Gene AqueK356 (A.queenslandica)

AqueK356

Species: A.queenslandica
Alias: AqueK356
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK356.AA Protein None 2201 None Fasta, JSON
AqueK356.kin_dom Protein Kinase Domain None 163 None Fasta, JSON

Protein domain

Protein domains of AqueK356.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Calx-beta AqueK356.AA Calx-beta 613-658 28 3.3e-05 21.35 Pfam 60-109 (109) Show / Hide 
Range on Protein: 613-658
Range on HMM: 60-109/109
Sequence Identity: 28% (14 aa)

AKSG--SDFVAETKE-MPFTSDD-LRVCAKFIIINDDIVEKNESFLITVM
|. |  .|... . .   |  |   . | .  ||.|||.|..| | .  .
ATAGPGDDYEPTEGTILTFNPDEDTHKCINVTIIDDDIYEGDEHFFVHLS
Calx-beta AqueK356.AA Calx-beta 669-773 30 5e-09 35.13 Pfam 1-109 (109) Show / Hide 
Range on Protein: 669-773
Range on HMM: 1-109/109
Sequence Identity: 30% (34 aa)

INITITDEDDAAVISFTNDTYTFP-ENIDLDAQVCVETTKE---LSDDIRINFTTRSSDFDGAATAD--SDYISKSET-KTLRSGS-RTVCINIEIKPDV
...|| |.||| ||.| . .|.   .. .  ..|||. . .   |. .  ....|     || |||.  .||.....|  |   .     |||..|  | 
ATVTILDDDDAIVIGFEPTHYQVDVNENCGTVEVCVVRMGGAPTLRRTVTVMYRT----EDGTATAGPGDDYEPTEGTILTFNPDEDTHKCINVTIIDDD

TREPTEFFYVQLE
  |..| |.|.| 
IYEGDEHFFVHLS
Calx_beta AqueK356.AA Calx_beta 669-773 31 3.4e-05 16.34 SMART 1-106 (106) Show / Hide 
Range on Protein: 669-773
Range on HMM: 1-106/106
Sequence Identity: 31% (35 aa)

INITITDEDDAAVISFTNDTYTFPENIDLDAQVCVETTKE-LSDDIRINFTTRSSDFDGAATAD-SDYISK--SETKTLRSGS-RTVCINIEIKPDVTRE
 ...| |.|.. ...|.. .||  ||    ..|||. | . ..   .....|     || |||  |||.      | |   |     ||.|.|  |   |
ATVMILDDDHMGTVFFEQPHYTVNENCG-EFEVCVVRTGGTARGTVVVPYRTQ----DGTATAGGSDYEPWDIPGTLTFPPGEGTMKCIRIKIIDDDIYE

P-TEFFYVQLE
  .| |||.|.
KRDEHFYVRLS
VWA AqueK356.AA VWA 817-957 24 8.3e-17 55.99 Pfam 1-147 (190) Show / Hide 
Range on Protein: 817-957
Range on HMM: 1-147/190
Sequence Identity: 24% (38 aa)

DLILLISESSSMQENQ-FTMVKDLGAEILN-QLPIGKNMTHAGIVRLSNSNRTQIISPLGNVTDLKQLKQIVRNISMDDKDDRGLATH-LNYSMILAMTE
|....|  |.|| | . |  |||   .... .|.||.. |. |.|  |.  |  .. ||.. .. . ..| |    ....  .|  |. ..  .  |. .
DIVFVIDGSGSMGEQNRFEKVKDFIKNFVEKNLDIGPDGTRVGLVQYSDDVR--TEFPLNDYQSKDDVLQAV----NRNMYYMGGGTNNTGKALQYAYQH

IKKR-----GRP-NSRKIIVIITDGLHSHESWPYNIARNARAL----GYDIFAV
. ..     .|| | .|.|...|||  . .. ..  | ..|.     |  .|.|
LFHSMRSAGSRPENVPKVIIVFTDGYSQDGPDVP-PAAKLRDKKKGVGIYVFGV
VWA AqueK356.AA VWA 815-991 18 3.6e-13 51.01 SMART 1-193 (193) Show / Hide 
Range on Protein: 815-991
Range on HMM: 1-193/193
Sequence Identity: 18% (38 aa)

YADLILLISESSSMQENQFTMVKDLGAEILNQLPIGKNMTHAGIVRLSNSNRTQIISPLGNVTDLKQLKQIVRNISM--DDKDDRGLATHLNYSMILAMT
 .|....|  |.|| .| |. ||.   ....||.     .. |||  |.  ......||.  .|.........|..    .... |  |...  .  || 
WLDIVFVIDGSGSMGPNNFQQVKQFI-KFVEQLD----GDRVGIVQFSD--DVRVEFPLN-YQDKDDVLKAIDNLQYKGKHDYFMGGGTNTG-ALQYAMQ

E---IKKRGRP---------NSRKIIVIITDGLHS----HESWPYNIARNARALGYDIFAVRLFTDASLSNWEELTGYKERV-----------LFLNTFN
.    ... |.         |..|.|...||| ..     .. .. .||..|  |. ||.. . .|     ...... . ..           |. ... 
NLFHERQG-RRGAGRPTKFWNVPKVIIVFTDGYSNDGPHDPEDIRKAARELRRSGVKIFVIGVGND-DM-ELRQIASCP-GEHHFFDVYDYDDLPDIFQH

SGHSEG
  ..  
IIDWLC
I-set AqueK356.AA I-set 1007-1102 26 1.2e-14 52.26 Pfam 1-81 (92) Show / Hide 
Range on Protein: 1007-1102
Range on HMM: 1-81/92
Sequence Identity: 26% (25 aa)

PQLLNTIGEERKINVGETVSFNCTADGVPVPDLVWRKDGKYIIPEANRRNTSSSEPTDGFRINDIPQVKQRTSELIITDLTVSDTGKYSCRADNGV
|. . ..    ....|||. |.|...| | |. .| |||. . |           ..| ...         |. |.|.. . .|.|||.|.| | .
PKFTQKP-KDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRP-----------DSDRHQMTYDG---DGTYTLTISNVQPDDEGKYTCVATNSF
IGc2 AqueK356.AA IGc2 1020-1103 22 4.6e-13 50.65 SMART 1-56 (56) Show / Hide 
Range on Protein: 1020-1103
Range on HMM: 1-56/56
Sequence Identity: 22% (19 aa)

NVGETVSFNCTADGVPVPDLVWRKDGKYIIPEANRRNTSSSEPTDGFRINDIPQVKQRTSELIITDLTVSDTGKYSCRADNGVE
. |..|...| |.| |.|.  |.| |. .                              ..| |.. |..| |.|.|.| | . 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP---------------------------WNWTLTIKNVTPEDSGYYTCYARNPWG
IG AqueK356.AA IG 1014-1117 14 4.1e-11 44.16 SMART 1-58 (58) Show / Hide 
Range on Protein: 1014-1117
Range on HMM: 1-58/58
Sequence Identity: 14% (16 aa)

GEERKINVGETVSFNCTADGVPVPDLVWRKDGKYIIPEANRRNTSSSEPTDGFRINDIPQVKQRTSELIITDLTVSDT---GKYSCRADNGVERGVVLHI
 .    ..||||...| .       . |.                                      |.| .....|.   | | |.|      . . . 
PP-VTVKEGETVTLTC-VS-----QIWWY--------------------------------------LTI-NVQPEDSQQHGTYYCQAT-----HGQYWS

--PYHLTVE
  . .|||.
IQGTTLTVQ
V-set AqueK356.AA V-set 1007-1124 13 0.000446 15.89 Pfam 1-128 (128) Show / Hide 
Range on Protein: 1007-1124
Range on HMM: 1-128/128
Sequence Identity: 13% (19 aa)

