Gene AqueK143 (A.queenslandica)

AqueK143

Species: A.queenslandica
Alias: AqueK143
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH-C

Sequence

Name Sequence Type Origin Length Description Download
AqueK143.AA Protein None 207 None Fasta, JSON
AqueK143.kin_dom Protein Kinase Domain None 156 None Fasta, JSON

Protein domain

Protein domains of AqueK143.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK143.AA TKL 55-200 22 6.5e-30 104.9 In-house 1-205 (364) Show / Hide 
Range on Protein: 55-200
Range on HMM: 1-205/364
Sequence Identity: 22% (48 aa)

LERGSYAVVTVGIFRG----------LSVAVKSLHTIIISDYNL-------------------------RLFSREMSIASRVRHPNLVQFIGATK-----
. .|....|  |..||            |||| ...   .  ..                           . .|. . || ||||.|||.|. .     
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

---------VGNPLVLTELM-STSLNQELRRNRLTNQQILSIAQDVALGLNYLHLFKP-----QPIIHRDVSSPNVLLKPCTGP---------AGYEAKV
          |..   .|..   ||   |       .|....|.|.|.|.||||  .|      ||||||  |.|.|..    .         | . .|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKI

ADYGTAKVVQ
.|.|......
CDFGLSRFMS
Kinase AqueK143.AA MLK 49-197 25 3.8e-24 80.75 In-house 1-181 (291) Show / Hide 
Range on Protein: 49-197
Range on HMM: 1-181/291
Sequence Identity: 25% (46 aa)

TLTEEELERGSYAVVTVGIFRGLS-----VAVKSLHTIIISDYNL-----RLFSREMSIASRVRHPN----LVQFIGA-TKVGN-PLVLTELMST-SLNQ
 ...| .  ||. .|  | .|.       ||||  .. |. |        . | .|  ......|||     .|| |. .. ..  ....| ..  ||. 
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

ELRRNR---------------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKP-CTGPAGYEAKVADYGTAK
 |. .|                . ......| ..| |..|||  .|.||||||  |.|.|.   |   ..  .|..| ||..
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR
Kinase AqueK143.AA TKL-Unique 51-207 28 2.4e-22 75.75 In-house 1-175 (290) Show / Hide 
Range on Protein: 51-207
Range on HMM: 1-175/290
Sequence Identity: 28% (50 aa)

TEEELERGSYAVVTVGIFRGLSVAVKSLHTIIISDYNLR---LFSREMSIASRVR-HPNLVQFIGATK---VGNP--LVLTELMST-SLNQELR------
  . . .|.|..|  |..|| .||.|..|    .| ...    |..| .. .. . |||.|...|...   | .|     .| ..  ||.  |       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-----RNRLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGPAGYEAKVADYGTAKVVQAENTGTV
      . |..||....|.|.|.|..|||  .|  |||||  |.|.|.      | . .|..| |..|.   .|..|.
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTN
Kinase AqueK143.AA TK 49-194 15 2.2e-21 67.77 In-house 1-296 (486) Show / Hide 
Range on Protein: 49-194
Range on HMM: 1-296/486
Sequence Identity: 15% (45 aa)

TLTEEELERGSYA---VVTVGIFRGL---------------------------SVAVKSLHTIIISDYNLRL---------------FSREMSIAS--RV
   ...| .| .    .|  |. ||.                            |||| |.    .. . ..               . .||.. .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHPNLVQFIG-ATKVGN------------PLVLTELMS-TS----LNQELRRNR----------------------------------------------
.|||.|...|  |....            .....|.|.  .    | . ||..|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LTNQQILSIAQDVALGLNYLHLFKP---QPIIHRDVSSPNVLLKPCTG------PAGYEAKVADYG
                               || .| | .....| |. |||  .    | ..|||.   |.|.             |. .|.||.|
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG
Kinase AqueK143.AA CZAK 69-177 36 6.1e-20 69.22 In-house 21-142 (279) Show / Hide 
Range on Protein: 69-177
Range on HMM: 21-142/279
Sequence Identity: 36% (45 aa)

RGLSVAVKSLHTIIISDYNL----RLFSREMSIASRVRHPNLVQFIGATKVGN---PLVLTELMS-TSLNQELR-RNRLTNQ---QILSIAQDVALGLNY
|| .||.| .| .   .         | .| || |  .||| |||.||   ..     . .| |   || . |  .  .  |     ...| |.| | ||
RGKDVAIKIIHRNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWMGGGSLRRLLTDHYFYHKQNPHLQWNMAIDIARGMNY

LHL-FKPQPIIHRDVSSPNVLL
||  .|| ||.||| || |.||
LHDNWKPNPILHRDLSSRNILL
Kinase AqueK143.AA Dicty4 51-169 32 2e-19 61.57 In-house 3-139 (277) Show / Hide 
Range on Protein: 51-169
Range on HMM: 3-139/277
Sequence Identity: 32% (45 aa)

TEEELERGSYAVVTVGIFRGLSVAVKSL--HTIIISDYNLRLFSREMSIASRVRHPNLVQFIGA-T----KVGNPLVLTELM-STSLNQELRR------N
.|... .||.. |  |. ||  |||| |  | .  . . |  | .| .| .  ||||...| || |    . | ..  ||.| ...|   |.        
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

RLTNQ--QILS---IAQDVALGLNYLHLFKPQPIIHRD
. . .   |..   .| |.|.|.|.||   |  |||||
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRD
Kinase AqueK143.AA STE 50-197 17 4.1e-18 60.66 In-house 1-195 (359) Show / Hide 
Range on Protein: 50-197
Range on HMM: 1-195/359
Sequence Identity: 17% (37 aa)

LTE-EELERGSYAVVTVGIFR-----------------GLSVAVKSLH---------------TIIISDYNLRLFSREMSIASRVR--HPNLVQFIGATK
..  |.. .|.. .|  .. .                 |  .|.| ..               . .. . ..  . .|..| .. .  ||| |...|.  
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG--------NPLVLTELMS-TSLNQELRRN---------------RLTNQQILSIAQDVALG-LNYLHLFKPQPIIHRDVSSPNVLLKPCTGPAGYEAK
..        .  .  |.|.  || . ....               |.  .||  |....  | |.|||  .   |||||. . |.||          .|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----------VK

VADYGTAK
 .| |...
LCDFGVCG
Kinase AqueK143.AA LRRK 49-195 22 1.3e-17 58.91 In-house 1-224 (351) Show / Hide 
Range on Protein: 49-195
Range on HMM: 1-224/351
Sequence Identity: 22% (51 aa)

TLTEEELERGSYA-VVTVGIFRG----------------------------LSVAVKSLHT--------------------------------IIISDYN
   ||.. ||... .|  ...||                             .||.|....                                .. .  .
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

LRLFSREMSIASRVRHPNLVQFIGATKVGNPLVL-TELMST-SLNQELR---RNR-------LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNV
.|.| .|..| |. .|||.|. .| .   .|| . .|...  .|.. |.   ...       .. . .| || ..| |..||| ..| ||||||  |||.
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNI

LLKPCTGP-------AGYEAKVADYGT
||.  . .       | . ||.||.|.
LLWSSPQNHSPNYPNAHVCAKIADFGI
Pkinase_Tyr AqueK143.AA Pkinase_Tyr 48-194 25 2.7e-15 52.4 Pfam 1-156 (270) Show / Hide 
Range on Protein: 48-194
Range on HMM: 1-156/270
Sequence Identity: 25% (42 aa)

VTLTEEELERGSYAVVTVGIFR------GLSVAVKSLHTIIISDYN--LRLFSREMSIASRV-RHPNLVQFIGATK-VGNP---LVLTELMST-SLNQEL
.|.  ..| .|.. .|  |. .      .. ||||.|     .. .  .. | ||..| .   .|||.|...|.    | |   .. .|.|   .|   |
ITFG-KKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

RRN-----RLTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGPAGYEAKVADYG
|..     .|| ...|......| |..||.  .   .||||.   |.|..      .  .|..| |
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTE-----NNVVKICDFG
Kinase AqueK143.AA LISK 54-203 30 9e-15 44.22 In-house 1-159 (296) Show / Hide 
Range on Protein: 54-203
Range on HMM: 1-159/296
Sequence Identity: 30% (50 aa)

ELERGSYAVVTVGIFR--GLSVAVKSLHT---IIISDYNLRLFSREMSIASRVRHPNLVQFIGATKV-GNPL-VLTELMST-SLNQELRRN-----RLTN
|. .|... |  |  |  |  .|.| .|.     . . ... . ||. .  . |||| |||.|. .     |  .||...   | | |...      |. 
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYHNDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPW

QQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGPAGYEAKVADYGTAKVVQAEN
.| ..|| |.|.|. |||    . |||||  | |.|..   .  ....||.| | |.... ||
PQRVKIALDIACGMSYLHS---MNIIHRDLKSKNCLVREN-DNNQWRIKVCDFGFARMMDCEN
Kinase AqueK143.AA DRK 57-176 36 4.8e-14 43.99 In-house 9-132 (258) Show / Hide 
Range on Protein: 57-176
Range on HMM: 9-132/258
Sequence Identity: 36% (46 aa)

RGSYAVVTVGIFRGLSVAVKSLHTIIISDYN-LRLFSREMSIASRVRHPNLVQFIGA-TKVGNPLVLTELMST-SLNQELRRNRLTNQ--QILSIAQDVA
||.|. |  |  ||  |||| |    | | | |  | ||  . .. |||| .||.|. .    ... .| |.  || . |    .  .   ..... |.|
RGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMKQMMFDCA

LGLNYLHLFKPQPIIHRDVSSPNVL
 |..|||   |  |||||  | | |
KGMIYLHCCNPI-IIHRDLKSHNLL
Kinase AqueK143.AA Pkinase 49-170 20 1.2e-08 31.62 Pfam 1-134 (293) Show / Hide 
Range on Protein: 49-170
Range on HMM: 1-134/293
Sequence Identity: 20% (28 aa)

TLTEEELERGSYAVVTVGIFRGLS--VAVKSLHTIIISD----YNLRLFSREMSIASRVRHPNLVQFIGATK-VGNPLVLTELMST-----SLNQELR--
  ... . .||...|  .. .| .  |||| .    ...    ...||  .| .|  |..||| |.....    ... . .|..       .|   ..  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRL--SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

-RNRL--TNQQILSIAQDVALGLNYLHLFKPQPIIHRDV
 ....  . ... ...  .. ||.|.|      |||||.
RHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDL
Kinase AqueK143.AA S_TKc 49-207 11 6.6e-08 -60.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 49-207
Range on HMM: 1-231/231
Sequence Identity: 11% (30 aa)

TLTEEELERGSYAVVTVGIFRG--LSVAVKSLHTIIISDYNLRLFSREMSIASRVRHPNLVQFIGATKVGNPLVLTELMST---SLNQELRRNR------
    ... .|....|  .. ..    ||.| ..         . . ||..| .. .|||.|.....   ..  . .|....   .| . .....      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCTGPAGYEAKVADYGTAKVV-------------------------------------
 ..  .. .... ....|.|.|  .   |||||.   |.||         . |..| | |...                                     
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-------HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCG

-------------------------------------QAEN-------TGTV
                                     .| .          .
YPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase AqueK143.AA TyrKc 49-207 15 8.6e-08 -96.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 49-207
Range on HMM: 1-280/280
Sequence Identity: 15% (44 aa)

TLTEEELERGSYAVVTVGIFRGLSVAVKSLHTIIISDYNLRLFSREMSIASRV--RHPNLVQFIGATKV--------GNPLVLTELMST-SLNQELRRNR
   ...| .| . .|  |. . . ||||.|.        .. | ||..| ...  .|||.|...|.           . .....|.|.  .|.. ||..|
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--LTNQQILSIAQDVALGLNYLHLFKPQPIIHRDVSSPNVLLKPCT------------GPAG---------YEAK---VAD-------------------
  |.... ||.. ..| | .|||     ..||||    |.|..               .  .         | .|    ..                   
PKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

----------------------YGT------------AKVVQA------EN----------------------------------TGTV
                      |              ..| |       .|                                      
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF