Gene AqueK199 (A.queenslandica)

AqueK199

Species: A.queenslandica
Alias: AqueK199
External Links:
Annotation:

Classification

Group: Other
Family: PEK
Subfamily: PEK

Sequence

Name Sequence Type Origin Length Description Download
AqueK199.AA Protein None 1189 None Fasta, JSON
AqueK199.kin_dom Protein Kinase Domain None 314 None Fasta, JSON

Protein domain

Protein domains of AqueK199.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK199.AA PEK 860-1171 17 6.4e-76 258.54 In-house 60-655 (655) Show / Hide 
Range on Protein: 860-1171
Range on HMM: 60-655/655
Sequence Identity: 17% (108 aa)

KVKREVHALSVLYHPGIVRYYNSFIDCAPVGW-------------------------------------------------------------DDNAMDE
|| ||| .|. | ||.||||.|. |   ...|                                                              ...  .
KVLREVKTLARLNHPNIVRYHNAWIEKPEEKWQQQQDEMWQLDSSTDWPNGKHKSKDYNFHPFEKEWDDEEAQESNVMSECEDREQKGKKKCWSESNSHS

PSTSFGQSNLSSVQSARTLSPVGA-----SINTSGTESSS------------------------------------------------------------
.. .. .|. .|.   .  |...      |||. ||| ..                                                            
SKNNYEESMEWSCSEHSDSSSFPNIENQFSINF-GTENENESHISYWSSSVYMSSSWDNPFDSSFSNSCDSTNFNKDEDHSFFSCSSYSSCSTDCDDSKD

------------------------------------------------IEFRDDSSQKNRSQEKGIPTHTKVTDETLTDDATDDTTPYSSLSGYQ-----
                                                ... |... ||   .. | . ..  .|.     ..... . ... ..     
SSPFNWDGGCDNWEQYEYSDQDDEHEQNDCQSKQCDSKNQSHKKCMEMTWIQDQEDNKN-NCSHHIGSSSQSQEEM----ENNTNNNKNKFKQMHNTKQY

--KYLFIQMELCQRETLRDWLSKNV-------------------------------------------RNRYRIKVFNYFEQILDAVIYMHDKDYIHRDL
   ||.||||.|. .|||||.. |                                            .....  ....|.|||... |.| .  |||||
QCHYLYIQMEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQGMIHRDL

KPSNILFAMNDS-----IKVGDFGLVKQNA--------------------ATKHSAPQTDVQGS----------------------------HTSEIGTS
|||||.. ...      .|.|||||.....                    |.. .  ..  | .                            ||. .|| 
KPSNIFLDCDGQHHQMQVKIGDFGLATNHEMLSQSQKNYNQQDQSYWKYVANDNCQWWNTNQQNSPTGQDTHMWSNNYHIQPTSMFYCEHCHHTGGVGTC

FYVSPEQEAGH-----RYNERADVYSLGIILFELYFPFSTVM-ERAKVLGDVKS-NRRLPKEFK-ENLHN----EAKLVELMLKPISD-RPSSSEIKEID
.|.||||. |       ||...|.||||||.||...||.| | ||.|.| |... .  .| .|  ... |    .|... .||..  . |||...| . .
LYMSPEQLSGQHYQKSHYNHKVDMYSLGIIFFEMWYPFFTTMMERVKTLTDLRDESIQFPGDFPPKWFDNKYPKQADFIQWMLSHDPQQRPSAQQILQHE

AF
 |
FF
Kinase AqueK199.AA GCN2 982-1165 30 1.9e-53 183.89 In-house 281-505 (511) Show / Hide 
Range on Protein: 982-1165
Range on HMM: 281-505/511
Sequence Identity: 30% (70 aa)

YLFIQMELCQRETLRDWLSKNVRNRYRIKVFNYFEQILDAVIYMHDKDYIHRDLKPSNILFAMNDSIKVGDFGLVK------------------------
||.|||| |.. |||. .. .. .. .  .. || |||... |.|..  ||||||||||..  .. .|.|||||..                        
YLYIQMEYCEGKTLRQYIDNHGWCMDHDELWRYFRQILEGLNYIHSQGMIHRDLKPSNIFLDCCGNVKIGDFGLATNNKMESQINRKQQKQQQQASSHWA

------QNAATKHSAPQTDVQG------SHTSEIGTSFYVSPEQEAGHRYNERADVYSL-GIILFELYFP-FSTVMERAKVLGDVKSNRRLPKEFK---E
      |....   . |.. ..      .||. .|| ||..|||.    ||...|.||| |||.||. .| |.| |||...| . . .  .|. |    .
IQNEICQDDQFNQQQSQFSQWDQQDEQVHHTGKVGTPFYMCPEQQ-KSHYNQKVDMYSLGGIIFFEMWYPPFCTQMERVQILKQLR-SCEFPQDFDKKVD

NLHN-EAKLVELMLKPISD-RPSSSEI
| |  ...... .|.. .. ||| ...
NHHKDQQDMIRWCLNHDPQKRPSAQQL
Kinase AqueK199.AA HRI 982-1171 32 4.1e-36 124.73 In-house 393-613 (613) Show / Hide 
Range on Protein: 982-1171
Range on HMM: 393-613/613
Sequence Identity: 32% (72 aa)

YLFIQMELCQRETLRDWLS-KNVR---------NRYRIKV----FNYFEQILDAVIYMHDKDYIHRDLKPSNILFAMNDS----IKVGDFGLVKQNAATK
.|.|||.||   .|.||.|  | |         . | .       . | ||.  . | | .  .|||.|| ||     |     .|.|||||  .   ..
MLHIQMQLCEL-SLWDWISERNKRSREYVDETECPYVMANEKVIQKIFQQIVEGMFYIHNMFIVHRDVKPRNIFLHDPDQGHPQVKIGDFGLACEDILQE

--------------HSAPQTDVQGSHTSEIGTSFYVSPEQEAGHRYNERADVYSLGIILFELYFPFSTVMERAKVLGDVKSNRRLPKEFKENLHNEAKLV
               .     |   ||| .||  | ||||  |  |  . | ||.|.|||||. || | ||||.||  |.   ..|   .      || .
PKTPMRFRRDQDFDWTNRNPCVTQTHTSRVGTCTYASPEQLDGSQYDNKSDMYSMGVILFELFQPFGTEMERAEVLTGVRTG-QIPESLRKRCPVQAKYI

ELML-KPISDRPSSSEIKEIDAF
 ..  .  | |||   .   . |
QHLTRRNASQRPSAIQLLQSELF
Kinase AqueK199.AA PEK 982-1062 36 4.9e-32 103.38 In-house 413-519 (758) Show / Hide 
Range on Protein: 982-1062
Range on HMM: 413-519/758
Sequence Identity: 36% (39 aa)

YLFIQMELCQRETLRDWLSK--NVRNRYRIKVFNYFEQILDAVIYMHDKDYIHRDLKPSNILFAMNDS------------------------IKVGDFGL
|..|||.||  |||.||..   . ..| . .. . | ||...| | | |  |||||||||| |.| .                         ||.|||||
YMYIQMQLCRKETLKDWMRNRCTMESRPWMHMLHWFHQICEGVNYIHSKGMIHRDLKPSNIFFSMDSQHHQQSSFSNISSSFEENSDGGHQIIKIGDFGL

VKQNAAT
|..  ..
VTDHTIV
Kinase AqueK199.AA PEK 1075-1171 33 1.7e-30 98.17 In-house 645-758 (758) Show / Hide 
Range on Protein: 1075-1171
Range on HMM: 645-758/758
Sequence Identity: 33% (39 aa)

HTSEIGTSFYVSPEQEAGH----------------RYNERADVYSLGIILFELYFP-FSTVMERAKVLGDVKSNRRLPKEFKENLHNEAKLVELMLKPI-
||   ||. | ||||  .                  ||.  | ||||.|.|||..| ||| |||.... |.. |  .|| |  ..  |.... .|...  
HTVQVGTHLYMSPEQCHHQSVFGTGTYTNPEQKKTWYNHKVDIYSLGLIFFELIHPGFSTQMERIRTMCDLR-NGQWPKWFTQKYPQEYEFIQQMMSMNP

SDRPSSSEIKEIDAF
. ||....|.. | |
DERPTADQISMHDFF
Kinase AqueK199.AA Ciliate-E2 980-1171 19 4e-30 100.58 In-house 106-365 (365) Show / Hide 
Range on Protein: 980-1171
Range on HMM: 106-365/365
Sequence Identity: 19% (55 aa)

QKYLFIQMELCQRETLRDWLSKN----------VRNRYRIKVF-NYFEQILD---------------AVIYMHDKD-YIHRDLKPSNILFAMNDSIKVGD
...... ||.||  .|.|.. .|            ... .|   ....|||.               |. |.| |   ||||.||.||||     ||. |
DNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----IKIID

FGLVKQNA---------ATKHSAPQTDVQGSHTSE--------------IGTSFYVSPEQEA---------GHRYNERADVYSLGIILFEL---YFPFST
||| |..                ..  .. | |.               .||  |..||            ...|.. .|..|||.||.|.   ..||  
FGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--

VMERAKVLGDVKSNRRLPKEFK----------------ENLHNEAKLVELMLK--------PISDRPS-SSEIKEIDAF
           . .   . .|                 .... . .   |. |          . |..  ..|..   |
----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase AqueK199.AA Ciliate-E2-Unclassified 980-1171 24 1.1e-28 96.58 In-house 93-352 (352) Show / Hide 
Range on Protein: 980-1171
Range on HMM: 93-352/352
Sequence Identity: 24% (64 aa)

QKYLFIQMELCQRETLRDWLSKN----------VRNRYRIKVF-----------NYFEQILDAVIYMHDKD-YIHRDLKPSNILFAMND---SIKVGDFG
.....| ||.|.  .|.....|.          ..|... | |           .|| |||..  |.| |   ||||.||.||||  |     ||. |||
KQNIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFG

LVKQNAA---------TKHSAPQTDVQGSHTSEIGTSFYV----SPEQEAGHRYNER----ADVYSLGIILFEL---YFPFS--TVME------------
. |..           .| . .. . .   .. .||  |     .||   |. |...    .|..|||.||.|.   |.||.  .  .            
ISKKYQQNNNCDTNQQQKMQIWKQQMM---WTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNA

-RAKVLGDVKSNRRLPKEFKE-----NLHNEAK-LVE----LMLKPISD-RPSSSEIKEIDAF
 |  .. . | .    ..|..     ....||| ...     |||   . |.. ..|..   |
YRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase AqueK199.AA Pkinase 981-1113 30 2.5e-28 101.26 Pfam 73-207 (293) Show / Hide 
Range on Protein: 981-1113
Range on HMM: 73-207/293
Sequence Identity: 30% (45 aa)

KYLFIQMELCQRE----TLRDWLS--KNVRN--RYRIKVFNYFEQILDAVIYMHDKDYIHRDLKPSNILFAMNDSI----KVGDFGLVKQNAATKHSAPQ
... . ||.|.       | |..|  .. .    ..  . .|. ||| .. |.|..  |||||||.|||.  |. |    |..|||| ||          
DHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWE-CKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--------

TDVQGSHTSEIGTSFYVSPEQEA-GHRYNERADVYSLGIILFELYF
.  ..  |.  ||..|..||    |  |  ..|..|.|.||.|...
Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC
Kinase AqueK199.AA PKR 981-1169 36 3.3e-28 98.02 In-house 94-272 (272) Show / Hide 
Range on Protein: 981-1169
Range on HMM: 94-272/272
Sequence Identity: 36% (69 aa)

KYLFIQMELCQRETLRDWLSKNVRNRY-RIKVFNYFEQILDAVIYMHDKDYIHRDLKPSNILFAMNDSIKVGDFGLVKQNAATKHSAPQTDVQGSHTSEI
. |||||| | . ||  |. .   ..  .. . . .|||   | |.| |  ||||||||||    .  ||.||||||         | . | . | |   
RCLFIQMEFCDKGTLEQWMRNRRQEKVDKVLILDLYEQIVKGVDYIHSKKLIHRDLKPSNIFLVDERHIKIGDFGLV--------TALKNDGK-SRTRRK

GTSFYVSPEQEAGHRYNERADVYSLGIILFELYFPFSTVMERAKVLGDVKSNRRLPKEFKENLHNEAKLVELMLKPISDRPSSSEIKEID
||  |.||||   . |    |.| ||.|| ||     | .|. |   |..        | .     . |  |. |   |||  |||    
GTLQYMSPEQIFSQHYGKEVDIYALGLILAELLHVCFTEFEKIKFFEDLRDGDFSNDIFDN--KEKTLLQKLLSKKPKDRPNTSEILRTL
Kinase AqueK199.AA TKL 987-1169 18 6.6e-24 82.98 In-house 117-364 (364) Show / Hide 
Range on Protein: 987-1169
Range on HMM: 117-364/364
Sequence Identity: 18% (48 aa)

MELCQRETLRDWLSKNVRNRYRIKVFNYFEQILDAVIYMHDKD--------YIHRDLKPSNILFAMNDS--------------IKVGDFGLVKQNAATKH
||.|.. .|.. |          . ..   .|  .. |.| ..         ||||||..|||   |                .|..|||| . .  ...
MEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGN

SAPQTDVQG----------SHTSEIGTSFYVSPEQEAGH----------------RYNERADVYSLGIILFELYF---PFSTVMERAKV---------LG
.  .   ..           . ...||  . .||   |.                 |.|..|||| ||.|.|..    |..  ...  .          .
MNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMM

DVKSNRRLPKEFKENL-------HNE----AKLVELMLKP-ISDRPSSSEIKEID
... ..|.|     .        ..     .|| .   ..  ..||| .||... 
VCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK199.AA STE 860-1111 16 8.2e-24 81.03 In-house 74-261 (359) Show / Hide 
Range on Protein: 860-1111
Range on HMM: 74-261/359
Sequence Identity: 16% (46 aa)

KVKREVHALSVLY--HPGIVRYYNSFIDCAPVGWDDNAMDEPSTSFGQSNLSSVQSARTLSPVGASINTSGTESSSIEFRDDSSQKNRSQEKGIPTHTKV
....|.  .. .   || ||.|| ....  .                                                                     
QILKEIKIMKKCNHMHPNIVKYYGCYFKEGHN--------------------------------------------------------------------

TDETLTDDATDDTTPYSSLSGYQKYLFIQMELCQRETLRDWLS-KNVRNR---------YRIK---VFNYFEQILDA-VIYMHDKDYIHRDLKPSNILFA
                   ..   .|.| ||..   .|.| .  |  ...          |..   .  .  ||| .   | |.. .||||.||.|||. 
-------------------HKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-

MNDSIKVGDFGLVKQNAATKHSAPQTD---------VQGSHTSEIGTSFYVSPEQEAGHR------YNERADVYSLGIILFEL
    .|  |||. .| . .  .  |            |.  .. .||  . .||   . .      |....|..|||. . |.
----VKLCDFGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEM
Kinase AqueK199.AA PEK-Unclassified 1076-1138 39 8.7e-17 54.44 In-house 731-803 (835) Show / Hide 
Range on Protein: 1076-1138
Range on HMM: 731-803/835
Sequence Identity: 39% (29 aa)

TSEIGTSFYVSPEQE-----------AGHRYNERADVYSLGIILFELYFPFSTVMERAKVLGDVKSNRRLPKEF
|| .||  | |.|||            .  || |.|.||.|||.|..  .. | ||| | .  .|    ||| |
TSTCGTYTYSSNEQESQKKVRIKAHFQADFYNHRTDIYSVGIIFFQMFHQMNTTMERVKTIQNCK-KGELPKHF
Kinase AqueK199.AA S_TKc 897-1171 19 1.1e-15 53.11 SMART 1-231 (231) Show / Hide 
Range on Protein: 897-1171
Range on HMM: 1-231/231
Sequence Identity: 19% (59 aa)

DEPSTSFGQSNLSSVQSARTLS----------PVGASINTSGTESSSIEFRDDSSQKNRSQEKGIPTHTKVTDETLTDDATDDTTPYSSLSGYQKYLFIQ
 |     |.   ..|  .|  .          .                             . |    ..  .       .    .       ..|.. 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------------------------EHIRREIQILKK-----HHPNIVKLYDVFQD-DHLYMV

MELCQR--ETLRDWLSKNVRNR----YRIKVFNYFEQILDAVIYMHDKDYIHRDLKPSNILFAMNDSIKVGDFGLVKQNAATKHSAPQTDVQGSHTSEIG
||.|     .|.| . |. |..    .   .  |. ||..|. |.|..  |||||||.|||.     ||..|||| .|                 |. .|
MEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------------TTFCG

TSFYVSPEQEAGHRYNE-RADVYSLGIILFELYF---PFSTVMERAKVLGDVKSNRRLPKEFKENLHNEAK-LVELMLK-PISDRPSSSEIKE-------
| .|..||      |.  ..|..|.|.||.|..    ||.   . ....  ..               ||| ... .|.   ..||.  |. .       
TPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

IDAF
   |
HPWF
Kinase AqueK199.AA PEK-Unclassified 1017-1058 47 1.1e-09 28.9 In-house 621-664 (835) Show / Hide 
Range on Protein: 1017-1058
Range on HMM: 621-664/835
Sequence Identity: 47% (21 aa)

QILDAVIYMHDKD-YIHRDLKPSNILFAMN-DSIKVGDFGLVKQ
||. |  . |    ..|||.|| ||    |   ||.|||||||.
QIIKALYHIHHQCKMVHRDIKPHNIFVCQNPMQIKIGDFGLVKK
Kinase AqueK199.AA TyrKc 955-1171 18 1.1e-08 -82.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 955-1171
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

TKVTDE---------------------TLTDDATDDTTPYSSL-------SGY---------------Q--------KYLFIQMELCQRETLRDWLSKNV
 .  ..                     .| .||         .       . .               |        . |.| ||..    |.| | |. 
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

RNRYRIKVFNYFEQILDAVIYMHDKDYIHRDLKPSNILFAMNDSIKVGDFGLVKQNAAT---KHSAPQTDVQGSHTSEI--GTSFYVSPEQEAGHRYNER
..    .  ..  || .   | |.| .|||||   |.| . |  .|..|||| .           . .. .. .| ..         .||    ..... 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-ESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTK

ADVYSLGIILFELY----FPFSTV----MERAKVLGDVKSNRRLPKEFK--ENL---HNEAKLVELMLK----PISDRPSSSEIKEIDAF
 ||.| |. ..|..     | . .    |. . |. .||. .|.|.     . .   .  ... ..|..      .|||. |||  .. |
SDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase AqueK199.AA PEK 860-882 56 7e-06 14.38 In-house 51-73 (758) Show / Hide 
Range on Protein: 860-882
Range on HMM: 51-73/758
Sequence Identity: 56% (13 aa)

KVKREVHALSVLYHPGIVRYYNS
|| ||| .|  | |..||||.|.
KVMREVRTLAMLDHHNIVRYFNA
Kinase AqueK199.AA GCN2 859-884 46 0.000302 10.29 In-house 46-71 (511) Show / Hide 
Range on Protein: 859-884
Range on HMM: 46-71/511
Sequence Identity: 46% (12 aa)

GKVKREVHALSVLYHPGIVRYYNSFI
.| .|||  |. | |...||||.. |
HKIMREVKLLCRLHHQHVVRYYQAWI
Kinase AqueK199.AA HRI 860-885 46 0.002369 6.63 In-house 44-69 (613) Show / Hide 
Range on Protein: 860-885
Range on HMM: 44-69/613
Sequence Identity: 46% (12 aa)

KVKREVHALSVLYHPGIVRYYNSFID
|. |||  |  | |. ||||  . |.
KMQREVKVLACLQHHNIVRYHQAWIE
Kinase AqueK199.AA PEK-Unclassified 863-884 45 0.003083 5.76 In-house 52-73 (835) Show / Hide 
Range on Protein: 863-884
Range on HMM: 52-73/835
Sequence Identity: 45% (10 aa)

REVHALSVLYHPGIVRYYNSFI
.|| ..  . || |.||| | |
MEVRYMAQVNHPNIIRYYHSWI