Gene AqueK243 (A.queenslandica)

AqueK243

Species: A.queenslandica
Alias: AqueK243
External Links:
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: MEK1

Sequence

Name Sequence Type Origin Length Description Download
AqueK243.AA Protein None 389 None Fasta, JSON
AqueK243.kin_dom Protein Kinase Domain None 284 None Fasta, JSON

Protein domain

Protein domains of AqueK243.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK243.AA MEK1 75-358 56 6.2e-148 497.75 In-house 1-297 (297) Show / Hide 
Range on Protein: 75-358
Range on HMM: 1-297/297
Sequence Identity: 56% (167 aa)

FERLSELGHGNGGVVLKVMHKPSGIIMARKMILLDIKPTVRNQIMRELKVLHDCNASYIVGFFGSFHVNNEISILMQHMDGGSLDLVL-NTGRIPVDMIG
||...|||||||||| |. |...|.|||||.| |.|||..||||.|||.|||.||  |||||.| |  ..|||| | .|||||||.|| . |||| ...|
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKAGRIPEKILG

QITVAVLNGLKYLRDTHHIIHRDVKPSNILVNSEGEIKLCDFGVSGQLINSMANSFVGTRSYMAPERLQGEVYSVLSDIWSLGVSLIEMAIGSYPIPAPP
...|||| || |||| |.|.|||||||||||||.||||||||||||||| |||||||||||||.||||||  |.| |||||.|.||.||||| ||||.| 
KVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGRYPIPPPD

KEQLDEEMR--------NPPAGSLPPRRNPYASHA----NAIRMPVFELLQMIFTDDPPRLPDEYFDDKFKSFVALCLQKDVKKRGTLSALLEHKFV
......           . |.   |  | .|   .    .   | .||.|. |  . ||.||.. | . |. ||  ||.|  . | .|  |. | |.
QKEYETMFGDNVYCEQEGEPHNIDPRERPNYHPISHGMDSPRAMAIFEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase AqueK243.AA STE7 75-358 45 6.6e-143 481.06 In-house 1-288 (288) Show / Hide 
Range on Protein: 75-358
Range on HMM: 1-288/288
Sequence Identity: 45% (140 aa)

FERLSELGHGNGGVVLKVMHKPSGIIMARKMILLDIK-PTVRNQIMRELKVLHDCN-ASYIVGFFGSFHVNNE--ISILMQHMDGGSLDLVL--------
.|...||||||.||| |..|||||.|||.| | |... |. ..||..||.||| ||   |||.|.| |  ...  |.| | .||||.||...        
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

--NTGRIPVDMIGQITVAVLNGLKYLRDTHHIIHRDVKPSNILVNSEGEIKLCDFGVSGQLINSM--ANSFVGTRSYMAPERLQG--EVYSVLSDIWSLG
    |||| . .| |.|||..||.||...|.|||||||||||||||.|..||||||..|||..||  |..|||...||||||..|  . |.| ||.||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

VSL-IEMAIGSYPIP-----APPKEQLDEEMRNPPAGSLPPRRNPYASHANAIRMPVFELLQMIFTD-DPPRLPDEYFDDKFKSFVALCLQKDVKKRGTL
... ||||.| ||.|     .|...|...                         |..||.|..| .. .|||||   | . |..||..||||| ..| ..
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQ-------------------PE-MAIFEQLTCIVNENPPPRLP--KFSPEFQDFVNKCLQKDPNERPKY

SALLE-HKFV
. |.. | |.
HQLMKEHPFI
Kinase AqueK243.AA STE7-Unclassified 75-358 36 4.90000000001e-113 381.83 In-house 1-301 (301) Show / Hide 
Range on Protein: 75-358
Range on HMM: 1-301/301
Sequence Identity: 36% (120 aa)

FERLSELGHGNGGVVLKVMHKP------SGIIMARKMILLDIK-PTVRNQIMRELKVLHDCN-ASYIVGFFGSFHVNNE---ISILMQHMDGGSLD----
.|||..||||..|.| |. ||.      .|.||| | | ...  .. ..|| ||||.|| |.   |||...| .        | |.|  ||.||||    
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

LVLNT--------GRIPVDMIGQITVAVLNGLKYLRDTHHIIHRDVKPSNILVNSEGEIKLCDFGVSGQLINSM--ANSFVGTRSYMAPERLQGE-----
.. ..        |.||   .| |. .|..||.|| . |||||||.||.||||||.|..|.|||||.|||.|..  |...||. .||.|||.||.     
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

VYSVLSDIWSLGVSLIEMAIGSYPIP------------APPKEQLDEEMRNPPAGSLPPRRNPYASHANAIRMPVFELLQMIFTDDPPRLPDEY----FD
.||| ||||||| ...|.|.| ||..            .|                                |  .|||..| .   |||||.     . 
SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQP------------------------------ENMSFWELLSCIVNFPVPRLPDDPEDIIWS

DKFKSFVALCLQKDVKKRGTLSALLE-HKFV
  |..|.. |..|. . | . ..||. | ..
KEFMDFISKCCKKHPRERPDIHQLLNEHPWI
Kinase AqueK243.AA STE 75-358 28 7.8e-96 324.68 In-house 1-359 (359) Show / Hide 
Range on Protein: 75-358
Range on HMM: 1-359/359
Sequence Identity: 28% (113 aa)

FERLSELGHGNGG-VVLKVMHKPS--------------GIIMARKMILLDIK----------------PTVRNQIMRELKVLHDCN--ASYIVGFFGSFH
.|.....|.|..| |.... ||..              | ||| | . |. .                .. ..||..|.|....||    .|| ..|.. 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VN-------NEISILMQHMDGGSLDLVLNT---------------GRIPVDMIGQITVAVLNG-LKYLRDTHHIIHRDVKPSNILVNSEGEIKLCDFGVS
..       .|. | | .||||||| ....               .|.| . |. |....| | |.|| . | |||||.||.|||.     .|||||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

GQLINS------------------MANSFVGTRSYMAPERLQGEV------YSVLSDIWSLGVSLIEMAIGSYPI---PAP------PKE-----QLDEE
|||..|                  . |.||||  .||||..|..       |.. .||||||  .|||| | .|    . .      |..     |    
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ----

MRNPPAGSLPPRRNPYASHANAIRMPVFELLQMIFTDDPPRLPD------------------EYFDDKFKSFVALCLQKDVKKRGTLSALLE--HKFV
                           ||.| .|  ..||.|||                  . . ..|| |...||||| .|| | | ||.  |.|.
---------------------------FEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase AqueK243.AA MEK5 76-276 52 1.4e-85 290.6 In-house 2-198 (254) Show / Hide 
Range on Protein: 76-276
Range on HMM: 2-198/254
Sequence Identity: 52% (105 aa)

ERLSELGHGNGGVVLKVMHKPSGIIMARKMILLDIKPTVRNQIMRELKVLHDCNASYIVGFFGSFHVNNEISILMQHMDGGSLDLVLNTGRIPVDMIGQI
     ||||||| | |  | ||| |.| |.|||||   .. ||| ||..|. | ..||.||.| | | | |||    |||||||.     .||  ..| .
RYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYR---CIPEHILGRM

TVAVLNGLKYLRDTHHIIHRDVKPSNILVNSEGEIKLCDFGVSGQLINSMANSFVGTRSYMAPERLQGEVYSVLSDIWSLGVSLIEMAIGSYPIPAPPKE
|||.  || || .   |.||||||||.||| .|.||||||||| ||.||..  ..||  ||||||. |. | . ||.||||....|||.| .| |. ...
TVAIVKGLNYLWNL-KIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRFPYPQIQRD

Q
|
Q
Kinase AqueK243.AA S_TKc 75-358 26 1.9e-73 251.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 75-358
Range on HMM: 1-231/231
Sequence Identity: 26% (80 aa)

FERLSELGHGNGGVVLKVMHKPSGIIMARKMILLDIKPTVRNQIMRELKVLHDCNASYIVGFFGSFHVNNEISILMQHMDG--GSLDLVLNTGR------
.| | ..|.|  |.| |. || .| |.| |.|         ..|.||...|.  .  .|| ....|.  ... . | ..||  |.|  ..   .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-IPVDMIGQITVAVLNGLKYLRDTHHIIHRDVKPSNILVNSEGEIKLCDFGVSGQLINSMANSFVGTRSYMAPERLQGEVYSV-LSDIWSLGVSLIEMAI
 .|  ..  ..  ....|.|. .  .|||||.||.|||...  .||.||||.. ||     ..|.||. ||||| |    |.   .|.||.|. |.||. 
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GSYPIPAPPKEQLDEEMRNPPAGSLPPRRNPYASHANAIRMPVFELLQMIFTDDPPRLPDEYFDDKFKSFVALCLQKDVKKRGTLSALLE-------HKF
|  | |     |... ...                                            .. .|.|.  ||||| .|| |   .|.       | .
GYPPFP-----QMQMMFKKIG------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

V
.
F
Kinase AqueK243.AA Pkinase 75-358 25 1.9e-61 215.24 Pfam 1-293 (293) Show / Hide 
Range on Protein: 75-358
Range on HMM: 1-293/293
Sequence Identity: 25% (79 aa)

FERLSELGHGNGGVVLKVMHKPSGI-IMARKMILLDIKPTVRNQIMR--ELKVLHDCNASYIVGFFGSFHVNNEISILMQHMDGG----SLDLVLN---T
..... .| |. |.| | .|| .|.     .. . ..|. .. .  |  |..... .|  .|| ....|. ...| . | ...||    .|  ..     
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRI--PVDMIGQITVAVLNGLKYLRDTHHIIHRDVKPSNILVNSEGEI----KLCDFGVSG---QLINSMANSFVGTRSYMAPERLQ-GEVYSVLSDIWS
|..  . . .  .   .| ||.|. . . |||||.||.|||....|.|    |.||||..       || ...|.||. ||||| .. |. |.  .|.||
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVSLIEMAIGSYPIPAP-------PKEQLDEEMRNPPAGSLPPRRNPYASHANAIRMPVFELLQMIFTDDPPRLPDEYFDDKFKSFVALCLQKDVKKRG
.|. |.||. |  | |         ... ... |. |.  . |  .... .. .  . .           . ...   . .. .|.|.  ||.|| ||| 
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H-----------F-HWTF-HNWSEECKDFIKWCLCKDPKKRP

TLSALLEHKFV
|   .|.|...
TAEQILQHPWF
Kinase AqueK243.AA STE20 75-263 36 7.2e-54 185.28 In-house 1-221 (288) Show / Hide 
Range on Protein: 75-263
Range on HMM: 1-221/288
Sequence Identity: 36% (80 aa)

FERLSELGHGNGGVVLKVMHKPSGII----MARKMILLDIKP---TVRNQIMRELKVLHDCNASYIVGFFGSFHVN----NEISILMQHMDGGSL-DLVL
.| | ..|.|. |.| |. |||.| .     | |.. |. .      .. |. |  .. .|.  .|| ..||. ..    .|. |.| ...|||| |.. 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---NTG------RIPVDMIGQITVAVLNGLKYLRDTHHIIHRDVKPSNILVNSEGEIKLCDFGVSGQLIN----SMA---NSFVGTRSYMAPERLQGEV-
   ..|      ..  . |  |.  || ||.||   .||||||.|  |||....||.||.||||..||..    .|.   |.||||  .|||| .|..  
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHS-NHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

----YSVLSDIWSLGVSLIEMA
    |   .||||||  .||||
PDKGYDYKCDIWSLGITAIEMA
Kinase AqueK243.AA MEK7 75-268 39 4.1e-52 175.11 In-house 1-206 (269) Show / Hide 
Range on Protein: 75-268
Range on HMM: 1-206/269
Sequence Identity: 39% (81 aa)

FERLSELGHGNGGVVLKVMHKPSGIIMARKMILLDIKPTVRNQIMRELKVLHDCN-ASYIVGFFGSFHVNNEISILMQHMDGGSLDLVLNTGRIP----V
 . ....|||  | | |..|| || ||| |             | . | |   |.   |||  || |  . .. | |. | .  .|  |   . |    .
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECM-STCCDKLLKRIKHPKLDFI

--DMIGQITVAVLNGLKYLRDTHHIIHRDVKPSNILVNSEGEIKLCDFGVSGQLINSMANS-FVGTRSYMAPERLQG-----EVYSVLSDIWSLGVSLIE
    || ..||. | |.|| . | |.||||||||||    | |||||||.|| .. |.|..   |   ||||||.         | . .|.||||..|.|
PEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVE

MAIGSYP
.| | ||
LATGQYP
Kinase AqueK243.AA MEK4 166-268 50 1.9e-49 159.43 In-house 104-211 (275) Show / Hide 
Range on Protein: 166-268
Range on HMM: 104-211/275
Sequence Identity: 50% (55 aa)

RIPVDMIGQITVAVLNGLKYLRDTHHIIHRDVKPSNILVNSEGEIKLCDFGVSGQLINSMANSF-VGTRSYMAPERLQG----EVYSVLSDIWSLGVSLI
||| . .|.|||.. . | ||  ||.||||||||||||.. .| .||||||..||| .|.| .  .| | ||||||..     . | . ||.||||. ..
RIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGITMY

EMAIGSYP
| | | .|
EVATGKFP
Kinase AqueK243.AA MEK3 166-268 50 9.6e-47 156.99 In-house 98-205 (264) Show / Hide 
Range on Protein: 166-268
Range on HMM: 98-205/264
Sequence Identity: 50% (54 aa)

RIPVDMIGQITVAVLNGLKYLRDTHHIIHRDVKPSNILVNSEGEIKLCDFGVSGQLINSMANSF-VGTRSYMAPERLQGEV----YSVLSDIWSLGVSLI
.|| | .|.| . .  .|.|..    .|||||||||.|.| .| .|.||||.||.|..|||     | . ||||||  .|.    |.| ||.||||. .|
HIPEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMI

EMAIGSYP
||||| ||
EMAIGRYP
Kinase AqueK243.AA YSK 75-265 34 5.3e-42 124.03 In-house 1-197 (257) Show / Hide 
Range on Protein: 75-265
Range on HMM: 1-197/257
Sequence Identity: 34% (68 aa)

FERLSELGHGNGGVVLKVMHKPSGIIMARKMILLDIKPTVRNQIMRELKVLHDCNASYIVGFFGSFHVNNEISILMQHMDGGSLDLVLNT---GRIPVDM
| ...  | |. |.| |   .  . . | | | |.        | .|  .| .|  .||  ..||.     . | | .  |||.   .     | ..   
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IGQITVAVLNGLKYLRDTHHIIHRDVKPSNILVNSEGEIKLCDFGVSGQLINSMA--NSFVGTRSYMAPERLQG--EVYSVLSDIWSLGVSLIEMAIG
|. |   .| ||.||      ||||.|  |.|.. .|..|||||||.||. ...   | ||||  .||||  .     |    ||||||.  .||| |
IAIILREILKGLDYLH-SERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKG
Kinase AqueK243.AA YSK 311-358 37 4.8e-15 41.38 In-house 210-257 (257) Show / Hide 
Range on Protein: 311-358
Range on HMM: 210-257/257
Sequence Identity: 37% (18 aa)

LQMIFTDDPPRLPDEYFDDKFKSFVALCLQKDVKKRGTLSALLEHKFV
.. |  . ||.| .. . . || ||..|| || ..| . . || |||.
MFLIPKNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase AqueK243.AA MEK7 308-358 37 7.4e-14 43.4 In-house 214-269 (269) Show / Hide 
Range on Protein: 308-358
Range on HMM: 214-269/269
Sequence Identity: 37% (21 aa)

FELLQMIFTD--DPPRLPDEY---FDDKFKSFVALCLQKDVKKRGTLSALLEHKFV
|| .  |  |  .||.|| .    |   | .|| .|||||...|     |..| |.
FEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase AqueK243.AA TyrKc 75-357 21 1e-12 -17.05 SMART 1-280 (280) Show / Hide 
Range on Protein: 75-357
Range on HMM: 1-280/280
Sequence Identity: 21% (67 aa)

FERLSELGHGNGGVVLKVMHKPSGIIMARKMILLDIKPTVRNQIMRELKVLHDC--NASYIVGFFGSFHVN-------NEISILMQHMDGGSLDLVLNTG
 . . .||.|. |.| | . |   |  | ||.  |     |  .|||.....    .   || ..|              . |.| .|..|.|.  |   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

