Gene AqueK135 (A.queenslandica)

AqueK135

Species: A.queenslandica
Alias: AqueK135
External Links:
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: HH498

Sequence

Name Sequence Type Origin Length Description Download
AqueK135.AA Protein None 925 None Fasta, JSON
AqueK135.kin_dom Protein Kinase Domain None 129 None Fasta, JSON

Protein domain

Protein domains of AqueK135.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kelch_1 AqueK135.AA Kelch_1 17-73 19 40.145268 0.62 Pfam 1-45 (45) Show / Hide 
Range on Protein: 17-73
Range on HMM: 1-45/45
Sequence Identity: 19% (11 aa)

ERWGHYPVKVGDYLYMWGGYPPDLPQVHNNEVKKSMCSVMEVCDLRTGIWEQKPTTG
 | ||  . .....|  ||. .            .  .  |. |..|. |.. |. .
PRCGHGVCVHNGKIYVIGGCDG------------QYLNSVECYDPETNQWTRCPPMP
Kelch_1 AqueK135.AA Kelch_1 78-125 16 1.2e-05 23.97 Pfam 1-45 (45) Show / Hide 
Range on Protein: 78-125
Range on HMM: 1-45/45
Sequence Identity: 16% (8 aa)

GVIYYAAAAIGREIFYFGGYCNHDNCCHNSLYSFNVDTFNWKELSPTT
   ........ .|. .||...    . || ......|  |....| .
PRCGHGVCVHNGKIYVIGGCDG---QYLNSVECYDPETNQWTRCPPMP
Kelch_1 AqueK135.AA Kelch_1 267-297 17 0.048009 11.1 Pfam 8-41 (45) Show / Hide 
Range on Protein: 267-297
Range on HMM: 8-41/45
Sequence Identity: 17% (6 aa)

TSSGPHLLVMGGYG---TNDIWIFDINNKSWKEL
.. . .. |.||.    .|.....|  ...|...
CVHNGKIYVIGGCDGQYLNSVECYDPETNQWTRC
Kinase AqueK135.AA TKL 658-780 23 1.5e-24 85.35 In-house 1-173 (364) Show / Hide 
Range on Protein: 658-780
Range on HMM: 1-173/364
Sequence Identity: 23% (41 aa)

LGKGGWGEVKVVHFRG----------LKVAAKCLYEVIISPYNI-------------------------GTFSREMNIASKIRHPNLLQFIGATTEGN--
.|.|| |||   ..||            || | . .   .  ..                          .. .|... |..||||..||.|. ....  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------AIILTELM-PTSLRMELESGGVAYPAILSISLDVACALNYLHLFKP-----HPILHRDVSSANVLL
              | .|..   ||.  |       . .....||.|...||||  .|      ||.|||  |.|.|.
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILV
Kinase AqueK135.AA MLK 652-780 21 1.2e-14 47.34 In-house 1-160 (291) Show / Hide 
Range on Protein: 652-780
Range on HMM: 1-160/291
Sequence Identity: 21% (35 aa)

TMTEVVLGKGGWGEVKVVHFRGLKVAAKC--LYEVIISPYNIGT-------FSREMNIASKIRHPN----LLQFIGATTE-GN-AIILTELMPT-SLRME
  .. ..|.|. |.|    .|.  . ||   ...| .... ..        | .| .......|||      || |. .. ..   |..| ..  ||   
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LESG---------------GVAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
| ..                .    .....|..| ...|||  .|.|| |||  | |.|.
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILI
Kinase AqueK135.AA Dicty4 654-779 32 7.6e-13 39.35 In-house 3-146 (277) Show / Hide 
Range on Protein: 654-779
Range on HMM: 3-146/277
Sequence Identity: 32% (47 aa)

TEVVLGKGGWGEVKVVHFRGLKVAAKCL--YEVIISPYNIGTFSREMNIASKIRHPNLLQFIGATT-----EGNAIILTELM-PTSLRMELES------G
.|. .|||. |||     || .|| | |    .  . . .  | .| .| .||||||...| || |      |   | ||.|  ..|   | .       
IEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQ

GVAYP--AILS---ISLDVACALNYLHLFKPHPILHRDVSSANVL
 .  .   |..   . .|.|  .|.||   |  |.|||  |.| |
SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLL
Kinase AqueK135.AA DRK 653-779 35 3.9e-12 37.45 In-house 2-132 (258) Show / Hide 
Range on Protein: 653-779
Range on HMM: 2-132/258
Sequence Identity: 35% (47 aa)

MTEVVLGKGGWGEVKVVHFRGLKVAAKCLYEVIIS-PYNIGTFSREMNIASKIRHPNLLQFIGATTEGNAI-ILTELMPT-SLRMEL--ESGGVAYPAIL
   .  |.|..|||     || .|| | |    |     .  | || |. .. ||||  ||.|. ..   | | .| ||  ||   |  ||     | ..
KIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPLMK

SISLDVACALNYLHLFKPHPILHRDVSSANVL
.. .|.|  ..|||   |  |.|||  | | |
QMMFDCAKGMIYLHCCNPI-IIHRDLKSHNLL
Kinase AqueK135.AA LISK 657-715 31 2.7e-11 32.77 In-house 1-64 (296) Show / Hide 
Range on Protein: 657-715
Range on HMM: 1-64/296
Sequence Identity: 31% (20 aa)

VLGKGGWGEV-KVVHF-RGLKVAAKCLY---EVIISPYNIGTFSREMNIASKIRHPNLLQFIGA
..|||. |.| |. |.  |  .| | .    .. . | .. .. ||. .  ..|||| .||.|.
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGV
Kinase AqueK135.AA CZAK 747-780 54 2.8e-11 37.38 In-house 108-142 (279) Show / Hide 
Range on Protein: 747-780
Range on HMM: 108-142/279
Sequence Identity: 54% (19 aa)

LSISLDVACALNYLHL-FKPHPILHRDVSSANVLL
... .|.|   ||||  .|| |||||| || |.||
WNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILL
Kinase AqueK135.AA Dicty5 689-780 28 3.2e-11 34.87 In-house 38-137 (260) Show / Hide 
Range on Protein: 689-780
Range on HMM: 38-137/260
Sequence Identity: 28% (29 aa)

YNIGTFSREMNIASKIR--HPNLLQFIGATTEGNAI--ILTELMPT-SLRMELESGGV------AYPAILSISLDVACALNYLHLFKPHPILHRDVSSAN
...  | ||  | | .   |||.  . || .       ..||.    ||.  |           ||. .|.. .|.| .. .||      | |||. | |
FDWNEFYREVTIMSIFQSDHPNFIRCYGAHQYNDKYPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMN

VLL
.|.
FLI
Kinase AqueK135.AA TK 696-780 13 5.6e-10 28.84 In-house 87-273 (486) Show / Hide 
Range on Protein: 696-780
Range on HMM: 87-273/486
Sequence Identity: 13% (25 aa)

REMNIASKIR-----HPNLLQFIGATTEGN-------------AIILTELMP-TS----LRMELESGG--------------------------------
.|...... .     |||.....|. |.|               .|..|.||  .    ||  | .                                  
EEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITY

---------------------------------------------VAYPAILSISLDVACALNYLHLFKPHPI----LHRDVSSANVLL
                                             .  .  | .....||.. |||  .         |||.   |.|.
SHESNSPCPEEQDYDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLV
Kinase AqueK135.AA HH498 744-786 46 5.7e-10 27.38 In-house 121-163 (284) Show / Hide 
Range on Protein: 744-786
Range on HMM: 121-163/284
Sequence Identity: 46% (20 aa)

PAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGA
. .. ||.|||   ||||   .||| |||  | |.|.   | |
QSKMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIHEDGHA
Kinase AqueK135.AA Pkinase 652-780 19 1.8e-09 34.58 Pfam 1-141 (293) Show / Hide 
Range on Protein: 652-780
Range on HMM: 1-141/293
Sequence Identity: 19% (28 aa)

TMTEVVLGKGGWGEVKVVHFRGLK--VAAKCLYEVIISPYNIGTFSR--EMNIASKIRHPNLLQFIGAT-TEGNAIILTELMPT-----SLRMELE---S
  .. ..|.|. |.|.  | .|    || |..  . ...    |  |  |  |  ...||| ......  ....  . .|...      .|   ..   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GGV--AYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
|..   .  . .. . ....|.|.|      |.|||. ..|.|.
GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILI
Kinase AqueK135.AA CZAK 655-728 32 2.5e-09 30.19 In-house 4-84 (279) Show / Hide 
Range on Protein: 655-728
Range on HMM: 4-84/279
Sequence Identity: 32% (27 aa)

EVVLGKGGWGEVKVVHFRGLKVAAKCLYEVIISPYNIGT------FSREMNIASKIRHPNLLQFIGATTEGN---AIILTELM
. . |.|  |||.    ||  || | ..   ..  |         | .|  | || .||| .||.|| .|..     | .| |
GQTIGQGFFGEVYKAYWRGKDVAIKIIH--RNQFRNKDENKEENMFQKEVSIMSKLCHPNCVQFLGACSEDGPNHHCIVMEWM
Kinase AqueK135.AA Pkinase_Tyr 694-780 24 2.7e-09 32.1 Pfam 50-144 (270) Show / Hide 
Range on Protein: 694-780
Range on HMM: 50-144/270
Sequence Identity: 24% (24 aa)

FSREMNIASKI-RHPNLLQFIGATT--EGN--AIILTELMPT-----SLRME-LESGGVAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
| ||..| ... .|||.....|. |  ..    .| .|.||       ||    . . .  . .|......|....||.  .   . |||.   |.|.
FMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLV
Kinase AqueK135.AA TKL-Unique 657-726 28 4.2e-09 28.42 In-house 4-80 (290) Show / Hide 
Range on Protein: 657-726
Range on HMM: 4-80/290
Sequence Identity: 28% (22 aa)

VLGKGGWGEVKVVHFRGLKVAAKCLY-EVIISPYNIGTFSREMNIASKIR-HPNLLQFIGATT-----EGNAIILTE
..| || |.|. . .|| .|| | .  .  .|.  . .|..| |. .|.. |||.....|...     ..| .| .|
KIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVME
Kinase AqueK135.AA S_TKc 652-894 14 1.3e-08 -50.75 SMART 1-231 (231) Show / Hide 
Range on Protein: 652-894
Range on HMM: 1-231/231
Sequence Identity: 14% (43 aa)

TMTEVVLGKGGWGEVKVVHFRG--LKVAAKCLYEVIISPYNIGTFSREMNIASKIRHPNLLQFIGATTEGNAIILTELMPT---SLRMELESGG------
     ..|||. |.|. .. ..   .|| |..           .. ||..| .| .|||. .....  ...  . .|....   .|.  ... |      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-VAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMGGAADAISSMNL----FDLGGQFLRVGWALTPPLPLFPPNAAPVLPSLLTSAA---
      . ..   ..|||.|.|  .   |.|||.  .|.||             ..    | |  |.                       ..  .     
PFPE-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE-----------HIKICDFGLARQL----------------------TTFCGTPWYMA

---LGYSSSQNKDPNLC-IVDVWSVTPTT-----------NWIIVFGGKRNFSTIISDPAV----------IELRYTSNNDWS-------TSII
   |         .  .  .|.||.  .            .   .|   .      |..|            | |.|                .
PEVL---------GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
TyrKc AqueK135.AA TyrKc 651-863 18 2.9e-07 -105.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 651-863
Range on HMM: 1-280/280
Sequence Identity: 18% (54 aa)

ITMTEVVLGKGGWGEVKVVHFRGLKVAAKCLYEVIISPYNIGTFSREMNIASKI--RHPNLLQFIGATTE--------GNAIILTELMPT-SLRMELESG
||. . .|| |  |||   . . ..|| |.| |       .  | ||..| .|.  .|||.....|. |.        .   |..|.||  .|.  | . 
ITLGK-KLGEGAFGEVYKGTWK-IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

G--VAYPAILSISLDVACALNYLHLFKPHPILHRDVSSANVLLQPMG-------GAADAISSM-------NLFDL----GGQF-----------LRVG--
.  .  .  ||.....||  .|||    ... |||    |.|.   .       | . .| .           .     || .           .. |  
RPKLCMKDLLSFCWQIACGMEYLHS---KNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

------WA--------LTPPLPLFPP-----NAAPVLPSLLTSAALGYSSSQNKDPNL----C-------IVDVWSVTPT-----TNWIIVF
      |.        .|   .  |        .  .  .. .         .  | .    |       . . |   |      .. .  |
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK135.AA TKL-Unique 746-780 37 0.000102 12.77 In-house 112-145 (290) Show / Hide 
Range on Protein: 746-780
Range on HMM: 112-145/290
Sequence Identity: 37% (13 aa)

ILSISLDVACALNYLHLFKPHPILHRDVSSANVLL
.... .|.| ...|||  .|  |.|||  | |.|.
RVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLV
Kinase AqueK135.AA LISK 747-780 44 0.0004 9.07 In-house 104-134 (296) Show / Hide 
Range on Protein: 747-780
Range on HMM: 104-134/296
Sequence Identity: 44% (15 aa)

LSISLDVACALNYLHLFKPHPILHRDVSSANVLL
..|.||.||.. |||  .   |.|||  | |.|.
VKIALDIACGMSYLHSMN---IIHRDLKSKNCLV
Kinase AqueK135.AA HH498 694-716 39 0.084677 1.03 In-house 49-71 (284) Show / Hide 
Range on Protein: 694-716
Range on HMM: 49-71/284
Sequence Identity: 39% (9 aa)

FSREMNIASKIRHPNLLQFIGAT
| ||  | ..  ||.  ||..|.
FCREVSIMCRLNHPCVVQFVYAC