Gene AqueK298 (A.queenslandica)

AqueK298

Species: A.queenslandica
Alias: AqueK298
External Links:
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
AqueK298.AA Protein None 184 None Fasta, JSON
AqueK298.kin_dom Protein Kinase Domain None 145 None Fasta, JSON

Protein domain

Protein domains of AqueK298.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Pkinase_Tyr AqueK298.AA Pkinase_Tyr 1-145 44 8e-79 267.58 Pfam 124-270 (270) Show / Hide 
Range on Protein: 1-145
Range on HMM: 124-270/270
Sequence Identity: 44% (67 aa)

MEYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDESYY--ISQSKKIPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSIGHKP-FENSTN
||||..|...||||||||.||..  ....||.|||..||.....||   ... |.||||.|||...|.|....|||||.| .|.|| . | .| ... .|
MEYLESKNCIHRDLAARNCLVTE--NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSN

QECIRLV-DSGYRLPPPPGCPKPMYKLMMQCWNPDTHDRPSFSDISSSF
.| .... ..|||.|.|..||...|.||.|||..|  |||.||.| . .
EEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK298.AA Eph 1-145 50 1.8e-73 246.11 In-house 118-264 (264) Show / Hide 
Range on Protein: 1-145
Range on HMM: 118-264/264
Sequence Identity: 50% (75 aa)

MEYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDES----YYISQSKKIPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSIGHKPFENST
| |||   .||||||||||||. .   .||..|||.|| |.|..     | ... ||||.||||||. |.|..||||||||| || |. | | .|. . .
MKYLSDMNYVHRDLAARNILVNSN--LVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMS

NQECIRLVDSGYRLPPPPGCPKPMYKLMMQCWNPDTHDRPSFSDISSSF
||. |  .. |||||||..||.....||..||  | ..|| |..| | .
NQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase AqueK298.AA TK 1-145 30 7e-72 240.04 In-house 247-486 (486) Show / Hide 
Range on Protein: 1-145
Range on HMM: 247-486/486
Sequence Identity: 30% (73 aa)

MEYLSRK------KFVHRDLAARNILVSDEGT---------GICKIADFGMS--------RDL-QDESYYISQ------------------------SKK
||||..|      .||||||||||.||.....          .|||||||.|        ||. .|. || ..                        . |
MEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGK

IPIKWTAPEALH---------YKKYSSASDVWSYGAVMYEIWSIGHKPFEN-STN---------QECIRLVDSG--------------YRLPPPPGCP--
.||.|.|||.|          |.|....|||||.| .|.||.. | .|.    .|         || .... .|              .|.|.||.||  
LPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDW

------------KPMYKLMMQCWNPDTHDRPSFSDISSSF
            . .| ||.|||..|  |||.||.. . .
MRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK298.AA Src 1-145 42 1.3e-66 225.27 In-house 110-255 (255) Show / Hide 
Range on Protein: 1-145
Range on HMM: 110-255/255
Sequence Identity: 42% (63 aa)

MEYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQ--DESYYISQSKKIPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSIGHKPFENSTNQ
|.||......||||||||.||...   .||.||||  | ..  |. |  ..  |.|||||||||..| ...  |||||.|  ..|| . |  | .  ||.
MAYLESMNYIHRDLAARNVLVGENN--VCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMTNH

ECIRLVDSGYRLPPPPGCPKPMYK-LMMQCWNPDTHDRPSFSDISSSF
| .. |. |||.| |..||. .|. .|.|||. |  .|| |  . . .
EVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK298.AA UTK 1-145 42 7.3e-66 224.29 In-house 131-296 (296) Show / Hide 
Range on Protein: 1-145
Range on HMM: 131-296/296
Sequence Identity: 42% (70 aa)

MEYLSRKKFVHRDLAARNILVSDEG-----TGICKIADFG---MSRDLQD--------ES-YYISQ-SKKIPIKWTAPEALHYK-KYSSASDVWSYGAVM
|.||....||||||||||.|| . .       .|||||||   |||....        || || .|  ...||.|.||||| .  .....|||||.| |.
MQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVC

YEIWSIGHKPFENSTNQECIRLVDSG--YRLPPPPGCPKPMYKLMMQCWNPDTHDRPSFSDISSSF
.|||. | .|... .|.. .  |  |  ||.|.|..|| |.|.||..||..|  .||.| |. . .
WEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase AqueK298.AA SFK-Src 1-138 49 1.2e-64 190.25 In-house 109-248 (259) Show / Hide 
Range on Protein: 1-138
Range on HMM: 109-248/259
Sequence Identity: 49% (70 aa)

MEYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDESY-YISQSK-KIPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSIGHKPFENSTNQ
| ||  . ||||||||||.|| |    .||..|||||| | ...  |  .   | |||||||||  . ..|  |||||.|  |.||   | .|..  ||.
MAYLEAQNFVHRDLAARNVLVGDN--NVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVTYGRIPYPGMTNM

ECIRLVDS--GYRLPPPPGCPKPMYKLMMQCWNPDTHDRPSF
| .. ||   |||.| ||.||  .||.|..||     ||| |
EVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTF
Kinase AqueK298.AA Fer 1-146 36 1.9e-60 204.56 In-house 124-283 (283) Show / Hide 
Range on Protein: 1-146
Range on HMM: 124-283/283
Sequence Identity: 36% (59 aa)

MEYLSRKKFVHRDLAARNILVSDEGTGI-CKIADFGMSRDLQDESYYIS---QSKKIPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSIGHKPFEN--
||||  |. .|||.||||.|...... . |||.||||||.. |. |  .    ..|.||.|.|||.. .. ||...||||.| ...|| . | .|...  
MEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQP

----STNQ--ECIRL-VDSGYRLPPPPGCPKPMYKLMM-QCWNPDTHDRPSFSDISSSFS
     ||.  ....  ...||..|.|...|......|| |||. |. |||....|   . 
HGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase AqueK298.AA SRM 1-146 44 5.5e-60 199.28 In-house 110-253 (253) Show / Hide 
Range on Protein: 1-146
Range on HMM: 110-253/253
Sequence Identity: 44% (65 aa)

MEYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDESYYISQSKKIPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSIGHKPFENSTNQEC
| ||  ....||||||||.|| |. .  ||..|||. | . |  |  | . .||.|||||||. |  ||  |||||.|  ..|. . |  |..  || | 
MCYLEEQNYIHRDLAARNVLVGDNNL--CKVGDFGLARLIKDDIYSPSHDHNIPYKWTAPEAANYRHYSQKSDVWSFGILLHEMFTYGQCPYPGMTNHET

IRLVDSGYRLPPPPGCPKPMYKLMMQCWNPDTHDRPSFSDISSSFS
.  .| |||.| |  ||   .|||..||  |  .||.| |     .
FQQIDRGYRMPCPAECPPEVHKLMLECWCRDPEQRPCFKDLREKLT
Kinase AqueK298.AA TK-Unique 1-145 41 2.2e-59 203.37 In-house 144-294 (294) Show / Hide 
Range on Protein: 1-145
Range on HMM: 144-294/294
Sequence Identity: 41% (63 aa)

MEYLSR--KKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDESYYISQ-S-KKIPIKWTAPEALH--YKKY-SSASDVWSYGAVMYEIWSIGHKPFE
||||..  ||.|||||.|||.|...   ..|||.||||.||....  |... | ..|||.| |||.|   .. | .. |||||.| .|.|| . |  |. 
MEYLASQRKKIVHRDLCARNVLLTE--DKVCKICDFGMARDVYTNGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYP

NSTNQECIRLVDSGYRLPPPPGC-PKPMYKLMMQCWNPDTHDRPSFSDISSSF
.  . . ....  |||.| |..| .. ||.|| .||. . ..||||..| . .
GMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK298.AA Syk 1-139 46 1.5e-56 193.13 In-house 119-257 (257) Show / Hide 
Range on Protein: 1-139
Range on HMM: 119-257/257
Sequence Identity: 46% (66 aa)

MEYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDL-QDESYYISQSK-KIPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSIGHKPFENSTNQ
| ||  |.||||||||||.|  ..  .  || |||||. |  |..|| ...  | |.|| |||   | | |..|||||.|  | |  | | ||    ..|
MCYLEEKHFVHRDLAARNVLLVNR--HYAKISDFGMSKALGADSQYYQATTHGKWPVKWYAPECIYYYKFSHKSDVWSFGVTMWEMFSYGQKPYGEMKGQ

ECIRLVDSGYRLPPPPGCPKPMYKLMMQCWNPDTHDRPSFS
| . ....| |.. |.|||. || || .||  .  ||| |.
EVMKFIENGHRMNCPNGCPQEMYQLMNKCWIYKWCDRPTFV
Kinase AqueK298.AA Tec 1-147 42 1.8e-55 190.63 In-house 110-254 (254) Show / Hide 
Range on Protein: 1-147
Range on HMM: 110-254/254
Sequence Identity: 42% (63 aa)

MEYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDESYYISQSKKIPIKWTAPEALHYKKYSSASDVWSYGAVMYEIWSIGHKPFENSTNQEC
|.|| |..|.|||||||| ||.|.  .. |..||||.|   |  |  |   | |.|| .|| .|| .||| ||||..|  | |..| |  |.|| .| | 
MAYLERHCFIHRDLAARNCLVGDQ--CVVKVSDFGMTRYVLDDQYTSSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYENMSNSEV

IRLVDSGYRLPPPPGCPKPMYKLMMQCWNPDTHDRPSFSDISSSFSS
.  |  |.||  |  |.. .|. | .||     .||.|..  ..   
VEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase AqueK298.AA TyrKc 1-145 25 1.2e-26 95.81 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-145
Range on HMM: 1-280/280
Sequence Identity: 25% (72 aa)

M---------------------------------------------------------------------------------------------------
                                                                                                    
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMK

-------------EYLSRKKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDE-------SYYISQ---SKK--IPIKWTAPEALHYKKYSSASDVWS
             |||..|...||||||||.||....  ..||.|||.|||. |.       .|| ..   ..|  .||.|.|||.. |.|....|||||
DLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWS

YGAVMYEIWSIGHKPFEN-----STNQECIRLVDSGYRLPPPPG--------CPKPMYKLMMQCWNPDTHDRPSFSDISSSF
.| .|.|| . | .| ..      .||| |..|..|||.|.||         ||. ||..| |||. | .|||.||.| . |
FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase AqueK298.AA Pkinase 1-145 20 8e-18 64.1 Pfam 121-293 (293) Show / Hide 
Range on Protein: 1-145
Range on HMM: 121-293/293
Sequence Identity: 20% (37 aa)

MEYLSRKKFVHRDLAARNILVSDEGTGIC----KIADFGMSRDLQDESYYISQSKKIPIKWTAPEALH-YKKYSSASDVWSYGAVMYEIWSIGHKPFENS
.||. .....||||   |||..   .| .    ||.||| .. ..  ..   ..    . . ||| .  ...|....|.||.| ..||  . |. || ..
LEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGH

------TNQECIRLVDS-GYRLPPPPGCP-------------------KPMYKLMMQCWNPDTHDRPSFSDISSS--F
      . ...|... .  .. . |  |.                   ... ...  |...| ..||.. .|  .  |
CWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase AqueK298.AA S_TKc 1-146 13 4e-07 -72.46 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-146
Range on HMM: 1-231/231
Sequence Identity: 13% (35 aa)

M-----------------------------------------------------------------EYLSR-----------------------------
                                                                  ||..                              
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPEHARFYM

------------KKFVHRDLAARNILVSDEGTGICKIADFGMSRDLQDESYYISQSKKIPIKWTAPEALHYKKYSS-ASDVWSYGAVMYEIWSIGHKPFE
            ....||||   |||...      ||.|||..| |         .      . ||| |   .|.  ..|.|| | ..||  . |  ||.
YQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC-GYPPFP

NSTNQECIRLVDSGYRLPPPPGCPKPMYKLMMQCWNPDTHDRPSFSDISS--------SFS
  . |. ....            ....  ....|.. |  .||.  ..           . 
--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF