Gene AqueK392 (A.queenslandica)

AqueK392

Species: A.queenslandica
Alias: AqueK392
External Links:
Annotation:

Classification

Group: TK
Family: REF

Sequence

Name Sequence Type Origin Length Description Download
AqueK392.AA Protein None 196 None Fasta, JSON
AqueK392.kin_dom Protein Kinase Domain None 85 None Fasta, JSON

Protein domain

Protein domains of AqueK392.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AqueK392.AA Pkinase_Tyr 112-196 48 1.9e-44 151.16 Pfam 125-209 (270) Show / Hide 
Range on Protein: 112-196
Range on HMM: 125-209/270
Sequence Identity: 48% (42 aa)

EYLSSIGIIHRDLACRNVLIDADKNLRISDFGMSRKVGGADEAY-VKKTRGRLPWKWMAIESLTEREFSFKSDVWSYGVTLWEIVT
|||.|...||||||.||.|.. ..  .|.|||..| .   |. | .|.. |.|| |||| |.. ...|. ||||||.||..|||.|
EYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDI-YNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFT
Kinase AqueK392.AA TK 112-196 30 3.7e-43 142.05 In-house 248-389 (486) Show / Hide 
Range on Protein: 112-196
Range on HMM: 248-389/486
Sequence Identity: 30% (43 aa)

EYLSSI------GIIHRDLACRNVLIDADKN-----------LRISDFGMSR-------KVGGADEAYVKKT------------------------RGRL
|||.|       ...|||||.||.|.. ...            .|.|||.||       .  . |. |..|.                        .|.|
EYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKL

PWKWMAIESLTERE---------FSFKSDVWSYGVTLWEIVT
| .||| |.|..|.         |. ||||||.||..|||.|
PIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase AqueK392.AA UTK 112-196 40 9.6e-41 137.11 In-house 132-235 (296) Show / Hide 
Range on Protein: 112-196
Range on HMM: 132-235/296
Sequence Identity: 40% (42 aa)

EYLSSIGIIHRDLACRNVLIDAD-------KNLRISDFG---MSRKVGG--------ADEAYVKKTRGRLPWKWMAIESLTER-EFSFKSDVWSYGVTLW
.||.| |..|||||.||.|....          .|.|||   ||| |..         .. | .  ..|.|..||| |.||..  |..||||||.||..|
QYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCW

EIVT
||.|
EIWT
Kinase AqueK392.AA FGFR 112-196 56 1.8e-36 121.76 In-house 150-233 (293) Show / Hide 
Range on Protein: 112-196
Range on HMM: 150-233/293
Sequence Identity: 56% (48 aa)

EYLSSIGIIHRDLACRNVLIDADKNLRISDFGMSRKVGGADEAYVKKTRGRLPWKWMAIESLTEREFSFKSDVWSYGVTLWEIVT
||| |  .|||||| ||||.  |  . |.||| .| .   |  | |.| |||| |||| |.| .| .  .|||||||| |||| |
EYLASRKCIHRDLAARNVLVTDDYVMKICDFGLARDIHCID-YYRKTTNGRLPIKWMAPEALFDRVYTHQSDVWSYGVLLWEIMT
Kinase AqueK392.AA TK-Unique 112-196 48 7.1e-35 117.74 In-house 145-234 (294) Show / Hide 
Range on Protein: 112-196
Range on HMM: 145-234/294
Sequence Identity: 48% (44 aa)

EYLSS--IGIIHRDLACRNVLIDADKNLRISDFGMSRKVGGADEAYVKK-TRGRLPWKWMAIESLT--EREF-SFKSDVWSYGVTLWEIVT
|||.|   .|.||||. ||||.  ||.. |.||||.|.|   ...|... ..||.| .||| |||   .. . . ||||||.||..|||.|
EYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT-NGVYSMMCSQGRIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase AqueK392.AA Ret 113-196 54 1.5e-34 115.41 In-house 150-232 (293) Show / Hide 
Range on Protein: 113-196
Range on HMM: 150-232/293
Sequence Identity: 54% (46 aa)

YLSSIGIIHRDLACRNVLIDADKNLRISDFGMSRKVGGADEAYVKKTRGRLPWKWMAIESLTEREFSFKSDVWSYGVTLWEIVT
|||.. ..||||| ||||.   . . ||||| .| |   | .|||. ..|.| ||||||||    .  ||||||.|| .|||||
YLSEMKLVHRDLAARNVLVAEGRICKISDFGLTRDVYEDD-SYVKRSKDRIPVKWMAIESLYDHVYTTKSDVWSFGVLCWEIVT
Kinase AqueK392.AA VEGFR 112-194 51 1.8e-34 120.85 In-house 187-270 (332) Show / Hide 
Range on Protein: 112-194
Range on HMM: 187-270/332
Sequence Identity: 51% (43 aa)

EYLSSIGIIHRDLACRNVLIDADKNLRISDFGMSRKVGGADEAYVKKTR-GRLPWKWMAIESLTEREFSFKSDVWSYGVTLWEI
|.|.|  .|||||| ||.|.. .. . |.||| .|     |  ||.|.. |||| ||||.||. .. .. .|||||||| ||||
EFLASRKCIHRDLAARNILLCENNVVKICDFGLARHGIYKDPDYVRKGDQGRLPIKWMAPESIFDKVYTTYSDVWSYGVFLWEI
Kinase AqueK392.AA Fer 112-194 44 2.5e-34 114.4 In-house 125-211 (283) Show / Hide 
Range on Protein: 112-194
Range on HMM: 125-211/283
Sequence Identity: 44% (39 aa)

EYLSSIGIIHRDLACRNVLIDADKNLR---ISDFGMSRKVGGADEAYVKK-TRGRLPWKWMAIESLTEREFSFKSDVWSYGVTLWEI
||| | ..||||.| ||.|...||.     ||||||||.  .  ..| .| .  ..| .|.| |... ...|.|.||||.||..|||
EYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTDVWSFGVMCWEI
Kinase AqueK392.AA Ack 113-193 44 5.7e-34 111.98 In-house 120-203 (266) Show / Hide 
Range on Protein: 113-193
Range on HMM: 120-203/266
Sequence Identity: 44% (37 aa)

YLSSIGIIHRDLACRNVLIDAD-KNLRISDFGMSRKVGGADEAYVKKTRG--RLPWKWMAIESLTEREFSFKSDVWSYGVTLWE
|| . ..||||||.||.|  .| .   |.||| .|  |...  |. . .    .|  |.| |.|. | || .||||..||||||
YLEMKRCIHRDLAARNILLFSDDRKVKICDFGLMRALGQNEDYYRMEFHRNLKVPFAWCAPECLRHRQFSHASDVWMFGVTLWE
Kinase AqueK392.AA RTKB 113-194 49 4.8e-32 105.32 In-house 124-203 (264) Show / Hide 
Range on Protein: 113-194
Range on HMM: 124-203/264
Sequence Identity: 49% (41 aa)

YLSSIGIIHRDLACRNVLIDADKNLRISDFGMSRKVGGADEAYVKKTRGRLPWKWMAIESLTEREFSFKS-DVWSYGVTLWEI
.|.. ..|||||. ||||.| .   .|.||||.|..   |.  ...|  ||| ||||.||. .| .. || ||||.||| |||
FLHQHNVIHRDLCARNVLVDQQLHCKICDFGMAREI---DHECYETTCTRLPIKWMAPESWAHRIYTTKSGDVWSFGVTMWEI
Kinase AqueK392.AA Src 112-196 43 1.2e-31 104.78 In-house 111-195 (255) Show / Hide 
Range on Protein: 112-196
Range on HMM: 111-195/255
Sequence Identity: 43% (37 aa)

EYLSSIGIIHRDLACRNVLIDADKNLRISDFGMSRKVGGADEAYVKKTRGRLPWKWMAIESLTEREFSFKSDVWSYGVTLWEIVT
.||.|  .|||||| ||||.. .    . |||  | .   |. |. ..  ..|.||.| | .... |. ||||||.|. |.||||
AYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEIVT
Kinase AqueK392.AA TyrKc 1-195 22 1.5e-14 12.72 SMART 1-280 (280) Show / Hide 
Range on Protein: 1-195
Range on HMM: 1-280/280
Sequence Identity: 22% (70 aa)

IILESQLSEGAFGTVHKGYICGPASIPVAVKMNKS**G*SRSTERDRADEANKRREP------------------------PPHC*HDRLCHHTGA-DTA
| |. .| |||||.|.||       |.||||| |.        ..|  .||.  ..                         .|..    .. | |. .  
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDLKDY

LHDNH*TRRSIEIPKTLCMPLPLPSLSFSLSLLLS--------*EYLSSIGIIHRDLACRNVLIDADKNLRISDFGMSRKVGGA------DEAYVKKT--
|.... .                    .... |||         |||.| ..||||||.||.|.....  .|||||.||...        .. |.||.  
LRKHRPK--------------------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHK

RGR--LPWKWMAIESLTEREFSFKSDVWSYGVTLWEI---------------------------------------------------------------
 |.  || .|||.|.. ...|..||||||.||..|||                                                               
GGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPED

----------V
           
RPTFSEIHECF
Kinase AqueK392.AA TK 1-55 22 5.7e-09 25.4 In-house 1-96 (486) Show / Hide 
Range on Protein: 1-55
Range on HMM: 1-96/486
Sequence Identity: 22% (22 aa)

IILESQLSEGAFG---TVHKGYICGPAS------------------------IPVAVKMNKS**G*SRSTERD--------------RADEANKRR
|.|. .| ||.||   .|.||   |.                          .|||||| |.  . |   ..|               | |. . .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMC
Kinase AqueK392.AA Pkinase 112-196 34 7.7e-09 32.33 Pfam 122-207 (293) Show / Hide 
Range on Protein: 112-196
Range on HMM: 122-207/293
Sequence Identity: 34% (31 aa)

EYLSSIGIIHRDLACRNVLIDADKNL----RISDFGMSRKVGGADEAYVKKTRGRLPWKWMAIESLT-EREFSFKSDVWSYGVTLWEIVT
||. | |||||||   |.||| . ..    .|.||| ....         .|.   || .|| | .   .. . |.|.||.|..|.| ..
EYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPW-YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC
Kinase AqueK392.AA Fer 1-35 31 5.6e-07 19.93 In-house 1-44 (283) Show / Hide 
Range on Protein: 1-35
Range on HMM: 1-44/283
Sequence Identity: 31% (14 aa)

IILESQLSEGAFGTVHKG------YI---CGPASIPVAVKMNKS
..|. .| |||||.|.||      .    . . ...|.||..|.
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKC
Kinase AqueK392.AA TK-Unique 1-34 35 1e-06 19.21 In-house 1-39 (294) Show / Hide 
Range on Protein: 1-34
Range on HMM: 1-39/294
Sequence Identity: 35% (14 aa)

IILESQLSEGAFGTVHKGYICG-----PASIPVAVKMNK
. ..... |||||.|..| ..|      . . |||||.|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLK
Kinase AqueK392.AA S_TKc 1-196 16 2.5e-05 -98.84 SMART 1-220 (231) Show / Hide 
Range on Protein: 1-196
Range on HMM: 1-220/231
Sequence Identity: 16% (43 aa)

IILESQLSEGAFGTVHKGYICGPASIPVAVKMNKS**G*SRSTERDRADEANKRREPPPHC*HDRLCHHTGADTALHDNH*TRRSIEIPKTLCMPLPLPS
  .  .. .||||.|.|..  .     ||.|. |                         |    . ...      .   . . ..    . |.| . . .
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------------------------EHIRREIQILKK-HHPNIVKLYDVFQD----DHLYMVMEYCD

L--------------------------SFSLSLLLS*EYLSSIGIIHRDLACRNVLIDADKNLRISDFGMSRKVGGADEAYVKKTRGRLPWKWMAIESLT
                           ..   ...  ||. | |||||||   |.|.|   .. |.|||..|..          |       .|| | | 
GDLGDLFDYIKKRGRHGLRFPFPEHARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL-

EREFSF-KSDVWSYGVTLWE------------------------------------------IVT
   ... |.|.|| |..|.|                                          . .
--GYGKCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQ
Kinase AqueK392.AA Pkinase_Tyr 1-32 48 4e-05 17.97 Pfam 1-35 (270) Show / Hide 
Range on Protein: 1-32
Range on HMM: 1-35/270
Sequence Identity: 48% (17 aa)

IILESQLSEGAFGTVHKGYIC---GPASIPVAVKM
|..  .| |||||.|.||.     .   |||||||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKM
Kinase AqueK392.AA RTKB 1-21 33 0.001153 8.25 In-house 1-21 (264) Show / Hide 
Range on Protein: 1-21
Range on HMM: 1-21/264
Sequence Identity: 33% (7 aa)

IILESQLSEGAFGTVHKGYIC
. |  .| .|||| | .....
VWLGEKLGNGAFGEVFQAWVR
Kinase AqueK392.AA UTK 1-18 55 0.001196 8.36 In-house 1-18 (296) Show / Hide 
Range on Protein: 1-18
Range on HMM: 1-18/296
Sequence Identity: 55% (10 aa)

IILESQLSEGAFGTVHKG
..|  || .||||.|||.
VQLGRQLGQGAFGEVHKA
Kinase AqueK392.AA Src 1-31 45 0.004354 6.28 In-house 1-29 (255) Show / Hide 
Range on Protein: 1-31
Range on HMM: 1-29/255
Sequence Identity: 45% (14 aa)

IILESQLSEGAFGTVHKGYICGPASIPVAVK
| |. .| .| || | .||  |  ...||||
IKLCRKLGQGQFGEVWMGYWNG--NTKVAVK
Kinase AqueK392.AA Ack 1-31 42 0.015285 4.4 In-house 1-33 (266) Show / Hide 
Range on Protein: 1-31
Range on HMM: 1-33/266
Sequence Identity: 42% (14 aa)

IILESQLSEGAFGTVHKGY--ICGPASIPVAVK
| |  .| .| || |..|     |  .|.||||
ITLCEKLGDGCFGVVWRGEWTNPGGKHIQVAVK
Kinase AqueK392.AA FGFR 1-35 34 0.022339 3.85 In-house 1-41 (293) Show / Hide 
Range on Protein: 1-35
Range on HMM: 1-41/293
Sequence Identity: 34% (14 aa)

IILESQLSEGAFGTVHKGYIC--GPA----SIPVAVKMNKS
  | . | ||.|| | ..      ..     | ||||| |.
LTLGKMLGEGCFGQVWMAEAKGIDCDRPEKEITVAVKMLKM
Kinase AqueK392.AA Ret 1-18 44 0.103315 1.57 In-house 1-18 (293) Show / Hide 
Range on Protein: 1-18
Range on HMM: 1-18/293
Sequence Identity: 44% (8 aa)

IILESQLSEGAFGTVHKG
 .|.  | || || | |.
LQLDDTLGEGHFGQVVKA
Kinase AqueK392.AA VEGFR 1-18 44 0.260087 0.95 In-house 1-18 (332) Show / Hide 
Range on Protein: 1-18
Range on HMM: 1-18/332
Sequence Identity: 44% (8 aa)

IILESQLSEGAFGTVHKG
. |  .| .|||| ||..
LKLGKMLGRGAFGQVHEA
Kinase AqueK392.AA Pkinase 1-31 30 3.726571 1.63 Pfam 1-30 (293) Show / Hide 
Range on Protein: 1-31
Range on HMM: 1-30/293
Sequence Identity: 30% (10 aa)

IILESQLSEGAFGTVHKGYICGPASIP--VAVK
. ..... .|.||.|   |.|   . .  ||||
YHIGRKIGSGSFGCV---YKCHHKGTGKIVAVK