R--IPVDMIGQITVAVLNGLKYLRDTHHIIHRDVKPSNILVNSEGEIKLCDFGVSGQLINSM------ANSFV-----GTRS-----YMAPERLQGEVYS
|  ....   .. . . .|  || . ...||||    |.||.... .| .||| |   | .           .     |...      |||| ..  ...
RPKLCMKDLLSFCWQIACGMEYLHS-KNCIHRDLAARNCLVGENHTVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

VLSDIWSLGVSLIEMAIGSYPIPAPPKEQLDEEMRNPPAGSLPPRRNPYASHANAIRMPVFELLQMIFTDDPPRLPDEY-------FDDKFKSFVALCLQ
  ||.|| || . |.   .|  .                        ||   .    |. .|... . . . .. |...         |.  .    | .
TKSDVWSFGVCMWEIF--TYGQQ------------------------PYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWH

KDVKKRGTLSALLEHKF
 | ..| | |..  ..|
EDPEDRPTFSEI-HECF
Kinase AqueK243.AA MEK4 305-358 25 3.9e-12 35.73 In-house 216-275 (275) Show / Hide 
Range on Protein: 305-358
Range on HMM: 216-275/275
Sequence Identity: 25% (15 aa)

M--PVFELLQMIFTDDPPRLPDEYF----DDKFKSFVALCLQKDVKKRGTLSALLEHKFV
.  .||. ..|.   |||.|  ...     . ...|...|| || ..|   . |....|.
NDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase AqueK243.AA MEK3 308-358 32 8.1e-11 33.02 In-house 213-264 (264) Show / Hide 
Range on Protein: 308-358
Range on HMM: 213-264/264
Sequence Identity: 32% (17 aa)

FELLQMIFTDDPPRLPDEY-FDDKFKSFVALCLQKDVKKRGTLSALLEHKFV
|. |. .  . ||.|| |  |   .. |.. ||.|. . | .   |.|| |.
FQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase AqueK243.AA STE20 329-358 53 1.1e-10 35.57 In-house 259-288 (288) Show / Hide 
Range on Protein: 329-358
Range on HMM: 259-288/288
Sequence Identity: 53% (16 aa)

DKFKSFVALCLQKDVKKRGTLSALLEHKFV
..|. ||..|||||..|| | | ||.|.|.
PEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase AqueK243.AA MEK5 305-358 40 8.5e-10 31.96 In-house 202-254 (254) Show / Hide 
Range on Protein: 305-358
Range on HMM: 202-254/254
Sequence Identity: 40% (22 aa)

MPVFELLQMIFTDDPPRLPDEYFDDKFKSFVALCLQKDVKKRGTLSALLEHKFV
||. .||| |  ..||||| . | . |  |.  |.||  | |     |..| |.
MPI-QLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase AqueK243.AA MEK3 75-106 46 8.9e-09 25.98 In-house 1-32 (264) Show / Hide 
Range on Protein: 75-106
Range on HMM: 1-32/264
Sequence Identity: 46% (15 aa)

FERLSELGHGNGGVVLKVMHKPSGIIMARKMI
 . ..||| |  |.| |. |..||.||| | |
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRI
Kinase AqueK243.AA MEK4 75-138 33 5.1e-08 22.08 In-house 1-71 (275) Show / Hide 
Range on Protein: 75-138
Range on HMM: 1-71/275
Sequence Identity: 33% (24 aa)

FERLSELGHGNGGVVLKVMHKPSGIIMARKMIL-LDIK-----PTVRNQIMRELKVLHDC-NASYIVGFFG
 . |.|.| |. |.| | .||.|| ||| | |    .           .  .|. |     |  ||| |.|
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYG
Kinase AqueK243.AA Pkinase_Tyr 190-262 30 2e-06 22.8 Pfam 130-207 (270) Show / Hide 
Range on Protein: 190-262
Range on HMM: 130-207/270
Sequence Identity: 30% (24 aa)

HHIIHRDVKPSNILVNSEGEIKLCDFGVSGQLINSMANSFVGTRS-------YMAPERLQGEVYSVLSDIWSLGVSLIEM
...||||.   |.||.... .| |||| .  .  .  .  . .|.        |||| ..  .... ||.|| || . |.
KNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEI