Gene AqueK384 (A.queenslandica)

AqueK384

Species: A.queenslandica
Alias: AqueK384
External Links:
Annotation:

Classification

Group: TK
Family: Met

Sequence

Name Sequence Type Origin Length Description Download
AqueK384.AA Protein None 1006 None Fasta, JSON
AqueK384.kin_dom Protein Kinase Domain None 281 None Fasta, JSON

Protein domain

Protein domains of AqueK384.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
IG AqueK384.AA IG 37-128 13 0.143688 4.58 SMART 1-58 (58) Show / Hide 
Range on Protein: 37-128
Range on HMM: 1-58/58
Sequence Identity: 13% (13 aa)

PVLVYAN---FATFYIKCSVCGEPPFEMSWIYSPQNDSLSNHTILKSTFIDSNSSNSMWKFRLQVNLTDTSAT---GYYYCRANSSFSYIH--SSAYYVK
|  |...    .|.    |       ...|                                |..     . .   | |||.|. . .|    .   .|.
PP-VTVKEGETVTLTC-VS-------QIWWY-------------------------------LTI-NVQPEDSQQHGTYYCQAT-HGQYWSIQGTTLTVQ
IG AqueK384.AA IG 298-417 8 0.448833 0.29 SMART 1-58 (58) Show / Hide 
Range on Protein: 298-417
Range on HMM: 1-58/58
Sequence Identity: 8% (12 aa)

PREIATVAGENASISCNAKSVHKISAKWIQLPEPWFNDSGLFRTQSSRGDVFNVLNSTISFPITAEAPFSFRIRCQVQSVFTVQEFDFTRTLWLLSNGLF
|. .  ..||.....| ..     . .|                                                                      | 
PP-VTVKEGETVTLTC-VS-----QIWWY---------------------------------------------------------------------LT

FKRLKFYYT--------TAQ--QATS-----LTVK
. ....  .        .|.  |..|     |||.
I-NVQPEDSQQHGTYYCQATHGQYWSIQGTTLTVQ
IGc2 AqueK384.AA IGc2 432-502 32 3.3e-11 44.48 SMART 1-56 (56) Show / Hide 
Range on Protein: 432-502
Range on HMM: 1-56/56
Sequence Identity: 32% (23 aa)

NETGKITLWCFATGNPQPTIYWYYNNKTLHSNDHHVTIAHRLAHQSVLIISPSNRIRDEGVYTCEAINNVA
.| . .|| |.||||| |.| ||. .. |              . . | |..     |.|.|||.| |.. 
HEGQSVTLTCPATGNPDPNIHWYK-GQPLP-------------WNWTLTIKNVT-PEDSGYYTCYARNPWG
IG AqueK384.AA IG 426-516 18 1e-06 29.56 SMART 1-58 (58) Show / Hide 
Range on Protein: 426-516
Range on HMM: 1-58/58
Sequence Identity: 18% (18 aa)

TTEVTVNETGKITLWCFATGNPQPTIYWYYNNKTLHSNDHHVTIAHRLAHQSVLIISPSNRIRDE---GVYTCEAINNVANLINARQ--TCHMKVN
   |||.| . .|| | ..     .|.||                        |.|  . .  |.   |.|.|.|        .. .  . . .| 
PP-VTVKEGETVTLTC-VS-----QIWWY------------------------LTI--NVQPEDSQQHGTYYCQAT-----HGQYWSIQGTTLTVQ
I-set AqueK384.AA I-set 429-497 28 1e-06 25.15 Pfam 10-77 (92) Show / Hide 
Range on Protein: 429-497
Range on HMM: 10-77/92
Sequence Identity: 28% (20 aa)

VTVNETGKITLWCFATGNPQPTIYWYYNNKTLHSNDHHVTIAHRLAHQSVLIISPSNRIRDEGVYTCEA
|.|.|   ... | .||.|.|.. |..... |....... .  .    . |.||  . ..|||.||| |
VEVQEGETARFECQVTGDPPPQVSWFKDGQPLRPDSDRHQMTYDGDGTYTLTISNVQ-PDDEGKYTCVA
V-set AqueK384.AA V-set 419-499 18 0.021989 10.05 Pfam 1-114 (128) Show / Hide 
Range on Protein: 419-499
Range on HMM: 1-114/128
Sequence Identity: 18% (22 aa)

PSSVRT-NTT----EVTVNETGKITLWCFATGNP----QP-TIYWYYNNKTL--------HSNDHHVTI------------AHRLAHQSV-----LIISP
.|.| . ...    .|||.| ...|| |. . ..    .. .||||.   ..        ... |...               .....       | || 
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQ-QPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISN

SNRIRDEGVYTCEAIN
  .  |.|.|.| ..|
-LQPSDSGTYYCAVWN
IG AqueK384.AA IG 526-619 16 7.2e-10 40.03 SMART 1-58 (58) Show / Hide 
Range on Protein: 526-619
Range on HMM: 1-58/58
Sequence Identity: 16% (16 aa)

PDRITAYKGDNANITVQIVGPNPPVSSDSIKWSYWNEASSNVSILDTNSNKMNTTKDSASLIITDVTSDDE---GYYQVMVWHPAGITSK--ATYLSVE
|  .|.  |.....|  .          .|.|.                           |.| .|. .|.   | |. ...  .| ...   |.|.|.
PP-VTVKEGETVTLTC-VS---------QIWWY---------------------------LTI-NVQPEDSQQHGTYYCQAT--HGQYWSIQGTTLTVQ
V-set AqueK384.AA V-set 518-618 15 2.8e-08 30.37 Pfam 1-128 (128) Show / Hide 
Range on Protein: 518-618
Range on HMM: 1-128/128
Sequence Identity: 15% (20 aa)

QVSPKLDLPD----RITAYKGDNANITVQIV-GPNPPVSSDSIKWSY-WNEASSNVSIL--------------------DTNSNKMNTTKDSASLIITDV
|.. .   |      .|.  |... .. .   ..... .. .| |..  . ..... |                     .. .  .|..|...|| |...
QSQVTQHPPRGCPWWVTVQEGQSVTLPCHYSDDYTCWEHNFYIYWYRQQPPGQKPQWIISYYTHYYYNFGHGYYYPRFKGRVTFSGNPSKNDFSLTISNL

TSDDEGYYQVMVWHP-AGITSKATYLSV
...|.| |   ||..  ..  . | | |
QPSDSGTYYCAVWNCNEDYFGHGTRLTV
I-set AqueK384.AA I-set 573-601 34 0.161962 7.66 Pfam 44-75 (92) Show / Hide 
Range on Protein: 573-601
Range on HMM: 44-75/92
Sequence Identity: 34% (11 aa)

NSNKMNTTKDS---ASLIITDVTSDDEGYYQV
.|.... | |    ..|.|..|..|||| | .
DSDRHQMTYDGDGTYTLTISNVQPDDEGKYTC
TyrKc AqueK384.AA TyrKc 713-991 34 6.9e-106 359.0 SMART 1-280 (280) Show / Hide 
Range on Protein: 713-991
Range on HMM: 1-280/280
Sequence Identity: 34% (105 aa)

IKILGCIGQGEFAKVYKGHYYFNNQCTTVAVKTLKGTMDKYSQEDMKELIFESLVMQDL--DHPNVMGLIGLCLDAG------PSPLVVLPYMEGGNLLK
|. .  .| |.| .||||...     ..||||.||          ..... |  .|  |  .|||.  |.| |.. |      . ...|. ||..|.|..
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

HLVRNRESLLIDETTGEDEINQVRSQLLSISLQIGKGMQYIAEKKLIHRDLAARNCMIDGTGNIKVADFGLSKNIIGD------NVYYRQEKANGVK--L
.| ..|.            ..   ..|||...|| .||.|...|..||||||||||...  . .|..|||||..|  |        |||. .  | |  |
YLRKHRPK-----------LCM--KDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML

PIKWMAIESIEDGIFTEKTDIWSFGITVWEVFSGGKMPYGG-----FSPFTVKTMLADGHKLEAPLNLA------SNDDIYQKIMLPCWERNPTKRPTFA
||.|||.|.| .|.||.|.|.||||.. ||.|. |..|| |      |.. |   . .|. .. | |          |..|| ||. ||...| .||||.
PIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFS

QIVVEI
.|. ..
EIHECF
Pkinase_Tyr AqueK384.AA Pkinase_Tyr 713-991 37 5.1e-105 356.31 Pfam 1-270 (270) Show / Hide 
Range on Protein: 713-991
Range on HMM: 1-270/270
Sequence Identity: 37% (107 aa)

IKILGCIGQGEFAKVYKGHYY--FNNQCTTVAVKTLKGTMDKYSQED--MKELIFESLVMQDL-DHPNVMGLIGLCL-DAGP-SPLVVLPYMEGGNLLKH
|...  .|.|.| .||||...    |....||||.||   .....|.  ..... |  .|  | .|||.  |.| |. . .| ....|..||..|.||..
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK---EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LVRNRESLLIDETTGEDEINQVRSQLLSISLQIGKGMQYIAEKKLIHRDLAARNCMIDGTGNIKVADFGLSKNIIGDNVYYRQEKANGVKLPIKWMAIES
| ..|          ||. .   ..||....|| |||.| ..|..||||||||||... .. .|..||||.. |  |  |  . . .|  ||||||| |.
LRKHR----------EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGK-LPIKWMAPEC

IEDGIFTEKTDIWSFGITVWEVFSGGKMP-YGGFSPFTVKTML-ADGHKLEAPLNLASNDDIYQKIMLPCWERNPTKRPTFAQIVVEI
| .|.||.|.|.||||.. ||.|. |..| | | |.. |. ..  ||. ...| |    |.||. .|. ||. .| .||||..|. ..
INYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPEN--CPDEIYD-LMKQCWHYDPEDRPTFSEIHEQL
Kinase AqueK384.AA TK 713-991 20 3.8e-95 319.39 In-house 1-486 (486) Show / Hide 
Range on Protein: 713-991
Range on HMM: 1-486/486
Sequence Identity: 20% (102 aa)

IKILGCIGQGEFA---KVYKGHYYF-----------------------NNQCTTVAVKTLKGTMDKYSQEDMK-------------ELIFESLVMQD--L
|...  .|.|.|    .|||| ..                        ....|.||||.|| . .  ..| .              |.  |  .|.   .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

DHPNVMGLIGLCLDAGPS-----------PLVVLPYMEGGN----LLKHLVRNRESLLIDETTGED----------------------------------
.|||.  |.| |.. .|.           ...|. ||..|.    |...| ..|.     . ....                                  
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

--------EINQVRSQLLS-------------------ISLQIGKGMQYIAEK------KLIHRDLAARNCMIDGTGN-----------IKVADFG----
        .     ..||.                   ...|| .||.|...|      ...|||||||||...  ..           .|.||||    
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LSKNIIGDNVYYRQEKAN---------------------GVKLPIKWMAIESIEDGI---------FTEKTDIWSFGITVWEVFSGG-KMPYGGFS
    |.. |  |  |||..                        | ||||.||| |...|..         ||.|.|.||||...||.|. | ...||| |
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

P---------FTVKTMLADGHK------------LEAPLNLASND-------------DIYQKIMLPCWERNPTKRPTFAQIVVEI
            |  .| .|..            .. |      |             ..|. .|. ||...| .||||.|.. ..
NQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase AqueK384.AA UTK 713-991 27 5e-78 265.52 In-house 1-296 (296) Show / Hide 
Range on Protein: 713-991
Range on HMM: 1-296/296
Sequence Identity: 27% (86 aa)

IKILGCIGQGEFAKVYKGHYYFNN---QCTTVAVKTLKGTMDKYSQEDMK---ELIFESL---VMQDLD-HPNVMGLIGLCLDAGPSPLVVLPYMEGGNL
.... ..|||.|  |.|... . .   .   ||||...   .. .| ..    ... |.    .|. .. ||||..|.|.|.. .| ...|. |||.|.|
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQ--HHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP-WMIVTEYMENGDL

LKHLVRNRESLLIDETTGEDEINQVRSQ-LLSISLQIGKGMQYIAEKKLIHRDLAARNCMIDGTG-------NIKVADFG---LSKNII---------GD
.. | |.|...        ..  ....  .|. ...|  ||||.......||||||||| ..  .        .|.||||   .|...          ..
RSYLRRHRPTPP-------ACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWES

NVYYRQEKANGVKLPIKWMAIESIEDG-IFTEKTDIWSFGITVWEVFSGGKMPYGGFSPFTVKTMLADG--HKLEAPLNLASNDDIYQKIMLPCWERNPT
. |..|.     ..||.||| |.. ..  ||.|.|.||||...||....|..||.| |   | . . .|  . ...|      ...|. .|. ||. .| 
YYYMAQHQ---DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCP--HPVYR-LMHRCWHYDPQ

KRPTFAQIVVEI
.||.| ..| ..
ERPDFEDLVQQM
Kinase AqueK384.AA Met 714-985 36 5.3e-78 255.29 In-house 1-271 (271) Show / Hide 
Range on Protein: 714-985
Range on HMM: 1-271/271
Sequence Identity: 36% (106 aa)

KILGCIGQGEFAKVYKGHYYF-NNQCTTVAVKTLK----GTMDKYSQEDMKELIFESLVMQDLDHPNVMGLIGLCLDAGP-SPLVVLPYMEGGNLLKHLV
  .  |||| |  ||.| |     . . .|.|.|.    ... . ||        | ..| ..|||||  ||| |||    .|.||||||..|  ||. .
HFDDVIGQGHFGCVYHGMYHDNDGNEHHCACKSLHGERITDIQHISQ-----FLREGIMMKHFDHPNVLSLIGICLDPEGHMPWVVLPYMKHGD-LKTFI

RNRESLLIDETTGEDEINQVRSQLLSISLQIGKGMQYIAEKKLIHRDLAARNCMIDGTGNIKVADFGLSKNI-IGDNVYYRQEKANG-VKLPIKWMAIES
|| .  .            || .|..  .|. |||.| |..| .|||||.||||.|    .|||||||.  . . |  || |.   .  .||.|||| |.
RNPQNNP-----------CVR-DLIEFCHQVAKGMMYMASQKFVHRDLACRNCMLDEHFTVKVADFGLCRDMDY-DKEYYSQMHHTHPARLPVKWMAPEC

IE--------DGI-FTEKTDIWSFGITVWEVFSGGKMPYGGFSP-FTVKTMLADG--HKLEAPLNLASNDDIYQKIMLPCWERNPTKRPTFA
 .        . . || |.|.||||.  || .  |  ||.  .. | . . |. |    |  |      | .|  .|| ||. || .||.| 
LQQGVCLGCPTYRQFTTKSDVWSFGVVMWELMTRGAPPYPHVDNWFDITHWLHQGETRRLPQPEYCP--DHLYTDVMLCCWHANPEDRPQFS
Kinase AqueK384.AA TK-Unique 713-991 28 1e-70 241.27 In-house 1-294 (294) Show / Hide 
Range on Protein: 713-991
Range on HMM: 1-294/294
Sequence Identity: 28% (85 aa)

IKILGCIGQGEFAKVYKGHYY-FN---NQCTTVAVKTLKGTMDKYSQEDMKELIFESLVMQDLD-HPNVMGLIGLCLDAGPSPLVVLPYMEGGNLLKHLV
....  ||.|.|  |..| .  ..   .. . ||||.||   |. ...| ...  |  .|. |. |||.  ..| | . . ... ...|...|||...| 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLK---DNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLR

RNR----ES-------LLIDETTGEDEINQVR-SQLLSISLQIGKGMQYIAE--KKLIHRDLAARNCMIDGTGNIKVADFGLSKNIIGDNVYYRQEKANG
..|    ..          .  . ... . .   .|...  || .||.|.|.  || .||||.|||... . ...|..|||... .  ..|| .... . 
TCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG-

VKLPIKWMAIESIE--DGIF-TEKTDIWSFGITVWEVFSGGKMPYGGFSPFTVKTMLADGHKLEAPLNLASNDDIYQKIMLPCWERNPTKRPTFAQIVVE
 ..||.||| ||.   .|.. |.|.|.||||.. ||.|. |..||.| ..  . ... ||. .. | .  .....|. .|  || ..|..||.|.||. .
-RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQP-EHCCSHEMYN-LMKSCWQWEPEERPSFRQIKHR

I
.
L
Kinase AqueK384.AA Axl 715-989 37 5.3e-68 232.23 In-house 2-267 (267) Show / Hide 
Range on Protein: 715-989
Range on HMM: 2-267/267
Sequence Identity: 37% (107 aa)

ILG-CIGQGEFAKVYKGHYYFNN-QCTTVAVKTLKGTMDKYSQEDMKELIFESLVMQDLDHPNVMGLIGLCLDAG-----PSPLVVLPYMEGGNLLKHLV
.||  .|.|||  |  |.   .      ||||..|  .|  .| .. | . |   |.. |||||| ||| |. .      | |.|.||.|  | |  .|.
VLGKMLGEGEFGSVMEGQLKQEDGSFVKVAVKMMK--IDICTQSEIEEFLSEAACMKEFDHPNVMRLIGVCIQMSERQRIPKPMVILPFMKHGDLHTFLL

RNRESLLIDETTGEDEINQVRSQLLSISLQIGKGMQYIAEKKLIHRDLAARNCMIDGTGNIKVADFGLSKNII-GDNVYYRQEKANGVKLPIKWMAIESI
  |         |.. ..     |.   . |  || |..... |||||||||||.     . |||||||| |  ||  |||| ..   |.|.||.||||.
YSR--------LGDQPFYLPLQMLVKFMVDIACGMEYLSNRNFIHRDLAARNCMLREDMTVCVADFGLSKKIYSGD--YYRQGCI--AKMPVKWIAIESL

EDGIFTEKTDIWSFGITVWEVFSGGKMPYGGFSPFTVKTMLADGHKLEAPLNLASNDDIYQKIMLPCWERNPTKRPTFAQIVV
 | ..| | |.|.||.|.||.   |. || |     .   | .||.|  | .    |..|. .|  ||| .| .||.|...  
ADRVYTSKSDVWAFGVTMWEIMTRGQTPYPGVENHEMYDYLIHGHRLKQPEDCM--DELYD-LMYQCWEADPKDRPSFSVLRE
Kinase AqueK384.AA Src 713-991 35 1.2e-65 222.02 In-house 1-255 (255) Show / Hide 
Range on Protein: 713-991
Range on HMM: 1-255/255
Sequence Identity: 35% (99 aa)

IKILGCIGQGEFAKVYKGHYYFNNQCTTVAVKTLK-GTMDKYSQEDMKELIFESLVMQDLDHPNVMGLIGLCLDAGPSPLVVLPYMEGGNLLKHLVRNRE
|| .  .||| |  |..| .   |. | ||||||| |||      . . .  |  .|  |.|...  |   | .  |  . |  ||. |.||. | .   
IKLCRKLGQGQFGEVWMGYW---NGNTKVAVKTLKPGTM------SPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPI-YIVTEYMSHGSLLDYLKK---

SLLIDETTGEDEINQVRSQLLSISLQIGKGMQYIAEKKLIHRDLAARNCMIDGTGNIKVADFGLSKNIIG--DNVYYRQEKANGVKLPIKWMAIESIEDG
         ... .    ||.... |. .||.|. ....|||||||||  .. .   ||||||| . .|   |..|  ..   | |.||||.| | |  |
--------DGEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLAR-LIKEDDDEYCARH---GAKFPIKWTAPEAINYG

IFTEKTDIWSFGITVWEVFSGGKMPYGGFSPFTVKTMLADGHKLEAPLNLASNDDIYQKIMLPCWERNPTKRPTFAQIVVEI
 || |.| |||||  .|... |..|| | .   | ...  | ..  | |    | .|..||| ||.. | .||||. .    
RFTIKSDVWSFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHN--CPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase AqueK384.AA EGFR 713-992 32 5.5e-64 211.29 In-house 1-258 (258) Show / Hide 
Range on Protein: 713-992
Range on HMM: 1-258/258
Sequence Identity: 32% (92 aa)

IKILGCIGQGEFAKVYKGHYYFNNQCTT--VAVKTLKGTMDKYSQEDMKELIFESLVMQDLDHPNVMGLIGLCLDAGPSPLVVLPYMEGGNLLKHLVRNR
.| ..  | | | .|||| .. . .     ||.| |.   .. ...  .|.. | .||  .|||... |.|.|.       .|  ||  |.|| ..  ..
LKKVKVLGSGAFGTVYKGIWIPEGENVKIPVAIKVLR---EQTGPKANEEMLDEAYVMASVDHPHLVRLLGVCMHSQ--MQLVTQYMPYGCLLDYVRQHK

ESLLIDETTGEDEINQVRSQLLSISLQIGKGMQYIAEKKLIHRDLAARNCMIDGTGNIKVADFGLSKNIIGDNVYYRQEKANGVKLPIKWMAIESIEDGI
. .      |  .       ||  ..|| |||||  |....|||||||| ..     .|..||||.|    |.  |   .|.| |.||||||.|.|. ..
DNI------GSQH-------LLNWCVQIAKGMQYLEEHRMVHRDLAARNVLVKSPNHVKITDFGLAKLLEHDEKEY---HAQGGKMPIKWMALECIHHRC

FTEKTDIWSFGITVWEVFSGGKMPYGGFSPFTVKTMLADGHKLEAPLNLASNDDIYQKIMLPCWERNPTKRPTFAQIVVEIE
.| . |.||.|.|.||.   |. || | .   .  .| .| .|. | .     |.|. .|. ||   .  |||| ... | .
YTHQSDVWSYGVTCWELMTFGQKPYDGIPAREIPDLLEKGERLPQPPICTI--DVYM-VMVKCWMIDEDMRPTFKELYEEFK
Kinase AqueK384.AA Fer 713-992 29 7.8e-62 209.37 In-house 1-283 (283) Show / Hide 
Range on Protein: 713-992
Range on HMM: 1-283/283
Sequence Identity: 29% (89 aa)

IKILGCIGQGEFAKVYKG----HYYFNNQCTT--VAVKTLKGTMDKYSQEDMKELIFESLVMQD-LDHPNVMGLIGLCLDAGPSPLVVLPYMEGGNLLKH
...   .| | | .||||    . .   ....  ||||. |  ... . | .||.  |  .|.  .|||||  ..| | |  |  ..|. .. ||.|...
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPI-MIVMEFCNGGSLDSY

LVRNRESLLIDETTGEDEINQVRSQLLSISLQIGKGMQYIAEKKLIHRDLAARNCMID-GTGNIK--VADFGLSKNIIGDNVYYRQE-KANGVKLPIKWM
|  | .             .    ... ...|. .||.|. .|. ||||.||||| .. .  ..|  ..|||.|..  .. . |.   ||   |.||.|.
LKKNKNK------------TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKAC--KVPIRWL

AIESIEDGIFTEKTDIWSFGITVWEVFSGGKMPYGG----FSPFTV-----KTMLADGHKLEAPLNLASNDDIYQKIML-PCWERNPTKRPTFAQIVVEI
| |....||...|||.||||.. ||.|. |. ||.|    . . .|     |    .|. .  |.. .   .   .||.  ||...| .|||...|. ..
APETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMP---PEIMQIMMKQCWQKDPEDRPTMKEICQKL

E
.
K
Kinase AqueK384.AA TKL 719-991 20 2.8e-56 193.3 In-house 1-364 (364) Show / Hide 
Range on Protein: 719-991
Range on HMM: 1-364/364
Sequence Identity: 20% (78 aa)

IGQGEFAKVYKGHYYFNN------QCTTVAVKTLKGTM-----------------------DKYSQEDMKELIFESLVMQDLDHPNVMGLIGLCLDAGP-
||.| |..||||..  ..       ...||||..| .                        |. ..  ......| ..|  |.|||.  ..| |.. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------SPLVVLPYMEGGNLLKHLVRNRESLLIDETTGEDEINQVRSQLLSISLQIGKGMQYIAE--------KKLIHRDLAARNCMIDGTGN--
            .  |  |..||.|| .|                      .|.....|.| .||.|           ...|||||  .|...|  ..  
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNV

------------IKVADFGLSKNIIGDNVYYRQE--------------KANGVKLPIKWMAIESIEDG----------------IFTEKTDIWSFGITVW
            .|..|||||... ...   ...              . . .   . ||| | ...                  ..||.|..||||  |
SNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLW

EVFSGGKMPYGGFSPFTVK---------TMLAD-GHKLEAPLNLAS------NDDI---YQKIMLPCWERNPTKRPTFAQIVVEI
|.... . || .. .....          | .| |.... |    .      ..|.   . |.|  ||. .|.|||.| .|. ..
EILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase AqueK384.AA HMTK 837-990 39 1.2e-50 174.55 In-house 136-291 (291) Show / Hide 
Range on Protein: 837-990
Range on HMM: 136-291/291
Sequence Identity: 39% (62 aa)

QIGKGMQYIAEKKLIHRDLAARNCMIDGTGNIKVADFGLSKNIIGDNVYYRQEKANGVKLPIKWMAIESIE--DGIFTEKTDIWSFGITVWEVFSGGKMP
|. .||.|||.. ..|.|||||||..     .|.|||||.  .  .  |....|.  |||||||||.|     ..|| ||.|.|.||.|.||... | .|
QCASGMAYIASQRMVHMDLAARNCLVGHNNQVKIADFGLTRRLDPGQDYWHLRKHM-VKLPIKWMAPEAMDGKRKIFSEKSDVWAFGVTMWEIWMYGEQP

YG--GFSPFTVKTMLADGHKLEAPLNLASNDDIYQKIMLPCWERNPTKRPTFAQIVVE
|.  ..    |  .. .|  |. |   . .||...  |  ||.. | .||||||   .
YESQQIKNKEVQRHVREGRRLTQPPPDDCPDDFWD-LMCTCWHKDPHQRPTFAQLQKM
Kinase AqueK384.AA Pkinase 713-991 22 6.9e-35 124.44 Pfam 1-293 (293) Show / Hide 
Range on Protein: 713-991
Range on HMM: 1-293/293
Sequence Identity: 22% (72 aa)

IKILGCIGQGEFAKVYKGHYYFNNQCTTVAVKTLKGTMDKYSQEDMKELIFESLVMQDLDHPNVMGLIGLCLDAGPSPLVVLPYMEGG----NLLKHLVR
..|...||.| |..|||.|   ...  .||||..|   .| ...  . .. |  .|. |.|||.  |.. . | .... .|..|.|||     |  .. .
YHIGRKIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST

NRESLLIDETTGEDEINQ--VRSQLLSISLQIGKGMQYIAEKKLIHRDLAARNCMIDGTGNI----KVADFGLSKNIIGDNVYYRQEKANGVKLPIKWMA
            ... .      .. .. .|| .|..|. ... |||||   |..|| .|.|    |..||||.| .     | ... ....   . .||
------------WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMA

IESIE-DGIFTEKTDIWSFGITVWEVFSGGKMPYGGF------SPFTVKTMLADGHKLEAPLNLASND-----------------DIYQKIMLPCWERNP
 | |  .   . | |.||.|....|... |. |. |       ..  .  .  ..   .   .. |.                  .  ....  |....|
PEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDP

TKRPTFAQIVVE--I
.||||..||.    .
KKRPTAEQILQHPWF
Kinase AqueK384.AA S_TKc 713-994 21 4.6e-33 117.08 SMART 1-231 (231) Show / Hide 
Range on Protein: 713-994
Range on HMM: 1-231/231
Sequence Identity: 21% (62 aa)

IKILGCIGQGEFAKVYKGHYYFNNQCTTVAVKTLKGTMDKYSQEDMKELIFESLVMQDLDHPNVMGLIGLCLDAGPSPLVVLPYMEG--GNLLKHLVRNR
 .||  ||.| |.||||..         ||.| .|           . .. |  ...  .|||.  |.. . |   .  .|. |..|  |.|........
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRG

ESLL---IDETTGEDEINQVRSQLLSISLQIGKGMQYIAEKKLIHRDLAARNCMIDGTGNIKVADFGLSKNIIGDNVYYRQEKANGVKLPIKWMAIESIE
   |   ..| .             ..  || ....|. ... |||||   | ..|   .||..||||.. .            . .     .|| | . 
RHGLRFPFPE-H-----------ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL-

DGIFTE-KTDIWSFGITVWEVFSGGKMPYGGFSPFTVKTMLADGHKLEAPLNLASNDDIYQKIMLPCWERNPTKRPTFAQIVV-E-----IEVL
   ..  | |.||.|....| .. |. |.      ....|.               ..  . ..  |....|.||||  ..   |      . .
--GYGKCKCDWWSCGCILYEMLC-GYPPFP-----QMQMMFKKIG----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AqueK384.AA HMTK 713-802 32 8e-06 16.4 In-house 1-111 (291) Show / Hide 
Range on Protein: 713-802
Range on HMM: 1-111/291
Sequence Identity: 32% (37 aa)

IKILGCIGQGEFA-----------------KVYKG-HY-------YFNNQCTTVAVKTLKGTMDKYSQEDMKELIFESLVMQDLDHPNVMGLIGLCLDAG
.| .  ||.| |                  ||| . .        .  || ...|||.|.|     | ||  |   |. ||. |.|||.  |.| |.   
LKAIKVIGAGQFGMVQCLRLAPPDEGCTSLKVYLAEWSVKDGDGKDDSNQPHHRAVKMLRGDA---SHEDREEFLREAEVMCQLRHPNLVQLVGVCMQQR

PSPLVVLPYMEGGNL
|  |.|| ||. |.|
PW-LCVLEYMQYGDL