Gene AqueK374 (A.queenslandica)

AqueK374

Species: A.queenslandica
Alias: AqueK374
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK374.AA Protein None 839 None Fasta, JSON
AqueK374.kin_dom Protein Kinase Domain None 274 None Fasta, JSON

Protein domain

Protein domains of AqueK374.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SRCR AqueK374.AA SRCR 201-244 56 4.4e-21 72.63 Pfam 1-48 (112) Show / Hide 
Range on Protein: 201-244
Range on HMM: 1-48/112
Sequence Identity: 56% (27 aa)

VDGTNSSEGRVEVCS-GGVWGTVCDD-Y-WDNTDAGVVCRQLGY-DSG
|.|....||||||.  .|.|||||||   ||..|| |||||||. . .
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGA
SRCR AqueK374.AA SRCR 149-192 54 4.9e-21 72.49 Pfam 1-48 (112) Show / Hide 
Range on Protein: 149-192
Range on HMM: 1-48/112
Sequence Identity: 54% (26 aa)

VDGTNSSEGRVEVCS-GGVWGTVCDD-H-WDNTDARVVCRQLEY-DSG
|.|....||||||.  .|.||||||| . ||..||.|||||| . . .
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGA
SR AqueK374.AA SR 146-237 34 2.3e-18 68.24 SMART 1-118 (118) Show / Hide 
Range on Protein: 146-237
Range on HMM: 1-118/118
Sequence Identity: 34% (41 aa)

IRLVDGTNSSEGRVEVCSGG----VWGTVCDDHWDNTDARVVCRQLEYDSGCIDG------SIRLVDGT----------NSSEGRVEVCSGGVWGTV---
.|||.|.|..||||||  .|    .|||||||.|| .||.|||||| . ..          . .  .|.          . .|.. . |.   ||     
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPHWGWGQHNNC

CDD---YWDNTDAGVVCR
|.      .. |||||| 
CSHNHHRNRQEDAGVVCS
SR AqueK374.AA SR 250-347 49 1.4e-50 175.26 SMART 1-118 (118) Show / Hide 
Range on Protein: 250-347
Range on HMM: 1-118/118
Sequence Identity: 49% (58 aa)

IRLVGGTNSKEGRVEVCSGG----VWGTVCDDYWDSTDATVVCRQLGYGSGTAFD------SAYFGQGTEAIVMDDVDCNGTESYLTNCTH--TTEHN--
.|||||.|. ||||||  .|    .|||||||.|| .|| |||||||.|.. .        .|.||||.  |.||.|.|.|||. |..|.|    .||  
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPHWGWGQHNNC

CVH------SEDAGVRCV
| |      .|||||.| 
CSHNHHRNRQEDAGVVCS
SRCR AqueK374.AA SRCR 253-347 50 3.5e-42 143.51 Pfam 1-112 (112) Show / Hide 
Range on Protein: 253-347
Range on HMM: 1-112/112
Sequence Identity: 50% (56 aa)

VGGTNSKEGRVEVCS-GGVWGTVCDD-Y-WDSTDATVVCRQLGYGSG---TAFDSAY--FG--QGTEAIVMDDVDCNGTESYLTNC--THTTE--HN--C
|||... ||||||.  .|.|||||||   || .|| |||||||.|.|   . . .||  ||  .||  |.||.|.|.|.|. |..|  .....  ||  |
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMC

VHS-EDAGVRCV
 || |||||.| 
SHSREDAGVICS
SR AqueK374.AA SR 354-452 46 1.5e-45 158.61 SMART 1-118 (118) Show / Hide 
Range on Protein: 354-452
Range on HMM: 1-118/118
Sequence Identity: 46% (55 aa)

IRIVNGSHDWEGRVEVCVSE----SWGTVCDDLWDSTEAAVVCRQLGWGTSGTALS-----NAYFGEGTGRILLDNVRCLGTEQLLTNCAH--STTHN--
.| |.|..  ||||||  .     .||||||| || ..| ||||||| |.  .| .      |.||.|.|.|..||||| |||. |..|.|     ||  
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPHWGWGQHNNC

CGH------DEDAGVICN
|.|      .|||||.|.
CSHNHHRNRQEDAGVVCS
SRCR AqueK374.AA SRCR 357-452 49 2.6e-41 140.6 Pfam 1-112 (112) Show / Hide 
Range on Protein: 357-452
Range on HMM: 1-112/112
Sequence Identity: 49% (55 aa)

VNGSHDWEGRVEVCV-SESWGTVCDD-L-WDSTEAAVVCRQLG--WGTSGTALSNAY--FG--EGTGRILLDNVRCLGTEQLLTNC--AHSTT--HN--C
|.||.  ||||||.    .|||||||   || ..| |||||||  .| . .  . ||  ||  .|||.|..||||| |.|. |..|   ...   ||  |
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMC

GHD-EDAGVICN
.|. |||||||.
SHSREDAGVICS
Kinase AqueK374.AA Pkinase_Tyr 558-824 39 5.5e-108 366.36 Pfam 11-270 (270) Show / Hide 
Range on Protein: 558-824
Range on HMM: 11-270/270
Sequence Identity: 39% (109 aa)

EFGIVYRGVMT-TENEMSQAVAVKTLKGFYNKND--IDSLLDECIIMMSF-DNLNVLPLIGVCLDLGPA--PCIVMPFMSRGSLLSYLKKERLNLTVADT
.|| ||.|...  . .  . ||||.||  . . .  ..... |  ||... .. |.. |.|||.| |    ..|||..|  |.||.||.| |        
AFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR--------

SEEDIVLNVRKRLLSICLQVANGMSYLASQRFIHRDLAARNCMIDGDGIIKVADFGLSEDIYDQNYFRQLKDSSSTIKLPLKWMAIESIHDGLFSEKSDV
 |..  |..   ||..|.|.|.||.||.|...||||||||||... ....|..||||. |||.  |   .. ....  || |||| |.|..| |..||||
-EDKQPLTMKD-LLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY--YRKRGGGK-LPIKWMAPECINYGKFTTKSDV

WSYGVLCWEVFSLGRMP-YPGLDPVGVVELL-DAGGRLQNPNNEACSQEIYSLMMSCWSESPDDRLVFSDLVSSV
||.|||.||.|..|..| |||...  |.|.. . |.|.  | |  |..|||.||..|| . |.||  ||....  
WSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN--CPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
TyrKc AqueK374.AA TyrKc 553-824 35 6.4e-106 359.11 SMART 1-280 (280) Show / Hide 
Range on Protein: 553-824
Range on HMM: 1-280/280
Sequence Identity: 35% (108 aa)

VRCG-----CEFGIVYRGVMTTENEMSQAVAVKTLKGFYNKNDIDSLLDECIIMMSF--DNLNVLPLIGVCLDLG------PAPCIVMPFMSRGSLLSYL
.. |     ..||.||.|...      . ||||.||       .  ...|  ||...  .. |.. |.|||.. |      . ..||| .|. |.|..||
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

KKERLNLTVADTSEEDIVLNVRKRLLSICLQVANGMSYLASQRFIHRDLAARNCMIDGDGIIKVADFGLSEDIYDQ-------NYFRQLKDSSSTIKLPL
.| | .            |.... |||.|.|.|.||.||.|...||||||||||... ....|..||||| ||||         | |. . ...   ||.
RKHRPK------------LCMKD-LLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPI

KWMAIESIHDGLFSEKSDVWSYGVLCWEVFSLGRMPYPG-----LDPVGVVELLDAGGRLQNPNNEA------CSQEIYSLMMSCWSESPDDRLVFSDLV
.|||.|.| .| |..||||||.||..||.|..| .||||     ...  |.|....|.|.  | |        |..|.|..| .|| | |.||  ||...
RWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIH

SSV
.  
ECF
Kinase AqueK374.AA TK 558-824 22 6.8e-93 311.73 In-house 11-486 (486) Show / Hide 
Range on Protein: 558-824
Range on HMM: 11-486/486
Sequence Identity: 22% (109 aa)

EFG---IVYRGVMTTEN----------------------EMSQAVAVKTLKGFYNKNDIDSLL---------------DECIIMMS---FDNLNVLPLIG
.||    ||.| . ..|                      .  . ||||.||   . .. . ..                | . ||.   ..  |.. |.|
QFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYG

VCLDLG-----------PAPCIVMPFMSRGS----LLSYLKKERLNLTVA---------------------------------DTSEEDIVLNV------
||.. .           . ..||| .|. |.    |..||.| | . .                                   . .||. ...       
VCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPC-PEEQDYDDDLIKDHP

------------------------RKRLLSICLQVANGMSYLASQ------RFIHRDLAARNCMIDGDGI-----------IKVADFG--------LSED
                         ..|| .|.|.|.||.||.|.      .|.|||||||||... ...           .|.||||        |. |
PPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARD

IY-DQNYFRQLKDSSS-------------------TIKLPLKWMAIESIHDGL---------FSEKSDVWSYGVLCWEVFSLGRMPYPGLDPV-------
|| |..| |.   . .                     |||..||| |.. |.          |..||||||.|||.||.|..|..||.|  .        
IYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDG

---GVVELLDAGGR------------LQNPNNEACS--------------QEIYSLMMSCWSESPDDRLVFSDLVSSV
    |.|.| .|||            .. |  . |.              .|.| ||..||.. |.||  ||.|..  
DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK374.AA UTK 558-824 30 5.5e-85 288.66 In-house 11-296 (296) Show / Hide 
Range on Protein: 558-824
Range on HMM: 11-296/296
Sequence Identity: 30% (93 aa)

EFGIVYRGVMTTEN--EMSQAVAVKTLKGFYNKND----ID---SLLDECI---IMMSFD-NLNVLPLIGVCLDLGPAPCIVMPFMSRGSLLSYLKKERL
.||.|...  |...  .  ..||||...   .. |     .    .. |.    .|. |.   ||| |.|||.. .| ..||. .|..|.|.||| . | 
AFGEVHKARFTQCSEHMYEMDVAVKVCQ---HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDLRSYLRRHRP

NLTVADTSEEDIVLNVRKR-LLSICLQVANGMSYLASQRFIHRDLAARNCMIDGDG-------IIKVADFG---LSEDIY---------DQNYFRQLKDS
..        .  . .... .|. ....|.||.||.|..|.||||||||| .. ..       ..|.||||   .| ...         ...|...    
TPP-------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMA----

SSTIKLPLKWMAIESIHDG-LFSEKSDVWSYGVLCWEVFSLGRMPYPGLDPVGVVELLDAGGRLQNPNNEACSQEIYSLMMSCWSESPDDRLVFSDLVSS
..  ..|..||| |.. ..  |..||||||.||.|||... ||.||||.  . |.. . .|||.. | ...|. ..| ||..||  .|..|  | |||. 
QHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQ

V
.
M
Kinase AqueK374.AA Met 559-818 38 1.3e-82 270.64 In-house 11-271 (271) Show / Hide 
Range on Protein: 559-818
Range on HMM: 11-271/271
Sequence Identity: 38% (107 aa)

FGIVYRGVMTTENEMSQAVAVKTLK--GFYNKNDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGP-APCIVMPFMSRGSLLSYLKKERLNLTVADTSEED
|| ||.| .. .      .|.|.|.       . |   | | |.|  ||  ||| |||.|||     | .| |.|  | |... . .  |..| |     
FGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQFLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGDLKTFIRNPQNNPCVRD-----

IVLNVRKRLLSICLQVANGMSYLASQRFIHRDLAARNCMIDGDGIIKVADFGLSEDI-YDQNYFRQLKDSSSTI--KLPLKWMAIESIH--------DGL
        |.. |.||| ||.|.|||.|.|||||.||||.| . ..|||||||. |. ||  |  |    . |   .||.|||| |.          .  
--------LIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDYDKEYYSQ---MHHTHPARLPVKWMAPECLQQGVCLGCPTYR

-FSEKSDVWSYGVLCWEVFSLGRMPYPGLDP-VGVVELLDAG--GRLQNPNNEACSQEIY-SLMMSCWSESPDDRLVFS
 |. |||||| ||. || .  |  |||  |. . .   |  |   ||  |  | |   .|  .| .||. .| ||  ||
QFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQP--EYCPDHLYTDVMLCCWHANPEDRPQFS
Kinase AqueK374.AA TK-Unique 557-824 32 1.5e-81 277.28 In-house 10-294 (294) Show / Hide 
Range on Protein: 557-824
Range on HMM: 10-294/294
Sequence Identity: 32% (94 aa)

CEFGIVYRGVMTTEN---EMSQAVAVKTLKGFYNKNDIDSLLDECIIMMSFD-NLNVLPLIGVCLDLGPAPCIVMPFMSRGSLLSYLKKER-L-------
..|| |.|| ... .   .  . ||||.||   .. | . .|.|  .|.. .   |.. ..|.| . .  ..|.|.....|.|..||.. |         
GAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTY

-NLTVADTSEEDIVLN--VR-KRLLSICLQVANGMSYLAS--QRFIHRDLAARNCMIDGDGIIKVADFGLSEDIYDQNYFRQLKDSSSTIKLPLKWMAIE
 ||     ...|....  .  |.|.... |.|.||.||||  ....||||.|||... .|...|..|||...|.|.    ...  . |  ..|..||| |
GNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT---NGVYSMMCSQGRIPIRWMAPE

SIH--DGLF-SEKSDVWSYGVLCWEVFSLGRMPYPGLDPVGVVELLDAGGRLQNPNNEAC-SQEIYSLMMSCWSESPDDRLVFSDLVSSV
|.   .| . ..||||||.||| ||.|.|| .||||...  ..|.. .| |.. |..  | |.|.|.|| |||...|..|  |.....  
SLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEH--CCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase AqueK374.AA Axl 558-822 39 2.7e-69 236.54 In-house 11-267 (267) Show / Hide 
Range on Protein: 558-822
Range on HMM: 11-267/267
Sequence Identity: 39% (108 aa)

EFGIVYRGVMTTENEMSQAVAVKTLK-GFYNKNDIDSLLDECIIMMSFDNLNVLPLIGVCLDLG-----PAPCIVMPFMSRGSLLSYLKKERLNLTVADT
||| |  | .  |   .. ||||..|     . .|.  | | . |  ||  ||. |||||. .      |.| ...|||  | | ..|   ||.      
EFGSVMEGQLKQEDGSFVKVAVKMMKIDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLLYSRLG------

SEEDIVLNVRKRLLSICLQVANGMSYLASQRFIHRDLAARNCMIDGDGIIKVADFGLSEDIYDQNYFRQLKDSSSTIKLPLKWMAIESIHDGLFSEKSDV
 .. . | .   |.   . .| || ||....||||||||||||.  |  . |||||||  ||.  |.|| . .    |.| ||.||||. | ..  ||||
-DQPFYLPLQM-LVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGDYYRQGCIA----KMPVKWIAIESLADRVYTSKSDV

WSYGVLCWEVFSLGRMPYPGLDPVGVVELLDAGGRLQNPNNEACSQEIYSLMMSCWSESPDDRLVFSDLVS
|..||  ||.   |. ||||..   . . |  | ||. |  | | .|.| || .||.  | ||  || |  
WAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQP--EDCMDELYDLMYQCWEADPKDRPSFSVLRE
Kinase AqueK374.AA Tec 614-826 38 5.1e-65 222.31 In-house 61-254 (254) Show / Hide 
Range on Protein: 614-826
Range on HMM: 61-254/254
Sequence Identity: 38% (83 aa)

GVCLDLGPAPCIVMPFMSRGSLLSYLKKERLNLTVADTSEEDIVLNVRKRLLSICLQVANGMSYLASQRFIHRDLAARNCMIDGDGIIKVADFGLSEDIY
|||.   |  .||  .|..|.||.||....  .      ...  .     ||..|..|  || || .. ||||||||||| .. ....||.|||..  . 
GVCSQQRPI-YIVTEYMEHGCLLNYLREHKHHF------QKNMAI-----LLEMCQDVCEGMAYLERHCFIHRDLAARNCLVGDQCVVKVSDFGMTRYVL

DQNYFRQLKDSSSTIKLPLKWMAIESIHDGLFSEKSDVWSYGVLCWEVFSLGRMPYPGLDPVGVVELLDAGGRLQNPNNEACSQEIYSLMMSCWSESPDD
|  |      ||.  | | || . |  |   .| |||||..||| |||||.|.|||. .. . |||    | ||  |  . ||..||  | .||.|.|..
DDQYT-----SSVGTKFPVKWCPPEVFHYSRYSSKSDVWAFGVLMWEVFSCGKMPYENMSNSEVVEHVSQGHRLYRP--HLCSMHIYQIMYHCWHEKPEE

RLVFSDLVSSVNA
|  |..| ...  
RPTFQQLLRQITE
Kinase AqueK374.AA Src 577-824 38 1.9e-64 217.83 In-house 26-255 (255) Show / Hide 
Range on Protein: 577-824
Range on HMM: 26-255/255
Sequence Identity: 38% (97 aa)

VAVKTLKGFYNKNDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPCIVMPFMSRGSLLSYLKKERLNLTVADTSEEDIVLNVRKRLLSICLQVANGMS
|||||||      . . .| |  || ...  ... |  || .  |   ||  .||.|||| ||||          ..|   |.... |...  |||.||.
VAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK----------DGEGRHLHLPQ-LIDMAAQVAEGMA

YLASQRFIHRDLAARNCMIDGDGIIKVADFGLSEDIY--DQNY-FRQLKDSSSTIKLPLKWMAIESIHDGLFSEKSDVWSYGVLCWEVFSLGRMPYPGLD
|| |...|||||||||  .. . . |||||||   |   | .|  |.        |.| ||.| | |. | |. ||||||.|.| .|... ||.|||| .
YLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARH------GAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVTYGRVPYPGMT

PVGVVELLDAGGRLQNPNNEACSQEIYS-LMMSCWSESPDDRLVFSDLVSSV
   |.. ...| |. .| |  | .|.|  .|. || ..|..|  |  | .  
NHEVLQQVERGYRMPCPHN--CPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK374.AA InsR 559-826 33 5.1e-64 213.9 In-house 12-278 (278) Show / Hide 
Range on Protein: 559-826
Range on HMM: 12-278/278
Sequence Identity: 33% (94 aa)

FGIVYRG----VMTTENEMSQAVAVKTLKGFYNKNDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPCIVMPFMSRGSLLSYLKKERLNLTVADTSEE
|| || |    ..  | . . ..|.||..      .    | |  .|  |.  .|  | |||    |.  .|| .| .| | |||   |           
FGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPM-YVVMEMMTYGDLKSYLRSRRPEEEF-----N

DIVLN------VRKRLLSICLQVANGMSYLASQRFIHRDLAARNCMIDGDGIIKVADFGLSEDIYDQNYFRQLKDSSSTIKLPLKWMAIESIHDGLFSEK
....|       . ....   ... ||.|||.  |.|||||.||||...|. .|..|||.  |||.  | |  . .    .||  ||| ||. || |. .
NPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDFTVKIGDFGMTRDIYEHDYYRKGGKG----MLPVRWMAPESLKDGVFTTH

SDVWSYGVLCWEVFSLGRMPYPGLDPVGVVELL-DAGGRLQNPNNEACSQEIYSLMMSCWSESPDDRLVFSDLVSSVNA
|||||.||. ||. .||  || ||    | .    .|. |. |  | |..  . ||| ||  .| .|  | |....   
SDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPP--ENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase AqueK374.AA ALK 559-826 37 1.6e-62 214.01 In-house 12-273 (273) Show / Hide 
Range on Protein: 559-826
Range on HMM: 12-273/273
Sequence Identity: 37% (104 aa)

FGIVYRGVMTT-ENEMSQ-AVAVKTLKGFYNKNDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPCIVMPFMSRGSLLSYLKKERLNLTVADTSEEDI
|| || |  .  ..  .. .||.|||.    . |    . |  ||  |.  ||  .||.|..  |   ||  .|. | ..|.|.  | .      |   .
FGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPY-MIVLEYMEGGDMKSFLRECRPHPESLQPSQ--L

VLNVRKRLLSICLQVANGMSYLASQRFIHRDLAARNCMIDGDG---IIKVADFGLSEDI-YDQNYFRQLKDSSSTIKLPLKWMAIESIHDGLFSEKSDVW
.    | || .|. || |  || ...||||| |||||     |   . |.|||| . || |   |.|       .. .| |||  |   ||.|  |.|||
TM---KDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRK---GGRAM-MPVKWMPPEAFMDGIFTSKTDVW

SYGVLCWEVFSLGRMPYPGLDPVGVVELLDAGGRLQNPNNEACSQEIYSLMMSCWSESPDDRLVFSDLVSSVNA
|.||||||.||||.|||||     | |.. .|||.  | |  | | .| .|  ||   | ||  | ... .  .
SFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRN--CPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase AqueK374.AA HMTK 664-823 39 7.5e-59 201.84 In-house 130-291 (291) Show / Hide 
Range on Protein: 664-823
Range on HMM: 130-291/291
Sequence Identity: 39% (65 aa)

LLSICLQVANGMSYLASQRFIHRDLAARNCMIDGDGIIKVADFGLSEDIY-DQNYFRQLKDSSSTIKLPLKWMAIESIH--DGLFSEKSDVWSYGVLCWE
.|..| |.| ||.|.||||..|.|||||||..    ..|.|||||.  .  .|.|... | .   .|||.||||.|     .. ||||||||..||..||
QLYFCVQCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHLRKHM---VKLPIKWMAPEAMDGKRKIFSEKSDVWAFGVTMWE

VFSLGRMPYP--GLDPVGVVELLDAGGRLQNPNNEACSQEIYSLMMSCWSESPDDRLVFSDLVSS
... |..||.  ..    |   . .|.||  |.  .|. ... || .||   |. |  |..|  .
IWMYGEQPYESQQIKNKEVQRHVREGRRLTQPPPDDCPDDFWDLMCTCWHKDPHQRPTFAQLQKM
SR AqueK374.AA SR 459-556 48 5.2e-50 173.37 SMART 1-118 (118) Show / Hide 
Range on Protein: 459-556
Range on HMM: 1-118/118
Sequence Identity: 48% (57 aa)

VRLVDESNSIEGRVELCHNG----RWGTVCDDYWDNTDASVVCRQLGYDSGTAFD------SAYFGQGTGTIVMNEVHCNGTESYLTNCTH--TMNHN--
||||. .|. |||||  |||    .|||||||.|| .||.|||||||. .. .        .|.||||.| |.| .|.|.|||. |..|.|    .||  
VRLVGGNNPCEGRVEVYHNGGGQGQWGTVCDDNWDIRDANVVCRQLGCGGAVSASQTLPATWAHFGQGSGPIWMDNVRCTGTETSLWDCPHWGWGQHNNC

CNH------SEDAGVRCG
|.|      .|||||.| 
CSHNHHRNRQEDAGVVCS
SRCR AqueK374.AA SRCR 462-556 48 2.8e-44 150.56 Pfam 1-112 (112) Show / Hide 
Range on Protein: 462-556
Range on HMM: 1-112/112
Sequence Identity: 48% (54 aa)

VDESNSIEGRVELCH-NGRWGTVCDD-Y-WDNTDASVVCRQLGYDSG---TAFDSAY--FG--QGTGTIVMNEVHCNGTESYLTNC--THTMN--HN--C
|. |.. |||||... ||.|||||||   ||..||.|||||||. .|   . . .||  ||  .||| |.|..|.|.|.|. |..|  ... .  ||  |
VGGSSPCEGRVEVRYHNGQWGTVCDDDGNWDMRDAHVVCRQLGCGGGAVQAWSCCAYAWFGNCPGTGPIWMDNVRCHGNETSLWQCPHSPWGWHRHNPMC

NHS-EDAGVRCG
.|| |||||.| 
SHSREDAGVICS
S_TKc AqueK374.AA S_TKc 553-828 19 1.4e-25 92.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 553-828
Range on HMM: 1-231/231
Sequence Identity: 19% (57 aa)

VRCGCE-----FGIVYRGVMTTENEMSQAVAVKTLKGFYNKNDIDSLLDECIIMMSFDNLNVLPLIGVCLDLGPAPCIVMPFMSR--GSLLSYLKKER--
 . . .     || ||... .      . ||.| .|        .... |  |... .  |.  |..|. |     ..|| ...   |.|..|.|| .  
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LNLTVADTSEEDIVLNVRKRLLSICLQVANGMSYLASQRFIHRDLAARNCMIDGDGIIKVADFGLSEDIYDQNYFRQLKDSSSTIKLPLKWMAIE
     ..  .|                ... |..... |. |...|||||   | ..|    ||..||||.  .             .|.   . .|| |
GLRFPFPE-HA---------------RFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------------TTFCGTPWYMAPE

SIHDGLFSE-KSDVWSYGVLCWEVFSLGRMPYPGLDPVGVVELLDAGGRLQNPNNEACSQEIYSLMMSCWSESPDDRLVFSDLVS-----SVNALI
 .    ..  |.|.|| |.. .| .. |. |.|      . ....  |          |.|  .... |.   |..|.   ..            .
VL---GYGKCKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK374.AA Pkinase 559-824 20 2.8e-21 76.31 Pfam 12-293 (293) Show / Hide 
Range on Protein: 559-824
Range on HMM: 12-293/293
Sequence Identity: 20% (64 aa)

FGIVYRGVMTTENEMSQAVAVKTLKGFYNKNDID--SLL-DECIIMMSFDNLNVLPLIGVCLDLGPAPCIVMPFMSRG----SLLSYLKKERLNLTVADT
|| ||...   ...    ||||..|   .| . |   ..  |. || ...  |.. |.... | .. ...||...  |    .| .|..           
FGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST----------

SEEDIVL--NVRKRLLSICLQVANGMSYLASQRFIHRDLAARNCMIDGDGII----KVADFGLSEDIYDQNYFRQLKDSSSTIKLPLKWMAIESIH-DGL
 ... ..     . . ....|.. |. |. |...|||||   |..|| .| |    |..||||.. ..        .   .|.   . .|| | |  .  
-WRHGCFYFS-EWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMAPEVIRGGQY

FSEKSDVWSYGVLCWEVFSLGRMPYPGL----DPVGVVELLDAGGR--LQNPNNEACS-------------------QEIYSLMMSCWSESPDDRLVFSD
 . |.|.||.|....|... || |.||     . .   ....  ..  |  .  . ||                   .|  ... .|.   | .|. . .
YGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQ

LVSS--V
.. .  .
ILQHPWF
Kinase AqueK374.AA HMTK 574-617 31 0.02183 4.25 In-house 51-94 (291) Show / Hide 
Range on Protein: 574-617
Range on HMM: 51-94/291
Sequence Identity: 31% (14 aa)

SQAVAVKTLKGFYNKNDIDSLLDECIIMMSFDNLNVLPLIGVCL
.. .|||.|.|    .|..  | |.. |  ..  |.. |.|||.
PHHRAVKMLRGDASHEDREEFLREAEVMCQLRHPNLVQLVGVCM