PQLLNT-IGE----ERKINVGETVSFNCTAD-----GVPVPDLVWRK-DGK-------------YIIPEANRRNTSSSEPTDGFRINDIPQVKQRTSELI
.. . .   .    .   ..|..|...|.         .. .. | .                 |  .. . . ...   .  |  |      . .  | 
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPS----KNDFSLT

ITDLTVSDTGKYSCRADNGVERGVVLHIPYHLTVEGXVRFTV
|..|..||.| | | . |.          .... .. .| ||
ISNLQPSDSGTYYCAVWNC----------NEDYFGHGTRLTV
IGc2 AqueK356.AA IGc2 1138-1196 33 3.5e-12 47.73 SMART 1-56 (56) Show / Hide 
Range on Protein: 1138-1196
Range on HMM: 1-56/56
Sequence Identity: 33% (20 aa)

QIYSSVNFTCKAIGSPAPSIHWYKNNKLINSTDPYLLMFNDLSLMDRGVYHCEARSVIN
..  || .||.| |.|.|.||||| .. .. .. .|  . . .. |.|.|.|.||. ..
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-WNWTLT-IKNVTPEDSGYYTCYARNPWG
I-set AqueK356.AA I-set 1126-1192 24 7.3e-11 39.38 Pfam 1-78 (92) Show / Hide 
Range on Protein: 1126-1192
Range on HMM: 1-78/92
Sequence Identity: 24% (19 aa)

PKIIEFRQPVNTQIYSSVNFTCKAIGSPAPSIHWYKNNKLINS--------TDP---YLLMFNDLSLMDRGVYHCEAR
||..   ..|  |. ....|.|...|.| |.. |.|... ...         |    | |.. .    | |.| | |.
PKFTQKPKDVEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQPDDEGKYTCVAT
IG AqueK356.AA IG 1132-1203 18 5.5e-09 37.09 SMART 1-58 (58) Show / Hide 
Range on Protein: 1132-1203
Range on HMM: 1-58/58
Sequence Identity: 18% (15 aa)

RQPVNTQIYSSVNFTCKAIGSPAPSIHWYKNNKLINSTDPYLLMFNDLSLMDR---GVYHCEAR--SVIN--GANISVN
 . |  .  ..|..|| .      .|.||             | . .... |    |.| |.|.  ..    |....| 
PP-VTVKEGETVTLTC-VS-----QIWWY-------------LTI-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
GPS AqueK356.AA GPS 1569-1617 54 1.8e-15 57.94 Pfam 1-49 (49) Show / Hide 
Range on Protein: 1569-1617
Range on HMM: 1-49/49
Sequence Identity: 54% (27 aa)

SFPQCVFWDQSLNSGYGDWSSDNCNT-SYDSVTQAIKCFCNHLTSFAVIQ
. ||||||| |||.| |.||.| | .  . . |. ..| |||||||||. 
YNPQCVFWDFSLNEGMGGWSTDGCRVGVHTNHTH-THCQCNHLTSFAVLM
GPS AqueK356.AA GPS 1569-1622 38 5.6e-13 50.36 SMART 1-51 (51) Show / Hide 
Range on Protein: 1569-1622
Range on HMM: 1-51/51
Sequence Identity: 38% (21 aa)

SFPQCVFWDQSLNSGYGDWSSDNCNTSYDSV-TQAIKCFCNHLTSFAVIQDVSPT
. |.||.|..|     | ||. .| ... .  |... | |||||.|||. |..| 
FNPICVWWNHSQ---TGHWSTRGCEVVETNKWTHTH-CQCNHLTTFAVLMDHPPN
Pkinase_Tyr AqueK356.AA Pkinase_Tyr 1958-2148 35 3.5e-63 214.62 Pfam 1-182 (270) Show / Hide 
Range on Protein: 1958-2148
Range on HMM: 1-182/270
Sequence Identity: 35% (70 aa)

IKLQEAVGQGEFGIVYRAFLA-TDKDIPQVVAVKTLKGLFSRSD--VTSIVEESLIMSNF-DHPNVLSLIGVSLDLGPA--PCIIMPFMSRGSLLSYLKN
|.. .  |.|.|| ||.. .   ...  . ||||.||   . ..    .  .|  ||... .|||...|.|| .| |    ..|.|..|  |.||.||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

DRLNITITDGNDEEIILNVRKHLLSICLQVANGMCYLASKYFVHRDLAARNCMIDNNGVIKVADFGLSEEVYTKTYFNQFKDKSDAESVKLPIKWMA
 |         ...  |..   ||..|.|.|.|| ||.|| ..|||||||||....|.|.|..||||.  .| . |   .. ....    |||||||
HR---------EDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY--YRKRGGGK---LPIKWMA
Kinase AqueK356.AA Met 1959-2148 36 3.3e-60 196.0 In-house 1-178 (271) Show / Hide 
Range on Protein: 1959-2148
Range on HMM: 1-178/271
Sequence Identity: 36% (72 aa)

KLQEAVGQGEFGIVYRAFLATDKDIPQVVAVKTLK--GLFSRSDVTSIVEESLIMSNFDHPNVLSLIGVSLDLGP-APCIIMPFMSRGSLLSYLKNDRLN
 . . .||| || ||.. .   .     .|.|.|.         .    .| ..|. |||||||||||..||     | .. |.|  | |... .|   |
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNN

ITITDGNDEEIILNVRKHLLSICLQVANGMCYLASKYFVHRDLAARNCMIDNNGVIKVADFGLSEEV-YTKTYFNQFKDKSD-AESVKLPIKWMA
...             . |.. |.||| || |.||. |||||||.||||.|   ..|||||||.  . | | |  | ... . |   .||.||||
PCV-------------RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQ-MHHTHPA---RLPVKWMA
Kinase AqueK356.AA TK 1958-2148 20 7.4e-54 178.55 In-house 1-353 (486) Show / Hide 
Range on Protein: 1958-2148
Range on HMM: 1-353/486
Sequence Identity: 20% (72 aa)

IKLQEAVGQGEFG---IVYRAFLATDK----------------------DIPQVVAVKTLKGLFSRSDVT----------------SIVEESLIMSN--F
|.| .  |.|.||    ||.. . ...                      . .. ||||.||   . |.                  . .||  .|..  .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHPNVLSLIGVSLDLG-----------PAPCIIMPFMSRGS----LLSYLKNDRLNITI----------------------------TDGNDEEIILNV-
.|||...|.||... .           . ..|.| .|. |.    |..||.. | . .                             .. |... . .  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

--------------RKHLLS-------------------ICLQVANGMCYLASK------YFVHRDLAARNCMIDNNGV-----------IKVADFG---
               |.||.                   .|.|.|.|| ||.||       |||||||||||....|.|           .|.||||   
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LSEEVYTKTYFNQFKDKSDAE------------------SVKLPIKWMA
     |. ..| ...    ......                   . ||||.|||
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMA
Kinase AqueK356.AA UTK 1958-2148 31 1.3e-50 171.34 In-house 1-207 (296) Show / Hide 
Range on Protein: 1958-2148
Range on HMM: 1-207/296
Sequence Identity: 31% (67 aa)

IKLQEAVGQGEFGIVYRAFLATDKDIPQV--VAVKTLK-GLFSRSDVT---SIVEESL---IMSNFD-HPNVLSLIGVSLDLGPAPCIIMPFMSRGSLLS
..| .  |||.||.|..| . ..... ..  ||||... . ... . .    . ||.    .|..|. ||||| |.|| .. .| ..|.. .|..|.|.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

YLKNDRLNITITDGNDEEIILNVRKHLLSICLQVANGMCYLASKYFVHRDLAARNCMIDNNG-------VIKVADFG---LSEEVYTKTYFNQFKDKSDA
|| . | .       ... .|. . ..|. ....|.|| ||.|. ||||||||||| .. ..       |.|.||||   .| .|.| . |   ..... 
YLRRHRPTPP-----ACPHWLTLH-QRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFH-FSN-RYWESY

ESVK-----LPIKWMA
.. .     .||.|||
YYMAQHQDRWPIRWMA
Kinase AqueK356.AA TK-Unique 1958-2148 29 2.8e-47 161.07 In-house 1-204 (294) Show / Hide 
Range on Protein: 1958-2148
Range on HMM: 1-204/294
Sequence Identity: 29% (62 aa)

IKLQEAVGQGEFGIVYRAFLATDK---DIPQVVAVKTLKGLFSRSDVTSIVEESLIMSNFD-HPNVLSLIGVSLDLGPAPCIIMPFMSRGSLLSYLKNDR
..... .|.|.|| |.|. . ...   | ...||||.||  ..  |.     |  .|.. . |||.....|.. . .  ..|||.....|.|..||.. |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-L--------NITITDGNDEEIILN--VR-KHLLSICLQVANGMCYLAS--KYFVHRDLAARNCMIDNNGVIKVADFGLSEEVYTKTYFNQFKDKSDA-E
          |. .. ...... ..  .  | |.... |.|.|| ||||  | .|||||.|||... ...|.|..|||....|||       .. |   .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT------NGVYSMMCS

SVKLPIKWMA
. ..||.|||
QGRIPIRWMA
Kinase AqueK356.AA Axl 1958-2149 35 9.2e-42 145.06 In-house 1-184 (267) Show / Hide 
Range on Protein: 1958-2149
Range on HMM: 1-184/267
Sequence Identity: 35% (71 aa)

IKLQEAVGQGEFGIVYRAFLATDKDIPQVVAVKTLK-GLFSRSDVTSIVEESLIMSNFDHPNVLSLIGVSLDLG-----PAPCIIMPFMSRGSLLSYLKN
. |   .|.|||| |  . |  .    . ||||..|   ...|..   . |   | .||||||. ||||.. .      |.| .|.|||  | | ..|  
FVLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLY

DRLNITITDGNDEEIILNVRKHLLSICLQVANGMCYLASKYFVHRDLAARNCMIDNNGVIKVADFGLSEEVYTKTYFNQFKDKSDAESVKLPIKWMAM
 ||       .|. . | . . |.   . .| || ||... |.||||||||||. ..  . |||||||  .|   |. |          |.|.||.|.
SRL-------GDQPFYLPL-QMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQ------GCIAKMPVKWIAI
Kinase AqueK356.AA TyrKc 1958-2186 27 1.3e-36 128.82 SMART 1-280 (280) Show / Hide 
Range on Protein: 1958-2186
Range on HMM: 1-280/280
Sequence Identity: 27% (84 aa)

IKLQEAVGQGEFGIVYRAFLATDKDIPQVVAVKTLK-GLFSRSDVTSIVEESLIMSNF--DHPNVLSLIGVSLDLG------PAPCIIMPFMSRGSLLSY
|.| .  | |.||.||.. .       . ||||.|| .      .  . .|  ||...  .|||.. |.|| .. |      . ..|.| .|. |.|..|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LKNDRLNITITDGNDEEIILNVRKHLLSICLQVANGMCYLASKYFVHRDLAARNCMIDNNGVIKVADFGLSEEVYTK---TYFNQFKDKSDAE--SVK--
|.. | .            |.. |.|||.|.|.|.|| ||.|| ..|||||||||....|...|..||||| ..| .         . .. .|  . |  
LRKHRPK------------LCM-KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG--ESKDYYRKKEHKGGKTM

LPIKWMA--------------------------MRAXXXXFN--------------------------CC------CS---YELMLLCWLECPNDRPLFS
|||.|||                           .      .                           .      |.   |..|. || | |.||| ||
LPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFS

ELNTSI
|.   .
EIHECF
Kinase AqueK356.AA TKL 1964-2119 21 7.5e-36 125.42 In-house 1-201 (364) Show / Hide 
Range on Protein: 1964-2119
Range on HMM: 1-201/364
Sequence Identity: 21% (49 aa)

VGQGEFGIVYRAFLAT---DKDIP----QVVAVKTLKGL--------------------------FSRSDVTSIVEESLIMSNFDHPNVLSLIGVSLDLG
.|.| ||.||.. .      .  |    ..||||..|                            ...     ..|| ..||...|||.....|.... .
IGSGGFGEVYKGKWRGWGGKC--PSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPP

PA------------PCIIMPFMSRGSLLSYLKNDRLNITITDGNDEEIILNVRKHLLSICLQVANGMCYLASKY--------FVHRDLAARNCMIDNNGV
.             .||.| ....||||.||                       ......|..| ||.|| |.          .||||  .|...|.|. 
CGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWT

--------------IKVADFGLS
              .|..|||||
NVSNYMYNPNADWCCKICDFGLS
Kinase AqueK356.AA Src 1958-2148 35 3.1e-34 113.7 In-house 1-168 (255) Show / Hide 
Range on Protein: 1958-2148
Range on HMM: 1-168/255
Sequence Identity: 35% (68 aa)

IKLQEAVGQGEFGIVYRAFLATDKDIPQVVAVKTLKGLFSRSDVTSIVEESLIMSNFDHPNVLSLIGVSLDLGPAPCIIMPFMSRGSLLSYLKNDRLNIT
||| .  ||| || |. .      .    |||||||      ...   .|  || ...|.....|  |  .  |   |.  .||.|||| |||.      
IKLCRKLGQGQFGEVWMGYWNGNTK----VAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK------

ITDGNDEEIILNVRKHLLSICLQVANGMCYLASKYFVHRDLAARNCMIDNNGVIKVADFGLSEEVYTKTYFNQFKDKSDAESVKLPIKWMA
    ..|.  |... .|...  |||.||.|| |. ..||||||||  ...| | |||||||   .  .   .    ...|   |.||||.|
----DGEGRHLHLP-QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKED-DDEYCARHGA---KFPIKWTA
Kinase AqueK356.AA InsR 1958-2148 29 2.4e-33 109.3 In-house 1-189 (278) Show / Hide 
Range on Protein: 1958-2148
Range on HMM: 1-189/278
Sequence Identity: 29% (58 aa)

IKLQEAVGQGEFGIVY----RAFLATDKDIPQVVAVKTLKGLFSRSDVTSIVEESLIMSNFDHPNVLSLIGVSLDLGPAPCIIMPFMSRGSLLSYLKNDR
| |    ||| || ||    .....  ...   .|.||..   |  . .    |  .| .|.. .|  | ||     |.  ..| .| .| | |||   |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPM-YVVMEMMTYGDLKSYLRSRR

LNITITDGNDEEII----LNVRKHLLSICLQVANGMCYLASKYFVHRDLAARNCMIDNNGVIKVADFGLSEEVYTKTYFNQFKDKSDAESVKLPIKWMA
        |.  ..       .  ...   ... || |||.| |||||||.||||..  . .|..|||.   .|   |    .        .||. |||
PEEEF---NNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKG------MLPVRWMA
Kinase AqueK356.AA Tec 1958-2119 32 2.8e-31 106.56 In-house 1-144 (254) Show / Hide 
Range on Protein: 1958-2119
Range on HMM: 1-144/254
Sequence Identity: 32% (53 aa)

IKLQEAVGQGEFGIVYRAFLATDKDIPQVVAVKTLK-GLFSRSDVTSIVEESLIMSNFDHPNVLSLIGVSLDLGPAPCIIMPFMSRGSLLSYLKNDRLNI
... . .|.| ||.| .. .    |    ||.|..| |  |  |    .||  .| .  ||.   | || .   |  .|.  .|..|.||.||.  .   
LTFMKELGSGQFGVVHLGKWRHQYD----VAIKMIKEGSMSEED---FIEEAKVMMKLSHPKLVQLYGVCSQQRPI-YIVTEYMEHGCLLNYLREHKHHF

TITDGNDEEIILNVRKHLLSICLQVANGMCYLASKYFVHRDLAARNCMIDNNGVIKVADFGLS
       ..  .     ||..|..|  || || .. |.||||||||| .. ..|.||.|||..
Q------KNMAI-----LLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMT
Kinase AqueK356.AA Pkinase 1958-2130 24 2.9e-26 93.96 Pfam 1-166 (293) Show / Hide 
Range on Protein: 1958-2130
Range on HMM: 1-166/293
Sequence Identity: 24% (46 aa)

IKLQEAVGQGEFGIVYRAFLATDKDIPQVVAVKTLKGLFSRSDVTSIVE---ESLIMSNFDHPNVLSLIGVSLDLGPAPCIIMPFMSRG----SLLSYLK
... . .|.| || |   .....|. ...||||..|    .|..  .     |  || ...|||.. |...  | .. ....|...  |    .| .|..
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIS

NDRLNITITDGNDEEIIL--NVRKHLLSICLQVANGMCYLASKYFVHRDLAARNCMIDNNGVI----KVADFGLSEEVYTKTYFNQ
            ...  .     ... ....|.. |. |. |. ..||||   |..|||||.|    |..||||.. ..   | |.
T-----------WRHGCFYFS-EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NN
Kinase AqueK356.AA HMTK 2074-2148 46 6e-22 73.4 In-house 130-200 (291) Show / Hide 
Range on Protein: 2074-2148
Range on HMM: 130-200/291
Sequence Identity: 46% (35 aa)

LLSICLQVANGMCYLASKYFVHRDLAARNCMIDNNGVIKVADFGLSEEVY-TKTYFNQFKDKSDAESVKLPIKWMA
.|..| |.| || |.||. .||.|||||||..  | ..|.|||||.  .   . |.     ...  .|||||||||
QLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYW-----HLRKHMVKLPIKWMA
Kinase AqueK356.AA S_TKc 1958-2190 17 4.1e-12 0.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 1958-2190
Range on HMM: 1-231/231
Sequence Identity: 17% (49 aa)

IKLQEAVGQGEFGIVYRAFLATDKDIPQVVAVKTLKGLFSRSDVTSIVEESLIMSNFDHPNVLSLIGVSLDLGPAPCIIMPFMSR--GSLLSYLKNDRLN
 .. . .|.| || ||..         ..||.| .|         .|  |  |... .|||.  |..|  |     ...| ...   |.|..|.|. . .
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----ITITDGNDEEIILNVRKHLLSICLQVANGMCYLASKYFVHRDLAARNCMIDNNGVIKVADFGLSEEVYTKTYFNQFKDKSDAESVKLPIKWMAMR
     ..  .               ... |..... |. |. ..||||   | ..|.  .||..||||. ..                ..     .||  
GLRFPFPE-H-------------ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPE

AXXXXFNC---------CCSYELML-------------------------LCWLECPNDRPLFSELNTSI-----NALI
     ...         |. ||..                           |.   |..||   |. ..         .
VL--GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK356.AA HMTK 1958-2027 26 4.9e-11 34.82 In-house 1-94 (291) Show / Hide 
Range on Protein: 1958-2027
Range on HMM: 1-94/291
Sequence Identity: 26% (25 aa)

IKLQEAVGQGEFG-----------------IVYRAFLA-------TDKDIPQVVAVKTLKGLFSRSDVTSIVEESLIMSNFDHPNVLSLIGVSL
.| . . |.| ||                  || | ..       .| . |. .|||.|.|  |  | .    |.  |....|||...|.||..
LKAIKVIGAGQFGMVQCLRLAPPDEGCTSLKVYLAEWSVKDGDGKDDSNQPHHRAVKMLRGDASHEDREEFLREAEVMCQLRHPNLVQLVGVCM
Kinase AqueK356.AA TK 2162-2186 48 6.3e-07 18.45 In-house 462-486 (486) Show / Hide 
Range on Protein: 2162-2186
Range on HMM: 462-486/486
Sequence Identity: 48% (12 aa)

YELMLLCWLECPNDRPLFSELNTSI
|.||. || . |.||| ||.|   .
YDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK356.AA Tec 2162-2188 40 9.5e-07 19.7 In-house 228-254 (254) Show / Hide 
Range on Protein: 2162-2188
Range on HMM: 228-254/254
Sequence Identity: 40% (11 aa)

YELMLLCWLECPNDRPLFSELNTSINA
|. |  || | | .|| |..|  .|  
YQIMYHCWHEKPEERPTFQQLLRQITE
Kinase AqueK356.AA Met 2162-2180 55 1e-06 17.57 In-house 252-271 (271) Show / Hide 
Range on Protein: 2162-2180
Range on HMM: 252-271/271
Sequence Identity: 55% (11 aa)

Y-ELMLLCWLECPNDRPLFS
| ..|| ||   | ||| ||
YTDVMLCCWHANPEDRPQFS
Kinase AqueK356.AA Pkinase_Tyr 2162-2186 48 7e-06 20.51 Pfam 246-270 (270) Show / Hide 
Range on Protein: 2162-2186
Range on HMM: 246-270/270
Sequence Identity: 48% (12 aa)

YELMLLCWLECPNDRPLFSELNTSI
|.||..|| . |.||| |||.   .
YDLMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK356.AA Axl 2162-2184 52 1.2e-05 15.67 In-house 245-267 (267) Show / Hide 
Range on Protein: 2162-2184
Range on HMM: 245-267/267
Sequence Identity: 52% (12 aa)

YELMLLCWLECPNDRPLFSELNT
|.||  ||   | ||| ||.|  
YDLMYQCWEADPKDRPSFSVLRE
Kinase AqueK356.AA InsR 2162-2188 33 1.5e-05 14.54 In-house 252-278 (278) Show / Hide 
Range on Protein: 2162-2188
Range on HMM: 252-278/278
Sequence Identity: 33% (9 aa)

YELMLLCWLECPNDRPLFSELNTSINA
.|||  ||   | .||.| ... ..  
QELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase AqueK356.AA HMTK 2162-2185 37 2.6e-05 14.61 In-house 268-291 (291) Show / Hide 
Range on Protein: 2162-2185
Range on HMM: 268-291/291
Sequence Identity: 37% (9 aa)

YELMLLCWLECPNDRPLFSELNTS
..||  ||   |. || |..|  .
WDLMCTCWHKDPHQRPTFAQLQKM
Kinase AqueK356.AA Src 2162-2186 42 6.2e-05 12.65 In-house 230-255 (255) Show / Hide 
Range on Protein: 2162-2186
Range on HMM: 230-255/255
Sequence Identity: 42% (11 aa)

YE-LMLLCWLECPNDRPLFSELNTSI
|| .|| || . | .|| |  |.   
YEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK356.AA TK-Unique 2162-2186 36 7.2e-05 12.86 In-house 270-294 (294) Show / Hide 
Range on Protein: 2162-2186
Range on HMM: 270-294/294
Sequence Identity: 36% (9 aa)

YELMLLCWLECPNDRPLFSELNTSI
|.||  || . | .|| |...   .
YNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK356.AA UTK 2162-2186 40 0.000251 10.71 In-house 272-296 (296) Show / Hide 
Range on Protein: 2162-2186
Range on HMM: 272-296/296
Sequence Identity: 40% (10 aa)

YELMLLCWLECPNDRPLFSELNTSI
|.||. ||   | .|| | .|   .
YRLMHRCWHYDPQERPDFEDLVQQM
Kinase AqueK356.AA TKL 2158-2186 31 0.000881 9.51 In-house 330-364 (364) Show / Hide 
Range on Protein: 2158-2186
Range on HMM: 330-364/364
Sequence Identity: 31% (11 aa)

CCCSY------ELMLLCWLECPNDRPLFSELNTSI
|.|..      .||  || . |..|| |.|.   .
CPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL