AqueK338

Species: A.queenslandica
Alias: AqueK338
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK338.AA Protein None 924 None Fasta, JSON
AqueK338.kin_dom Protein Kinase Domain None 86 None Fasta, JSON

Protein domain

Protein domains of AqueK338.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

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Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG AqueK338.AA IG 47-111 17 0.286569 1.98 SMART 1-58 (58) Show / Hide
Range on Protein: 47-111
Range on HMM: 1-58/58
Sequence Identity: 17% (13 aa)

SSDYTIISGSKVS-NIVYNPNSDDEGYVWWNSSLLLNPINNSTV---GYYYCRANTSFGLMYSK----PVYVR
.. .|   |. |. .  ..       ..||   | . ..  .     | |||.|.   . .|..     ..|.
PP-VTVKEGETVTLTC-VS-------QIWWY--LTI-NVQPEDSQQHGTYYCQAT---HGQYWSIQGTTLTVQ

IG AqueK338.AA IG 231-327 14 4.5e-08 34.05 SMART 1-58 (58) Show / Hide
Range on Protein: 231-327
Range on HMM: 1-58/58
Sequence Identity: 14% (15 aa)

PENIAAYENENIIITVKVIRAHPPVLPDHISWTHTTSYGSASLNQSIEEGYDSRVNISENGRSLYISDLTSDDE---GYYQVLIWHPAGYKNK--TTYLK
|. . . | |.. .|  |          .|.|.                              | | ... .|.   | |.   .  .| . .  .|.|.
PP-VTVKEGETVTLTC-VS---------QIWWY------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLT

IN
. 
VQ

V-set AqueK338.AA V-set 225-326 16 1e-06 24.51 Pfam 1-128 (128) Show / Hide
Range on Protein: 225-326
Range on HMM: 1-128/128
Sequence Identity: 16% (21 aa)

APEIEL--PE----NIAAYENENIIITVKVI-RAHPPVLPDHISWTH-TTS-------------YGSASLNQSIEEGYDSRVNISENGR----SLYISDL
. ...   |.     . . | ... .. ..    ...  . .|.|    ..             | . . ..  .. .  || .| |..    || ||.|
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TSDDEGYYQVLIWHP-AGYKNKTTYLKI
...|.| |   .|..  .|  . | | .
QPSDSGTYYCAVWNCNEDYFGHGTRLTV

Pkinase_Tyr AqueK338.AA Pkinase_Tyr 430-515 33 1.2e-24 84.08 Pfam 1-90 (270) Show / Hide
Range on Protein: 430-515
Range on HMM: 1-90/270
Sequence Identity: 33% (31 aa)

LKILDCVGQGEFAKVYKGHYY--IDSQCITVAVKALKGTLDRYSSES--MKELIEESLVMKDL-QHPNVMGLIGICL-DAGP-SPLIVLPYME
....   |.|.| .||||...   |...|.|||| ||   . ...|   ......|  .|| | .|||.  |.|.|. . .| ...||..||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK---EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMP

Kinase AqueK338.AA Met 431-515 37 1.9e-23 73.51 In-house 1-86 (271) Show / Hide
Range on Protein: 431-515
Range on HMM: 1-86/271
Sequence Identity: 37% (34 aa)

KILDCVGQGEFAKVYKGHYYI-DSQCITVAVKALK----GTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAGP-SPLIVLPYME
  .| .||| |  ||.| |   |.. . .|.| |.    ...   |     .  .| ..||...||||  |||||||    .|..|||||.
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHIS-----QFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMK

Kinase AqueK338.AA TK 430-515 21 4e-20 63.46 In-house 1-138 (486) Show / Hide
Range on Protein: 430-515
Range on HMM: 1-138/486
Sequence Identity: 21% (29 aa)

LKILDCVGQGEFA---KVYKGHYYIDS-----------------------QCITVAVKALKGTLDRYSSESMK-------------ELIEESLVMKD--L
.....  |.|.|    .|||| .. ..                       ....|||| || . .  . | .              |. ||  .|.   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHPNVMGLIGICLDAGPS-----------PLIVLPYME
.|||.  |.|.|.. .|.           ..||. ||.
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMP

Kinase AqueK338.AA UTK 430-515 29 4.4e-20 65.41 In-house 1-93 (296) Show / Hide
Range on Protein: 430-515
Range on HMM: 1-93/296
Sequence Identity: 29% (28 aa)

LKILDCVGQGEFAKVYKGHYYIDS---QCITVAVKALKGTLDRYSSESMK---ELIEESL---VMKDLQ-HPNVMGLIGICLDAGPSPLIVLPYME
...... |||.|  |.|...  .|   .   ||||...   .  .  ..    ...||.    .|| .. ||||..|.|.|.. .| ..||. |||
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ--HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYME

Kinase AqueK338.AA TKL 436-515 21 2e-16 55.68 In-house 1-121 (364) Show / Hide
Range on Protein: 436-515
Range on HMM: 1-121/364
Sequence Identity: 21% (26 aa)

VGQGEFAKVYKGHYYIDS------QCITVAVKALKGTL-----------------------DRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAGP-
.|.| |..||||..   .       . .|||| .| .                        |. .|  .....|| ..|. |.|||.  ..|.|.. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------SPLIVLPYME
            . ||  |..
CVCMHPVGPWGQLCIVMEYCP

Kinase AqueK338.AA Axl 430-514 32 1.1e-14 48.3 In-house 1-89 (267) Show / Hide
Range on Protein: 430-514
Range on HMM: 1-89/267
Sequence Identity: 32% (30 aa)

LKILDCVGQGEFAKVYKGHYYIDS-QCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAG-----PSPLIVLPYM
. .   .|.|||  |  |.   .    . |||| .|  .|  ..  . | . |   ||. .||||| |||.|. .      | |...||.|
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMK--IDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFM

Kinase AqueK338.AA TKL-Unique 432-515 30 5.7e-13 42.23 In-house 1-83 (290) Show / Hide
Range on Protein: 432-515
Range on HMM: 1-83/290
Sequence Identity: 30% (27 aa)

ILDCVGQGEFAKVYKGHYYIDSQCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQ-HPNVMGLIGICLDAGPSPL---IVLPYME
..  .|.|....|||| .  ..    ||.| ..  .   |.|.|.|...|  .|| |. |||.  ..|.| |  ..|    ||. |..
FWNKIGEGGYGQVYKGKWRGYP----VAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCP

Kinase AqueK338.AA EGFR 430-501 29 7.2e-13 38.89 In-house 1-71 (258) Show / Hide
Range on Protein: 430-501
Range on HMM: 1-71/258
Sequence Identity: 29% (21 aa)

LKILDCVGQGEFAKVYKGHYYIDSQCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICL
|| .   | | | .|||| .. . . . . | | |   .  . .. .|...| .||  ..||... |.|.|.
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPV-AIKVLREQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCM

Kinase AqueK338.AA Pkinase 430-515 28 1.5e-12 45.49 Pfam 1-83 (293) Show / Hide
Range on Protein: 430-515
Range on HMM: 1-83/293
Sequence Identity: 28% (26 aa)

LKILDCVGQGEFAKVYKGHYYIDSQCITVAVKALKGTLDRYSSESMKELIE-----ESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYME
..|. ..|.| |..|||.|   ...  .|||| .|     ...|.......     |  .|| |.|||.  |.... | .... .|..|.|
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIK-----KRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCE

Kinase AqueK338.AA Ror 430-501 30 1.6e-12 46.29 In-house 1-72 (308) Show / Hide
Range on Protein: 430-501
Range on HMM: 1-72/308
Sequence Identity: 30% (23 aa)

LKILDCVGQGEFAKVYKGHYYIDS---QCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICL
.. .   | . | ||||||..      .|..||.|..|   .  |    ...  |  .| .|.|||.  |.|.|.
VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCK---HDASPAQWQDFRQEIMLMATLHHPNIVCLLGVCT

Kinase AqueK338.AA ALK 430-515 34 8.8e-12 36.95 In-house 1-85 (273) Show / Hide
Range on Protein: 430-515
Range on HMM: 1-85/273
Sequence Identity: 34% (31 aa)

LKILDCVGQGEFAKVYKGHYYI---DSQCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYME
.. .   |.| |  || | |     ||  . ||.| |.      | ..      | |.|   .|.||  .||||... |  .||| |||
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLP---EDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPY-MIVLEYME

Kinase AqueK338.AA STE 430-515 18 6e-11 35.01 In-house 1-120 (359) Show / Hide
Range on Protein: 430-515
Range on HMM: 1-120/359
Sequence Identity: 18% (22 aa)

LKILDCVGQGEFAKVYKGHYYI-----DSQCI--------TVAVKALKGTLDRYSS---------------ESMKELIEESLVMKDLQ--HPNVMGLIGI
.......|.| | .|||. .       ... .         .|.| ..  |.. ..               | |.....|  .||...  |||.   .| 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMN--LENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGC

CLDAGP------SPLIVLPYME
... |.      .  |.. ||.
YFKEGHNHKNDDELWICMEYMD

Kinase AqueK338.AA TyrKc 430-658 14 2.5e-07 -104.18 SMART 1-280 (280) Show / Hide
Range on Protein: 430-658
Range on HMM: 1-280/280
Sequence Identity: 14% (50 aa)

LKILDCVGQGEFAKVYKGHYYIDSQCITVAVKALKGTLDRYSSESMKELIEESLVMKDL--QHPNVMGLIGICLDAG------PSPLIVLPYMEVPVILQ
.. ..  | |.| .||||...     |.|||| ||          ......|  .|. |  .|||.  |.|.|.. |      . ..||. ||.    |.
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLK

NPFLYYLDYKTVYVNCSVYGESPFEVSW--------------------------------LYSTDE------------ISNR-----SSDYTIIS---GS
. .| .   |               ...                                |.. .             | .      |.||   .   |.
D-YLRKHRPK---------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGG

K------------VSNIVYSPNSD---------------DEGYVW-----WNSSLLLNPINNSTAGYYYCRVNT----SFGLNYSKPVYVRSTYLPRLNS
|                .... ||               .. |        . . .   |..  .||.  .       |                     
KTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEV---IEYVKQGYRMPQPPNDYPMS---------------------

TRFVKSGQAYVNFLAL----------SFTERKVTF
  ||   ..  .              .|.| .  |
--FVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase AqueK338.AA IGc2 528-614 13 0.000113 19.68 SMART 1-56 (56) Show / Hide
Range on Protein: 528-614
Range on HMM: 1-56/56
Sequence Identity: 13% (12 aa)

LDYKTVYVNCSVYGESPFEVSWLYSTDEISNRSSDYTIISGSKVSNIVYSPNSDDEGYVWWNSSLLLNPINNSTAGYYYCRVNTSFG
.   .|  .| . |    ...|..   ...                              ||..| . ..  . .||| |..  . |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG

Kinase AqueK338.AA S_TKc 430-622 11 0.000608 -119.1 SMART 1-231 (231) Show / Hide
Range on Protein: 430-622
Range on HMM: 1-231/231
Sequence Identity: 11% (33 aa)

LKILDCVGQGEFAKVYKGHYYIDSQCITVAVKALKGTLDRYSSESMKELIEESLVMKDLQHPNVMGLIGICLDAGPSPLIVLPYMEV------PVILQNP
 .||. .|.| |.||||..         ||.| .|           . .. |  ..|  .|||.  |.... |   .  .|. |..        .| ...
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRG

F---------------------LYYLDYKTV------------------------------------------YVNC--------------SVYGESPFE
                      | |.  . .                                            ..               ..|. ||.
RHGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDEHIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP

VSWLYSTDEISNRSSDYTIISGSKVSNIVYSPNSDDEGYVWWNSSLLLNPINNSTAGYYYCRVNTSFGLNYS-----KPVY
       ... ..                              |. ... |..        |      |..       |  
-----QMQMMFKKIG----------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK338.AA IG 522-626 11 0.001677 18.88 SMART 1-58 (58) Show / Hide
Range on Protein: 522-626
Range on HMM: 1-58/58
Sequence Identity: 11% (13 aa)

NPFLYYLDYKTVYVNCSVYGESPFEVSWLYSTDEISNRSSDYTIISGSKVSNIVYSPNSDDEGYVWWNSSLLLNPINNSTA---GYYYCRVNTSFGLNYS
 | ..     ||  .| |      ...|.                                         | . ..  . .   | |||...   |  .|
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWS

-KPVYVRST
 ...... .
IQGTTLTVQ

IGc2 AqueK338.AA IGc2 799-885 16 0.000283 15.87 SMART 1-56 (56) Show / Hide
Range on Protein: 799-885
Range on HMM: 1-56/56
Sequence Identity: 16% (14 aa)

LDYKTVHVNCSVYGESPFEVSWLYSTDEISNRSSDYTIISGSKVSNIVYSPNSDDEGYVWWNSSLLLNPINNLTVGYYYCRANNSFG
.   .|  .| . |    ...|..   ...                              ||..| . ..     ||| |.| |. |
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP------------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG

IG AqueK338.AA IG 744-897 10 0.027845 10.76 SMART 1-58 (58) Show / Hide
Range on Protein: 744-897
Range on HMM: 1-58/58
Sequence Identity: 10% (16 aa)

PEASTYVPGETLTQKCSARSLYPMTVTWQESEFLFPIKDKIDSRPVIFQDPFLYYLDYKTVHVNCSVYGESPFEVSWLYSTDEISNRSSDYTIISGSKVS
|.  | ..|||.| .| .      ...|                                                                        
PP-VTVKEGETVTLTC-VS-----QIWWY-----------------------------------------------------------------------

NIVYSPNSDDEGYVWWNSSLLLNPINNLTV---GYYYCRANNSFGLMYS-KPVYIRKT
                   | . ..        | |||.|.   |  .| ...... .
-------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