Gene AqueK183 (A.queenslandica)

AqueK183

Species: A.queenslandica
Alias: AqueK183
External Links:
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK8

Sequence

Name Sequence Type Origin Length Description Download
AqueK183.AA Protein None 760 None Fasta, JSON
AqueK183.kin_dom Protein Kinase Domain None 258 None Fasta, JSON

Protein domain

Protein domains of AqueK183.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK183.AA NEK8 4-261 48 1.6e-177 511.53 In-house 1-278 (278) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-278/278
Sequence Identity: 48% (136 aa)

YEKIRVIGQGAFGKVFLCKNLGNN--NHVVIKQIPVDELPSEERKSAMNEVNVLSMLQHPNIIGYYASFVEDKSLMIAMEYAPGGTLYELIQERNG-KHI
||.|||.|.|||| . |.     .    |..|||.. .. ..|| .|.||..|||||||||||.|| .| ||..|||.||||.|||||..||.. . .. 
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

EEE----------------TILQLFVQILVAIEHVHSLNILHRDLKPQNIMLNKKKTVVKIGDFGISKVLSSKITSAQ--TVVGTPCYISPEICEGRVYR
||.                .||  |.|.. |. |.|. ||||||||.||| ... ..|||||||||||....|.  .   ||||||.|.|||.|||. | 
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

KKSDIWSLGCILYELLALRKAFEGPNFPALVLKIMQGSNALQPLSDNYTSSLCTLVHAMLQRNPDDRPNIENIMANPVI
 |||.|.|||.|||.. |..|||. | ||||.||||.  |  |.|| |.. .  |||. ||  |. ||    |||.| .
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQC-RAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase AqueK183.AA NEK 4-261 42 2e-138 466.17 In-house 1-286 (286) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-286/286
Sequence Identity: 42% (122 aa)

YEKIRVIGQGAFGKVFLCKNLGNNNH-----VVIKQIPVDELPSEERKSAM-NEVNVLSMLQHPNIIGYYASFVEDK--SLMIAMEYAP-GGTLYEL---
||.|..||||.||||....   ...|     .|.|.| .... ..|.. |. |||..|..|.||||..|| ||.|..  .|.| |||.  ||.||..   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

IQERN--GKHIEEETILQLFVQILVAIEHVHSL-----NILHRDLKPQNIMLNKKKT---VVKIGDFGISKVLSSKITSAQT-VVGTPCYISPEICEGRV
|...   ||..|||.|.  |.|.. |. ..|.      .|||||.|||||.|.|. .   .||||||||||||... . |.| .||||.|.|||.|... 
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YRKKSDIWSLGCILYELLAL--RKAFEGP--NFPALVLKIMQGSNALQPLSDN--YTSSLCTLVHAMLQRNPDDRPNIENIMANPVI
|  |||||||||.|||. .|  ...||.   |.|.|..|||.|    .|....  | . |  |.. |||..|..||... |...| |
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKG-PQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase AqueK183.AA NEK1 4-261 42 4.8e-114 385.18 In-house 1-276 (276) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-276/276
Sequence Identity: 42% (119 aa)

YEKIRVIGQGAFGKVFLCKNLGNNNHVVIKQIPVDELPSEERKSAMNEVNVLSMLQHPNIIGYYASFVEDKS--LMIAMEYAPGGTLYELIQER--NGKH
|..|..||.|.|||..| |    . | ||| | | . ...||  .||||..|... ||||..|. ||.|  .  | | |||. || |.  |...   || 
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

IEEETILQLFVQILVAIEHVHSLNILHRDLKPQNIMLN--KKKT--------------VVKIGDFGISKVLSSKITSAQTVVGTPCYISPEICEGRVYRK
. | .|.. |.||  |  |.|. .|||||.|.||| |   |.                .||.|||||...|..    |.|..||| |.|||||. . |  
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWSLGCILYELLALRKAFEGPNFPALVLKIMQGSNALQPLSDNYTSSLCTLVHAMLQRNPDDRPNIENIMANPVI
|||||||||.||||..|  .||. |...||||| ||.    |..  |   |  ||  |..||| .|| .  |   | |
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGT--YPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase AqueK183.AA S_TKc 4-261 30 4.1e-93 316.56 SMART 1-231 (231) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-231/231
Sequence Identity: 30% (84 aa)

YEKIRVIGQGAFGKVFLCKNLGNNNHVVIKQIPVDELPSEERKSAMNEVNVLSMLQHPNIIGYYASFVEDKSLMIAMEYAPG--GTLYELIQERNGKH--
||..|.||.||||||..|.. . . .| ||.|.         .....|...|.. .||||. .| .|.. ..| . |||..|  |.|...|..|...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--IEEETILQLFVQILVAIEHVHSLNILHRDLKPQNIMLNKKKTVVKIGDFGISKVLSSKITSAQTVVGTPCYISPEICEGRVYRK-KSDIWSLGCILYE
  . | ..  .. ||. |.|. ||..|.||||||.||.|..   ..||.|||....|        |..||| |..||..    | | |.|.||.||||||
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LLALRKAFEGPNFPALVLKIMQGSNALQPLSDNYTSSLCTLVHAMLQRNPDDRPNIENIMA-------NPVI
.|. .  |.    .....|..             ..... ..  .||..|..|| .  ...        | .
MLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK183.AA NEK4 4-261 40 6.4e-87 295.08 In-house 1-257 (257) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-257/257
Sequence Identity: 40% (105 aa)

YEKIRVIGQGAFGKVFLCKNLGNNNHVVIKQIPVDELPSEERKSAMNEVNVLSMLQHPNIIGYYASFVEDKS--LMIAMEYAPGGTLYELIQERNGKHIE
|. ..|.|.| .| |.| ..       |.| .   .  ..||| |  |...|| |.||||. |  |.  .    | | | .  || ||.  ... .. .|
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EETILQLFVQILVAIEHVHSLNILHRDLKPQNIMLNKKKTVVKIGDFGISKVLSSKITSAQTVVGTPCYISPEICEGRVYRKKSDIWSLGCILYELLALR
|. ..  ||||  |    |  .||||||| ||| | ||  ..||||||||.||  .   |.|..||| |.|||.   | |  ||||||||| .||.  |.
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKN-IIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLK

KAFEGPNFPALVLKIMQGSNALQPLSDNYTSSLCTLVHAMLQRNPDDRPNIENIMANPVI
 ||.  . . |. .|.||   . |.. ||   |  ||  ||.. |..|| | .|.  | |
HAFDAKDMNSLIYQIIQG--QPPPMPPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase AqueK183.AA Pkinase 4-261 28 5.1e-82 283.6 Pfam 1-293 (293) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-293/293
Sequence Identity: 28% (84 aa)

YEKIRVIGQGAFGKVFLCKNLGNNNHVVIKQIPVDELPSEERKSAMN--EVNVLSMLQHPNIIGYYASFVEDKSLMIAMEYAPGG----TLYELIQERNG
|...|.||.|.||.|..|.. |..  |..|.|....  |...... .  |. .. .|.||||. .| .| ..... . |||..||     |...|. ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KHI--EEETILQLFVQILVAIEHVHSLNILHRDLKPQNIMLNKKKTV---VKIGDFGISKVL-SSKITSAQTVVGTPCYISPEICE-GRVYRKKSDIWSL
. .  .|...   . ||| ..|. || .|.||||||.||..... ..   |||.|||..|..   . . ..|..||| |..||..  |. | .|.|.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCILYELLALRKAFEGP------NFPALVLKIMQGSNALQPLSDNYT------------------SSLCTLVHAMLQRNPDDRPNIENIMANPVI
||||||.|  |  | |       .  ... .||.. .  .   ..                    .... ..  .|...| .||..| |.  | .
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK183.AA CAMK 9-261 22 1.2e-78 252.84 In-house 1-425 (425) Show / Hide 
Range on Protein: 9-261
Range on HMM: 1-425/425
Sequence Identity: 22% (94 aa)

VIGQGAFGKVFLCKNLGNN------------NHVVIKQIPVDELP--------------------------SEERKSAMNEVNVLSMLQ-------HPNI
..|.|.||||.||..  ..             .| || |. . |.                           . ||. ..|......||       ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IGYYASFVE-------------------DKSLMIAM---EYAPGG----TLYELIQERNG-------------KHIEEETILQLFVQILVAIEHVHSLNI
|  |  .                     || . . |   ||..||     |.. |.|. .             ....|.   ..| ||. |... ||.||
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

LHRDLKPQNIMLNKKK----------------TVVKIGDFGISKVLSSKITS-----------------------AQTVVGTPCYIS-PEICEG------
 |||||| ||.|....                  .|| ||| .... ..  .                        .|..|||.|.. ||. .|      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------RVYRKKSDIWSLGCILYELLALRKAFEGP-------------NFPALVLKIMQGSNA-LQPL------------SDNYTSS--------LCT
        . | .|.|.||.|.||| .|  .  |.|.             | . |  |||.|      |              |. . .           
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LVHAMLQRNPDDRPNIENIMANPVI
|.  |||..|..|..|| ... | .
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase AqueK183.AA ULK 4-261 28 5.9e-73 248.68 In-house 1-329 (329) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-329/329
Sequence Identity: 28% (93 aa)

YEKIRVIGQGAFGKVFLCKNLGN----NNHVVIKQIP---VDELPSE-----ERKSAMNEVNVLSML--------QHPNIIGYYASFVED--KSLMIAME
|......|.|.||||.  .|  .    |  |..|.|.    .. . |       .. .||. .. .|        .||||. .|  | ..  . . | ||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

YAPGGTLYELIQER--------NGKHIEEETILQLFVQILVAIEHVHSLNILHRDLKPQNIMLNKKKT-----------VVKIGDFGISKVLSSK---IT
| .||.| ..|...        ..|...|. ..| | ||| .  . |. || |||.|||||.......           |.||.||| .|....    . 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

SAQTVV------GTPCYISPEICEGR-----VYRKKSDIWSLGCILYELLALRKAFEGPNFPALVLKIMQGSNAL----------QPLSDN-------YT
 ..| |      ||| | .|.| .|.      | .|.||||||||.||.|  .  |... |  ..|.|.|    .          |||  .         
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQIS

SSLCTLVHAMLQRNPDDRPNIENIMANPVI
. .  |   |||....|| ..| . ..|..
PECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase AqueK183.AA NEK-Unclassified 4-261 37 8.2e-73 240.33 In-house 1-258 (258) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-258/258
Sequence Identity: 37% (99 aa)

YEKIRVIGQGAFGKVFLCKNLGNNNHVVIKQIPVDELPSEERKSAMNEVNVLSMLQHPNIIGYYASFVEDKSLMIAMEYAPGGTLYELIQERNGK--HIE
|.||  .|||  | |.| .      |.| .||         .|   | . .|| | || |. |  || |   |    .|  || | ..|| . .|   ..
YDKITTLGQGGGGAVYLVRHQISKRHLV-QQISK----RKKKKKRQNKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFD

EETILQLFVQILVAIEHVHSLNILHRDLKPQNIMLNKKKTVVKIGDFGISKVLSSKITSAQTVVGTPCYISPEICEGRVYRKKSDIWSLGCILYELLALR
|  | | ..|.  |.  .|.  |.||||||||| | .  ||  .||||||...    . |.| |||.|..|||.|.   |  .||.||||||.||. .  
EGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVS-MGDFGISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCE

KAFEGPNFPALVLKIMQGSN----ALQPLSDNYTSSLCTLVHAMLQRNPDDRPNIENIMANPVI
 .|   |   .  || |. |    || | |  |   |  ..  ||.||.. ||    |.  . |
PFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRRNFQQRPSATEIVEQDYI
Kinase AqueK183.AA ULK 4-261 28 1.2e-71 244.36 In-house 1-324 (324) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-324/324
Sequence Identity: 28% (92 aa)

YEKIRVIGQGAFG-KVFLCKNLGN---NNHVVIKQIP---VDELPSE-----ERKSAMNEVNVLSMLQ---HPN--IIGYYASFVED--KSLMIAMEYAP
|......|.|.|| ||.  .|  .   | .| .|.|.     . ..|       .. .||.... .|    |||  |. .|  | ..  . . | ||| .
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GGTLYELIQER-------NGKHIEEETILQLFVQILVAIEHVHSLNILHRDLKPQNIMLNKKKT-----------VVKIGDFGISKVLS---SKITSAQT
||.| ..|...       ..| ..|. ..| | ||. .  . |. || |||.|||||.......           |.||.||| .|..       .  ||
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

VV------GTPCYISPEICEGR-----VYRKKSDIWSLGCILYELLALRKAFEGPNFPALVLKIMQGS----------NALQPLSDN-------YTSSLC
 |      ||| | .|.| .|.      | .|.||||||||.||.|  .  |... |  ..|. .|               ||.  .         . . 
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLY-IQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

TLVHAMLQRNPDDRPNIENIMANPVI
 |   |||....|| ..| | ..|..
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase AqueK183.AA Ciliate-E2 4-261 23 7.9e-70 238.29 In-house 1-365 (365) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-365/365
Sequence Identity: 23% (91 aa)

YEKIRVIGQGAFGKVFLCKNLGNNNH-----------------------VVIKQIPVDELPSEER-KSAMNEVN----------VLSMLQHPNIIGYYAS
|..|..||||.||.|..||.  ...                        . .|..  ... . .. .. |.|.|          .|. |.||||| .| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FV--EDKSLMIAMEYAPGGTLYELIQERNGKH---------IEEETILQLFVQILV---------------AIEHVHSLN-ILHRDLKPQNIMLNKKKTV
|    |... . |||. ||.|...|.... |.         . |. |.... |||                |.|. || | |.|||.||.||..      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

VKIGDFGISK------------VLSSKITSAQ--------------------TVVGTPCYISPEICE---------GRVYRKKSDIWSLGCILYELLALR
.|| |||.||            ... ...  .                    |..||| | .||| .         .  | .|.||||||.||||.|  .
IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGK

KAFEGPNFPALVLKIMQGSNALQPL---------------SDNYTSSLCTLVHA----MLQRNPDDRPN-IENIMANPVI
  |          .|.|.   ...                 .. . .   |       |||..|. |.. .| |. .| .
PPF--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase AqueK183.AA STE 4-261 22 4.7e-67 229.08 In-house 1-359 (359) Show / Hide 
Range on Protein: 4-261
Range on HMM: 1-359/359
Sequence Identity: 22% (81 aa)

YEKIRVIGQGAFGKVFLCKNL------GNNNH---------VVIKQIPVDELPS---------------EERKSAMNEVNVLSMLQ--HPNIIGYYASFV
.|.|..||.||||.|....|        ...          . |||.....  .               ||... ..|..... ..  ||||. || ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

ED-------KSLMIAMEYAPGGTLYELIQ---ERNG---------KHIEEETILQLFVQILVA-IEHVHSLNILHRDLKPQNIMLNKKKTVVKIGDFGIS
 .        .| |.||| .||.| ..|.   ....         ....|. |    .||| .  .. ||..| |||.||.||.|      ||. |||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL------VKLCDFGVC

KVLSSKIT----------------SAQTVVGTPCYISPEICEG------RVYRKKSDIWSLGCILYELLALRKAFEGPNFPALVLKIMQGS---------
. |.....                  .|.|||| . .||. ..        |  |.||||||| . |..  .  .   . .   . |....         
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

----NALQPLSD-------------------NYTSSLCTLVHAMLQRNPDDRPNIENIMA--NPVI
    .   || |                   .......  .   ||..|..||. .  .    | |
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase AqueK183.AA Pkinase_Tyr 4-200 24 9.2e-32 108.2 Pfam 1-210 (270) Show / Hide 
Range on Protein: 4-200
Range on HMM: 1-210/270
Sequence Identity: 24% (53 aa)

YEKIRVIGQGAFGKVFLCKNL----GNNNHVVIKQIPVDELPSEE--RKSAMNEVNVLSML-QHPNIIGYYASFV-EDKS--LMIAMEYAPGGTLYELIQ
 ......|.||||.|....      ... .| .| .  .   .|.  |.. |.|..... | .||||. .|.  . ....  ..| |||.|.| |..  .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

ER--NGKHIEEETILQLFVQILVAIEHVHSLNILHRDLKPQNIMLNKKKTVVKIGDFGISKVLSSKITSAQT-VVGT-----PCYISPEICEGRVYRKKS
..  .....  ...||  .||  . |. .| |. ||||   |....... ||||.||| .. .       .  ....         .||    ...  ||
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENN-VVKICDFGLARDI---YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKS

DIWSLGCILYELLAL
|.|| |  ..|.. .
DVWSFGVLMWEIFTY
Kinase AqueK183.AA TyrKc 4-265 21 4.3e-25 90.6 SMART 1-280 (280) Show / Hide 
Range on Protein: 4-265
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

YEKIRVIGQGAFGKVFLCKNLGNNNHVVIKQIPVDELPSEERKSAMNEVNVLSML--QHPNIIGYYASFVED-------KSLMIAMEYAPGGTLYELIQE
 ......| ||||.|....       | .| .  |      |.  |.| .....|  .||||.  |.  ...       . ||| |||.|.| | . ...
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RNGKHIEEETILQLFVQILVAIEHVHSLNILHRDLKPQNIMLNKKKTVVKIGDFGISKVLSSK--------ITSAQTVVGTP--C---YISPEICEGRVY
. .| .  .. |.  .||    |. || |. ||||   |....... .|||.||| |. . ..          ....  |.         .||    ...
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

RKKSDIWSLGCILYELLALRKAFEGP-----NFPALVLKIMQGSNALQPLSDNY-------TSSLCTLVHAMLQRNPDDRPNIENIMANPVIVNAL
  |||.|| |  ..|.. . .            .. |..  .  . . .  ..|       .. . ..     ...|.|||. ..|      .  .
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI------HECF
RCC1 AqueK183.AA RCC1 335-361 20 1.827451 4.39 Pfam 25-52 (52) Show / Hide 
Range on Protein: 335-361
Range on HMM: 25-52/52
Sequence Identity: 20% (6 aa)

SVPMI-LPQPAE-KSVTSLSVGRSHRAAI
.||.  .. .   ..|.. . |..| .|.
HVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 AqueK183.AA RCC1 399-424 37 0.000608 15.68 Pfam 27-52 (52) Show / Hide 
Range on Protein: 399-424
Range on HMM: 27-52/52
Sequence Identity: 37% (10 aa)

PQL-VEGFSASVVIKKVSCGDLFTACL
||. ||..   | ...|.||. .|..|
PQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 AqueK183.AA RCC1 427-476 29 2.2e-10 36.61 Pfam 1-52 (52) Show / Hide 
Range on Protein: 427-476
Range on HMM: 1-52/52
Sequence Identity: 29% (16 aa)

KGILMTFGSGINGCLG--HGDYDDVPKAKL-VRAMLQ-YETIDVACGANHVVAV
.| . |.|.. .|.||  |||  .. . .. |      .. ..||||..|..|.
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 AqueK183.AA RCC1 479-540 32 5.2e-15 51.61 Pfam 1-52 (52) Show / Hide 
Range on Protein: 479-540
Range on HMM: 1-52/52
Sequence Identity: 32% (21 aa)

DHTVHSWGRNENGQLG--TGDTLACNEPKQ-VLPVEGEEGGGEGGGGGKEVISSVTCGSDCSILL
|  | .||.|..||||  .|||  |. |.| |    |           .. ...| ||.. ...|
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-G-----------NVRVVQVACGWQHTMAL
RCC1 AqueK183.AA RCC1 635-657 34 0.002356 13.77 Pfam 28-52 (52) Show / Hide 
Range on Protein: 635-657
Range on HMM: 28-52/52
Sequence Identity: 34% (9 aa)

CK-VEILEG--EVTAIAAGTNHTAFI
.. ||.| |  .|. .|.| .||...
QQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 AqueK183.AA RCC1 660-703 33 2.6e-07 26.59 Pfam 1-52 (52) Show / Hide 
Range on Protein: 660-703
Range on HMM: 1-52/52
Sequence Identity: 33% (18 aa)

KGHCITSGSNAYGQLG--HSHSVPAVVPKL-------VSVTRISCGDNFTIAA
.|.. | |.| |||||  | ..    ||..       |.|. ..||...|.| 
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFLGNVRVVQVACGWQHTMAL
RCC1 AqueK183.AA RCC1 706-755 29 5.9e-13 44.94 Pfam 1-52 (52) Show / Hide 
Range on Protein: 706-755
Range on HMM: 1-52/52
Sequence Identity: 29% (16 aa)

DGRMYSWGCGRRGRLG--YESEPIRAEPTL-MTFENT-QTVQSIQSSHSVTMAM
||| |.|||...|.||    ..  .  |..  .|    . |... . .. ||| 
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL