

DGTIEFTSIDAHDGASPSRRGDLEILGYCLLQWSCGRLPWEDYIN--DMPMVASLKRRYKDVPTNLIKDCFKGKTYPKCLKSYM
.||.||||.||| | .||||.||||||||...|..| |||.|     | . |   | .. | .  . . ||. |  .. .  ||
NGTCEFTSMDAHKGCAPSRRSDLEILGYCMMMWLYGYLPWMDCLQQQDPEKVQDAKQKFMDNIPEMMQKCFPWKQVCCEIGKYM
Kinase AqueK092.AA CK1 457-736 23 3.7e-64 219.47 In-house 1-339 (339) Show / Hide 
Range on Protein: 457-736
Range on HMM: 1-339/339
Sequence Identity: 23% (82 aa)

WRLEKSIRNGGFG-LINEVSPT--TKSSGS-------YAIKVKPQD-NGPLFCEVAFYRRAATSDLINDWVK------SHDLK-YLAIPQFIDCGKHESS
|...| |  ||||  | .|...  . ....       ||.|| | . .|... .  .|.. .    ...| |       |..|  ...| .. .. |   
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKW-KASILKHKHFCKKHCGCPHPCMYWYHGEE

SLQYRFLIMKRFGDNIEKLFE---EAGSKFGVKTVCYLALRILEALEYLHDSHYVHANIKGAHILTGY--------------SHRDQVYLVDYGLAF-RY
   |....| ..| |.|.|..     . || .||.  .|...||||||.|| ...| .|| . .. |.              . ..|||..|.|.|  .|
DDYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKY

SPNGEHK----------PYKPDPR----RSHDG-TIEFTSIDAHDGASPSRRGDLEILGYCLLQWSCGR--LPWED-YINDM----PMVASLKRRYKDVP
 ....|.           ..| ..    ... | |....||..|.|  ..|| ||. ..|.|. |  |   ||| .   ...      |   |. ..| .
RDKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQ-VEKMKYEFIDEK

TNLIKDCFKGKT-----YPKCLKSYMESIYKLSYEEIPKYENL
 .. ...  ..      .|...  .|. | .|.|...|.||..
KMSTPFF-LCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase AqueK092.AA CK1-A 541-736 32 2.7e-27 93.43 In-house 68-261 (261) Show / Hide 
Range on Protein: 541-736
Range on HMM: 68-261/261
Sequence Identity: 32% (64 aa)

QYRFLIMKRFGDNIEKLFEEAGSKFGVKTVCYLALRILEALEYLHDSHYVHANIKGAHILTGYS-HRDQVYLVDYGLAFRY--SPNGEHKPYKPDPRRSH
.|  ..|   |  .| ||     .| .|||  ||  ..  .||.|   ..|  ||    | |   |  ...|.|.||| .|  |   .| ||. |  .  
DYNVMVMDLLGPSLEDLFNFCKRRFTMKTVLMLADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYRED--KNL

DGTIEFTSIDAHDGASPSRRGDLEILGYCLLQWSCGRLPWEDYINDMPMVASLKRRYKDVPTNLIKDCFKGKTYPKCLKSYMESIYKLSYEEIPKYENL
 ||. . ||.|| |   ||| |.| .||... .  |.|||             |   | . | . . |   | .|  .  ||. . .| .|| | |  |
TGTARYASINAHLGIEQSRRDDMESMGYVMMYFNRGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLC---KGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase AqueK092.AA CK1-D 541-736 32 1.3e-25 87.25 In-house 68-261 (261) Show / Hide 
Range on Protein: 541-736
Range on HMM: 68-261/261
Sequence Identity: 32% (65 aa)

QYRFLIMKRFGDNIEKLFEEAGSKFGVKTVCYLALRILEALEYLHDSHYVHANIKGAHILTGYSHR-DQVYLVDYGLAFRYSPNG--EHKPYKPDPRRSH
.|  ..|   |  .| ||   . || .|||  ||. ..  .||.|   ..|  ||    | |  .| . ||..|.||| ||      .| ||. .  .. 
DYNVMVMDLLGPSLEDLFNYCHRKFSLKTVLMLADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYREN--KNL

DGTIEFTSIDAHDGASPSRRGDLEILGYCLLQWSCGRLPWEDYINDMPMVASLKRRYKDVPTNLIKDCFKGKTYPKCLKSYMESIYKLSYEEIPKYENL
 ||  . ||  | |   ||| ||| ||| |. .  | |||             .   | . |.. . |   | ||.  . ||.   .| ... | |  |
TGTARYASINTHQGIEQSRRDDLESLGYVLMYFNRGSLPWQGLKAATKRQKYERICEKKMSTKIDTLC---KGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase AqueK092.AA CK1-Unclassified 541-677 38 4e-23 65.12 In-house 75-216 (244) Show / Hide 
Range on Protein: 541-677
Range on HMM: 75-216/244
Sequence Identity: 38% (55 aa)

Q--YRFLIMKRFGDNIEKLFEEAGSKFGVKTVCYLALRILEALEYLHDSHYVHANIKGAHILTG--YSHRDQVYLVDYGLAFRYS---PNGEHKPYKPDP
|  | ...|   | ..|.||   . || .|||  .|  ... .||||  ...|  ||   .| |    ...|||..|.||. ||     .|.| ||. . 
QGDYNIMVMDLLGPSLEDLFNMCNRKFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYREN-

RRSHDGTIEFTSIDAHDGASPSRRGDLEILGYCLLQWSCGRLPW
 ..  ||  ..|| || |   ||| ||| |||.|.    |.|||
-KNLTGTARYASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPW
Kinase AqueK092.AA CK1 526-677 36 5.7e-21 69.08 In-house 65-216 (271) Show / Hide 
Range on Protein: 526-677
Range on HMM: 65-216/271
Sequence Identity: 36% (58 aa)

IPQFIDCGKHESSSLQ--YRFLIMKRFGDNIEKLFEEAGSKFGVKTVCYLALRILEALEYLHDSHYVHANIKGAHILTGY--SHRDQVYLVDYGLAFRY-
||. . ||. |    |  | ...|   | . |.||   . || .|||. .|  ... .||.|  ...|  ||   .| |    | .|||..|.||| || 
IPHMYWCGQEE----QGDYNIMVMDLLGPSLEDLFNFCNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYR

-SPNGEHKPYKPDPRRSHDGTIEFTSIDAHDGASPSRRGDLEILGYCLLQWSCGRLPW
 . ...| ||. .  ..  ||  ..|| .| |   ||| |.| |||.|.    | |||
DDKTHQHIPYREN--KNLTGTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGSLPW
Kinase AqueK092.AA CK1-G 542-736 30 4.3e-18 57.82 In-house 70-266 (266) Show / Hide 
Range on Protein: 542-736
Range on HMM: 70-266/266
Sequence Identity: 30% (62 aa)

YRFLIMKRFGDNIEKLFEEAGSKFGVKTVCYLALRILEALEYLHDSHYVHANIKGAHILTG-YSHRDQ--VYLVDYGLAFRY--SPNGEHKPYKPDPRRS
|  ..|   |   | ||.  . || ||||| .|  ... .||.|. | .   .|    | | .| .||  ....|.|.|  |     . | ||    ..|
YNIMVMDLLGPSLEDLFDWCDRKFSVKTVCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYR--EHKS

HDGTIEFTSIDAHDGASPSRRGDLEILGYCLLQWSCGRLPWEDYINDMPMVASLKRRYKDV----PTNLIKDCFKGKTYPKCLKSYMESIYKLSYEEIPK
  ||  . ||  | |   ||| |.| ||   .    | |||     |      .| ||. .        |.|  .....|. .  |.. . .|...| | 
LTGTARYMSINTHLGREQSRRDDMEALGHMFMYFLRGSLPWQGLKADN-----NKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPD

YENL
|. |
YDYL
Kinase AqueK092.AA TTBKL 526-740 27 9.5e-14 42.87 In-house 62-288 (288) Show / Hide 
Range on Protein: 526-740
Range on HMM: 62-288/288
Sequence Identity: 27% (64 aa)

IPQFIDCGKHESSSLQYRFLIMKRFGDNIEKLFEEAGSK--FGVKTVCYLALRILEALEYLHDSHYVHANIKGAHILTGYS-H----RDQVYLVDYGLAF
.|.....|| .    .|.|..|   |.|. .|      |  | . |.  .. ..|.|| ..||  ..|  .| . . .||. |    .  |||.|.|.| 
FPKCHCSGKRK----DYNFMVMTLCGPNLQDLRKMMPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMAR

RYS-PNGEH----KPYKPDPRRSHD--------GTIEFTSIDAHDGASPSRRGDLEILGYCLLQWSCGRLPWEDYINDM-PM-VASLKRRYKDVPTNLIK
.|  ..||     .  |   ||  .        ||. ..|...||..  .|  ||  . | .    || |||.   | . .| ....|.  ||   .| |
QYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNMHDRKEQGRHDDLWSWMYMIIELHCG-LPWT---NMEDKMEIEHMKKNMKDE--DLFK

DCFKGKTYPKCLKSYMESIYKLSYEEIPKYENLKNLF
|... .  |... . |. .  |.| . | || . ..|
DMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase AqueK092.AA Worm6 527-736 21 2.8e-13 44.3 In-house 64-279 (279) Show / Hide 
Range on Protein: 527-736
Range on HMM: 64-279/279
Sequence Identity: 21% (48 aa)

PQFIDCGKHESSSLQ-YRFLIMKRFGDNIEKLFEEA-GSKFGVKTVCYLALRILEALEYLHDSHYVHANIKGAHILTGY------SHRDQVYLVDYGLAF
....|.|| ..     .....|. .| | . | ... . || . |   .|.  |||.| ||  ...| ..| ..   |         . ..|..|.|.. 
CKIEDRGKVDN---RGFNYIVMTLVGKNLWDLRKNRPDRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCR

-RYSPNGEHKPYKPD-PRRSHDGTIEFTSIDAHDGASPSRRGDLEILGYCLLQWSCGRLPWEDYINDMPMVASLKRRYKDVPTNLIKDCFKGKTYPKCLK
 ..  | . . ..|  ..    ||  . .. .|.|   .|. |.|   | .. . .|.|||   ..|.  |. .|..  .  .  .. .| |.. .. ..
RKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWR-HMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFN

SYMESIYKLSYEEIPKYENL
  |. | ..||.. | |...
DIMDYIDQYSYWDRPDYKFI
Kinase AqueK092.AA TTBK 528-736 29 6.8e-13 41.93 In-house 60-257 (257) Show / Hide 
Range on Protein: 528-736
Range on HMM: 60-257/257
Sequence Identity: 29% (63 aa)

QFIDCGKHESSSLQYRFLIMKRFGDNIEKLFEEAGS-KFGVKTVCYLALRILEALEYLHDSHYVHANIKGAHILTGY--SHRDQVYLVDYGLAFRY-SPN
.|| || ..    .. ...|.  | |   |  ..   .| . |   | . ||...|  |.  . |  ||      |   | . ..|..|.||| .|    
RFIGCGRND----KFNYMVMQLQGKNLADLRRKQPRGCFSLSTTLRLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNAC

GEHKPYKPDPRRS--HDGTIEFTSIDAHDGASPSRRGDLEILGYCLLQWSCGRLPWEDYINDMPMVASLKRRYKDVPTNLIKDCFKGKTYPKCLKSYMES
||  |    || .    ||. . || ||      |. ||  | | |     | |||   | |   | ..| .|  .   |.|.|      |. .. .|. 
GEVRP----PREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEFVQGQLPWRK-IKDKDQVGEMKEKYDHR--MLLKHC------PHEFHQFMDH

IYKLSYEEIPKYENL
|  | ||. | |  .
IKSLNYEDRPDYQLI
Kinase AqueK092.AA CK1 706-734 31 0.005969 6.23 In-house 244-271 (271) Show / Hide 
Range on Protein: 706-734
Range on HMM: 244-271/271
Sequence Identity: 31% (9 aa)

FKGKTYPKCLKSYMESIYKLSYEEIPKYE
.||. .|. .  |.. . .|..|| |.|.
CKGN-FPNEFAMYLNYCRQLHFEEKPDYM
Kinase AqueK092.AA Worm6 457-488 30 0.044354 3.67 In-house 1-33 (279) Show / Hide 
Range on Protein: 457-488
Range on HMM: 1-33/279
Sequence Identity: 30% (10 aa)

WRLEKSIRNGGFGLINEVSPTTKSSG-SYAIKV
| ..| |  |||| . .|. ... .   .|.|.
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKC
Kinase AqueK092.AA TTBKL 457-488 31 0.123368 1.38 In-house 1-31 (288) Show / Hide 
Range on Protein: 457-488
Range on HMM: 1-31/288
Sequence Identity: 31% (10 aa)

WRLEKSIRNGGFGLINEVSPTTKSSGSYAIKV
|. .|.|  |||| . .|.  .|.....|...
WMIVKMIGEGGFGQVYHVW-DMKDKKDCAAMK
Kinase AqueK092.AA TTBK 457-488 40 0.174493 1.05 In-house 1-32 (257) Show / Hide 
Range on Protein: 457-488
Range on HMM: 1-32/257
Sequence Identity: 40% (13 aa)

WRLEKSIRNGGFGLINEVSPTTKSSGSYAIKV
|.  | |  |||| | |           ||||
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKV
Kinase AqueK092.AA Pkinase 563-586 29 7.577272 0.54 Pfam 104-126 (293) Show / Hide 
Range on Protein: 563-586
Range on HMM: 104-126/293
Sequence Identity: 29% (7 aa)

SKFGVKTVCYLALRILEALEYLHD
. |  ....  .. ||..|||.|.
Y-FSEWECKFYMYQILRGLEYCHS