AqueK361

Species: A.queenslandica
Alias: AqueK361
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK361.AA Protein None 466 None Fasta, JSON
AqueK361.kin_dom Protein Kinase Domain None 208 None Fasta, JSON

Protein domain

Protein domains of AqueK361.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Calx_beta AqueK361.AA Calx_beta 81-183 26 2.3e-10 41.7 SMART 1-106 (106) Show / Hide
Range on Protein: 81-183
Range on HMM: 1-106/106
Sequence Identity: 26% (29 aa)

LTGTDLKPL--LFVTFNSSSYFTTESNGQVLLYIERSNR-LSEVVTVTVKTKSSATTTSPANEN-SDYIPV--NQTIAFSARE-TVKTFFITIINDGVTE
.| ..| .    .| | .. |  .|. |.. . ..|.   ... |.|. .| .       |..  |||.|.   .|. | . | |.|.. | ||.| . |
ATVMILDDDHMGTVFFEQPHYTVNENCGEFEVCVVRTGGTARGTVVVPYRTQDGT-----ATAGGSDYEPWDIPGTLTFPPGEGTMKCIRIKIIDDDIYE

E-TEYFDVVIE
. .|.| |...
KRDEHFYVRLS

Calx-beta AqueK361.AA Calx-beta 81-183 28 7.4e-09 34.53 Pfam 1-109 (109) Show / Hide
Range on Protein: 81-183
Range on HMM: 1-109/109
Sequence Identity: 28% (32 aa)

LTGTDLKP--LLFVTFNSSSYFT--TESNGQVLLYIERSNR---LSEVVTVTVKTKSSATTTSPANEN--SDYIPVNQT-IAFSARE-TVKTFFITIIND
 | |.| .     . |  . |    .|. |.| . ..| .    |.  ||| ..|    |    |...  .||.|.. | . |.. | |.|.. .|||.|
ATVTILDDDDAIVIGFEPTHYQVDVNENCGTVEVCVVRMGGAPTLRRTVTVMYRTED-GT----ATAGPGDDYEPTEGTILTFNPDEDTHKCINVTIIDD

GVTEETEYFDVVIE
 . |..| | |.. 
DIYEGDEHFFVHLS

Pkinase_Tyr AqueK361.AA Pkinase_Tyr 244-451 36 1.5e-64 219.29 Pfam 1-197 (270) Show / Hide
Range on Protein: 244-451
Range on HMM: 1-197/270
Sequence Identity: 36% (79 aa)

IQVLEVTGQGEFGIVYRALMTLKSDEMPQVVAIKTLKGLFSKSD--IHSFVEECITMSNF-DDPNILPLFGVSLDLGPA--PCIIMPFMSRGSLLSYLEK
|. ... |.|.|| ||.. .. . |.  . ||.|.||   ....  . .| .|  .|... . |||. | || .| |    ..|.|..|  |.||.|| |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

ERPNLTVTDISDKDAVLNVRKQLLCICLQVAKGMFYLASQHFVHRDLAARNCMIDENGIIKIANFGLTEDIYMECYFNQFTDES-ESSKNVKLPVKWMAI
 |         . .  |..   ||..|.|.|||| ||.|....|||||||||...||...||. |||. ||       . .|.   .... |||.|||| 
HR---------EDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-------YNDDYYYRKRGGGKLPIKWMAP

ESLCHGIFSQKSDV
|.. .|.|. ||||
ECINYGKFTTKSDV

Kinase AqueK361.AA Met 245-451 36 1e-61 200.99 In-house 1-202 (271) Show / Hide
Range on Protein: 245-451
Range on HMM: 1-202/271
Sequence Identity: 36% (81 aa)

QVLEVTGQGEFGIVYRALMTL-KSDEMPQVVAIKTLK--GLFSKSDIHSFVEECITMSNFDDPNILPLFGVSLDLGP-APCIIMPFMSRGSLLSYLEKER
 ...| ||| || ||.. ..  .. | .  .|.|.|.         |  | .| |.|. || ||.| | |..||     | .. |.|  | |... . . 
HFDDVIGQGHFGCVYHGMYHDNDGNEHH--CACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQ

PNLTVTDISDKDAVLNVRKQLLCICLQVAKGMFYLASQHFVHRDLAARNCMIDENGIIKIANFGLTEDI-YMECYFNQFTDESESSKN-VKLPVKWMAIE
 |..|             ..|.  |.|||||| |.|||.|||||||.||||.||  ..|.| |||  |. |   |  |     ..     .||||||| |
NNPCV-------------RDLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQ-----MHHTHPARLPVKWMAPE

SLC--------HGI-FSQKSDV
.|           . |. ||||
CLQQGVCLGCPTYRQFTTKSDV

Kinase AqueK361.AA TK 244-451 21 5.9e-60 199.34 In-house 1-377 (486) Show / Hide
Range on Protein: 244-451
Range on HMM: 1-377/486
Sequence Identity: 21% (82 aa)

IQVLEVTGQGEFG---IVYRALMTLKS---------------------DEMPQVVAIKTLKGL--FSKSDIHS-----------FVEECITMSNFD----
|..... |.|.||    ||....  ..                     .. .. ||.|.||     |. . .            | ||.  |. ..    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-DPNILPLFGVSLDLG-----------PAPCIIMPFMSRGS----LLSYLEKERPNLTVT---------------------------------DISDKDA
  |||. |.||... .           . ..|.| .|. |.    |..|| | ||. .                                   . .....
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQD

VLNV----------RKQLLC-------------------ICLQVAKGMFYLASQ------HFVHRDLAARNCMIDENGI-----------IKIANFG---
...            |.||.                   .|.|.|.|| ||.|.      .|||||||||||...||..           .||| ||   
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LTEDIYM-ECYFNQF----------------TDESESSKNVKLPVKWMAIESLC---------HGIFSQKSDV
     |. |||  . |  .                 .|.  .... |||..||| |.|          .|.|. ||||
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDV

Kinase AqueK361.AA UTK 244-451 31 9.3e-57 192.69 In-house 1-223 (296) Show / Hide
Range on Protein: 244-451
Range on HMM: 1-223/296
Sequence Identity: 31% (73 aa)

IQVLEVTGQGEFGIVYRALMTLKSDEMPQ-VVAIKTLK-GLFSKSDIH---SFVEECI---TMSNFD-DPNILPLFGVSLDLGPAPCIIMPFMSRGSLLS
.| .. .|||.||.|..|  |  |. |.. .||.|... . ..  .      | ||.     |..|.  ||.| | || .. .| ..|.. .|..|.|.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRS

YLEKERPNLTVTDISDKDAVLNVRKQLLCICLQVAKGMFYLASQHFVHRDLAARNCMIDENG-------IIKIANFG---LTEDIY-----MECYFNQFT
|| . ||..      . .. |. . |.|| ....| || ||.|..||||||||||| .....       ..|||.||   .. ...           ...
YLRRHRPTPP-----ACPHWLTLH-QRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSN---RYWES

DESESSKNVKLPVKWMAIESLCHG-IFSQKSDV
... .. . ..|..||| |.|.|.  |..||||
YYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDV

Kinase AqueK361.AA TK-Unique 244-451 32 1.6e-49 168.92 In-house 1-222 (294) Show / Hide
Range on Protein: 244-451
Range on HMM: 1-222/294
Sequence Identity: 32% (73 aa)

IQVLEVTGQGEFGIVYRALMTL--KSDEMPQVVAIKTLKGLFSKSDIHSFVEECITMSNFD-DPNILPLFGVSLDLGPAPCIIMPFMSRGSLLSYLEKER
. |..| |.|.|| |.|. ..   |... ...||.|.||  ... |   |  |   |.. .  |||. ..|.. . .  ..|||.....|.|..|| . |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

P---------NLTVTDISDKDAVLN--VR-KQLLCICLQVAKGMFYLAS--QHFVHRDLAARNCMIDENGIIKIANFGLTEDIYMECYFNQFTDESESSK
|         ||  .  ...| ...  .  |.|. .. |.|.|| ||||  ...|||||.|||... |....||..||...|.|        .. | . .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT------NGVYSMMCS

NVKLPVKWMAIESLC--HGIF-SQKSDV
  ..|..||| |||.  ||.. . ||||
QGRIPIRWMAPESLKCYHGMYHTTKSDV

Kinase AqueK361.AA Axl 244-453 35 8.8e-41 141.8 In-house 1-200 (267) Show / Hide
Range on Protein: 244-453
Range on HMM: 1-200/267
Sequence Identity: 35% (76 aa)

IQVLEVTGQGEFGIVYRALMTLKSDE-MPQVVAIKTLK-GLFSKSDIHSFVEECITMSNFDDPNILPLFGVSLDLG-----PAPCIIMPFMSRGSLLSYL
. .  . |.|||| |  .   || ..   . ||.|..|   ...|.|  |. | . | .|| ||.. | ||.. .      |.| .|.|||  | | ..|
FVLGKMLGEGEFGSVMEG--QLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFL

EKERPNLTVTDISDKDAVLNVRKQLLCICLQVAKGMFYLASQHFVHRDLAARNCMIDENGIIKIANFGLTEDIYMECYFNQFTDESESSKNVKLPVKWMA
   |       . |.   | . . |.   . .| || ||....|.||||||||||. |.  . .| |||   ||   |. |        .  |.||||.|
LYSR-------LGDQPFYLPL-QMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQ-------GCIAKMPVKWIA

IESLCHGIFSQKSDVLS
||||   ..  |||| .
IESLADRVYTSKSDVWA

Kinase AqueK361.AA InsR 244-453 34 1.9e-39 130.13 In-house 1-206 (278) Show / Hide
Range on Protein: 244-453
Range on HMM: 1-206/278
Sequence Identity: 34% (74 aa)

IQVLEVTGQGEFGIVYRA-LMTLKSDEMPQ--VVAIKTLKGLFSKSDIHSFVEECITMSNFDDPNILPLFGVSLDLGPAPCIIMPFMSRGSLLSYLEKER
|  .   ||| || ||   .  . .||      .||||..   |  .   |  |   | .|.  ..  |.||     |.  ..| .| .| | |||   |
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPM-YVVMEMMTYGDLKSYLRSRR

PNLT--VTDISDKDAVLNVRKQLLCICLQVAKGMFYLASQHFVHRDLAARNCMIDENGIIKIANFGLTEDIYMECYFNQFTDESESSKNVKLPVKWMAIE
|      ... ..  |   . |..    ... || |||.  |||||||.||||... . .||. ||.| |||   |          ..  .||| ||| |
PEEEFNNPGCNRNQHVP-CLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRK-------GGKGMLPVRWMAPE

SLCHGIFSQKSDVLS
||  |.|. .||| |
SLKDGVFTTHSDVWS

Kinase AqueK361.AA TyrKc 244-463 25 1.2e-37 132.28 SMART 1-280 (280) Show / Hide
Range on Protein: 244-463
Range on HMM: 1-280/280
Sequence Identity: 25% (78 aa)

IQVLEVTGQGEFGIVYRALMTLKSDEMPQVVAIKTLK-GLFSKSDIHSFVEECITMSNF--DDPNILPLFGVSLDLG------PAPCIIMPFMSRGSLLS
|. ... | |.||.||.. ..       . ||.|.|| .      .  | .|   |...  . |||. |.|| .. |      . ..|.| .|. |.|..
ITLGKKLGEGAFGEVYKGTWK-------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLEKERPNLTVTDISDKDAVLNVRKQLLCICLQVAKGMFYLASQHFVHRDLAARNCMIDENGIIKIANFGLTEDIYME-CYFNQFTDESESSK------N
|| | ||.            |.. |.|| .|.|.|.|| ||.|....|||||||||...||...||. |||. ||| . .       ||.. .      .
YLRKHRPK------------LCM-KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-----ESKDYYRKKEHKG

VK--LPVKWMAIESLCHGIFSQKSDV----------------------------------------LSRSKV----------------------------
 |  ||..|||.|.. .|.|. ||||                                        . . .                             
GKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR

----QLGLEL
    ..  ..
PTFSEIHECF

Kinase AqueK361.AA ALK 244-451 33 2.5e-34 115.91 In-house 1-200 (273) Show / Hide
Range on Protein: 244-451
Range on HMM: 1-200/273
Sequence Identity: 33% (73 aa)

IQVLEVTGQGEFGIVYRALMTL-KSDEMPQVVAIKTLKGLFSKSDIHSFVEECITMSNFDDPNILPLFGVSLDLGPAPCIIMPFMSRGSLLSYLEKERPN
|. . . |.| || || .. .    |  |  ||.|||. . |. |   |  |   |..|...|.  . |....  |   |.  .|. | ..|.|   ||.
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPY-MIVLEYMEGGDMKSFLRECRPH

LT---VTDISDKDAVLNVRKQLLCICLQVAKGMFYLASQHFVHRDLAARNCMIDENG---IIKIANFGLTEDI-YMECYFNQFTDESESSKNVK--LPVK
      . .  ||        || .|. ||.|  || ..||.||| |||||     |   . ||| ||   || |   |.          |. .  .|||
PESLQPSQLTMKD--------LLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYR---------KGGRAMMPVK

WMAIESLCHGIFSQKSDV
||  | .  |||  |.||
WMPPEAFMDGIFTSKTDV

Kinase AqueK361.AA Src 244-451 32 5.2e-34 112.91 In-house 1-183 (255) Show / Hide
Range on Protein: 244-451
Range on HMM: 1-183/255
Sequence Identity: 32% (69 aa)

IQVLEVTGQGEFGIVYRALMTLKSDEMPQVVAIKTLKGLFSKSDIHSFVEECITMSNFDDPNILPLFGVSLDLGPAPCIIMPFMSRGSLLSYLEKERPNL
|. ..  ||| || |. ..   . .     ||.||||      . . | .|  .| ... .... |. |  .  |   |.  .||.|||| || |     
IKLCRKLGQGQFGEVWMGYWNGNTK-----VAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK-----

TVTDISDKDAVLNVRKQLLCICLQVAKGMFYLASQHFVHRDLAARNCMIDENGIIKIANFGLTEDIY--MECYFNQFTDESESSKNVKLPVKWMAIESLC
     ...   |... ||. .  |||.|| || |. ..||||||||  ..|| . |.| |||   |    . |        ....  |.|.||.| | . 
-----DGEGRHLHLP-QLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEY--------CARHGAKFPIKWTAPEAIN

HGIFSQKSDV
.| |..||||
YGRFTIKSDV

Kinase AqueK361.AA Ror 362-451 45 2.7e-23 83.7 In-house 122-204 (308) Show / Hide
Range on Protein: 362-451
Range on HMM: 122-204/308
Sequence Identity: 45% (41 aa)

LCICLQVAKGMFYLASQHFVHRDLAARNCMIDENGIIKIANFGLTEDIYMECYFNQFTDESESSKNVKLPVKWMAIESLCHGIFSQKSDV
| | .|.| || ||.| ||||||||||||.. |   .||. |||  |||   |       . |     .|. ||. |.   | ||  ||.
LHIAIQIAAGMEYLSSHHFVHRDLAARNCLVGEHHHVKISDFGLMRDIYSSDYYRMQ---HKSW----MPIRWMSPEAIMYGKFSEDSDI

Kinase AqueK361.AA HMTK 361-406 58 1.6e-20 68.35 In-house 130-175 (291) Show / Hide
Range on Protein: 361-406
Range on HMM: 130-175/291
Sequence Identity: 58% (27 aa)

LLCICLQVAKGMFYLASQHFVHRDLAARNCMIDENGIIKIANFGLT
.| .| |.|.|| |.|||..||.|||||||.. .| ..||| ||||
QLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLT

Kinase AqueK361.AA Pkinase 244-405 25 1.2e-15 56.44 Pfam 1-158 (293) Show / Hide
Range on Protein: 244-405
Range on HMM: 1-158/293
Sequence Identity: 25% (44 aa)

IQVLEVTGQGEFGIVYRALMTLKSDEMPQVVAIKTLKGLFSKS--DIHSFV--EECITMSNFDDPNILPLFGVSLDLGPAPCIIMPFMSRG----SLLSY
...... |.| || ||..     ..    .||.|..|    ||  |.. .   | .| | ... |||. |...  | .. ....|...  |    .| .|
YHIGRKIGSGSFGCVYKCHHKGTGK----IVAVKIIKKRHEKSWKDQTHRRLSEIQI-MKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDY

LEKERPNLTVTDISDKDAVLN--VRKQLLCICLQVAKGMFYLASQHFVHRDLAARNCMIDENGII----KIANFGL
..             ..        ... ....|...|. |. |. ..||||   |..||.|| |    ||. |||
IST------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGL

Kinase AqueK361.AA S_TKc 244-464 16 3.7e-11 -13.31 SMART 1-231 (231) Show / Hide
Range on Protein: 244-464
Range on HMM: 1-231/231
Sequence Identity: 16% (44 aa)

IQVLEVTGQGEFGIVYRALMTLKSDEMPQVVAIKTLKGLFSKSDIHSFVEECITMSNFDDPNILPLFGVSLDLGPAPCIIMPFMSR--GSLLSYLEKERP
 ..|.. |.| || ||..  .       ..|||| .|         ..  |   ... . |||  |..|  |     ...| ...   |.|..|..| ..
YEILRKIGKGAFGKVYKCRHKK----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGR

N-----LTVTDISDKDAVLNVRKQLLCICLQVAKGMFYLASQHFVHRDLAARNCMIDENGIIKIANFGLTEDI----------------YME--------
.     ..  ..              ... |..... |. |....||||   | ..||   |||. |||   .                |          
HGLRFPFPE-HAR-------------FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSC

-------CY----FNQFTDESESSKNVKLPVKWMAIESLCHGIFSQKSDVLSRSKVQLG-------LELA
       ..    |    .. .  |...         ..  ...    .        |         .  
GCILYEMLCGYPPFP---QMQMMFKKIG----SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase AqueK361.AA HMTK 428-451 61 1.8e-09 29.27 In-house 192-217 (291) Show / Hide
Range on Protein: 428-451
Range on HMM: 192-217/291
Sequence Identity: 61% (16 aa)

VKLPVKWMAIESLC--HGIFSQKSDV
||||.||||.| .    .||| ||||
VKLPIKWMAPEAMDGKRKIFSEKSDV

Kinase AqueK361.AA Ror 244-312 34 8e-09 31.5 In-house 1-70 (308) Show / Hide
Range on Protein: 244-312
Range on HMM: 1-70/308
Sequence Identity: 34% (24 aa)

IQVLEVTGQGEFGIVYR-ALMTLKSDEMPQVVAIKTLKGLFSKSDIHSFVEECITMSNFDDPNILPLFGV
....|  | . || ||.  || .   . .. |||||.|   |      |  |   |. .. |||  | ||
VRFMEELGECQFGKVYKGHLMGPNFMYHCMAVAIKTCKHDASPAQWQDFRQEIMLMATLHHPNIVCLLGV

Kinase AqueK361.AA HMTK 244-314 24 1e-06 19.19 In-house 1-94 (291) Show / Hide
Range on Protein: 244-314
Range on HMM: 1-94/291
Sequence Identity: 24% (23 aa)

IQVLEVTGQGEFG-----------------IVYRALMT------LKSDEMPQVVAIKTLKGLFSKSDIHSFVEECITMSNFDDPNILPLFGVSL
. .. | |.| ||                  || |.          . . |. .| |.|.|  |  |.  |  |...|.... ||.. | ||..
LKAIKVIGAGQFGMVQCLRLAPPDEGCTSLKVYLAEWSVKDGDGKDDSNQPHHRAVKMLRGDASHEDREEFLREAEVMCQLRHPNLVQLVGVCM