AqueK145

Species: A.queenslandica
Alias: AqueK145
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-a2

Sequence

Name Sequence Type Origin Length Description Download
AqueK145.AA Protein None 271 None Fasta, JSON
AqueK145.kin_dom Protein Kinase Domain None 95 None Fasta, JSON

Protein domain

Protein domains of AqueK145.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK145.AA TKL 149-264 20 3.2e-14 47.62 In-house 89-244 (364) Show / Hide
Range on Protein: 149-264
Range on HMM: 89-244/364
Sequence Identity: 20% (34 aa)

QFIGAVLDDP-----------SGYPMIITEVM-DTSLRKAYENKELTPDPSYRPVILSILHDVAVGLNYLHC--L----PDPIIHRDVSSANVLLESKGP
||.|.... |           .|...|..| .   ||.  .            ...... .|.| |.||||        . ||||||  |.|.|. ... 
QFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWT

----------GKWKTKVSDFGSANLVQN----------------------AVTKAPGAVVYSAPEA
            |. |..||| .  ...                      .  .  |   . |||.
NVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEV

Kinase AqueK145.AA MLK 191-264 28 3.1e-13 42.4 In-house 125-204 (291) Show / Hide
Range on Protein: 191-264
Range on HMM: 125-204/291
Sequence Identity: 28% (23 aa)

VILSILHDVAVGLNYLHC-LPDPIIHRDVSSANVLLES--KGPGKWKTKVSDFGSANLVQNA---VTKAPGAVVYSAPEA
..... ...| |..|||. .|.||||||  | |.|.    .  .. . |..||| .  ...     ....| . . |||.
HAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWMAPEV

Kinase AqueK145.AA HH498 198-241 51 4.3e-13 37.46 In-house 129-169 (284) Show / Hide
Range on Protein: 198-241
Range on HMM: 129-169/284
Sequence Identity: 51% (23 aa)

DVAVGLNYLHC-LPDPIIHRDVSSANVLLESKGPGKWKTKVSDFG
||| | ||||  |. ||||||  | |.|.   |    . .| |||
DVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDG----HAVVADFG

Kinase AqueK145.AA YSK 195-252 39 5.3e-11 29.01 In-house 104-155 (257) Show / Hide
Range on Protein: 195-252
Range on HMM: 104-155/257
Sequence Identity: 39% (23 aa)

ILHDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKVSDFGSANLVQNAVTK
||. . .|| |||.  .  ||||. .|||||  .|    . |. ||| |  . . ..|
ILREILKGLDYLHS--ERKIHRDIKAANVLLSEHG----DVKLCDFGVAGQITDTQIK

Kinase AqueK145.AA TK 149-241 13 8.9e-11 31.57 In-house 107-296 (486) Show / Hide
Range on Protein: 149-241
Range on HMM: 107-296/486
Sequence Identity: 13% (26 aa)

QFIGAVLDDPS----------GYPMIITEVMD-TS----LRKAYENKE----------------------------------------------------
...|..... .          . .||..| |.  .    ||.   ..                                                     
RLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIK

LTPDPSYRPVILS-------------------ILHDVAVGLNYLHCLPD----PIIHRDVSSANVLLESKGPGKWK-------TKVSDFG
. |.|      |.                   . ...| |. ||| ..      ..|||.   |.|. .... ||.        |..|||
DHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG

Kinase AqueK145.AA TKL-Unique 172-241 28 1.3e-10 33.79 In-house 86-162 (290) Show / Hide
Range on Protein: 172-241
Range on HMM: 86-162/290
Sequence Identity: 28% (23 aa)

SLRKAYE---------NKELTPDPSYRPVILSILHDVAVGLNYLHCLPDPIIHRDVSSANVLLESK-GPGKWKTKVSDFG
||..            |........   ..... .|.| |..||| .  ||||||  | |.|. ..    .|. |..|||
SLYDVLHQNNNNNNNNNNNCKLNMQ---QRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFG

Kinase AqueK145.AA STE 164-243 30 2e-10 33.12 In-house 114-194 (359) Show / Hide
Range on Protein: 164-243
Range on HMM: 114-194/359
Sequence Identity: 30% (28 aa)

IITEVMD-TSLRKAYEN--KELTPDPSYR--------PVILSILHDVAVG-LNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKVSDFGSA
|. | ||  ||.. ...  . . |... |        ..|  |....  | |.||| .   |||||. .||.||          | .||| .
ICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL---------VKLCDFGVC

Kinase AqueK145.AA CZAK 193-241 36 3.5e-10 33.31 In-house 108-167 (279) Show / Hide
Range on Protein: 193-241
Range on HMM: 108-167/279
Sequence Identity: 36% (22 aa)

LSILHDVAVGLNYLHC--LPDPIIHRDVSSANVLLESKGP---------GKWKTKVSDFG
...  |.| | ||||    | ||.||| || |.||..               . |..|||
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDHSYTPKNPVVSSRQDIICKINDFG

Kinase AqueK145.AA STE-Unique 192-244 37 2.2e-09 28.91 In-house 405-458 (616) Show / Hide
Range on Protein: 192-244
Range on HMM: 405-458/616
Sequence Identity: 37% (20 aa)

ILSILHDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKW-KTKVSDFGSAN
.. ..  .. ||.|||   .||||||. ..|... ..| |.  | |..||| |.
VIWYTYQILEGLEYLHSQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHAT

Kinase AqueK145.AA TK-Unique 193-264 25 3e-09 28.18 In-house 134-207 (294) Show / Hide
Range on Protein: 193-264
Range on HMM: 134-207/294
Sequence Identity: 25% (20 aa)

LSILHDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKVSDFGSA------NLVQNAVTKAPGAVVYSAPEA
.... ..| |..||. ... |.|||... |||| .    . . |..||| |      . ...  .. .  . . |||.
YHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE----DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPES

Kinase AqueK145.AA Pkinase_Tyr 192-241 30 3.8e-05 18.07 Pfam 113-156 (270) Show / Hide
Range on Protein: 192-241
Range on HMM: 113-156/270
Sequence Identity: 30% (15 aa)

ILSILHDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKTKVSDFG
.|.. ...| |..||.  .  .||||.   |.|...   .. . |..|||
LLQMCWQIAKGMEYLESKN--CIHRDLAARNCLVTE---NN-VVKICDFG

Kinase AqueK145.AA Pkinase 191-247 27 0.000667 14.88 Pfam 109-163 (293) Show / Hide
Range on Protein: 191-247
Range on HMM: 109-163/293
Sequence Identity: 27% (17 aa)

VILSILHDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKWKT----KVSDFGSANLVQ
.. ...  .. ||.|.|     |||||. ..|.|. ..|     .    |..|||.| ...
ECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNG----HIDACVKICDFGLAKQFD

S_TKc AqueK145.AA S_TKc 44-268 11 0.0009 -121.6 SMART 1-231 (231) Show / Hide
Range on Protein: 44-268
Range on HMM: 1-231/231
Sequence Identity: 11% (35 aa)

FKLDDRVAMESGQGELVTGTVRWVGLVRALKIESKLIAIGIETDNIIDPLNDFPGLSLNVTGKLFKVSPGHSSIFLPEGVVKYMYEEVEEKINNEELNHE
... . .   .  |.   .. .  | . |.|| .                                                    . | .|  .  .|.
YEILRKIGKGA-FGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------EHIRREIQILKK--HHP

WESSHQFIGAVLDDPSGYPMIITEVMDT---SLRKAYENKE-------LTPDPSYRPVILSILHDVAVGLNYLHCLPDPIIHRDVSSANVLLESKGPGKW
.    .....  |   ..  ...| .|.   .|..  ...        ..       .. .... .. .|.|.| .   |||||.  .|.|| .      
N--IVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP-----E-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE------

KTKVSDFGSANLVQNAVTKAPGAVVYSAPE----------------------------------------------------------------A-----
  |..|||.| ..    |   |   | |||                                                                .     
HIKICDFGLARQL----TTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDI

--HQTI
  |. .
KCHPWF