Gene AqueK136 (A.queenslandica)

AqueK136

Species: A.queenslandica
Alias: AqueK136
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a2

Sequence

Name Sequence Type Origin Length Description Download
AqueK136.AA Protein None 2522 None Fasta, JSON
AqueK136.kin_dom Protein Kinase Domain None 184 None Fasta, JSON

Protein domain

Protein domains of AqueK136.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
CAP_GLY AqueK136.AA CAP_GLY 103-179 32 2.1e-07 28.05 Pfam 1-72 (72) Show / Hide 
Range on Protein: 103-179
Range on HMM: 1-72/72
Sequence Identity: 32% (27 aa)

VGDKVIFKLEIAPRTATASVNGTIRYIGPHP-DSDGIVFGIEI-DARDQAYRGKGTSNGS----PYFTC-GPNNAAFVAMDKII
||| .        ..      ||.||.|| |  . |.  |.|  |      |||   .||     ||.|  || . ||  .|. 
VGDRCEV------WDGGGGRRGTVRYVGPTPGFKPGTWVGVEWDDEP----RGK--NDGSVQGVRYFECRPPNHGIFVRPSKVE
CAP_GLY AqueK136.AA CAP_GLY 264-288 40 0.361649 6.65 Pfam 1-24 (72) Show / Hide 
Range on Protein: 264-288
Range on HMM: 1-24/72
Sequence Identity: 40% (10 aa)

EGDRVIIQTVKEEVVGGTVRWVGPI
 |||. .    ..   ||||.|||.
VGDRCEV-WDGGGGRRGTVRYVGPT
Kinase AqueK136.AA TKL 718-780 23 4.5e-12 39.76 In-house 1-98 (364) Show / Hide 
Range on Protein: 718-780
Range on HMM: 1-98/364
Sequence Identity: 23% (23 aa)

LGSGGWGKVEVGLLHG----------QKVAVKMLHS-------------------------DIKSLYYNQLVRREISMLAKVRHPNLLLFIAGVLDHP
.|||| |.|  | ..|          . ||||...|                         | ..  ...  ..|| |. . ||||...|.. ... |
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP
Kinase AqueK136.AA MLK 712-781 27 1.7e-11 36.3 In-house 1-83 (291) Show / Hide 
Range on Protein: 712-781
Range on HMM: 1-83/291
Sequence Identity: 27% (23 aa)

LTNKDTLGSGGWGKVEVGLLHGQK-----VAVKMLHSDI--KSLYY--NQLVRREISMLAKVRHPN----LLLFIAGVLDHPS
....  .|||. |||. |  ...      ||||. ...|  ||  |   . ...|.  |....|||       | .. |..|.
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPC
Kinase AqueK136.AA Pkinase_Tyr 712-779 24 3.7e-10 35.03 Pfam 1-76 (270) Show / Hide 
Range on Protein: 712-779
Range on HMM: 1-76/270
Sequence Identity: 24% (19 aa)

LTNKDTLGSGGWGKVEVGLLH------GQKVAVKML--HSDIKSLYYNQLVRREISMLAKV-RHPNLLLFIAGVLDH
.|   .||.|  |.|  | ..      ...||||||  ... . . . .   ||.... .  .|||.. ... ..|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN-CREDFMREAKIMKQLGHHPNIVRLYGVCTDQ
Kinase AqueK136.AA Dicty4 712-772 33 4.4e-10 30.0 In-house 1-63 (277) Show / Hide 
Range on Protein: 712-772
Range on HMM: 1-63/277
Sequence Identity: 33% (21 aa)

LTNKDTLGSGGWGKVEVGLLHGQKVAVKML--HSDIKSLYYNQLVRREISMLAKVRHPNLLLF
..  . .|.|. |.|  |   |..||||.|  | .  ...  .  |.|.. ..| ||||..||
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLF
Kinase AqueK136.AA LISK 717-773 35 3.7e-09 25.7 In-house 1-62 (296) Show / Hide 
Range on Protein: 717-773
Range on HMM: 1-62/296
Sequence Identity: 35% (22 aa)

TLGSGGWGKVEVGLLH--GQKVAVKMLHS---DIKSLYYNQLVRREISMLAKVRHPNLLLFI
 .|.|. |||  | .   || .|.||.|.   | .   |   . ||. |. . |||| . |.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFM
Kinase AqueK136.AA Pkinase 712-773 27 7.1e-07 25.39 Pfam 1-66 (293) Show / Hide 
Range on Protein: 712-773
Range on HMM: 1-66/293
Sequence Identity: 27% (18 aa)

LTNKDTLGSGGWGKVEVGLLHGQK--VAVKMLHSDIKSLYYNQLVRR--EISMLAKVRHPNLLLFI
.. . ..|||. |.|  .  .|    |||| .  . ..   .|  ||  ||.......||| . ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLY
Kinase AqueK136.AA STE 712-768 16 9.9e-07 19.92 In-house 1-91 (359) Show / Hide 
Range on Protein: 712-768
Range on HMM: 1-91/359
Sequence Identity: 16% (15 aa)

LTNKDTLGSGGWGKVEVGLLH-----------------GQKVAVKMLHSDIKS---------------LYYNQLVRREISMLAKVR--HPN
... . .|.|. |.|  .. |                 |. .|.| .. . ..                   | . .||... | .  |||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPN
Kinase AqueK136.AA TKL-Unique 716-788 26 6e-06 17.21 In-house 3-80 (290) Show / Hide 
Range on Protein: 716-788
Range on HMM: 3-80/290
Sequence Identity: 26% (21 aa)

DTLGSGGWGKVEVGLLHGQKVAVKMLHSDIKSLYYNQLVR---REISMLAKVR-HPNLLLFIAGVLD---HPSGRELVIE
 ..|.|| |.|  |  .| .||.| .|   ...  |....   .|.. . | . |||.......  |   .|. . .| |
NKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVME
Kinase AqueK136.AA CZAK 712-773 28 1e-05 17.02 In-house 1-66 (279) Show / Hide 
Range on Protein: 712-773
Range on HMM: 1-66/279
Sequence Identity: 28% (19 aa)

LTNKDTLGSGGWGKVEVGLLHGQKVAVKMLHSDI-KSLYYN---QLVRREISMLAKVRHPNLLLFI
|.   | | |  |.|  .   |  ||.| .| .  . .  |       .|.| . | .||| . |.
LKFGQTIGQGFFGEVYKAYWRGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFL
Kinase AqueK136.AA DRK 719-773 35 3.7e-05 13.47 In-house 8-63 (258) Show / Hide 
Range on Protein: 719-773
Range on HMM: 8-63/258
Sequence Identity: 35% (20 aa)

GSGGWGKVEVGLLHGQKVAVKMLHSDIKS-LYYNQLVRREISMLAKVRHPNLLLFI
| |..| |  |   | .||||||  .    .   .  .||| .. . ||||  .|.
GRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFM
Kinase AqueK136.AA TK 712-779 16 7.2e-05 11.42 In-house 1-115 (486) Show / Hide 
Range on Protein: 712-779
Range on HMM: 1-115/486
Sequence Identity: 16% (19 aa)

LTNKDTLGSGG---WGKVEVGLLHG---------------------------QKVAVKMLHSDIKSLYYNQLV---------------RREISMLA--KV
.|  ..||.|    .|.|  |...|                           ..||||||...  .    ..                 .|..|.   . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNLLLFIAGVLDH
.|||.. ... ....
HHPNIVRLYGVCTQG
Kinase AqueK136.AA TK-Unique 712-770 26 0.000257 10.93 In-house 1-67 (294) Show / Hide 
Range on Protein: 712-770
Range on HMM: 1-67/294
Sequence Identity: 26% (18 aa)

LTNKDTLGSGGWGKVEVGLLHG--------QKVAVKMLHSDIKSLYYNQLVRREISMLAKVRHPNLL
|...|..|.|  | |  | . |        ..||||||. .   .   .. ..   | .. .|||..
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIV
CAP_GLY AqueK136.AA CAP_GLY 863-937 28 3.8e-07 27.19 Pfam 1-72 (72) Show / Hide 
Range on Protein: 863-937
Range on HMM: 1-72/72
Sequence Identity: 28% (23 aa)

IGDVVIFKLKVKPDAAPSIVKGIIRYIGPIQ-GKNGTHFGIEI-QEQRYRGRGTSNGD----PYFHC-GSKDAIFVSMDKIT
.|| .           ..  .|..||.||.. .|.||  |.|  .|    .||  .|      || |   . .|||  .|..
VGDRCEV------WDGGGGRRGTVRYVGPTPGFKPGTWVGVEWDDE----PRGKNDGSVQGVRYFECRPPNHGIFVRPSKVE
CAP_GLY AqueK136.AA CAP_GLY 991-1015 40 0.000208 17.79 Pfam 1-24 (72) Show / Hide 
Range on Protein: 991-1015
Range on HMM: 1-24/72
Sequence Identity: 40% (10 aa)

VGDRVVVKSVKDEVFNGTIKWVGTT
||||..| .  .. . ||...||.|
VGDRCEV-WDGGGGRRGTVRYVGPT
CAP_GLY AqueK136.AA CAP_GLY 1286-1356 27 5.4e-15 54.16 Pfam 1-72 (72) Show / Hide 
Range on Protein: 1286-1356
Range on HMM: 1-72/72
Sequence Identity: 27% (20 aa)

IGSMLCIDTQRGDPLYGVVQWIGTVPDYPG-TIAGVEL-ERPLRDCTDGTWGGRRFFTC-PYGRAYFCPLNNLK
.|.  ..  . |.  .|.| ..|..|  .. | .|||.   | |   ||...|.| |.| | ... |.. ....
VGDRCEV-WDGGGGRRGTVRYVGPTPGFKPGTWVGVEWDDEP-RGKNDGSVQGVRYFECRPPNHGIFVRPSKVE
BBOX AqueK136.AA BBOX 1598-1652 19 0.000412 15.17 SMART 1-51 (51) Show / Hide 
Range on Protein: 1598-1652
Range on HMM: 1-51/51
Sequence Identity: 19% (12 aa)

RGGQKCKVCL-RDSASSVC-YTCPKDPFNITDRYVYYCSECDER-VH---QGHKGHRVEAV
.  ..|...  .  |   |  .| .           .| .|||  .|   .  .||.|  .
HRPPMCDNHQQHEPAHFFCVEDCQQ----------CLCWDCDESGEHQANKLFRGHQVVPL
CAP_GLY AqueK136.AA CAP_GLY 1730-1786 33 7.1e-11 40.02 Pfam 15-72 (72) Show / Hide 
Range on Protein: 1730-1786
Range on HMM: 15-72/72
Sequence Identity: 33% (20 aa)

YGVVQWIGTLPNFNE-TIAGLEM-EKTVIGGTDGTVWDGRRFFSC-PPGKGYFCPLNTLK
.|.| ..|..|.|   | .| |.  .   |  ||.| .|.| |.| ||. | |.. ....
RGTVRYVGPTPGFKPGTWVGVEWDDEP-RGKNDGSV-QGVRYFECRPPNHGIFVRPSKVE
Kinase AqueK136.AA PIG-U 2339-2509 45 2.3e-69 241.55 Pfam 4-178 (178) Show / Hide 
Range on Protein: 2339-2509
Range on HMM: 4-178/178
Sequence Identity: 45% (79 aa)

LDRCIANNLLVPDFTPNVGLFWYFFMEMFDHFQVFFLCVFQINAFIHAIPLTIRFNQD--PMFLVYTLLSLISLFKSYPTVADFIIPVSLLPLWTHVFRY
|...  . |..|| |||.||.|||| ||||||. |||.||.|..|.  ||||||....  |.|.. .....||.||.||||.|  .  ||||.| |.|.|
LKNTYGFILTFPDLTPNIGLWWYFFTEMFDHFRPFFLFVFWIHVFFYIIPLTIRLRKQGDPFFAFCMCIGWISIFKPYPTVGDVGFYLSLLPIWKHIFPY

MRFTPVIIGCVLVSSIAGPITWYLWIHTGSANANFFFALTLTYCISQIFLLLDVCH--SYLTHQYDMTNGLPRTS
||.. .|.   |..|| .||.|..||  ||.|||||.| || ... ||... | .    .|...||  |... . 
MRYPFIIFCTLLHASILMPIFWHMWIYLGSGNANFFYAITLVWNCGQILIIMDMIWYIAMLRREYDLENPDCIKK
Kinase AqueK136.AA TKL 2192-2339 20 2e-31 110.4 In-house 132-364 (364) Show / Hide 
Range on Protein: 2192-2339
Range on HMM: 132-364/364
Sequence Identity: 20% (47 aa)

PVILSIMRDVAVGLNYLHC--L----PDPIIHRDVSSANVLLESKGH----------NKWKTKISDFGSAKFARA----------------------AVT
........|.| |.||||        . ||||||  |.|.|. ....          . |. ||.||| ..|                         .  
HQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTM

EAPGAAVYSAPESIATLHRRT-----------RKQTTKMDSYSYGVLLCEMITCHFPNA-EKFE------------TVKV--------------------
   |   . ||| .      |           .. ..|.| ||.|..|.|..|.  | . ....             . .                    
TQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCP

---SSPQLYELIVSCINEEPDKRPTMSEIILKL
     |.. .|.  | ...|.|||...||. .|
CPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK136.AA TK 2157-2339 14 1.2e-23 75.47 In-house 124-486 (486) Show / Hide 
Range on Protein: 2157-2339
Range on HMM: 124-486/486
Sequence Identity: 14% (52 aa)

LDHPSGNPMIITEVMD-TS----LRSAYERKE----------------------------------------------------LTTDPGCRPVILS---
  . .. .||..| |.  .    ||.   ..                                                     .  .| .    |.   
V-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAW

----------------IMRDVAVGLNYLHCLPD----PIIHRDVSSANVLLESKGHNKWK-------TKISDFGSAK-----FARAA-------VTEAPG
                .....| |. ||| ..      ..|||.   |.|. .....||.        ||.||| ..      ||.        ... .|
QWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYG

AAV-------------------------YSAPESIATLHRRTR----KQTTKMDSYSYGVLLCEMIT---CHFPN----------------AEKFET---
...                         . |||.... . ..     | ||| | .|.|||. |. |     ..                  |. ..   
TGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGR

------------------VKVSS-------------PQLYELIVSCINEEPDKRPTMSEIILKL
                  .  ..             . .|.|. .| ...|..|||.|..  .|
LCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK136.AA MLK 2193-2299 31 1.6e-17 57.47 In-house 125-235 (291) Show / Hide 
Range on Protein: 2193-2299
Range on HMM: 125-235/291
Sequence Identity: 31% (36 aa)

VILSIMRDVAVGLNYLHC-LPDPIIHRDVSSANVLLES--KGHNKWKTKISDFGSAKFARAA---VTEAPGAAVYSAPESIATLHR-RTRKQTTKMDSYS
...... ..| |..|||. .|.||||||  | |.|.    .  .. . ||.||| ...        . ..| . . |||    . . |  | . | | .|
HAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPE---VIQQFRCEKYSEKCDVWS

YGVLLCEMITCHFP
.||.| ||.|.  |
WGVVLWEMLTREVP
Kinase AqueK136.AA CZAK 2195-2300 32 3.9e-16 55.23 In-house 108-222 (279) Show / Hide 
Range on Protein: 2195-2300
Range on HMM: 108-222/279
Sequence Identity: 32% (39 aa)

LSIMRDVAVGLNYLHC--LPDPIIHRDVSSANVLLESKGH---------NKWKTKISDFGSA---KFARAAVTEAPGAAVYSAPES-IATLHRRTRKQTT
... .|.| | ||||    | ||.||| || |.||..               . ||.|||     .      | . |   . |||  .. .       | 
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFGLSREMMEQPFEMTQTMGCLCWMAPECFKGENY------TE

KMDSYSYGVLLCEMITCHFPN
| | ||.| .| ..|||  |.
KVDVYSFGMILWCIITCDQPY
Kinase AqueK136.AA Pkinase 2193-2339 22 7.6e-14 50.03 Pfam 109-293 (293) Show / Hide 
Range on Protein: 2193-2339
Range on HMM: 109-293/293
Sequence Identity: 22% (44 aa)

VILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGHNKWKTKISDFGSA----KFARAAVTEAPGAAVYSAPESIATLHRRTRKQTTKMDSYSYGV
.. ..|. .. ||.|.|     |||||. ..|.|. ..||.. . ||.|||.|           |   |   | ||| |       .. ..| | .|.|.
ECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVDMWSCGC

LLCEMIT--CHFPNA-------EKFETVKVSS-------------------------------PQLYELIVSCINEEPDKRPTMSEIILK--L
.| ||..    ||..       ...  ... .                               . . ..| .|..  | ||||  .|     .
ILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK136.AA TKL-Unique 2193-2299 27 3.3e-13 43.11 In-house 111-233 (290) Show / Hide 
Range on Protein: 2193-2299
Range on HMM: 111-233/290
Sequence Identity: 27% (35 aa)

VILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESK-GHNKWKTKISDFGSAKFARAAVTEAPGAA------------VYSAPESIATLHRRTRKQTT
..... .|.| |..||| .  ||||||  | |.|. ..   ..|. ||.||| .||.    ..  .               ..||| .  .     . ..
QRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNF---CQYSE

KMDSYSYGVLLCEMITCHF------P
| | ||.|. | |..| .       |
KSDVYSFGIVLWEIATRKITKTYKKP
S_TKc AqueK136.AA S_TKc 2092-2343 18 2.6e-12 3.54 SMART 1-231 (231) Show / Hide 
Range on Protein: 2092-2343
Range on HMM: 1-231/231
Sequence Identity: 18% (52 aa)

FSKMELL---------SVICIETSHYVC--YTRAGDKWLFHDSMADRLHDMYNVPRVVDVTAELQEWIYSR-------TARAVLDHPSGNPMIITEVMDT
. .....          .. ..| ..|     .                              ..|    .       .   | ..  ..  ...| .|.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------------------EHIRREIQILKKHHPNIVKLYDVFQD--DHLYMVMEYCDG

---SLRSAYERKEL--TTDPGCRPVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGHNKWKTKISDFGSAKFARAAVTEAPGAAVYSAPESIA
   .|..  ...    .  |    .. ..|. .. .|.|.| .   |||||.  .|.|| .        ||.|||.|..     |   |   | ||| . 
DLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE------HIKICDFGLARQL----TTFCGTPWYMAPEVL-

TLHRRTRKQTT-KMDSYSYGVLLCEMITCHFPNA---EKFETVKVSSPQLYELIVSCINEEPDKRPTMSEIIL-----KLDRCI
       . .. | | .| |..| ||..   |     . |. ..  ||.. ..|  | . .|.||||  |.       |..  .
-------GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK136.AA STE 2166-2334 20 7.3e-12 38.28 In-house 114-350 (359) Show / Hide 
Range on Protein: 2166-2334
Range on HMM: 114-350/359
Sequence Identity: 20% (51 aa)

IITEVMD-TSLRSAYER--KELTTDPGCR--------PVILSIMRDVAVG-LNYLHCLPDPIIHRDVSSANVLLESKGHNKWKTKISDFGSAKFARA---
|. | ||  ||.. ...  . . ...  |        ..|  | |..  | |.||| .   |||||. .||.||          |..||| ..       
ICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL---------VKLCDFGVCGQLTDSMA

-------------------AVTEAPGAAVYSAPESIATLHRR-TRKQTTKMDSYSYGVLLCEMITCHFPNAEKFET---------VKVSS----------
                    ..  |    . ||| |    .    . .|| | .| | ...||.| . | ..   .          ....          
NIQSNNIIDCIETMQQKRNTFVGTP----WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNG

-----------------------------PQLYELIVSCINEEPDKRPTMSE
                             | . . |  | . .|.|||| |.
PPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase AqueK136.AA TK-Unique 2195-2295 29 2.6e-10 31.87 In-house 134-234 (294) Show / Hide 
Range on Protein: 2195-2295
Range on HMM: 134-234/294
Sequence Identity: 29% (32 aa)

LSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGHNKWKTKISDFGSAK------FARAAVTEAPGAAVYSAPESIA-TLHRRTRKQ-TTKMDSYSY
.... ..| |..||. ... |.|||... |||| .    . . ||.||| |.            .. .    . ||||.  .    ..   ||| | .|.
YHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE----DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCY----HGMYHTTKSDVWSF

GVLLCEMIT
|||. |. |
GVLMWEIFT
TyrKc AqueK136.AA TyrKc 2138-2339 21 8.5e-10 -64.28 SMART 1-280 (280) Show / Hide 
Range on Protein: 2138-2339
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

VDVTAELQE----------WIYSRTARAV----------------------L--DHPS------------------GNPMIITEVMDT-SLRSAYERKEL
.    .| |          |.     . |                      |  .||                   . .||..| |.  .|..   ... 
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

TTDPGCRPVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGHNKWKTKISDFGSAKFARAA--------VTEA----PGAAV----YSAPESIA
.    | .  ||.. ..| | .|||    ..||||    |.|. ...      |||||| ...            .  .     | ..      |||.| 
K---LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

TLHRRTRKQTTKMDSYSYGVLLCEMIT------CH-----FPNAEKFETVKVS----SPQL-------------YELIVSCINEEPDKRPTMSEIILKL
    ...| ||| | .|.||.. |. |              .|.| .| ||       |.              |... .| .|.|..|||.|||. ..
----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK136.AA DRK 2192-2243 42 2.4e-09 27.82 In-house 98-145 (258) Show / Hide 
Range on Protein: 2192-2243
Range on HMM: 98-145/258
Sequence Identity: 42% (22 aa)

PVILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGHNKWKTKISDFG
| ....| |.| |..||||    |||||  | | |        |. |..|||
PLMKQMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVD----EHWQVKVADFG
Kinase AqueK136.AA TK-Unique 2308-2339 34 4.1e-09 27.69 In-house 263-294 (294) Show / Hide 
Range on Protein: 2308-2339
Range on HMM: 263-294/294
Sequence Identity: 34% (11 aa)

KVSSPQLYELIVSCINEEPDKRPTMSEIILKL
...|...|.|. ||...||..||. ..|. .|
HCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK136.AA Dicty4 2311-2341 33 7.6e-09 25.81 In-house 245-277 (277) Show / Hide 
Range on Protein: 2311-2341
Range on HMM: 245-277/277
Sequence Identity: 33% (11 aa)

SPQLYELIVSCINEEPDKRPTMSEIILK--LDR
.| . .||. | ...| .||...||| .  |. 
PPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase AqueK136.AA Pkinase_Tyr 2311-2339 37 3.1e-08 28.51 Pfam 242-270 (270) Show / Hide 
Range on Protein: 2311-2339
Range on HMM: 242-270/270
Sequence Identity: 37% (11 aa)

SPQLYELIVSCINEEPDKRPTMSEIILKL
.. .|.|. .| ...|..|||.|||. .|
PDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK136.AA Dicty4 2194-2243 40 6e-08 22.79 In-house 111-159 (277) Show / Hide 
Range on Protein: 2194-2243
Range on HMM: 111-159/277
Sequence Identity: 40% (22 aa)

ILS---IMRDVAVGLNYLHC-LPDPIIHRDVSSANVLLESKGHNKWKTKISDFG
|..   ...|.| |.|.|||  |. |||||  |.| |        |. |..|||
IKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVD----KNWRVKVCDFG
Kinase AqueK136.AA LISK 2199-2243 44 2e-06 16.52 In-house 108-150 (296) Show / Hide 
Range on Protein: 2199-2243
Range on HMM: 108-150/296
Sequence Identity: 44% (20 aa)

RDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGHNKWKTKISDFG
.|.| |. |||     |||||  | |.|.  .. | |. |. |||
LDIACGMSYLHS--MNIIHRDLKSKNCLVRENDNNQWRIKVCDFG
Kinase AqueK136.AA DRK 2311-2341 35 3e-06 17.01 In-house 228-258 (258) Show / Hide 
Range on Protein: 2311-2341
Range on HMM: 228-258/258
Sequence Identity: 35% (11 aa)

SPQLYELIVSCINEEPDKRPTMSEIILKLDR
.|    |.  | ||.|  ||.| |..  |. 
PPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase AqueK136.AA TKL-Unique 2312-2339 35 3e-06 18.32 In-house 263-290 (290) Show / Hide 
Range on Protein: 2312-2339
Range on HMM: 263-290/290
Sequence Identity: 35% (10 aa)

PQLYELIVSCINEEPDKRPTMSEIILKL
... .||  | . .|..||. .||| .|
KEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase AqueK136.AA MLK 2316-2339 37 3e-06 18.1 In-house 268-291 (291) Show / Hide 
Range on Protein: 2316-2339
Range on HMM: 268-291/291
Sequence Identity: 37% (9 aa)

ELIVSCINEEPDKRPTMSEIILKL
.|.  | |..| |||....|. .|
KLMKQCWNQDPHKRPSFRQIVQHL
Kinase AqueK136.AA Pkinase_Tyr 2194-2243 34 5e-06 21.06 Pfam 113-156 (270) Show / Hide 
Range on Protein: 2194-2243
Range on HMM: 113-156/270
Sequence Identity: 34% (17 aa)

ILSIMRDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGHNKWKTKISDFG
.|.. ...| |..||.  .  .||||.   |.|...   |. . ||.|||
LLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE---NN-VVKICDFG
Kinase AqueK136.AA LISK 2300-2339 25 0.000138 10.6 In-house 254-296 (296) Show / Hide 
Range on Protein: 2300-2339
Range on HMM: 254-296/296
Sequence Identity: 25% (11 aa)

NAEKFETVKVSS---PQLYELIVSCINEEPDKRPTMSEIILKL
. |.|.   ...   |....| . |.. .|..||. .||. .|
DYEEFWQKICPDDCPPPFLDLCFDCCKYDPKNRPSFKEIVQWL
Kinase AqueK136.AA CZAK 2314-2339 46 0.0002 12.16 In-house 254-279 (279) Show / Hide 
Range on Protein: 2314-2339
Range on HMM: 254-279/279
Sequence Identity: 46% (12 aa)

LYELIVSCINEEPDKRPTMSEIILKL
| |||  | |  || ||. ..|.  |
LGELIEMCWNKNPDERPSFKQILQHL
Kinase AqueK136.AA LISK 2284-2295 58 0.002196 6.63 In-house 223-234 (296) Show / Hide 
Range on Protein: 2284-2295
Range on HMM: 223-234/296
Sequence Identity: 58% (7 aa)

YSYGVLLCEMIT
.|.|..|||.||
FSFGIVLCEIIT
Kinase AqueK136.AA Pkinase_Tyr 2263-2295 42 3.455054 1.26 Pfam 182-209 (270) Show / Hide 
Range on Protein: 2263-2295
Range on HMM: 182-209/270
Sequence Identity: 42% (14 aa)

APESIATLHRRTRKQTTKMDSYSYGVLLCEMIT
|||.|..        ||| | .|.|||. |..|
APECINYGK-----FTTKSDVWSFGVLMWEIFT