Gene AqueK246 (A.queenslandica)

AqueK246

Species: A.queenslandica
Alias: AqueK246
External Links:
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: MEK4

Sequence

Name Sequence Type Origin Length Description Download
AqueK246.AA Protein None 361 None Fasta, JSON
AqueK246.kin_dom Protein Kinase Domain None 262 None Fasta, JSON

Protein domain

Protein domains of AqueK246.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK246.AA MEK4 77-338 49 1.5e-138 454.98 In-house 1-275 (275) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-275/275
Sequence Identity: 49% (137 aa)

LQDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMKDL-------RTSGGNVLELDVIKKVKECPFIVHFYGCLLREGHVWICMELLDSSMAQVSEIVYNK
|||.| || | ||.| || |     |||||.| .          .      .|.||..| ..|| || ||| . .||  |||||| |.||     .|| .
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV

MNERIPEDILGKMTVAVINALHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISGKLVDSIARTMDVGCRPYMAPERIDPARACLGYTIQSDVWSYGI
 ..||||.|.|. ||....|| .| ...|||||||||||||.   |  |||||||.| ||||||.|.|.||||||||||||| ..  || | ||||| ||
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI

TLVELAQGSFPYKKWN--TIFDQLNAVVSGDPPSLPPENF----TRELREFTAACLVKDSDQRPNYVQLQEKEFF
|..|.| | |||.|||   .|||.  ||.|||| | .. .    . .. .| . || || ..|| |..| . .|.
TMYEVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase AqueK246.AA STE7 77-338 45 3.8e-128 432.03 In-house 1-288 (288) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-288/288
Sequence Identity: 45% (133 aa)

LQDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMKDL--RTSGGNVLELDVIKKVKECPFIVHFYGCLLREGH--VWICMELLD-SSMAQVSEIVYNK--
|..|| .|.| .||| || |    .|||||.|.. .   .     . ||||..| ..||.||.|||.. .||   .|||||. | ... .. ..|. .  
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

--MNERIPEDILGKMTVAVINALHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISGKLVDSI-ARTMDVGCRPYMAPERIDPARACLGYTIQSDVWS
   . ||||.||||..||||..||.| ...|||||||||||||| . |. |||||||.|.||||. |.|..|||.|||||||||.     .|...|||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG--NKQHYDVRSDVWS

YGITL-VELAQGSFPYKKWNT-----------------IFDQLNAVVSG-DPPSLPPENFTRELREFTAACLVKDSDQRPNYVQLQE-KEFF
 |||. .|.| | .|| .|||                 ||.||. .| . .|| ||  .|. |...| . || || . ||.| || .  .|.
LGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP--KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase AqueK246.AA MEK3 77-338 47 6.8e-122 411.25 In-house 1-264 (264) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-264/264
Sequence Identity: 47% (125 aa)

LQDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMKDLRTSGGNVL-ELDVIKKVKECPFIVHFYGCLLREGHVWICMELLDSSMAQVSEIVYNKMNERIP
.  |   | | .|.| || |     |||||.|.|    ..    | ..|.      ||. ||||| . ||| ||||||. | .       ||   . .||
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP

EDILGKMTVAVINALHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISGKLVDSIARTMDVGCRPYMAPERIDPARACLGYTIQSDVWSYGITLVELA
||||||. . .. |||...  ||.|||||||||.|. . |  |.||||||| ||||.| |.| ||.||||||||||     || . ||||| |||..|.|
EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMA

QGSFPYKKWNTIFDQLNAVVSGDPPSLPPEN-FTRELREFTAACLVKDSDQRPNYVQLQEKEFF
 | .|| .| | |.||  || . || || |  |  .   |.. || |..  ||.| .| | .|.
IGRYPYDNWHTPFQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase AqueK246.AA MEK7 77-338 42 8.4e-93 314.61 In-house 1-269 (269) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-269/269
Sequence Identity: 42% (116 aa)

LQDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMKDLRTSGGNVL-ELDVIKKVKECPFIVHFYGCLLREGHVWICMELLDSSMAQVSEIVYNKMNER--
|. || .| |  | | || |  . .|||||  .  .       .|  |||. .  .||.||  .|.. ..  ||||||.    |.   .    .. .   
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMEC----MSTCCDKLLKRIKHPKL

--IPEDILGKMTVAVINALHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISGKLVDSIARTMDVGCRPYMAPERIDP-ARACLGYTIQSDVWSYGIT
  ||| |.|||.||.|||||.|     |.||||||||||    |  ||||||||| .||| |.|   || .|||||||||       | | .|||| |||
DFIPEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGIT

LVELAQGSFPYKKWNTIFDQLNAVVSG--DPPSLPPEN---FTRELREFTAACLVKDSDQRPNYVQLQEKEFF
||||| | .||.  .. |. .  .     .||.||..    |  . ..|   || ||  .||.| .| ...| 
LVELATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase AqueK246.AA STE 77-338 27 1e-85 291.06 In-house 1-359 (359) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-359/359
Sequence Identity: 27% (99 aa)

LQDIGSIGEGHFG-VVSKMNHTTA--------------KHIMAVKKIPMKD------------LRTSGGNVL-----ELDVIKKVKE-CPFIVHFYGCLL
...|. ||.| || |. .||| .               . |||.|......            |...  . .     |... || .  .|.||..||| .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

REG-------HVWICMELLD-SSMAQVSEIVYNKMN---------ERIPEDILGKMTVAVINALHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISG
.||       ..|||||..|  |  .. . .| . .          |.||........... .|  .  ...|||||.||.|||.      ||||||..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KLVDSIA-----------------RTMDVGCRPYMAPERIDPARAC--LGYTIQSDVWSYGITLVELAQGSFPYKK-WNT---------I-----FDQLN
.|.||.|                 |. .||.  .||||.|.. . .   ||....|.|| |.|..|.| |  |. .  ..         .     |.|| 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

AVVSGDPPSLP------------------PENFTRELREFTAACLVKDSDQRPNYVQLQE--KEFF
..| |.||.||                  |.... |...| . ||.|| ..||.. || .   .|.
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase AqueK246.AA STE7-Unclassified 77-338 32 5.8e-80 271.97 In-house 1-301 (301) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-301/301
Sequence Identity: 32% (99 aa)

LQDIGSIGEGHFGVVSKMNHTT------AKHIMAVKKIPMKDL--RTSGGNVLELDVIKKVKECPFIVHFYGCLLREGH---VWICMELLDSSMAQVSEI
|. .. .|.| .|.|.|  | .       . ||| |.||. |         . || ...|.. .|.|||.||.   |.    . ||||. | .       
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

VYNKMNE-------RIPEDILGKMTVAVINALHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISGKLVDSI--ARTMDVGCRPYMAPERIDPA---R
.| || |       .||| .|||.. .||..|..| ....|||||.||.||||.. |. |.||||..|.|....  | |. |||  ||.||||      |
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTW-VGCQMYMSPERIQGQMPHR

ACLGYTIQSDVWSYGITLVELAQGSFPY-------KKWNT-------IFDQLNAVVSGDPPSLPPEN----FTRELREFTAACLVKDSDQRPNYVQLQE-
.  .|...||.|| |.|. |.| | .||       .. ..       ... |...|    | || .     .  |.. | . |. |..  || ..|| . 
P--SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNE

KEFF
 .. 
HPWI
Kinase AqueK246.AA MEK1 77-280 45 3.5e-60 204.25 In-house 1-195 (297) Show / Hide 
Range on Protein: 77-280
Range on HMM: 1-195/297
Sequence Identity: 45% (95 aa)

LQDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMKDLRTSGGN--VLELDVIKKVKECPFIVHFYGCLLREGHVWICMELLD-SSMAQVSEIVYNKMNER
.. || .|.|  ||| |..|. .  ||| | | . ... .  |  . || |. .    |.|| |||    .| . |||| .|  |. ||   .     .|
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHL-EIKPAIRNQIIRELQVLHEC-NSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA-----GR

IPEDILGKMTVAVINALHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISGKLVDSIARTMDVGCRPYMAPERIDPARACLGYTIQSDVWSYGITLVE
|||.||||..|||.  | .|. . ||.|||||||||||   || ||||||.||.|.||.|    || | ||.|||.  .     ||.|||.|| |. |||
IPEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQGTH----YTVQSDIWSMGLSLVE

LAQGSFP
.| | .|
MAIGRYP
Kinase AqueK246.AA S_TKc 77-338 25 2.4e-56 194.41 SMART 1-231 (231) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-231/231
Sequence Identity: 25% (69 aa)

LQDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMKDLRTSGGNVLELDVIKKVKECPFIVHFYGCLLREGHVWICMELLDSSMAQVSEIVYNKMNER---
 . .  ||.| ||.| |  |.  ..|.|.|.|.            |... ||   .|.||..|..    .|....||..| .   . ..  ..  ..   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-IPEDILGKMTVAVINALHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISGKLVDSIARTMDVGCRPYMAPERIDPARACLGYTI-QSDVWSYGITL
 .||    ...  ...|| .. .  .|||||.||.|||...  . |.||||.. .|      |  .| . ||||| .       ||.   .|.|| |..|
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCIL

VELAQGSFPYKKWNTIFDQLNAVVSGDPPSLPPENFTRELREFTAACLVKDSDQRPNYVQLQE-------KEFF
 |.. |  |.    ...  .. ..            ..|...|   ||.|| ..||   .. .        ..|
YEMLCGYPPFP---QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK246.AA MEK5 77-338 38 3.4e-55 189.7 In-house 1-254 (254) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-254/254
Sequence Identity: 38% (104 aa)

LQDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMK-DLRTSGGNVLELDVIKKVKECPFIVHFYGCLLREGHVWICMELLDSSMAQVSEIVYNKMNERIP
..   ..| |  | | |  |  . .|.||| | .   |      . ||... |  . |.|. |||    |  . || | .|    .    .| .    ||
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSPYIIGFYGAFFVENRISICTEFMDGGSLD----MYRC----IP

EDILGKMTVAVINALHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISGKLVDSIARTMDVGCRPYMAPERIDPARACLGYTIQSDVWSYGITLVELA
| |||.||||..  | .|  .|||.||||||||.||   |. ||||||.| .||.||.||  .|   |||||||        | | ||||| || ..|.|
EHILGRMTVAIVKGLNYLW-NLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERI----SGDQYGIHSDVWSLGIFFMEMA

QGSFPYKKWNTIFDQ--------LNAVVSGDPPSLPPENFTRELREFTAACLVKDSDQRPNYVQLQEKEFF
 | ||| .  .  ||        |  .|  .|| || ..|     .|   |. |   .||   .| .  | 
TGRFPYPQ--IQRDQGELMPIQLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase AqueK246.AA Pkinase 77-338 22 9.3e-45 159.34 Pfam 1-293 (293) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

LQDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMKDLRTSGG--NVL--ELDVIKKVKECPFIVHFYGCLLREGHVWICMELLDSS--MAQVSEIVYNKM
.. .. ||.| ||.| |  |    .| |||.|. .. . .    ...  |. . |..  .|.|| .|..  ...|....||...     .  ....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

NERI--PEDILGKMTVAVINALHFLQKELKIIHRDVKPSNILVSKVGEF----KLCDFGISGK--LVDSIARTMDVGCRPYMAPERIDPARACLGYTIQS
. ..  .|. . ..   .. .| .. .  .|||||.||.|||... |.     |.||||.. .  .  .   |  .| ..||||| |     . .|.  .
HGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPKV

DVWSYGITLVELAQGSFPYKKWNT----IFDQLNAVVSGDPPSLPPENFT-----------------------RELREFTAACLVKDSDQRPNYVQLQEK
|.||.|..| |.. | .|..  .       .  ....  . .  .....                        .|...|   || ||  .||.  |. . 
DMWSCGCILYEMLCGRPPFP--GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

EFF
..|
PWF
Kinase AqueK246.AA SLK 78-338 30 1.9e-39 130.66 In-house 2-259 (259) Show / Hide 
Range on Protein: 78-338
Range on HMM: 2-259/259
Sequence Identity: 30% (81 aa)

QDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMKDLRTSGGNVLELDVIKKVKECPFIVHFYGCLLREGHVWICMELLDSSMAQVSEIVYNKMNERIPED
. || .|.| || | | .|   | . | | | .||       . |.|.. ..|  | ||. |.    ....|. .|  |     | .|. . ... . ||
EIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECK-HPNIVKLYEAYYYDNKLWMMIEFCDGGA--VDNIMVE-LEHPLTED

ILGKMTVAVINALHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISGKLVDSIARTMDVGCRPY-MAPERID-PARACLGYTIQSDVWSYGITLVELA
 .  .   ...||..| .. |.||||.|  |||.   |. .| |||.| |.   . .       || |||| .         |  ..|.||.||||.|.|
QIQYVCKHMCEALNWLHSN-KVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMA

QGSFPYKKWNTIFDQLNAVVSGDPPSLPPENFTRELREFTAACLVKDSDQRPNYVQLQEKEFF
|.  |..  | .   |    |  |  . |  ...| ..|   ||||| ..|.   || . ...
QMEPPHHEMNPMRVLLKIQKSEPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase AqueK246.AA STE20 77-338 27 4.1e-38 132.95 In-house 1-288 (288) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-288/288
Sequence Identity: 27% (82 aa)

LQDIGSIGEGHFGVVSKMNHTTAKHI----MAVKKIPMKDL----RTSGGNVLELDVIKKVKECPFIVHFYGCLLRE----GHVWICMELLDS-SMAQVS
 ...  ||.| .|.| | .|.  . .     |.||.....          .. | .. |. | .| ||..||. |..     . ||.||...  |  .. 
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

EIVYNKMNE----RIPEDILGKMTVAVINALHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISGKLVD----SIA---RTMDVGCRPYMAPERIDPA
. .... .     .. |.    ..  |  .|..| .. .|||||.|  |||... || ||.||| ...| .    ...    |. ||   .|||| |   
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTF-VGTPYWMAPEVI---

RAC-----LGYTIQSDVWSYGITLVELAQGSFPYKKWNTIFDQLNAVVSG--DPPSLP---PENFTRELREFTAACLVKDSDQRPNYVQLQEKEFF
 .|      ||.  .|.|| |||. |.| |  || . .  .  .  . ..  .|| |    |.... |...| . ||.|| ..||   || . .|.
-QCMEGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHP-MRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase AqueK246.AA TyrKc 77-338 22 2e-14 10.6 SMART 1-280 (280) Show / Hide 
Range on Protein: 77-338
Range on HMM: 1-280/280
Sequence Identity: 22% (67 aa)

LQDIGSIGEGHFGVVSK--MNHTTAKHIMAVKKIP---MKDLRTSGGNVLELDVIKKV-KECPFIVHFYGCLLRE-------GHVWICMELLDSSMAQVS
.. .  .|||.||.| |  ..        |||..    ..|..       |. . .|. .. | || .||. . .       . ..| ||.    |.  .
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDAREDFMR------EARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEY----MPHGD

EIVYNKMNER-IPEDILGKMTVAVINALHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISGKLVDS-IA----RTMDV----GCRP-----YMAPER
   | . ... .. . | .. . . .   .| .  ..||||    |.||.. .  | .||| | .. |   .     . ..    |..       |||| 
LKDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPEC

IDPARACLG-YTIQSDVWSYGITLVELA-QGSFPYKKW----NTIFDQLNAVVSGDPPSLPPEN-------FTRELREFTAACLVKDSDQRPNYVQLQEK
|       | .|..|||||.|... |.   |  ||        . .. .. | .|. .  ||..        . |. .    |   | ..||.  ..  .
I-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--H

EFF
|.|
ECF
Kinase AqueK246.AA MEK1 287-338 36 2.7e-10 30.87 In-house 246-297 (297) Show / Hide 
Range on Protein: 287-338
Range on HMM: 246-297/297
Sequence Identity: 36% (19 aa)

IFDQLNAVVSGDPPSLPPENFTRELREFTAACLVKDSDQRPNYVQLQEKEFF
||. |. .| . || || . |..|...|   || |  | | .  ||. . |.
IFEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase AqueK246.AA Pkinase_Tyr 208-338 25 2.9e-07 25.21 Pfam 141-270 (270) Show / Hide 
Range on Protein: 208-338
Range on HMM: 141-270/270
Sequence Identity: 25% (35 aa)

NILVSKVGEFKLCDFGISGKL-VDS---IARTMDVGCRPYMAPERIDPARACLGYTIQSDVWSYGITLVELAQ-GSFP-YKKWNTIFDQLNAVVSGDPPS
|.||.. .  | |||| .  .  |.    .|.      . |||| |   .    .|..|||||.|... |.   |  | |. . . .. ....       
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGK----FTTKSDVWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYIYEDGYRM

LPPENFTRELREFTAACLVKDSDQRPNYVQLQEKEFF
 .||| . |. .    |  .| ..||   ..   |..
PCPENCPDEIYDLMKQCWHYDPEDRPTFSEI--HEQL
Kinase AqueK246.AA Pkinase_Tyr 77-93 41 3.120117 1.41 Pfam 1-17 (270) Show / Hide 
Range on Protein: 77-93
Range on HMM: 1-17/270
Sequence Identity: 41% (7 aa)

LQDIGSIGEGHFGVVSK
.. .  .|||.||.| |
ITFGKKLGEGAFGEVYK
Kinase AqueK246.AA Pkinase_Tyr 122-154 27 4.534632 0.86 Pfam 53-88 (270) Show / Hide 
Range on Protein: 122-154
Range on HMM: 53-88/270
Sequence Identity: 27% (10 aa)

ELDVIKKVKECPFIVHFYGCLL-REGH--VWICMEL
|. . |.   .| || .||. . ....  ..| ||.
EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEY